Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch

No abstract is available for this paper.

• Publication year

  2004

• Venue

  EMBO Journal

• Publication date

  2004-03-10

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.emboj.7600115PMID 14976553PMCID PMC380972
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Euplotes La motif protein p43 has properties of a telomerase-specific subunit.

  2003cited by this paper
• A La protein requirement for efficient pre‐tRNA folding

  2003cited by this paper
• Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element.

  2003cited by this paper
• Structure of prokaryotic SECIS mRNA hairpin and its interaction with elongation factor SelB.

  2002cited by this paper
• The La protein.

  2002influential reference
• Crystal structure of an mRNA‐binding fragment of Moorella thermoacetica elongation factor SelB

  2002cited by this paper
• Recognition of Nascent RNA by the Human La Antigen: Conserved and Divergent Features of Structure and Function

  2001cited by this paper
• Contributions of the Individual Domains in Human La Protein to Its RNA 3′-End Binding Activity*

  2001cited by this paper
• Reconstitution of Transcription from the Human U6 Small Nuclear RNA Promoter with Eight Recombinant Polypeptides and a Partially Purified RNA Polymerase III Complex*

  2001cited by this paper
• Structure-based analysis of protein-RNA interactions using the program ENTANGLE.

  2001cited by this paper
• Phosphorylation of the Saccharomyces cerevisiae La protein does not appear to be required for its functions in tRNA maturation and nascent RNA stabilization.

  2001cited by this paper
• Precursors to the U3 Small Nucleolar RNA Lack Small Nucleolar RNP Proteins but Are Stabilized by La Binding

  2000cited by this paper
• Import of proteins into the trypanosome nucleus and their distribution at karyokinesis.

  2000cited by this paper
• Single-stranded-RNA binding proteins.

  2000cited by this paper
• Winged helix proteins.

  2000influential reference
• Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA.

  2000cited by this paper
• U snRNP assembly in yeast involves the La protein

  2000cited by this paper
• Two yeast La motif-containing proteins are RNA-binding proteins that associate with polyribosomes.

  1999influential reference
• Absence of interdomain contacts in the crystal structure of the RNA recognition motifs of Sex-lethal.

  1999cited by this paper
• A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase III transcripts

  1998cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
• RNA recognition by RNP proteins during RNA processing.

  1998cited by this paper
• 5′ Processing of tRNA Precursors Can Be Modulated by the Human La Antigen Phosphoprotein

  1998cited by this paper
• Efficient synthesis, termination and release of RNA polymerase III transcripts in Xenopus extracts depleted of La protein

  1998cited by this paper
• A carboxy-terminal basic region controls RNA polymerase III transcription factor activity of human La protein

  1997cited by this paper
• Electron-density map interpretation.

  1997cited by this paper
• Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes.

  1997cited by this paper
• Solution structure of the first three zinc fingers of TFIIIA bound to the cognate DNA sequence: determinants of affinity and sequence specificity.

  1997cited by this paper
• Preparation of selenomethionyl proteins for phase determination.

  1997cited by this paper
• [13] Practical cryocrystallography.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Structure of the multimodular endonuclease FokI bound to DNA

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• [29] Preparation of selenomethionyl proteins for phase determination.

  1997cited by this paper
• The La protein in Schizosaccharomyces pombe: a conserved yet dispensable phosphoprotein that functions in tRNA maturation.

  1997cited by this paper
• Transcription termination factor La is also an initiation factor for RNA polymerase III.

  1996cited by this paper
• La proteins from Drosophila melanogaster and Saccharomyces cerevisiae: a yeast homolog of the La autoantigen is dispensable for growth

  1994cited by this paper
• Developmental characterization of a Drosophila RNA-binding protein homologous to the human systemic lupus erythematosus-associated La/SS-B autoantigen

  1994cited by this paper
• Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

  1991cited by this paper
• A program to produce both detailed and schematic plots of protein structures

  1991cited by this paper
• Synthesis of long, capped transcripts in vitro by SP6 and T7 RNA polymerases.

  1989cited by this paper
• The RNA binding protein La influences both the accuracy and the efficiency of RNA polymerase III transcription in vitro.

  1989cited by this paper
• Genomic structure and amino acid sequence domains of the human La autoantigen.

  1988cited by this paper
• Purified lupus antigen La recognizes an oligouridylate stretch common to the 3' termini of RNA polymerase III transcripts.

  1984cited by this paper
• Antibodies to cellular antigens in Sjögren's syndrome.

  1975cited by this paper
• Heterogeneity of RNA protein antigens reactive with sera of patients with systemic lupus erythematosus. Description of a cytoplasmic nonribosomal antigen.

  1974cited by this paper
• NUCLEOTIDE SEQUENCE ANALYSIS OF POLYRIBONUCLEOTIDES BY MEANS OF PERIODATE OXIDATION FOLLOWED BY CLEAVAGE WITH AN AMINE.

  1964cited by this paper

• Key RNA-binding domains in the La protein establish tRNA modification levels in Trypanosoma brucei

  2025cites this paper
• Non-Canonical RNA Binding of Human La-related Protein 6

  2025cites this paper
• Noncanonical RNA binding of human La-related protein 6

  2025cites this paper
• A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals

  2025cites this paper
• Phage anti-CRISPR control by an RNA- and DNA-binding helix–turn–helix protein

  2024cites this paper
• Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR.

  2023cites this paper
• In silico identification, characterization, and expression analysis of RNA recognition motif (RRM) containing RNA-binding proteins in Aedes aegypti

  2023influential citation
• Identification and molecular evolution of the La and LARP genes in 16 plant species: A focus on the Gossypium hirsutum.

  2022cites this paper
• Altered tRNA processing is linked to a distinct and unusual La protein in Tetrahymena thermophila

  2022cites this paper
• The RNA binding protein OsLa influences grain and anther development in rice.

  2022cites this paper
• Structural basis of 3′-end poly(A) RNA recognition by LARP1

  2022cites this paper
• Utilizing Fluorescence Microscopy to Characterize the Subcellular Distribution of the Novel Protein Acheron

  2021influential citation
• Functional and structural aspects of La protein overexpression in lung cancer.

  2020cites this paper
• A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay

  2020cites this paper
• Crystal Structure of a Variant PAM2 Motif of LARP4B Bound to the MLLE Domain of PABPC1

  2020cites this paper
• Role of the RNA-binding protein La in cancer pathobiology

  2020cites this paper
• Resonance assignments of La protein RRM domain from Trypanosoma brucei

  2020cites this paper
• La proteins couple use of sequence-specific and non-specific binding modes to engage RNA substrates

  2019cites this paper
• The La-related proteins: structures and interactions of a versatile superfamily of RNA-binding proteins

  2019cites this paper
• The LARP1 La-Module recognizes both ends of TOP mRNAs

  2019cites this paper
• A telomerase subunit homolog La protein from Trypanosoma brucei plays an essential role in ribosomal biogenesis

  2019cites this paper
• LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA

  2019cites this paper
• La involvement in tRNA and other RNA processing events including differences among yeast and other eukaryotes.

  2018cites this paper
• LARP7 family proteins have conserved function in telomerase assembly

  2018cites this paper
• Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7

  2018cites this paper
• Human La Function in Expression of Coding Transcripts

  2018cites this paper
• The RIO protein kinase-encoding gene Sj-riok-2 is involved in key reproductive processes in Schistosoma japonicum

  2017cites this paper
• LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection

  2017cites this paper
• Structural and developmental expression of Ss-riok-2, an RIO protein kinase encoding gene of Strongyloides stercoralis

  2017cites this paper
• The La and related RNA‐binding proteins (LARPs): structures, functions, and evolving perspectives

  2017influential citation
• The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives

  2017influential citation
• RNA damage in biological conflicts and the diversity of responding RNA repair systems

  2016cites this paper
• RNA Chaperone Activity of the RRM2 Domain of Human La

  2015cites this paper
• A role for cell cycle protein E2F1 in HIV-induced neurotoxicity

  2015cites this paper
• Protein-protein interactions of the cold shock protein CspE of Salmonella typhimurium

  2015cites this paper
• LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation

  2015cites this paper
• Kinetics of peptide folding in lipid membranes

  2015cites this paper
• The Yeast La Related Protein Slf1p Is a Key Activator of Translation during the Oxidative Stress Response

  2015cites this paper
• The La-Related Proteins, a Family with Connections to Cancer

  2015cites this paper
• The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′TOP sequence

  2015cites this paper
• Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7

  2015cites this paper
• The FinO family of bacterial RNA chaperones.

  2015cites this paper
• The role of LARP1 in translation and beyond

  2015cites this paper
• Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module

  2014cites this paper
• Novel RNA chaperone domain of RNA-binding protein La is regulated by AKT phosphorylation

  2014cites this paper
• Spectroscopic Studies of Peptide-Membrane Interactions

  2013influential citation
• The association of a La module with the PABP-interacting motif PAM2 is a recurrent evolutionary process that led to the neofunctionalization of La-related proteins.

  2013cites this paper
• Conservation of RNA chaperone activity of the human La-related proteins 4, 6 and 7

  2013cites this paper
• LARP1 specifically recognizes the 3′ terminus of poly(A) mRNA

  2013cites this paper
• A Combined Molecular Dynamics, Rigidity Analysis Approach for Studying Protein Complexes

  2013cites this paper
• Molecular and structural insight into plasmodium falciparum RIO2 kinase

  2013cites this paper
• The role of the C-terminal helix of U 1 A protein in the interaction with U 1 hpII RNA

  2013cites this paper
• The role of the C-terminal helix of U1A protein in the interaction with U1hpII RNA

  2013cites this paper
• La-motif-dependent mRNA association with Slf1 promotes copper detoxification in yeast.

  2012influential citation
• In Silico Characterization of Atypical Kinase PFD0975w from Plasmodium Kinome: A Suitable Target For Drug Discovery

  2012cites this paper
• The structure and enzymatic properties of a novel RNase II family enzyme from Deinococcus radiodurans.

  2012cites this paper
• The Molecular Machinery Critical to the Degradation of Cellular RNA

  2012cites this paper
• Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65.

  2012influential citation
• Structural and functional aspects of winged-helix domains at the core of transcription initiation complexes

  2012cites this paper
• Regulation der eukaryotischen Translation durch RNA-bindende Faktoren : Strukturelle und funktionelle Charakterisierung des La-verwandten Proteins 4B (LARP4B)

  2012cites this paper
• Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein

  2011cites this paper
• An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors

  2011influential citation
• Eukaryotic 5S rRNA biogenesis

  2011cites this paper
• Aromatic-Aromatic Interactions Database, A(2)ID: an analysis of aromatic π-networks in proteins.

  2011cites this paper
• Resultados del Taller de Autoinmunidad de la Sociedad Española de Inmunología (SEI) 2010

  2011cites this paper
• Regulation der eukaryotischen Translation durch RNA- bindende Faktoren: Strukturelle und funktionelle Charakterisierung des La-verwandten Proteins 4B (LARP4B)

  2011cites this paper
• Yeast LA-related proteins and the LA-motif

  2011influential citation
• Mapping interactions between the RNA chaperone FinO and its RNA targets

  2011cites this paper
• RNA Chaperone Activity of Human La Protein Is Mediated by Variant RNA Recognition Motif*

  2011cites this paper
• Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit

  2011cites this paper
• La-Related Protein 4 Binds Poly(A), Interacts with the Poly(A)-Binding Protein MLLE Domain via a Variant PAM2w Motif, and Can Promote mRNA Stability

  2010influential citation
• A stimulatory role for the La-related protein 4B in translation.

  2010cites this paper
• Conserved and divergent features of the structure and function of La and La-related proteins (LARPs).

  2010cites this paper
• Akt phosphorylation of La regulates specific mRNA translation in glial progenitors

  2009cites this paper
• Precursor-product discrimination by La protein during tRNA metabolism

  2009cites this paper
• 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

  2009cites this paper
• Getting to the end of RNA: structural analysis of protein recognition of 5' and 3' termini.

  2009influential citation
• A comprehensive analysis of the La-motif protein superfamily.

  2009influential citation
• Detection of La/SS-B by western blot using nanogold-tagged antibodies and silver enhancement.

  2009cites this paper
• Relazione tra la proteina La e la regolazione traduzionale dei messaggeri TOP

  2009cites this paper
• Protein Blotting and Detection

  2009cites this paper
• The assembly of a spliceosomal small nuclear ribonucleoprotein particle

  2008cites this paper
• C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis.

  2008cites this paper
• Regulation of the catalytic function of topoisomerase II alpha through association with RNA

  2008cites this paper
• Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3′ Ends by the Human La Protein

  2008influential citation
• A bona fide La protein is required for embryogenesis in Arabidopsis thaliana

  2007cites this paper
• Structural insight into a molecular switch in tandem winged-helix motifs from elongation factor SelB.

  2007cites this paper
• DNA Binding Specificity of Mu Transcription Factor C and Crystallization of C : DNA Complex

  2007cites this paper
• Caractérisation de la fonction "La" chez Arabidopsis thaliana et identification d'une structure conservée pour les ARN non-codants de type SINE

  2007cites this paper
• A terminal affair: 3'-end recognition by the human La protein.

  2006cites this paper
• Molecular chaperones and quality control in noncoding RNA biogenesis.

  2006cites this paper
• The Carboxyl-terminal Nucleoplasmic Region of MAN1 Exhibits a DNA Binding Winged Helix Domain*

  2006cites this paper
• Molecular Basis for the Selenocysteine Incorporation

  2006cites this paper
• Isolation and identification of up-regulated genes in bermudagrass roots (Cynodon dactylon L.) grown under petroleum hydrocarbon stress

  2006cites this paper
• The Multifunctional RNA-Binding Protein La Is Required for Mouse Development and for the Establishment of EmbryonicStem Cells

  2006cites this paper
• Production de domaines recombinants PRODH en vue de l'analyse structurale & Caractérisation de la région 51-160 de la protéine KIN17 humaine par RMN et Modélisation Moléculaire

  2006cites this paper
• A Novel Plant-Specific Family Gene, ROOT PRIMORDIUM DEFECTIVE 1, Is Required for the Maintenance of Active Cell Proliferation1

  2006cites this paper
• Separate RNA-binding surfaces on the multifunctional La protein mediate distinguishable activities in tRNA maturation

  2006cites this paper
• Structural and biochemical basis for misfolded RNA recognition by the Ro autoantigen

  2006cites this paper
• The La protein-RNA complex surfaces.

  2006cites this paper