Attenuation of atherosclerosis in a modified strain of hypercholesterolemic Watanabe rabbits with use of a probucol analogue (MDL 29,311) that does not lower serum cholesterol.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Arteriosclerosis and Thrombosis A Journal of Vascular Biology

• Publication date

  1991-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1161/01.ATV.11.5.1266PMID 1911712
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Probucol does not affect lipoprotein metabolism in macrophages of Watanabe heritable hyperlipidemic rabbits

  1991cited by this paper
• Antioxidant activity of probucol and its analogues in hypercholesterolemic Watanabe rabbits.

  1991cited by this paper
• Ex vivo lipopolysaccharide‐induced interleukiri‐1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with antioxidant properties

  1990cited by this paper
• Probucol does not alter acetylated low density lipoprotein uptake by murine peritoneal macrophages.

  1990cited by this paper
• Effect of probucol on the physical properties of low-density lipoproteins oxidized by copper.

  1989cited by this paper
• Probucol attenuates the development of aortic atherosclerosis in cholesterol‐fed rabbits

  1989cited by this paper
• Concentration-dependent antioxidant activity of probucol in low density lipoproteins in vitro: probucol degradation precedes lipoprotein oxidation.

  1989cited by this paper
• Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

  1989cited by this paper
• Probucol. A reappraisal of its pharmacological properties and therapeutic use in hypercholesterolaemia.

  1989cited by this paper
• A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein.

  1989cited by this paper
• Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.

  1989cited by this paper
• Probucol

  1989cited by this paper
• Probucol does not affect lipoprotein metabolism in macrophages of Watanabe heritable hyperlipidemic rabbits.

  1989cited by this paper
• A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

  1989cited by this paper
• Low density lipoprotein undergoes oxidative modification in vivo.

  1989cited by this paper
• Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits.

  1988cited by this paper
• Probucol enhances cholesterol efflux from cultured human skin fibroblasts.

  1988cited by this paper
• Free Radicals and Antioxidant Protection: Mechanisms and Significance in Toxicology and Disease

  1988cited by this paper
• Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plasma.

  1988cited by this paper
• Enhanced Macrophage Uptake of Low Density Lipoprotein after Self‐Aggregation

  1988cited by this paper
• Changes in high-density lipoprotein subfraction distribution and increased cholesteryl ester transfer after probucol.

  1988cited by this paper
• Inhibition by probucol of interleukin 1 secretion and its implication in atherosclerosis.

  1988cited by this paper
• Antioxidant defenses and lipid peroxidation in human blood plasma.

  1988cited by this paper
• Biochemical and pathological features of a modified strain of Watanabe heritable hyperlipidaemic rabbits.

  1988influential reference
• Probucol, high-density lipoprotein metabolism and reverse cholesterol transport.

  1988cited by this paper
• Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

  1987cited by this paper
• Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

  1987cited by this paper
• Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

  1987cited by this paper
• Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products.

  1987cited by this paper
• Superoxide initiates oxidation of low density lipoprotein by human monocytes.

  1987cited by this paper
• Fatty streak expansion and maturation in Watanabe Heritable Hyperlipemic and comparably hypercholesterolemic fat-fed rabbits.

  1987cited by this paper
• Antioxidant activity of albumin-bound bilirubin.

  1987cited by this paper
• Detection of lipid hydroperoxides and hydrogen peroxide at picomole levels by an HPLC and isoluminol chemiluminescence assay.

  1987cited by this paper
• Fatty streak initiation in Watanabe Heritable Hyperlipemic and comparably hypercholesterolemic fat-fed rabbits.

  1987cited by this paper
• Oxidation of low-density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptor.

  1987cited by this paper
• Effects of probucol on xanthomata regression in familial hypercholesterolemia.

  1986cited by this paper
• Comparison of gas chromatography and high-performance liquid chromatography for the analysis of probucol in plasma.

  1986cited by this paper
• Macrophage Oxidation of Low Density Lipoprotein Generates a Modified Form Recognized by the Scavenger Receptor

  1986cited by this paper
• Quantification and immunolocalization of apolipoprotein E in experimental atherosclerosis.

  1986cited by this paper
• Probucol inhibits oxidative modification of low density lipoprotein.

  1986cited by this paper
• Role of endothelial cells and their products in the modification of low-density lipoproteins.

  1986cited by this paper
• The pathogenesis of atherosclerosis--an update.

  1986cited by this paper
• Foam Cell Characteristics in Coronary Arteries and Aortas of White Carneau Pigeons with Moderate Hypercholesterolemia a

  1985cited by this paper
• The importance of free radicals and catalytic metal ions in human diseases.

  1985cited by this paper
• The hypolipidemic action of probucol. Drug transport and lipoprotein composition in type IIa hyperlipoproteinemia.

  1985cited by this paper
• Endothelial and Smooth Muscle Cells Alter Low Density Lipoprotein In Vitro by Free Radical Oxidation

  1984cited by this paper
• Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.

  1984cited by this paper
• Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

  1984cited by this paper
• Monoclonal antibodies to human plasma low-density lipoproteins. I. Enhanced binding of 125I-labeled low-density lipoproteins by combined use of two monoclonal antibodies.

  1983cited by this paper
• Apolipoprotein A-I as a marker of angiographically assessed coronary-artery disease.

  1983cited by this paper
• ASSAY FOR SERUM LIPID PEROXIDE LEVEL AND ITS CLINICAL SIGNIFICANCE

  1982cited by this paper
• The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.

  1981cited by this paper
• Standardization of immunoassays for the quantitation of plasma Apo B protein.

  1981cited by this paper
• Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

  1981cited by this paper
• The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.

  1981cited by this paper
• Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages.

  1980cited by this paper
• Arterial foam cells with distinctive immunomorphologic and histochemical features of macrophages.

  1980cited by this paper
• Altered metabolism (in vivo and in vitro) of plasma lipoproteins after selective chemical modification of lysine residues of the apoproteins.

  1979cited by this paper
• Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. IV. Investigation of macrophage-like properties of aortic cell populations.

  1979cited by this paper
• LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture.

  1979cited by this paper
• Synthesis and hypocholesterolemic activity of alkylidenedithio bisphenols.

  1970cited by this paper
• Hypocholesterolemic effect of 4,4'-(isopropylidenedithio)-bis(2,6-di-t-butylphenol) (probucol).

  1970cited by this paper
• The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.

  1955cited by this paper

• Cholesteryl ester transfer protein: An enigmatic pharmacology - Antagonists and agonists.

  2018cites this paper
• Fatty Acid Composition and Vitamin E Content of Experimental Diets Component Study Diet Oleic Linoleic Oleic

  2017cites this paper
• Pharmacokinetics and tolerability of probucol after multiple oral administrations in healthy volunteers.

  2011cites this paper
• regions adjacent to prosthetic grafts in cholesterol-fed rabbits Probucol reduces the cellularity of aortic intimal thickening at anastomotic

  2011cites this paper
• The Response-to-Retention Hypothesis of Early Atherogenesis

  2010cites this paper
• Cloning and expression of human haptoglobin subunits in Escherichia coli: delineation of a major antioxidant domain.

  2007cites this paper
• Antioxidant Nature of Bovine Milk β-Lactoglobulin

  2007cites this paper
• Antioxidant nature of bovine milk beta-lactoglobulin.

  2007cites this paper
• The antiatherogenic effect of DiNAC: experimental findings supporting immunomodulation as a new treatment for atherosclerosis related diseases.

  2006cites this paper
• Oxidized LDL and Antioxidants in Atherosclerosis

  2006cites this paper
• Anti-inflammatory effects of different drugs/agents with antioxidant property on endothelial expression of adhesion molecules.

  2006cites this paper
• New trends in anti-atherosclerotic agents.

  2005cites this paper
• Inhibition of lipoprotein lipid oxidation.

  2005cites this paper
• Potential Targets for Stabilization and Regression

  2005cites this paper
• Oxidation, lipoproteins, and atherosclerosis: which is wrong, the antioxidants or the theory?

  2005cites this paper
• Antioxidant role of human haptoglobin

  2004cites this paper
• Probucol inhibits not only the progression of atherosclerotic disease, but causes a different composition of atherosclerotic lesions in WHHL-rabbits

  2004cites this paper
• Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs

  2004cites this paper
• Effects of α-tocopherol and astaxanthin on LDL oxidation and atherosclerosis in WHHL rabbits

  2004cites this paper
• Effects of alpha-tocopherol and astaxanthin on LDL oxidation and atherosclerosis in WHHL rabbits.

  2004cites this paper
• [Antioxidants in complex therapy of atherosclerosis: pro et contra].

  2004cites this paper
• Role of oxidative modifications in atherosclerosis.

  2004cites this paper
• Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants.

  2003cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2001cites this paper
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  2001cites this paper
• The smooth muscle cell membrane during atherogenesis: a potential target for amlodipine in atheroprotection.

  2001cites this paper
• The smooth muscle cell membrane during atherogenesis: A potential target for amlodipine in

  2001cites this paper
• Lipid peroxidation in mouse models of atherosclerosis.

  2001cites this paper
• The Oxidative Modification Hypothesis of Atherogenesis

  2000cites this paper
• Atherosclerosis: from lesion formation to plaque activation and endothelial dysfunction.

  2000cites this paper
• Antioxidants and Atherosclerosis: Animal Studies

  2000cites this paper
• Antioxidants and vascular disease: animal studies.

  2000cites this paper
• Inhibitory effect of Chinese green tea on endothelial cell-induced LDL oxidation.

  2000cites this paper
• Antioxidants and Cardiovascular Disease

  2000cites this paper
• Dissociation of atherogenesis from aortic accumulation of lipid hydro(pero)xides in Watanabe heritable hyperlipidemic rabbits.

  1999cites this paper
• The effects of estrogens and phytoestrogens on the metabolism and oxidation of plasma lipoproteins / Alice Jane Owen.

  1999cites this paper
• Antioxidant probucol as an effective scavenger of lipid radicals in low density lipoproteinsin vivo andin vitro

  1999cites this paper
• Dietary and pharmacological antioxidants in atherosclerosis.

  1999cites this paper
• Antioxidants and atherogenesis

  1998cites this paper
• Vessel size, antioxidants, and restenosis: never too small, not too little, but often too late.

  1998cites this paper
• LDL oxidation: therapeutic perspectives.

  1998cites this paper
• Effect of antioxidant in endothelial cells exposed to oxidized low-density lipoproteins.

  1998cites this paper
• Probucol treatment attenuates the aortic atherosclerosis in Watanabe heritable hyperlipidemic rabbits.

  1998cites this paper
• The mechanism of apolipoprotein B-100 thiol depletion during oxidative modification of low-density lipoprotein.

  1997cites this paper
• Lewis A. Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis.

  1997cites this paper
• Long-term probucol treatment reverses the severity of myocardial injury in watanabe heritable hyperlipidemic rabbits.

  1997cites this paper
• Extent of antioxidant protection of plasma LDL is not a predictor of the antiatherogenic effect of antioxidants.

  1997cites this paper
• Intramural coronary artery disease in swine with naturally occurring hypertrophic cardiomyopathy.

  1997cites this paper
• 5 – Antioxidants in Biology

  1997cites this paper
• 6 – Antioxidants in Disease and Oxidative Stress

  1997cites this paper
• [The antioxidant probucol as a regulator of the intensity of free-radical lipid peroxidation processes in the blood of patients with coronary atherosclerosis].

  1997cites this paper
• Advances in the development of pharmaceutical antioxidants

  1996cites this paper
• Autoantibody titers to oxidized low-density lipoprotein in patients with coronary atherosclerosis.

  1996cites this paper
• Cosupplementation with coenzyme Q prevents the prooxidant effect of alpha-tocopherol and increases the resistance of LDL to transition metal-dependent oxidation initiation.

  1996cites this paper
• The role of oxidized lipoproteins in atherogenesis.

  1996cites this paper
• Reproductive performance and changes in blood lipids in breeding females and in growing Watanabe Heritable Hyperlipidaemic and New Zealand White rabbits

  1996cites this paper
• Oxidized low density lipoproteins in atherogenesis: role of dietary modification.

  1996cites this paper
• Probucol suppresses oxidant stress in hypertensive arteries. Immunohistochemical evidence.

  1996cites this paper
• Review of progress in sterol oxidations: 1987–1995

  1996cites this paper
• Probucol reduces hepatic cholesterol secretion in hyperlipidemic Yoshida rats.

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• 3-Hydroxyanthranilic Acid Is an Efficient, Cell-derived Co-antioxidant for α-Tocopherol, Inhibiting Human Low Density Lipoprotein and Plasma Lipid Peroxidation*

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• Ten-year retrospective on the antioxidant hypothesis of arteriosclerosis: Threshold plasma levels of antioxidant micronutrients related to minimum cardiovascular risk

  1995cites this paper
• The importance of vitamin E in reducing cardiovascular risk.

  1995cites this paper
• New Approaches to the Prevention of Atherosclerosis

  1995cites this paper
• Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation.

  1995cites this paper
• Lipoprotein oxidation as a mediator of atherogenesis: insights from pharmacological studies.

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• The response-to-retention hypothesis of early atherogenesis.

  1995cites this paper
• Inhibition of the Oxidative Modification of LDL by Nitecapone

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  1995cites this paper
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  1995cites this paper
• Beta-carotene inhibits atherosclerosis in hypercholesterolemic rabbits.

  1995cites this paper
• Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action.

  1995cites this paper
• Effect of dietary antioxidants on the susceptibility to hepatic microsomal lipid peroxidation in the rat.

  1995cites this paper
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  1995cites this paper
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  1995cites this paper
• Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis

  1995cites this paper
• Susceptibility of human LDL to oxidative modification. Effects of variations in beta-carotene concentration and oxygen tension.

  1994cites this paper
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  1994cites this paper
• Multiple mechanisms for inhibition of low density lipoprotein oxidation by novel cyclic nitrone spin traps.

  1994cites this paper
• Oxidation-induced aggregation of rabbit low-density lipoprotein by azo initiator.

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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
• Oxidation, Lipoxygenase, and Atherogenesis

  1994cites this paper
• Probucol reduces the cellularity of aortic intimal thickening at anastomotic regions adjacent to prosthetic grafts in cholesterol-fed rabbits.

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• MDL 29311, An Analog of Probucol with Unique Lipid-Modulating Activity

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• 12 – Antioxidants as Antiatherogens: Animal Studies

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• Nitrone spin trap lipophilicity as a determinant for inhibition of low density lipoprotein oxidation and activation of interleukin-1 beta release from human monocytes.

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