Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Toxicological Sciences

• Publication date

  2009-12-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1093/toxsci/kfp219PMID 19770487
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Catalase and glutathione peroxidase mimics.

  2009cited by this paper
• Glutathione Peroxidase-1 Regulates Mitochondrial Function to Modulate Redox-dependent Cellular Responses*

  2009cited by this paper
• Contribution of vascular risk factors to the progression in Alzheimer disease.

  2009cited by this paper
• Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice.

  2009cited by this paper
• Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase.

  2009cited by this paper
• Where are we with probucol: a new life for an old drug?

  2009cited by this paper
• Selenoproteins*

  2009cited by this paper
• Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain.

  2008cited by this paper
• Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels.

  2008cited by this paper
• Inhibition of the Human Thioredoxin System

  2008cited by this paper
• Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on methylmercury-induced locomotor deficits and cerebellar toxicity in mice.

  2007cited by this paper
• Comparative study of activities in reactive oxygen species production/defense system in mitochondria of rat brain and liver, and their susceptibility to methylmercury toxicity

  2007cited by this paper
• Mercurial-induced hydrogen peroxide generation in mouse brain mitochondria: protective effects of quercetin.

  2007cited by this paper
• Developmental neurotoxicity of industrial chemicals.

  2007cited by this paper
• Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity.

  2007cited by this paper
• Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: specific induction of enzyme expression in reactive astrocytes following brain injury.

  2007cited by this paper
• Cell viability and proteomic analysis in cultured neurons exposed to methylmercury

  2007cited by this paper
• Developmental neurotoxicity of industrial chemicals.

  2007cited by this paper
• Inactivation of lactate dehydrogenase by several chemicals: implications for in vitro toxicology studies.

  2007cited by this paper
• Postnatal Methylmercury Exposure Induces Hyperlocomotor Activity and Cerebellar Oxidative Stress in Mice: Dependence on the Neurodevelopmental Period

  2006cited by this paper
• Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron‐mediated hydrogen peroxide toxicity

  2006cited by this paper
• Glutathione peroxidase 1 and a high cellular glutathione concentration are essential for effective organic hydroperoxide detoxification in astrocytes

  2006cited by this paper
• Probucol attenuates oxidative stress and energy decline in isoproterenol-induced heart failure in rat.

  2005cited by this paper
• Is chemical neurotransmission altered specifically during methylmercury-induced cerebellar dysfunction?

  2005cited by this paper
• Mercury compounds disrupt neuronal glutamate transport in cultured mouse cerebellar granule cells

  2005cited by this paper
• Peroxisomal Proliferation Protects from β-Amyloid Neurodegeneration*

  2005influential reference
• Peroxisomal proliferation protects from beta-amyloid neurodegeneration.

  2005cited by this paper
• Transforming Growth Factor-α Attenuates N-Methyl-D-aspartic Acid Toxicity in Cortical Cultures by Preventing Protein Synthesis Inhibition through an Erk1/2-dependent Mechanism*

  2003influential reference
• Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.

  2003cited by this paper
• Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice.

  2003cited by this paper
• The toxicology of mercury--current exposures and clinical manifestations.

  2003cited by this paper
• Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase.

  2001cited by this paper
• Adriamycin-Induced Early Changes in Myocardial Antioxidant Enzymes and Their Modulation by Probucol

  2000cited by this paper
• Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

  1999cited by this paper
• Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide*

  1998cited by this paper
• A fluorometric method for measurement of peroxyl radical scavenging activities of lipophilic antioxidants.

  1998cited by this paper
• The Mechanism for Hexachlorocyclohexane-Induced Cytotoxicity and Changes in Intracellular Ca2+Homeostasis in Cultured Cerebellar Granule Neurons Is Different for the γ- and δ-Isomers

  1997cited by this paper
• The mechanism for hexachlorocyclohexane-induced cytotoxicity and changes in intracellular Ca2+ homeostasis in cultured cerebellar granule neurons is different for the gamma- and delta-isomers.

  1997cited by this paper
• Biochemical and Molecular Roles of Nutrients Cellular Glutathione Peroxidase Knockout Mice Express Normal Levels of Selenium-Dependent Plasma and Phospholipid Hydroperoxide Glutathione Peroxidases in Various Tissues

  1997cited by this paper
• A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide.

  1996cited by this paper
• Measurement of striatal H2O2 by microdialysis following global forebrain ischemia and reperfusion in the rat: correlation with the cytotoxic potential of H2O2 in vitro.

  1995cited by this paper
• An analysis of autopsy brain tissue from infants prenatally exposed to methymercury.

  1995cited by this paper
• Oxidative processes and antioxidative defense mechanisms in the aging brain 1

  1995cited by this paper
• Direct evidence of free radical production after ischaemia and reperfusion and protective effect of desferrioxamine: ESR and vitamin E studies.

  1994cited by this paper
• Effects of methylmercury exposure during the second stage of rapid postnatal brain growth on negative geotaxis and on delta-aminolevulinate dehydratase of suckling rats.

  1993cited by this paper
• Synergistic interaction between the probucol phenoxyl radical and ascorbic acid in inhibiting the oxidation of low density lipoprotein.

  1992cited by this paper
• Glutathione reductase.

  1985cited by this paper
• [59] Glutathione reductase

  1985cited by this paper
• Kinetics and mechanism for the oxidation of ascorbic acid/ascorbate by HO_2/O_2-radicals. A pulse radiolysis and stopped-flow photolysis study.

  1983cited by this paper
• Kinetics and mechanism for the oxidation of ascorbic acid/ascorbate by HO2/O2- (hydroperoxyl/superoxide) radicals. A pulse radiolysis and stopped-flow photolysis study

  1983cited by this paper
• Selenium protection against mercury toxicity: high binding affinity of methylmercury by selenium-containing ligands in comparison with sulfur-containing ligands.

  1978cited by this paper
• Heterogeneity of erythrocyte catalase II. Isolation and characterization of normal and variant erythrocyte catalase and their subunits.

  1974cited by this paper
• Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.

  1969cited by this paper

• Hidden markers of health: how mercury affects gene expression in developing seabirds.

  2025cites this paper
• Revolutionizing drug delivery strategies with probucol to Combat oxidative stress in retinal Degeneration: A comprehensive review.

  2025cites this paper
• Selenization of Small Molecule Drugs: A New Player on the Board.

  2024cites this paper
• Dynamics of metal/metalloid bioaccumulation and sensitivity in post-larvae shrimp (Macrobrachium rosenbergii) exposed to settleable atmospheric particulate matter from an industrial source.

  2024cites this paper
• Mercury-induced toxicity: Mechanisms, molecular pathways, and gene regulation.

  2024cites this paper
• Heavy metals: toxicity and human health effects

  2024cites this paper
• Probucol neuroprotection against manganese-induced damage in adult Wistar rat brain slices

  2023cites this paper
• Mesenchymal stem cell‐derived rapid drug screening system for Alzheimer's disease for the identification of novel drugs

  2023cites this paper
• Investigations into ferroptosis in methylmercury‐induced acute kidney injury in mice

  2023cites this paper
• Methylmercury Decreases AMPA Receptor Subunit GluA2 Levels in Cultured Rat Cortical Neurons.

  2023cites this paper
• Metallomics Research 2022 (3)

  2023cites this paper
• Ferroptosis as a mechanism of non-ferrous metal toxicity

  2022cites this paper
• A Novel Diselenide-Probucol-Analogue Protects Against Methylmercury-Induced Toxicity in HT22 Cells by Upregulating Peroxide Detoxification Systems: a Comparison with Diphenyl Diselenide

  2022cites this paper
• Protective Effects of Probucol on Different Brain Cells Exposed to Manganese

  2022cites this paper
• Ferroptosis contributes to methylmercury-induced cytotoxicity in rat primary astrocytes and Buffalo rat liver cells.

  2022cites this paper
• Detoxification of organomercurials by thiones and selones: A short review

  2022cites this paper
• Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals

  2022cites this paper
• Mercury and selenium in squids from the Pacific Ocean and Indian Ocean: The distribution and human health implications.

  2021cites this paper
• Prevention of ferroptosis in acute scenarios: an in vitro study with classic and novel anti-ferroptotic compounds

  2021cites this paper
• Heavy Metal Contamination from Construction Materials

  2021cites this paper
• Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment.

  2021cites this paper
• The Roles of Oxidative Stress in Regulating Autophagy in Methylmercury-induced Neurotoxicity.

  2021cites this paper
• Environmentally Relevant Developmental Methylmercury Exposures Alter Neuronal Differentiation in a Human-Induced Pluripotent Stem Cell Model.

  2021cites this paper
• Methylmercury, oxidative stress, and neurodegeneration

  2021cites this paper
• Methylmercury-Mediated Oxidative Stress and Activation of the Cellular Protective System

  2020cites this paper
• Decreased plasma thiol antioxidant capacity precedes neurological signs in a rat methylmercury intoxication model.

  2020cites this paper
• Oxidative Stress Biomarkers in Erythrocytes of Captive Pre-Juvenile Loggerhead Turtles Following Acute Exposure to Methylmercury

  2020cites this paper
• New Probucol Analogues Inhibit Ferroptosis, Improve Mitochondrial Parameters, and Induce Glutathione Peroxidase in HT22 Cells

  2020cites this paper
• Methylmercury and developmental neurotoxicity: A global concern

  2020cites this paper
• Probucol Protects Neuronal Cells Against Peroxide-Induced Damage and Directly Activates Glutathione Peroxidase-1

  2020cites this paper
• The Effect of Selected Dental Materials Used in Conservative Dentistry, Endodontics, Surgery, and Orthodontics as Well as during the Periodontal Treatment on the Redox Balance in the Oral Cavity

  2020cites this paper
• Sulfhydryl groups as targets of mercury toxicity.

  2020cites this paper
• Human-induced pluripotent stems cells as a model to dissect the selective neurotoxicity of methylmercury.

  2019cites this paper
• Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay.

  2019cites this paper
• Methylmercury's chemistry: From the environment to the mammalian brain.

  2019cites this paper
• Post-translational modifications in MeHg-induced neurotoxicity.

  2019cites this paper
• Toxicity of mercury: Molecular evidence.

  2019cites this paper
• Deleterious effects of chronic mercury exposure on in vitro LTP, memory process, and oxidative stress

  2019cites this paper
• Metalloproteomic approach of mercury-binding proteins in liver and kidney tissues of Plagioscion squamosissimus (corvina) and Colossoma macropomum (tambaqui) from Amazon region: Possible identification of mercury contamination biomarkers.

  2019cites this paper
• Probucol, a “non-statin” cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice

  2019cites this paper
• Vascular Dysfunction Induced by Mercury Exposure

  2019cites this paper
• Environmental mercury exposure and selenium-associated biomarkers of antioxidant status at molecular and biochemical level. A short-term intervention study.

  2019cites this paper
• Stability and biological testing of taurine-conjugated bile acid antioxidant microcapsules for diabetes treatment.

  2019cites this paper
• Neurotransmitter amines and antioxidant agents in neuronal protection against methylmercury‐induced cytotoxicity in primary cultures of mice cortical neurons

  2018cites this paper
• Effects of perinatal exposure to n-3 polyunsaturated fatty acids and methylmercury on cerebellar and behavioral parameters in mice.

  2018cites this paper
• Sodium selenite protects from 3-nitropropionic acid-induced oxidative stress in cultured primary cortical neurons

  2018cites this paper
• Design, Synthesis, and In Vitro Evaluation of a Novel Probucol Derivative: Protective Activity in Neuronal Cells Through GPx Upregulation

  2018cites this paper
• Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington's Disease

  2018cites this paper
• Oxidative Stress in Methylmercury-Induced Cell Toxicity

  2018influential citation
• Methylmercury exposure alters RNA splicing in human neuroblastoma SK-N-SH cells: Implications from proteomic and post-transcriptional responses.

  2018cites this paper
• Paraquat and Maneb Exposure Alters Rat Neural Stem Cell Proliferation by Inducing Oxidative Stress: New Insights on Pesticide-Induced Neurodevelopmental Toxicity

  2018cites this paper
• Methylmercury induces oxidative stress and subsequent neural hyperactivity leading to cell death through the p38 MAPK‐CREB pathway in differentiated SH‐SY5Y cells

  2018cites this paper
• Reproductive dysfunction after mercury exposure at low levels: evidence for a role of glutathione peroxidase (GPx) 1 and GPx4 in male rats.

  2017cites this paper
• Superoxide anion generation and oxidative stress in methylmercury-induced endothelial toxicity in vitro.

  2017cites this paper
• Methylmercury‐induced developmental toxicity is associated with oxidative stress and cofilin phosphorylation. Cellular and human studies

  2017cites this paper
• Organoselenium compounds as mimics of selenoproteins and thiol modifier agents.

  2017cites this paper
• Biomarkers of mercury toxicity: Past, present, and future trends

  2017influential citation
• Methylmercury Causes Blood-Brain Barrier Damage in Rats via Upregulation of Vascular Endothelial Growth Factor Expression

  2017cites this paper
• Methylmercury-Induced Neurotoxicity: Focus on Pro-oxidative Events and Related Consequences.

  2017cites this paper
• Diphenyl diselenide protects against methylmercury‐induced inhibition of thioredoxin reductase and glutathione peroxidase in human neuroblastoma cells: a comparison with ebselen

  2017cites this paper
• In situ different antioxidative systems contribute to the site-specific methylmercury neurotoxicity in mice.

  2017cites this paper
• Synergistic effects of dietary vitamin E and selenomethionine on growth performance and tissue methylmercury accumulation on mercury-induced toxicity in juvenile olive flounder, Paralichthys olivaceus (Temminck et Schlegel)

  2017cites this paper
• Chapter 33 – Mercury

  2017cites this paper
• The catecholaminergic neurotransmitter system in methylmercury-induced neurotoxicity.

  2017cites this paper
• Sulforaphane Prevents Methylmercury-Induced Oxidative Damage and Excitotoxicity Through Activation of the Nrf2-ARE Pathway

  2016cites this paper
• Sex- and structure-specific differences in antioxidant responses to methylmercury during early development.

  2016cites this paper
• Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity

  2016cites this paper
• A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment

  2016cites this paper
• Neuroprotective Effect of Portulaca oleraceae Ethanolic Extract Ameliorates Methylmercury Induced Cognitive Dysfunction and Oxidative Stress in Cerebellum and Cortex of Rat Brain

  2016cites this paper
• Methylmercury and brain development: A review of recent literature.

  2016influential citation
• NAD+ Supplementation Attenuates Methylmercury Dopaminergic and Mitochondrial Toxicity in Caenorhabditis Elegans.

  2016cites this paper
• Alpha-lipoic acid protects against methylmercury-induced neurotoxic effects via inhibition of oxidative stress in rat cerebral cortex.

  2015cites this paper
• Protective Actions of 17β-Estradiol and Progesterone on Oxidative Neuronal Injury Induced by Organometallic Compounds

  2015cites this paper
• Probucol mitigates streptozotocin-induced cognitive and biochemical changes in mice.

  2015cites this paper
• Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants

  2015cites this paper
• Toxicological effects of thiomersal and ethylmercury: Inhibition of the thioredoxin system and NADP(+)-dependent dehydrogenases of the pentose phosphate pathway.

  2015cites this paper
• Antioxidant effects of Dendropanax morbifera Léveille extract in the hippocampus of mercury-exposed rats

  2015cites this paper
• Methyl Mercury Injury to CNS: Mitochondria at the Core of the Matter?

  2015cites this paper
• Mercury and Neurodegeneration

  2015cites this paper
• Mercury and metabolic syndrome: a review of experimental and clinical observations

  2015cites this paper
• Excitotoxicity and oxidative damages induced by methylmercury in rat cerebral cortex and the protective effects of tea polyphenols

  2014cites this paper
• Preventive Effects of Dextromethorphan on Methylmercury-Induced Glutamate Dyshomeostasis and Oxidative Damage in Rat Cerebral Cortex

  2014cites this paper
• Influence of prenatal exposure to environmental pollutants on human cord blood levels of glutamate.

  2014cites this paper
• Methylmercury Alters the Activities of Hsp90 Client Proteins, Prostaglandin E Synthase/p23 (PGES/23) and nNOS

  2014cites this paper
• TOXICIDADE IN VITRO E IN VIVO DO ORTOBENZAMOL, ANÁLOGO DO PARACETAMOL.

  2014cites this paper
• Identification and characterization of molecular modulators of methylmercury-induced toxicity and dopamine neuron degeneration in Caenorhabditis elegans

  2014cites this paper
• The effects of selenium on methylmercury toxicity in zebrafish

  2014cites this paper
• Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell.

  2014cites this paper
• The Effects of ROS and DNA Repair on Methylmercury-initiated Neurodevelopmental Deficits

  2014cites this paper
• Mercury toxicity and neurodegenerative effects.

  2014cites this paper
• Methionine Stimulates Motor Impairment And Cerebellar Mercury Deposition in Methylmercury-Exposed Mice

  2014cites this paper
• Selenium prevents downregulation of antioxidant selenoprotein genes by methylmercury.

  2014cites this paper
• A positive correlation between mercury and oxidative stress-related gene expression (GPX3 and GSTM3) is measured in female Double-crested Cormorant blood

  2014cites this paper
• The protective role of tea polyphenols against methylmercury-induced neurotoxic effects in rat cerebral cortex via inhibition of oxidative stress

  2014cites this paper
• S-mercuration of cellular proteins by methylmercury and its toxicological implications.

  2014cites this paper
• Dietary selenium fails to influence cigarette smoke-induced lung tumorigenesis in A/J mice.

  2013cites this paper
• Succinobucol versus probucol: higher efficiency of succinobucol in mitigating 3-NP-induced brain mitochondrial dysfunction and oxidative stress in vitro.

  2013cites this paper
• Probucol Increases Striatal Glutathione Peroxidase Activity and Protects against 3-Nitropropionic Acid-Induced Pro-Oxidative Damage in Rats

  2013cites this paper
• Protective Effects of Memantine Against Methylmercury-Induced Glutamate Dyshomeostasis and Oxidative Stress in Rat Cerebral Cortex

  2013influential citation
• Comparative study on methyl- and ethylmercury-induced toxicity in C6 glioma cells and the potential role of LAT-1 in mediating mercurial-thiol complexes uptake.

  2013cites this paper