From clinics to (cow)mics: a reproductive journey

This manuscript describes the different topics I have been involved in the fields of reproductive physiology and embryo biotechnologies with attempts to address practical issues raised mainly by the breeding industry. The journey started with phenotyping work in the field of reproductive physio-pathology. Other issues were related to the optimization of reproductive biotechnologies to favorize genetic selection. The implementation of genomic selection raised opportunities to develop the use embryo biotechnologies and showed the interest of combining them in the case of embryo genotyping. There is still a need to refine phenotyping for reproductive traits especially for the identification of markers of uterine dysfunction. It is believed that new knowledge generated by combining different molecular approaches will be the source of applications that may benefit AI practice and embryo technologies.

• Publication year

  2018

• Venue

  Animal Reproduction

• Publication date

  2018-08-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.21451/1984-3143-AR2018-0076PMID 34178151PMCID 8202462
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2018cited by this paper
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  2018cited by this paper
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  2018cited by this paper
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  2018cited by this paper
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  2018cited by this paper
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  2018cited by this paper
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  2017cited by this paper
• Effect of energy balance profiles on metabolic and reproductive response in Holstein and Swedish Red cows.

  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
• Long-Term Effects of the Periconception Period on Embryo Epigenetic Profile and Phenotype: The Role of Stress and How This Effect Is Mediated.

  2017cited by this paper
• Achievements and unmet promises of assisted reproduction technologies in large animals: a per-sonal perspective

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  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
• Acute bovine viral diarrhea virus infection inhibits expression of interferon tau-stimulated genes in bovine endometrium†

  2017cited by this paper
• The Consequences of Maternal-Embryonic Cross Talk During the Periconception Period on Subsequent Embryonic Development.

  2017cited by this paper
• Profiling inflammatory biomarkers in cervico-vaginal mucus (CVM) postpartum: Potential early indicators of bovine clinical endometritis?

  2017cited by this paper
• Changes in protein expression profiles in bovine endometrial epithelial cells exposed to E. coli LPS challenge.

  2017cited by this paper
• Ability of dairy cows to ensure pregnancy according to breed and genetic merit for production traits under contrasted pasture-based systems.

  2017cited by this paper
• Involvement of plasma adipokines in metabolic and reproductive parameters in Holstein dairy cows fed with diets with differing energy levels.

  2017cited by this paper
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  2017cited by this paper
• Assessment of ‘one-step’ versus ‘sequential’ embryo culture conditions through embryonic genome methylation and hydroxymethylation changes

  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
• The CD4+ T cell methylome contributes to a distinct CD4+ T cell transcriptional signature in Mycobacterium bovis-infected cattle

  2016cited by this paper
• Epigenetic programming alterations in alligators from environmentally contaminated lakes.

  2016cited by this paper
• Animal Reproduction Technologies—Future Perspectives

  2016cited by this paper
• Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. I. Effect of Lipopolysaccharide on Innate Immunity1

  2015cited by this paper
• Use of immobilized cryopreserved bovine semen in a blind artificial insemination trial.

  2015cited by this paper
• Epigenetics, embryo quality and developmental potential.

  2015cited by this paper
• Dietary propylene glycol and in vitro embryo production after ovum pick-up in heifers with different anti-Müllerian hormone profiles.

  2015cited by this paper
• Potential of promotion of alleles by genome editing to improve quantitative traits in livestock breeding programs

  2015cited by this paper
• Factors associated with pregnancy-associated glycoprotein (PAG) levels in plasma and milk of Holstein cows during early pregnancy and their effect on the accuracy of pregnancy diagnosis.

  2015cited by this paper
• The relationship between fatty acid profiles in milk identified by Fourier transform infrared spectroscopy and onset of luteal activity in Norwegian dairy cattle.

  2015cited by this paper
• Epigenetics and periconception environment: an introduction.

  2015cited by this paper
• The identification of proteomic markers of sperm freezing resilience in ram seminal plasma.

  2015cited by this paper
• Sire effect on early and late embryonic death in French Holstein cattle.

  2015cited by this paper
• Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide1

  2015cited by this paper
• Impact of whole-genome amplification on the reliability of pre-transfer cattle embryo breeding value estimates

  2014cited by this paper
• Ram seminal plasma proteome and its impact on liquid preservation of spermatozoa.

  2014cited by this paper
• Metabolomic Prediction of Pregnancy Viability in Superovulated Cattle Embryos and Recipients with Fourier Transform Infrared Spectroscopy

  2014cited by this paper
• Prediction of pregnancy viability in bovine in vitro-produced embryos and recipient plasma with Fourier transform infrared spectroscopy.

  2014cited by this paper
• Pre- and post-partum mild underfeeding influences gene expression in the reproductive tract of cyclic dairy cows.

  2013cited by this paper
• Cell-cell communication via extracellular membrane vesicles and its role in the immune response

  2013cited by this paper
• Specific expression patterns and cell distribution of ancient and modern PAG in bovine placenta during pregnancy.

  2013cited by this paper
• MIM: an indirect method to assess inbreeding and coancestry in large incomplete pedigrees of selected dairy cattle.

  2011cited by this paper
• Ovarian parameters and fertility of dairy cows selected for one QTL located on BTA3.

  2011cited by this paper
• 193 BOVINE EMBRYO GENOTYPING USING A 50K SINGLE NUCLEOTIDE POLYMORPHISM CHIP

  2011cited by this paper
• GENIFER : cartographie fine et effets de QTL de fertilité en race bovine Holstein

  2011cited by this paper
• Embryo transfer: a comparative biosecurity advantage in international movements of germplasm.

  2011cited by this paper
• Reproductive Technologies and Genomic Selection in Cattle

  2010cited by this paper
• Female fertility in French dairy breeds: current situation and strategies for improvement.

  2010influential reference
• Estimation of genetic parameters and genome scan for 15 semen characteristics traits of Holstein bulls.

  2009cited by this paper
• Epigenetics in reproduction.

  2009cited by this paper
• Negative energy balance alters global gene expression and immune responses in the uterus of postpartum dairy cows

  2009cited by this paper
• Impact of Energy Balance on Metabolic Changes and Reproductive Tissues; Consequences for Ovarian Activity and Fertility in Dairy and Beef Cattle

  2009cited by this paper
• 135 PREGNANCY RATES AFTER SINGLE DIRECT TRANSFER OF BIOPSIED FROZEN–THAWED BOVINE EMBRYOS ACCORDING TO QUALITY

  2009cited by this paper
• Effect of dietary-induced changes in plasma insulin concentrations during the early post partum period on pregnancy rate in dairy cows.

  2009cited by this paper
• Anti-Müllerian Hormone Is an Endocrine Marker of Ovarian Gonadotropin-Responsive Follicles and Can Help to Predict Superovulatory Responses in the Cow1

  2009cited by this paper
• 102 IDENTIFICATION OF CONTRASTED PHENOTYPES IN THE BOVINE FROM REPEATED IN VIVO AND IN VITRO EMBRYO PRODUCTION FOLLOWING SUPEROVULATION

  2008cited by this paper
• Alginate cell encapsulation: new advances in reproduction and cartilage regenerative medicine

  2008cited by this paper
• Weismann Rules! OK? Epigenetics and the Lamarckian temptation

  2007cited by this paper
• Reduction of body-weight gain enhances in vitro embryo production in overfed superovulated dairy heifers.

  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
• Precursors of taurine in female genital tract: Effects on developmental capacity of bovine embryo producedin vitro

  2005cited by this paper
• Influence of antral follicle size on oocyte characteristics and embryo development in the bovine.

  2005cited by this paper
• Seminal plasma and male factor signalling in the female reproductive tract

  2005cited by this paper
• Effect of stage of follicular growth during superovulation on developmental competence of bovine oocytes.

  2005influential reference
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  2002cited by this paper
• Kinetics of early in vitro development of bovine in vivo- and in vitro-derived zygotes produced and/or cultured in chemically defined or serum-containing media.

  2002cited by this paper
• Identified and unidentified challenges for reproductive biotechnologies regarding infectious diseases in animal and public health.

  2001cited by this paper
• Resumption of meiosis: mechanism involved in meiotic progression and its relation with developmental competence.

  2001cited by this paper
• Splitting and biopsy for bovine embryo sexing under field conditions.

  2001cited by this paper
• Reproductive loss in high-producing dairy cattle: where will it end?

  2001cited by this paper
• Use of pregnancy specific proteins and progesterone assays to monitor pregnancy and determine the timing, frequencies and sources of embryonic mortality in ruminants.

  2001cited by this paper
• Delipidating in vitro-produced bovine zygotes: effect on further development and consequences for freezability.

  2001cited by this paper
• Declining fertility in dairy cattle: changes in traditional and endocrine parameters of fertility.

  2000cited by this paper
• Effect of lecithin on in vitro and in vivo survival of in vitro produced bovine blastocysts after cryopreservation.

  1999cited by this paper
• Marker assisted estimation of breeding values when marker information is missing on many animals

  1999cited by this paper
• The effect of media, serum and temperature on in vitro survival of bovine blastocysts after Open Pulled Straw (OPS) vitrification.

  1999cited by this paper
• High bovine blastocyst development in a static in vitro production system using SOFaa medium supplemented with sodium citrate and myo-inositol with or without serum-proteins.

  1999cited by this paper
• Effect of time interval from insemination to first cleavage on the developmental characteristics, sex ratio and pregnancy rate after transfer of bovine embryos.

  1999cited by this paper
• Pregnancy associated glycoproteins in ruminants: inactive members of the aspartic proteinase family.

  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Pregnancy rates following direct transfer of glycerol sucrose or ethylene glycol cryopreserved bovine embryos

  1997cited by this paper
• Beneficial effects of Vero cells for developing IVF bovine eggs in two different coculture systems.

  1997cited by this paper
• Survival and development of bovine blastocysts produced in vitro after assisted hatching, vitrification and in-straw direct rehydration.

  1997cited by this paper
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  1997cited by this paper
• Pregnancy-specific protein B and progesterone concentrations in relation to nutritional regimen, placental mass and pregnancy outcome in growing adolescent ewes carrying singleton fetuses.

  1997cited by this paper
• Sources of variation of post-partum cyclicity, ovulation and pregnancy rates in primiparous Charolais cows treated with norgestomet implants and PMSG.

  1996cited by this paper
• The sexing of bovine embryos in the field

  1995cited by this paper

• Advances in Dairy Cattle Reproduction—A Foreword

  2024cites this paper
• Clinical Overview of Luteal Deficiency in Dairy Cattle

  2022cites this paper
• EMBRYO SURVIVAL TO ACCELERATE GENETIC PROGRESS IN DAIRY HERDS (review)

  2021cites this paper