Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Free Radical Biology & Medicine

• Publication date

  2009-08-15

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.freeradbiomed.2009.05.013PMID 19450679
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
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  2006influential reference
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  2006influential reference
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