Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP78 and Bcl-2

No abstract is available for this paper.

• Publication year

  2005

• Venue

  The Pharmacogenomics Journal

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.tpj.6500296PMID 15668729
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Valproic acid inhibits histone deacetylase activity and suppresses excitotoxicity-induced GAPDH nuclear accumulation and apoptotic death in neurons

  2004cited by this paper
• Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, an excitotoxic model of Huntington's disease

  2004cited by this paper
• The Pathophysiology of Mitochondrial Cell Death

  2004cited by this paper
• Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers

  2004cited by this paper
• Coupling endoplasmic reticulum stress to the cell death program

  2004cited by this paper
• A trip to the ER: coping with stress.

  2004cited by this paper
• Lithium inhibits Aβ‐induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation

  2003cited by this paper
• Lithium‐induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N‐methyl‐D‐aspartate receptor‐mediated excitotoxicity

  2003cited by this paper
• Regulation of c‐Jun N‐terminal kinase, p38 kinase and AP‐1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection

  2003cited by this paper
• Inhibitory Phosphorylation of Glycogen Synthase Kinase-3 (GSK-3) in Response to Lithium

  2003cited by this paper
• The Role of the Extracellular Signal-Regulated Kinase Signaling Pathway in Mood Modulation

  2003cited by this paper
• Endoplasmic reticulum: a primary target in various acute disorders and degenerative diseases of the brain.

  2003cited by this paper
• Chronic lithium treatment antagonizes glutamate-induced decrease of phosphorylated CREB in neurons via reducing protein phosphatase 1 and increasing MEK activities.

  2003cited by this paper
• Chronic Treatment With a Low Dose of Lithium Protects the Brain Against Ischemic Injury by Reducing Apoptotic Death

  2003cited by this paper
• Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model

  2003cited by this paper
• Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

  2002cited by this paper
• Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation

  2002cited by this paper
• Evaluation of neuroprotection by lithium and valproic acid against ouabain-induced cell damage.

  2002cited by this paper
• The mammalian endoplasmic reticulum as a sensor for cellular stress

  2002cited by this paper
• Long‐term lithium treatment prevents neurotoxic effects of β‐bungarotoxin in primary cultured neurons

  2002cited by this paper
• BH-3-only BIK Functions at the Endoplasmic Reticulum to Stimulate Cytochrome c Release from Mitochondria*

  2002cited by this paper
• Central Role of Glycogen Synthase Kinase-3β in Endoplasmic Reticulum Stress-induced Caspase-3 Activation*

  2002cited by this paper
• Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium.

  2002cited by this paper
• Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity.

  2002cited by this paper
• Lithium suppresses excitotoxicity-induced striatal lesions in a rat model of Huntington's disease.

  2001cited by this paper
• Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases.

  2001cited by this paper
• Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

  2001cited by this paper
• Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders.

  2001cited by this paper
• Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

  2000cited by this paper
• Glycogen Synthase Kinase-3β Facilitates Staurosporine- and Heat Shock-induced Apoptosis

  2000cited by this paper
• Involvement of c-Fos in signaling grp78 induction following ER calcium release

  2000cited by this paper
• beta-amyloid peptide-induced death of PC 12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment.

  2000cited by this paper
• Chronic valproate treatment increases expression of endoplasmic reticulum stress proteins in the rat cerebral cortex and hippocampus.

  2000cited by this paper
• Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells

  2000cited by this paper
• Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders.

  2000cited by this paper
• Increased expression of endoplasmic reticulum stress proteins following chronic valproate treatment of rat C6 glioma cells.

  2000cited by this paper
• reticulum-specific apoptosis and cytotoxicity by amyloid-b

  2000cited by this paper
• Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium.

  2000cited by this paper
• Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration.

  1999cited by this paper
• Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons.

  1999cited by this paper
• Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78.

  1999cited by this paper
• Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.

  1999cited by this paper
• Long Term Lithium Treatment Suppresses p53 and Bax Expression but Increases Bcl-2 Expression

  1999cited by this paper
• Characterization of a bioengineered chimeric Na+-nucleoside transporter.

  1999cited by this paper
• The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis.

  1999cited by this paper
• Lithium Activates the c‐Jun NH2‐Terminal Kinases In Vitro and in the CNS In Vivo

  1999cited by this paper
• Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

  1999cited by this paper
• The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS

  1999cited by this paper
• Lithium protects cultured neurons against β‐amyloid‐induced neurodegeneration

  1999cited by this paper
• Bcl‐2 Protects Against Apoptosis in Neuronal Cell Line Caused by Thapsigargin‐Induced Depletion of Intracellular Calcium Stores

  1998cited by this paper
• Mitogen‐Activated Protein Kinase Cascades as Regulators of Stress Responses

  1998cited by this paper
• Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine.

  1998cited by this paper
• Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx.

  1998cited by this paper
• Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats

  1998cited by this paper
• Induction of Bip mRNA upon programmed cell death of differentiated PC12 cells as well as rat sympathetic neurons.

  1997cited by this paper
• Maintenance of Calcium Homeostasis in the Endoplasmic Reticulum by Bcl-2

  1997cited by this paper
• Effects of chronic lithium treatment on ornithine decarboxylase induction and excitotoxic neuropathology in the rat.

  1997cited by this paper
• Lithium Increases Transcription Factor Binding to AP‐1 and Cyclic AMP‐Responsive Element in Cultured Neurons and Rat Brain

  1997cited by this paper
• Mechanism of Cellular 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Reduction

  1997cited by this paper
• Endoplasmic Reticulum Chaperones GRP78 and Calreticulin Prevent Oxidative Stress, Ca2+ Disturbances, and Cell Death in Renal Epithelial Cells*

  1997cited by this paper
• Inhibition of proliferation and apoptosis of human and rat T lymphocytes by curcumin, a curry pigment.

  1997cited by this paper
• Increase in AP-1 Transcription Factor DNA Binding Activity by Valproic Acid

  1997cited by this paper
• Carbamazepine inhibition of N-methyl-D-aspartate-evoked calcium influx in rat cerebellar granule cells.

  1996cited by this paper
• Dantrolene Is Cytoprotective in Two Models of Neuronal Cell Death

  1996cited by this paper
• A molecular mechanism for the effect of lithium on development.

  1996cited by this paper
• A protective effect of lithium on rat behaviour altered by ibotenic acid lesions of the basal forebrain cholinergic system.

  1995cited by this paper
• Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons.

  1994cited by this paper
• Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

  1994cited by this paper
• Long-term biphasic effects of lithium treatment on phospholipase C-coupled M3-muscarinic acetylcholine receptors in cultured cerebellar granule cells.

  1993cited by this paper
• Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

  1990cited by this paper
• Lithium augments fos protoonocogene expression in PC12 pheochromocytoma cells: implications for therapeutic action of lithium.

  1990cited by this paper
• A new generation of Ca2+ indicators with greatly improved fluorescence properties.

  1985cited by this paper

• Ecophysiological variance within fish populations occupying different trophic niches of contrasting ecoregions

  2025cites this paper
• Endoplasmic reticulum stress produced by Thapsigargin affects the occurrence of spike-wave discharge by modulating unfolded protein response pathways and activating immune responses in a dose-dependent manner.

  2024cites this paper
• New Advances in the Pharmacology and Toxicology of Lithium: A Neurobiologically Oriented Overview

  2024cites this paper
• The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca2+ transport in the pathogenesis of diseases

  2024cites this paper
• Lithium and hormesis: Enhancement of adaptive responses and biological performance via hormetic mechanisms.

  2023cites this paper
• The Neurobiological Role of Lithium Salts

  2023cites this paper
• [A systematic analysis of neurobiological roles of lithium].

  2022cites this paper
• Insight into the preparation of biopolymeric nanoparticles with lithium and their cellular uptake studies using PC 12 cells

  2022cites this paper
• Lithium and Erectile Dysfunction: An Overview

  2022cites this paper
• Replication of standard bovine viral diarrhea strain OregonC24Va induces endoplasmic reticulum stress–mediated apoptosis of bovine trophoblast cells

  2022cites this paper
• Potential mechanisms underlying lithium treatment for Alzheimer's disease and COVID-19.

  2022cites this paper
• Overexpression of Homer1b/c induces valproic acid resistance in epilepsy

  2022cites this paper
• Lithium Provides Broad Therapeutic Benefits in an Alzheimer’s Disease Mouse Model

  2022cites this paper
• Proteotoxicity and endoplasmic reticulum stress-mediated cell death

  2022cites this paper
• Characterization of chloride cells coupled with immunolocalization of Na + K+ ATPase in fishes of different migratory guilds of Indian Sundarbans

  2021cites this paper
• An in vivo drug repurposing screen and transcriptional analyses reveals the serotonin pathway and GSK3 as major therapeutic targets for NGLY1 deficiency

  2021cites this paper
• The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment

  2021cites this paper
• Vitamin K2 Modulates Organelle Damage and Tauopathy Induced by Streptozotocin and Menadione in SH-SY5Y Cells

  2021cites this paper
• Novel mechanism of action for the mood stabilizer lithium

  2020cites this paper
• Microbubbles in combination with focused ultrasound for the delivery of quercetin-modified sulfur nanoparticles through the blood brain barrier into the brain parenchyma and relief of endoplasmic reticulum stress to treat Alzheimer's disease.

  2020cites this paper
• Neurotrophic effects of lithium stimulate the reduction of ischemic and neurodegenerative brain damage

  2019cites this paper
• Induction of the unfolded protein response (UPR) during pseudorabies virus infection.

  2019cites this paper
• Molecular Mechanisms Linking ALS/FTD and Psychiatric Disorders, the Potential Effects of Lithium

  2019cites this paper
• The observed alteration in BCL2 expression following lithium treatment is influenced by the choice of normalization method

  2018cites this paper
• Inhibiting endoplasmic reticulum stress by lithium chloride contributes to the integrity of blood-spinal cord barrier and functional recovery after spinal cord injury.

  2017cites this paper
• Alzheimer’s disease pathology and the unfolded protein response: prospective pathways and therapeutic targets

  2017cites this paper
• Functional Consequences of CHRNA7 Copy-Number Alterations in Induced Pluripotent Stem Cells and Neural Progenitor Cells.

  2017cites this paper
• Lithium-responsive genes and gene networks in bipolar disorder patient-derived lymphoblastoid cell lines

  2016cites this paper
• Endoplasmic Reticulum Stress and Bipolar Disorder - Almost Forgotten Therapeutic Drug Targets in the Unfolded Protein Response Pathway Revisited.

  2016cites this paper
• Stress réticulaire et maladie d'Alzheimer : contribution du facteur de transcription XBP-1s

  2016cites this paper
• [Neurotrophic effects of lithium stimulate the reduction of ischemic and neurodegenerative brain damage].

  2016cites this paper
• Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors.

  2015cites this paper
• PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death

  2015cites this paper
• Synthesis and Pharmacological Evaluation of Different Piperine Analogs for Therapeutic Potential to Prevent ER Stress

  2015cites this paper
• Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease

  2015cites this paper
• Saturated Free Fatty Acid Sodium Palmitate-Induced Lipoapoptosis by Targeting Glycogen Synthase Kinase-3β Activation in Human Liver Cells

  2014cites this paper
• Chondrocyte‐Specific Pathology During Skeletal Growth and Therapeutics in a Murine Model of Pseudoachondroplasia

  2014cites this paper
• Chronic neuroprotective effects of low concentration lithium on SH-SY5Y cells: possible involvement of stress proteins and gene expression

  2014cites this paper
• Overexpression of CREB protein protects from tunicamycin-induced apoptosis in various rat cell types

  2014cites this paper
• Investigating the Protective Effect of Lithium Against High Glucose-Induced Neurotoxicity in PC12 Cells: Involvements of ROS, JNK and P38 MAPKs, and Apoptotic Mitochondria Pathway

  2014cites this paper
• Lithium Chloride Therapy Fails to Improve Motor Function in a Transgenic Mouse Model of Machado-Joseph Disease

  2014cites this paper
• Lithium Improves Survival of PC12 Pheochromocytoma Cells in High-Density Cultures and after Exposure to Toxic Compounds

  2014cites this paper
• Chronic inhibition of cGMP‐specific phosphodiesterase 5 suppresses endoplasmic reticulum stress in heart failure

  2013cites this paper
• Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder

  2013cites this paper
• Lithium treatment increases endothelial cell survival and autophagy in a mouse model of Fuchs endothelial corneal dystrophy

  2013cites this paper
• Lithium Induces ER Stress and N-Glycan Modification in Galactose-Grown Jurkat Cells

  2013cites this paper
• Increased bcl-2 Protein Levels in Rat Primary Astrocyte Culture Following Chronic Lithium Treatment

  2013cites this paper
• Lithium and valproate acid protect NSC34 cells from H2O2-induced oxidative stress and upregulate expressions of SIRT3 and CARM1.

  2013cites this paper
• Role of μ-opioid system in the formation of memory of placebo responses

  2013cites this paper
• Role of ER Stress in Dysfunction of the Nervous System

  2012cites this paper
• Systems Analysis Of Core Architectures Regulating Cellular Responses Under Stress In Eukaryotes

  2012cites this paper
• Le rôle de la protéine beta-arrestine 2 dans les effets neuroprotecteurs du lithium

  2012cites this paper
• Pharmacogenomics: The Significance of Genetics in the Metabolism of Natural Medicines

  2012influential citation
• The Role of Oxidative Stress on Neural TRPC3, TRPC5, TRPC6 Expression and/or Function and Relevance to Bipolar Disorder

  2012cites this paper
• Investigating the Role of Glycogen Synthase Kinase-3α in the Initiation and Progression of Atherosclerosis

  2012cites this paper
• Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy

  2012cites this paper
• The NMDA receptor/nitric oxide pathway: a target for the therapeutic and toxic effects of lithium.

  2011cites this paper
• The Role of Glutathione Metabolism in the Neuroprotective Effect of Mood Stabilizers

  2011influential citation
• Mechanisms of lithium ’ s neuroprotective actions 2 . 1 Lithium as a multi-functional neuroprotectant

  2011influential citation
• Urocortin modulates dopaminergic neuronal survival via inhibition of glycogen synthase kinase-3β and histone deacetylase.

  2011cites this paper
• Protective effect of erythropoietin on myocardial infarction in rats by inhibition of caspase-12 expression.

  2011cites this paper
• FTD and ALS: a tale of two diseases.

  2011cites this paper
• The common inhaled anesthetic isoflurane increases aggregation of huntingtin and alters calcium homeostasis in a cell model of Huntington's disease.

  2011cites this paper
• Bax inhibitor 1, a modulator of calcium homeostasis, confers affective resilience.

  2011cites this paper
• Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells.

  2011cites this paper
• Neuroprotective action of lithium in disorders of the central nervous system.

  2011cites this paper
• A review of the mammalian unfolded protein response

  2011cites this paper
• Neuroprotective and neurotrophic effects of long term lithium treatment in mouse brain

  2011cites this paper
• Effect of lithium on neuropathic pain induced by partial ligation of rat sciatic nerve

  2011cites this paper
• Mitochondrial complex I functionality and protein oxidative damage in lymphoblasts from lithium responsive patients with bipolar disorder, affected and unaffected relatives

  2011cites this paper
• Voltage-dependent calcium channel and NMDA receptor antagonists augment anticonvulsant effects of lithium chloride on pentylenetetrazole-induced clonic seizures in mice.

  2010cites this paper
• Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders.

  2010cites this paper
• Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells

  2010cites this paper
• Identification of eukaryotic elongation factor-2 as a novel cellular target of lithium and glycogen synthase kinase-3.

  2010cites this paper
• Porcine proximal tubular cells (LLC‐PK1) are able to tolerate high levels of lithium chloride in vitro: assessment of the influence of 1–20 mM LiCl on cell death and alterations in cell biology and biochemistry

  2010cites this paper
• Lithium protects against toxic effects of cadmium in the rat testes

  2010cites this paper
• Therapeutic implications of down-regulation of cyclophilin D in bipolar disorder.

  2010cites this paper
• Evidence Supporting a Role for Endoplasmic Reticulum Stress in the Development of Atherosclerosis in a Hyperglycaemic Mouse Model

  2009cites this paper
• Protective Role of Lithium in Ameliorating the Aluminium-induced Oxidative Stress and Histological Changes in Rat Brain

  2009cites this paper
• Review of Lithium Effects on Brain and Blood

  2009cites this paper
• Histone deacetylase inhibitors target diabetes via chromatin remodeling or as chemical chaperones?

  2009cites this paper
• Proteomic analysis of mitochondria in Raji cells following exposure to radiation: implications for radiotherapy response.

  2009cites this paper
• Modeling The Unfolded Protein Response And Its Connection To Cellular Stress

  2009cites this paper
• The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis.

  2009cites this paper
• Targeting histone deacetylases for the treatment of immune, endocrine & metabolic disorders.

  2009cites this paper
• Estudio del efecto neuroprotector de tratamientos farmacológicos en un modelo in vitro de lesión excitotóxica de médula espinal de rata basado en cultivos organotípicos

  2009cites this paper
• Sigma-1 receptor knockout mice display a depressive-like phenotype.

  2009cites this paper
• Long-term Exposure to Low Lithium Concentrations Stimulates Proliferation, Modifies Stress Protein Expression Pattern and Enhances Resistance to Oxidative Stress in SH-SY5Y Cells

  2009cites this paper
• Valproate and neuroprotective effects for bipolar disorder

  2009cites this paper
• Preliminary evidence on the association between XBP1-116C/G polymorphism and response to prophylactic treatment with valproate in bipolar disorders.

  2009cites this paper
• Mitochondrial DNA-dependent effects of valproate on mitochondrial calcium levels in transmitochondrial cybrids.

  2008cites this paper
• The Common Inhalational Anesthetic Isoflurane Induces Apoptosis via Activation of Inositol 1,4,5-Trisphosphate Receptors

  2008cites this paper
• Different effects of isoflurane and sevoflurane on cytotoxicity.

  2008cites this paper
• [Neurobiology of lithium].

  2008cites this paper
• Targeting histone deacetylases for the treatment of disease

  2008cites this paper
• HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation.

  2008cites this paper
• A Presenilin-1 Mutation Renders Neurons Vulnerable to Isoflurane Toxicity

  2008cites this paper
• GSK-3 beta inhibition and prevention of mitochondrial apoptosis inducing factor release are not involved in the antioxidant properties of SB-415286.

  2008cites this paper
• The aggregation state of -amyloid in Alzheimers Disease

  2008cites this paper
• Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

  2008cites this paper