Regulatory T Cells: Overcoming Suppression of T-Cell Immunity

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cancer Journal

• Publication date

  2010-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/PPO.0b013e3181eb336dPMID 20693845
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.

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• FOXP3 and the regulation of Treg/Th17 differentiation.

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• Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

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• Identification of IL-17-producing FOXP3+ regulatory T cells in humans

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• Plasticity of CD4(+) FoxP3(+) T cells.

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• Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor RORγt

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• Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells.

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• T-bet controls regulatory T cell homeostasis and function during type-1 inflammation

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• Partial Reduction of Human FOXP3+ CD4 T Cells In Vivo After CD25-directed Recombinant Immunotoxin Administration

  2008cited by this paper
• Acquisition of Suppressive Function by Activated Human CD4+CD25− T Cells Is Associated with the Expression of CTLA-4 Not FoxP31

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• Neuropilin-1 Expression on Regulatory T Cells Enhances Their Interactions with Dendritic Cells during Antigen Recognition

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• CD28 Costimulation Is Essential for Human T Regulatory Expansion and Function1

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• Molecular antagonism and plasticity of regulatory and inflammatory T cell programs.

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• Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II

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• Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.

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• The biology of interleukin-2.

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• Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

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• Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs.

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• A two-step process for thymic regulatory T cell development.

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• T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

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• Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II1

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• Regulatory T cells and immune tolerance.

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• Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines.

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• Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells1

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• Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease

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• A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

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• The inhibitory cytokine IL-35 contributes to regulatory T-cell function

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• Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

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• CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

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• Following Anti‐CD25 Treatment, A Functional CD4+CD25+ Regulatory T‐Cell Pool Is Present in Renal Transplant Recipients

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• Administration of a CD25-Directed Immunotoxin, LMB-2, to Patients with Metastatic Melanoma Induces a Selective Partial Reduction in Regulatory T Cells In Vivo1

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• Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

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• Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.

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• The Universal Character of the Tumor-Associated Antigen Survivin

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• The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery

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• IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells1

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• FOXP3 modifies the phenotypic and functional properties of regulatory T cells

  2007cited by this paper
• Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

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• Tumor Evasion of the Immune System by Converting CD4+CD25− T Cells into CD4+CD25+ T Regulatory Cells: Role of Tumor-Derived TGF-β

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• Depletion of CD4+CD25+ human regulatory T cells in vivo: Kinetics of Treg depletion and alterations in immune functions in vivo and in vitro

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• Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid

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• CD27 expression discriminates between regulatory and non‐regulatory cells after expansion of human peripheral blood CD4+ CD25+ cells

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• IL‐35 is a novel cytokine with therapeutic effects against collagen‐induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells

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• Increase of CD4+CD25+ regulatory T cells in the peripheral blood of patients with metastatic carcinoma: a Phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4+CD25+ T lymphocytes

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• OX40 costimulation turns off Foxp3+ Tregs.

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• Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients1

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• Manipulating T regulatory cells in cancer immunotherapy

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• Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-β

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• From vanilla to 28 flavors: multiple varieties of T regulatory cells.

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• CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

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• Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta.

  2006cited by this paper
• Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells.

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• Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

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• Natural versus adaptive regulatory T cells.

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• Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia

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• Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells

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• Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism1

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• A peripheral circulating compartment of natural naive CD4 Tregs.

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• Toll-Like Receptor 8-Mediated Reversal of CD4+ Regulatory T Cell Function

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• A Role for CD103 in the Retention of CD4+CD25+ Treg and Control of Leishmania major Infection1

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• CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset.

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• Regulatory T Cells in Ovarian Cancer: Biology and Therapeutic Potential

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• Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells.

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• A function for interleukin 2 in Foxp3-expressing regulatory T cells

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• Leukocyte CD40L deficiency affects the CD25(+) CD4 T cell population but does not affect atherosclerosis.

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• L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection.

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• Role of LAG-3 in regulatory T cells.

  2004cited by this paper
• Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors.

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• Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells1

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• Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta.

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• Cutting Edge: TGF-β Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells1

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• Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis.

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• CD25− T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion1

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• Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function.

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• Concomitant Tumor Immunity to a Poorly Immunogenic Melanoma Is Prevented by Regulatory T Cells

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• Distinct roles of CTLA‐4 and TGF‐β in CD4+CD25+ regulatory T cell function

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• Induction of foxP3+ Regulatory T Cells in the Periphery of T Cell Receptor Transgenic Mice Tolerized to Transplants1

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• Human CD4+CD25+ regulatory T cells.

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• TGF‐β Induces Foxp3 + T‐Regulatory Cells from CD4 + CD25 − Precursors

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• Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

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