Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Neuron

• Publication date

  2002-03-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0896-6273(02)00633-5PMID 11931747
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997influential reference
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