Stability and biological testing of taurine-conjugated bile acid antioxidant microcapsules for diabetes treatment.

AIM Taurine-conjugated bile acids possess positive formulation-stabilization effects, which are desirable in diabetes treatments. The taurine-conjugated bile acid, taurocholic acid (TCA), has shown promising formulation-stabilizing effects on the delivery of the antioxidant drug, probucol (PB), but success is limited due to its poor release profile. This study aimed to design new PB-TCA formulations using new polymers, and examine antioxidant and antidiabetic effects using β-cells for PB with or without TCA. MATERIALS AND METHODS Different formulations using alginate-insoluble esters of polymethylacrylate polymers encapsulating PB and TCA were developed, microencapsulated and examined for stability and biological activity. RESULTS TCA addition to new PB matrices improved osmotic and mechanical properties, and this effect was dependent on polymethylacrylate composition and concentration. CONCLUSION  TCA can optimize the oral delivery of anti-diabetic compounds.

• Publication year

  2019

• Venue

  Therapeutic delivery

• Publication date

  2019-02-07

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.4155/tde-2018-0034PMID 30729887
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sodium alginate capsulation increased brain delivery of probucol and suppressed neuroinflammation and neurodegeneration.

  2018cited by this paper
• The biological effects of the hypolipidaemic drug probucol microcapsules fed daily for 4 weeks, to an insulin-resistant mouse model: potential hypoglycaemic and anti-inflammatory effects

  2018cited by this paper
• Eudragit®-based microcapsules of probucol with a gut-bacterial processed secondary bile acid.

  2018cited by this paper
• Diabetes development increased concentrations of the conjugated bile acid, taurocholic acid in serum, while treatment with microencapsulated‐taurocholic acid exerted no hypoglycaemic effects

  2017cited by this paper
• Blood-Brain Barrier Dysfunction Precedes Cognitive Decline and Neurodegeneration in Diabetic Insulin Resistant Mouse Model: An Implication for Causal Link

  2017cited by this paper
• Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic β-cell line

  2016cited by this paper
• Swelling, mechanical strength, and release properties of probucol microcapsules with and without a bile acid, and their potential oral delivery in diabetes

  2016cited by this paper
• A comprehensive study of novel microcapsules incorporating gliclazide and a permeation enhancing bile acid: hypoglycemic effect in an animal model of Type-1 diabetes

  2016cited by this paper
• Viability and topographical analysis of microencapsulated β-cells exposed to a biotransformed tertiary bile acid: an ex vivo study

  2016cited by this paper
• Glucose and lipid effects of the ileal apical sodium‐dependent bile acid transporter inhibitor GSK2330672: double‐blind randomized trials with type 2 diabetes subjects taking metformin

  2016cited by this paper
• The Effects of Ionic Gelation- Vibrational Jet Flow Technique in Fabrication of Microcapsules Incorporating β-cell: Applications in Diabetes.

  2016cited by this paper
• Novel chenodeoxycholic acid–sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. An in vitro study

  2015cited by this paper
• Release and swelling studies of an innovative antidiabetic-bile acid microencapsulated formulation, as a novel targeted therapy for diabetes treatment

  2015cited by this paper
• An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations

  2015cited by this paper
• The effect of a tertiary bile acid, taurocholic acid, on the morphology and physical characteristics of microencapsulated probucol: potential applications in diabetes: a characterization study

  2015cited by this paper
• Probucol Release from Novel Multicompartmental Microcapsules for the Oral Targeted Delivery in Type 2 Diabetes

  2015cited by this paper
• Stability and Release Kinetics of an Advanced Gliclazide-Cholic Acid Formulation: The Use of Artificial-Cell Microencapsulation in Slow Release Targeted Oral Delivery of Antidiabetics

  2014cited by this paper
• Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol

  2014cited by this paper
• An optimized probucol microencapsulated formulation integrating a secondary bile acid (deoxycholic acid) as a permeation enhancer

  2014cited by this paper
• Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes

  2013cited by this paper
• Oral delivery of taurocholic acid linked heparin-docetaxel conjugates for cancer therapy.

  2013cited by this paper
• Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study

  2012cited by this paper
• Stress-Induced Hyperglycemia in Healthy Bungee Jumpers Without Diabetes Due to Decreased Pancreatic β-Cell Function and Increased Insulin Resistance

  2012cited by this paper
• Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure*

  2011cited by this paper
• Polyproline‐type helical‐structured low‐molecular weight heparin (LMWH)‐taurocholate conjugate as a new angiogenesis inhibitor

  2009cited by this paper
• Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells.

  2009cited by this paper
• Novel pathways for glycaemic control in type 2 diabetes: focus on bile acid modulation

  2008cited by this paper
• Endocrine functions of bile acids

  2006cited by this paper
• Interactions between food components and drugs. Part 8: Effect of pectins and bile acid preparations forming stable mixed micelles on transport of quinine in vitro.

  2000cited by this paper
• Protective effects of probucol against glutamate-induced cytotoxicity in neuronal cell line PC12.

  1995cited by this paper
• Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. III. The protective effect of antioxidants (probucol, catechin, vitamin E) against the cytotoxicity of oxidized LDL occurs in two different ways.

  1991cited by this paper
• NIT-1, a Pancreatic β-Cell Line Established From a Transgenic NOD/Lt Mouse

  1991cited by this paper
• Evaluation of the sustained release properties of Eudragit RS, RL and S (acrylic resins) microcapsules containing ketoprofen in beagle dogs.

  1988cited by this paper
• Taurine conjugation of bile acids protects human cells in culture.

  1987cited by this paper
• Polyacrylate resin (Eudragit retard) microcapsules as a controlled release drug delivery system-improved non-solvent addition phase separation process.

  1985cited by this paper
• Effect of streptozotocin-induced diabetes in neonatal rat on bile acid pool changes in adult life: selective sensitivity in females.

  1984cited by this paper

• Characterization of Taurocholic Acid Binding With Insulin for Potential Oral Formulation Using Different Methods

  2025cites this paper
• Novel polysaccharides-bile acid-cyclodextrin gel systems and effects on cellular viability and bioenergetic parameters.

  2024cites this paper
• Density functional studies of probucol excited states and spectral properties

  2023cites this paper
• Pharmacological Dose-Effect Profiles of Various Concentrations of Humanised Primary Bile Acid in Encapsulated Cells

  2022cites this paper
• The emerging role of bile acids as critical components in nanotechnology and bioengineering: Pharmacology, formulation optimizers and hydrogel-biomaterial applications.

  2022cites this paper
• Reduced Cytokine Tumour Necrosis Factor by Pharmacological Intervention in a Preclinical Study

  2022cites this paper
• Novel Nanoencapsulation Technology and its Potential Role in Bile Acid-Based Targeted Gene Delivery to the Inner Ear.

  2022cites this paper
• Taurine Grafted Micro-Implants Improved Functions without Direct Dependency between Interleukin-6 and the Bile Acid Lithocholic Acid in Plasma

  2022cites this paper
• Pharmaceutical formulation and polymer chemistry for cell encapsulation applied to the creation of a lab-on-a-chip bio-microsystem.

  2021cites this paper
• Prevention and reversal of chlorpromazine induced testicular dysfunction in rats by synergistic testicle-active flavonoids, taurine and coenzyme-10.

  2021cites this paper
• A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology

  2021cites this paper
• Enhanced Bilosomal Properties Resulted in Optimum Pharmacological Effects by Increased Acidification Pathways

  2021cites this paper
• Bile Acid Regulates the Colonization and Dissemination of Candida albicans from the Gastrointestinal Tract by Controlling Host Defense System and Microbiota

  2021cites this paper
• Chemotherapy-induced hearing loss: the applications of bio-nanotechnologies and bile acid-based delivery matrices.

  2021cites this paper
• Bile acid-permeation enhancement for inner ear cochlear drug - pharmacological uptake: bio-nanotechnologies in chemotherapy-induced hearing loss.

  2021cites this paper
• Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation

  2021cites this paper
• Bile Acid Regulates the Colonization and Dissemination of Candida albicans

  2021cites this paper
• Microencapsulation of Coenzyme Q10 and bile acids using ionic gelation vibrational jet flow technology for oral delivery.

  2020cites this paper
• Micro-Nano formulation of bile-gut delivery: rheological, stability and cell survival, basal and maximum respiration studies

  2020cites this paper
• Formulation buoyancy of nanoencapsulated gliclazide using primary, conjugated and deconjugated bile acids.

  2019cites this paper
• Bile acid-polymer-probucol microparticles: protective effect on pancreatic β-cells and decrease in type 1 diabetes development in a murine model

  2019cites this paper