Emotion processing and theory of mind in schizophrenia patients and their unaffected first-degree relatives.

Previous studies have suggested that social cognition is affected in individuals with schizophrenia. The purpose of this study was to explore to what extent social cognition deficits are shared by unaffected first-degree relatives, and the nature of the relationship between performance in different paradigms of social cognition. 20 Schizophrenia patients (7 females, 31+/-10 years), 20 healthy age- and gender-matched individuals, 20 unaffected first-degree relatives of the schizophrenia patients (11 females, 50+/-20 years), and 20 healthy individuals matched for age and gender were recruited. Patients showed deficits in the detection of social Faux Pas (0.80+/-0.17 vs. controls: 0.94+/-0.09, p=0.025) and the correct identification of Theory of Mind stories (0.71+/-0.13 vs. controls: 0.82+/-0.12, p=0.038). Relatives performed poorly in the Faces Test (0.83+/-0.14 vs. controls: 0.9+/-0.08, p=0.048), the Reading the Mind in the Eyes Test (0.59+/-0.17 vs. controls: 0.71+/-0.14, p=0.046) and the detection of social Faux Pas (0.8+/-0.2 vs. controls: 0.93+/-0.09, p=0.024). Abnormalities were independent of age, years of education, and general cognitive performance in patients and their relatives. Performance in an Emotion Processing task (Faces Test) was correlated with performance in theory of mind tests in healthy individuals and relatives of patients with schizophrenia only. These results suggest that schizophrenia patients and their unaffected first-degree relatives display similar but nonidentical patterns of social cognition processing.

• Publication year

  2010

• Venue

  Neuropsychologia

• Publication date

  2010-04-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.neuropsychologia.2009.12.019PMID 20026084
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Facial emotion processing in schizophrenia: a non-specific neuropsychological deficit?

  2009cited by this paper
• Enhanced ‘Reading the Mind in the Eyes’ in borderline personality disorder compared to healthy controls

  2009cited by this paper
• Emotion processing in persons at risk for schizophrenia.

  2008cited by this paper
• Brain imaging, genetics and emotion.

  2008cited by this paper
• A genome screen for quantitative trait loci influencing schizophrenia and neurocognitive phenotypes.

  2008cited by this paper
• The social-emotional processing stream: five core constructs and their translational potential for schizophrenia and beyond.

  2008cited by this paper
• Mental state attribution, neurocognitive functioning, and psychopathology: what predicts poor social competence in schizophrenia best?

  2007cited by this paper
• Social Cognition in Schizophrenia: An Overview

  2007cited by this paper
• Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia.

  2007cited by this paper
• Neurocognitive allied phenotypes for schizophrenia and bipolar disorder.

  2007cited by this paper
• A visual joke fMRI investigation into Theory of Mind and enhanced risk of schizophrenia

  2006cited by this paper
• Social Cognitive Impairments.

  2006cited by this paper
• Social functioning, theory of mind and neurocognition in outpatients with schizophrenia; mental state decoding may be a better predictor of social functioning than mental state reasoning.

  2006cited by this paper
• Self-face recognition and theory of mind in patients with schizophrenia and first-degree relatives.

  2006cited by this paper
• Theory of mind.

  2005cited by this paper
• Emotion recognition, 'theory of mind,' and social behavior in schizophrenia.

  2005cited by this paper
• Theory of mind and motion perception in schizophrenia.

  2005cited by this paper
• Evidence for sensory prediction deficits in schizophrenia.

  2005cited by this paper
• Social cognition in schizophrenia: recommendations from the measurement and treatment research to improve cognition in schizophrenia new approaches conference.

  2005cited by this paper
• Poor premorbid social functioning and theory of mind deficit in schizophrenia: evidence of reduced context processing?

  2005cited by this paper
• Understanding other minds: linking developmental psychology and functional neuroimaging.

  2004cited by this paper
• Do the siblings of schizophrenia patients demonstrate affect perception deficits?

  2004cited by this paper
• Do people with schizophrenia display theory of mind deficits in clinical interactions?

  2004cited by this paper
• Theory of mind and the role of IQ in chronic disorganized schizophrenia.

  2003cited by this paper
• Verbal Declarative Memory Dysfunction in Schizophrenia: From Clinical Assessment to Genetics and Brain Mechanisms

  2003cited by this paper
• The endophenotype concept in psychiatry: etymology and strategic intentions.

  2003cited by this paper
• Reasoning about physical causality and other's intentions in schizophrenia

  2003cited by this paper
• Implications for the neural basis of social cognition for the study of schizophrenia.

  2003cited by this paper
• Alterations in theory of mind in patients with schizophrenia and non‐psychotic relatives

  2003cited by this paper
• Cognitive neuroscience: Cognitive neuroscience of human social behaviour

  2003cited by this paper
• Dementia praecox and paraphrenia

  2002cited by this paper
• Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications.

  2002cited by this paper
• Social cognition and schizophrenia.

  2001cited by this paper
• The "Reading the Mind in the Eyes" Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism.

  2001cited by this paper
• Theory of mind and schizophrenia.

  2001cited by this paper
• Acquired mind-blindness following frontal lobe surgery? A single case study of impaired 'theory of mind' in a patient treated with stereotactic anterior capsulotomy.

  2001cited by this paper
• The FAB: A frontal assessment battery at bedside

  2000cited by this paper
• Impaired eye expression recognition in schizophrenia.

  2000cited by this paper
• Explaining the symptoms of schizophrenia: abnormalities in the awareness of action.

  2000cited by this paper
• A brief cognitive test battery to differentiate Alzheimer's disease and frontotemporal dementia

  2000cited by this paper
• Acquired 'theory of mind' impairments following stroke.

  1999cited by this paper
• Interacting minds--a biological basis.

  1999cited by this paper
• Social Cognition: Making Sense of People

  1999cited by this paper
• Attribution of mental States to others by schizophrenic patients.

  1997cited by this paper
• Is There a "Language of the Eyes"? Evidence from Normal Adults, and Adults with Autism or Asperger Syndrome

  1997cited by this paper
• A PET study of voluntary movement in schizophrenic patients experiencing passivity phenomena (delusions of alien control).

  1997cited by this paper
• Assessment of the dysexecutive syndrome in schizophrenia

  1997cited by this paper
• A critical review of genetic studies of schizophrenia. I. Epidemiological and brain studies

  1997cited by this paper
• Childhood adversity and adult psychiatric disorder in the US National Comorbidity Survey

  1997cited by this paper
• Machiavellian Intelligence II: Social intelligence and success: Don't be too clever in order to be smart

  1997cited by this paper
• Machiavellian intelligence II : extensions and evaluations

  1997cited by this paper
• Social cognition in schizophrenia.

  1997cited by this paper
• Cortical Systems for the Recognition of Emotion in Facial Expressions

  1996cited by this paper
• Handbook of Social Cognition

  1993cited by this paper
• The Cognitive Neuropsychology of Schizophrenia

  1992influential reference
• Psychiatry and the Holocaust

  1992cited by this paper
• The Composite International Diagnostic Interview. An epidemiologic Instrument suitable for use in conjunction with different diagnostic systems and in different cultures.

  1988cited by this paper
• The positive and negative syndrome scale (PANSS) for schizophrenia.

  1987cited by this paper
• Clinical genetics as clues to the "real" genetics of schizophrenia (a decade of modest gains while playing for time).

  1987cited by this paper
• The sovereignty of social cognition.

  1984cited by this paper
• Does the chimpanzee have a theory of mind?

  1978cited by this paper
• “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician

  1975cited by this paper
• Impairment in facial recognition in patients with cerebral disease.

  1968cited by this paper
• CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE The Biological Basis of Social Interaction

  year unknowncited by this paper

• The relationship between mental state decoding and real-world social functioning – An experience sampling investigation

  2026cites this paper
• A multi-site psychometric evaluation of the Reading the Mind in the Eyes Test – Revised

  2026cites this paper
• Social cognition and metacognition in family relatives of schizophrenia patients: comparing those with and without a current clinical high-risk state for psychosis

  2025cites this paper
• The 7 Muses of Neuro-Creative Cycle: How some patients with Parkinson's disease can unleash latent creativity

  2025cites this paper
• GPT-4o reads the mind in the eyes

  2024cites this paper
• Meta-analysis of Face Perception in Schizophrenia Spectrum Disorders: Evidence for Differential Impairment in Emotion Face Perception

  2024cites this paper
• Assessing social cognition in patients with schizophrenia and healthy controls using the reading the mind in the eyes test (RMET): a systematic review and meta-regression.

  2024cites this paper
• Abnormal brain network community structure related to psychological stress in schizophrenia.

  2023cites this paper
• Neurophysiological indices of face processing in people with psychosis and their siblings: An event‐related potential study

  2023cites this paper
• The Effects of Cannabidiol and δ-9-Tetrahydrocannabinol in Social Cognition: A Naturalistic Controlled Study

  2022cites this paper
• Validation of the Brazilian version of the Hinting Task and Facial Emotion Recognition Test (FERT-100) in patients with schizophrenia

  2022cites this paper
• Sex and age differences in “theory of mind” across 57 countries using the English version of the “Reading the Mind in the Eyes” Test

  2022cites this paper
• SOCIAL COGNITION IN YOUTH AT FHR FOR SCHIZOPHRENIA i Social cognition in young adults who have a first-degree relative with schizophrenia: A preliminary case series study

  2022cites this paper
• Potential intervention targets to improve cognitive empathy in older adulthood

  2022cites this paper
• The relationship between Alexithymia and Theory of Mind: A systematic review.

  2021cites this paper
• Pharmacological Treatment for Social Cognition: Current Evidence

  2021cites this paper
• Does our cognitive empathy diminish with age? The moderator role of educational level

  2021cites this paper
• Bottom-up processing of fearful and angry facial expressions is intact in schizophrenia

  2021cites this paper
• Social Cognition and Social Functioning in MCI and Dementia in an Epidemiological Sample

  2021cites this paper
• Subjective Cognitive Complaints in Unaffected First-Degree Relatives of Schizophrenia Patients: Relation to Cognitive Performance, Psychotic Experiences, and Social Functioning

  2021cites this paper
• Emotional and cognitive empathy in patients with non-epileptic seizures.

  2020cites this paper
• The impact of neurocognition on mentalizing in euthymic bipolar disorder versus schizophrenia

  2020cites this paper
• Social Cognition Training for Enhancing Affective and Cognitive Theory of Mind in Schizophrenia: A Systematic Review and a Meta-Analysis

  2020cites this paper
• “Reading the Mind in the Eyes” Is Associated with Top-Down Visual Attention

  2020cites this paper
• Systematic review and meta-analysis of the relationship between genetic risk for schizophrenia and facial emotion recognition

  2020cites this paper
• Negative and Neutral Valences of Affective Theory of Mind are More Impaired than Positive Valence in Clinically Stable Schizophrenia Patients

  2020cites this paper
• Social cognitions in siblings of patients with schizophrenia: a comparison with patients with schizophrenia and healthy controls - a cross-sectional study.

  2019cites this paper
• What Do You Have in Mind? Measures to Assess Mental State Reasoning in Neuropsychiatric Populations

  2019cites this paper
• Understanding of Faux Pas in patients with schizophrenia.

  2019cites this paper
• A meta-analysis of the associations between theory of mind and neurocognition in schizophrenia.

  2019cites this paper
• Differentiating implicit and explicit theory of mind and associated neural networks in youth at Clinical High Risk (CHR) for psychosis.

  2019cites this paper
• Distinct and opposite profiles of connectivity during self‐reference task and rest in youth at clinical high risk for psychosis

  2019cites this paper
• Theory of mind impairment in Huntington's disease patients and their relatives.

  2019cites this paper
• Impact of social cognitive deficits on community functioning

  2019cites this paper
• Face processing impairments in schizophrenia and other psychiatric disorders

  2018cites this paper
• The role of affective theory of mind in the association between trauma and psychotic-like experiences

  2018cites this paper
• Cognitive Impairment in Schizophrenia: Description and Cognitive Familiar Endophenotypes. A Review of the Literature

  2018cites this paper
• The Reading the Mind in the Eyes Test: A Portuguese version of the adults’ test

  2018cites this paper
• The Value of Neurocognitive Assessment for Diagnosis and Treatment in Schizophrenic Spectrum Disorders

  2018cites this paper
• Validation of the Reading the Mind in the Eyes Test in a healthy Spanish sample and women with anorexia nervosa

  2018cites this paper
• S0033291717002902jra 1359..1366

  2018cites this paper
• Theory of Mind Skills Are Related to Resting-State Frontolimbic Connectivity in Schizophrenia

  2018cites this paper
• Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition

  2018cites this paper
• Genetic and clinical features of social cognition in 22q11.2 deletion syndrome

  2018cites this paper
• Normal sexual dimorphism in theory of mind circuitry is reversed in Schizophrenia

  2018cites this paper
• Familial aggregation of MATRICS Consensus Cognitive Battery scores in a large sample of outpatients with schizophrenia and their unaffected relatives

  2017cites this paper
• Şizofreni Hastalarının Annelerinin Zihin Kuramı Kapasitelerinin Hastalık Şiddeti Üzerine Etkisinin İncelenmesi 2

  2017cites this paper
• The Reading the Mind in the Eyes Test: Validity and Reliability of the Thai Version

  2017influential citation
• Social cognition assessment in relation to cognitive dysfunctions and brain lesions among stroke survivors

  2017cites this paper
• Cognición Social en Esquizofrenia, Familiares No Afectados e Individuos en Riesgo Ultra-Alto de Psicosis: ¿Qué Sabemos Actualmente?

  2017cites this paper
• Social Cognition in Schizophrenia

  2017cites this paper
• Development and Validation of a Brief Assessment of Social Cognitive Abilities

  2017cites this paper
• Theory of Mind predicts cooperative behavior

  2017cites this paper
• Features of the broader autism phenotype in people with epilepsy support shared mechanisms between epilepsy and autism spectrum disorder

  2017cites this paper
• Clinical and therapeutic role of mentalization in schizophrenia—a review

  2017cites this paper
• Social Cognition in Schizophrenia, Unaffected Relatives and Ultra- High Risk for Psychosis: What Do We Currently Know?

  2017cites this paper
• Continuum autisme-schizophrénie : apport de l’étude de la cognition sociale et de marqueurs phénotypiques développementaux

  2017cites this paper
• Social cognition in neuropsychiatric populations: a comparison of theory of mind in schizophrenia and mesial temporal lobe epilepsy

  2017cites this paper
• Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity

  2016cites this paper
• Facial emotion perception in schizophrenia: Does sex matter?

  2016cites this paper
• Theory of mind network activity is altered in subjects with familial liability for schizophrenia.

  2016cites this paper
• Social cognition in people with schizophrenia: a cluster-analytic approach

  2016cites this paper
• Pathways to functional outcome in subjects with schizophrenia living in the community and their unaffected first-degree relatives.

  2016cites this paper
• Mentalizing Deficits in Parents of Patients with Schizophrenia: A Cross Sectional Study.

  2016cites this paper
• Social Endophenotypes in Mouse Models of Psychiatric Disease

  2016cites this paper
• Faux Pas Test in schizophrenic patients

  2016cites this paper
• La cognition sociale chez les apparentés de patients atteints de schizophrénie

  2016cites this paper
• Social Cognition in Schizophrenia Patients and Their First-Degree Relatives.

  2016cites this paper
• Emotion recognition in unaffected first-degree relatives of individuals with first-episode schizophrenia.

  2015cites this paper
• Social memory performance in schizophrenia

  2015cites this paper
• From Semantic to Social Deficits: Dysfunction of the Nondominant Posterior Perisylvian Area in Schizophrenia.

  2015cites this paper
• Perceiving Others’ Feelings

  2015cites this paper
• Predictability of Autism, Schizophrenic and Obsessive Spectra Diagnosis: Toward a Damage Network Approach

  2015cites this paper
• Theory of Mind and attachment styles in people with psychotic disorders, their siblings, and controls

  2015cites this paper
• Theory of mind impairments in patients with first-episode schizophrenia and their unaffected siblings.

  2015cites this paper
• Teoría de la mente y esquizofrenia: una revisión de la literatura disponible en los últimos cinco años (2010-2014)

  2015cites this paper
• [Eyes test performance among unaffected mothers of patients with schizophrenia].

  2015cites this paper
• Emotion processing in schizophrenia is state and trait dependent.

  2015cites this paper
• Self-other integration and distinction in schizophrenia: A theoretical analysis and a review of the evidence.

  2015cites this paper
• Abstract Representations of Attributed Emotion: Evidence From Neuroscience and Development

  2015cites this paper
• Chapitre 7. Troubles cognitifs précoces dans la psychose débutante

  2015cites this paper
• Sensibilidad en el Reconocimiento de Emociones Faciales Como Endofenotipo de Esquizofrenia

  2015cites this paper
• Sensitivity in the Recognition of Facial Emotions as an Endophenotype for Schizophrenia

  2015cites this paper
• Prospective memory and social cognition in people with chronic heart failure

  2015cites this paper
• Brain activation induced by psychological stress in patients with schizophrenia.

  2015cites this paper
• Semi-metric analysis of the functional brain network: Relationship with familial risk for psychotic disorder

  2015cites this paper
• Eyes Test Performance Among Unaffected Mothers of Patients with Scihozphrenia 2

  2015cites this paper
• Investigating the state-like and trait-like characters of social cognition in schizophrenia: a short term follow-up study.

  2014cites this paper
• Decreased default-mode network homogeneity in unaffected siblings of schizophrenia patients at rest.

  2014cites this paper
• From neural signatures of emotional modulation to social cognition: individual differences in healthy volunteers and psychiatric participants.

  2014influential citation
• Mentalizing Functions Provide a Conceptual Link of Brain Function and Social Cognition in Major Mental Disorders

  2014cites this paper
• Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia.

  2014cites this paper
• The relationship between insight and theory of mind in schizophrenia.

  2014cites this paper
• Cluster B personality symptoms in persons at genetic risk for schizophrenia are associated with social competence and activation of the right temporo-parietal junction during emotion processing.

  2014cites this paper
• Neural disruption to theory of mind predicts daily social functioning in individuals at familial high-risk for schizophrenia.

  2014cites this paper
• The Reading the Mind in the Eyes test: validation of a French version and exploration of cultural variations in a multi-ethnic city

  2014cites this paper
• Performance in multiple domains of social cognition in parents of patients with schizophrenia.

  2014influential citation
• Cognitive neuroscience of social emotions and implications for psychopathology: Examining embarrassment, guilt, envy, and schadenfreude

  2014cites this paper
• Distress and negative experiences of the caregiving relationship in early psychosis: does social cognition play a role?

  2014cites this paper
• Theory of mind and the social brain: implications for understanding the genetic basis of schizophrenia

  2014cites this paper