SCIENCE@home

Quality of life in Parkinson's disease

L. Findley

Published 1999 in International journal of clinical practice

ABSTRACT

We read with interest the study of Campbell et al' in the September 1998 issue of this journal and agree with the result that an initial loading dose of 400 μg budesonide twice daily may have an adavantage over 400 μg nocte. In general, local application of steroids is a first line strategy in asthma. However, we feel that the design does not consider current knowledge of chronotherapy with steroids. · Single morning doses may be much more effective than single evening doses and, more importantly, even if the overall risk of local steroids is small, they produce fewer side-effects when given in the morning. In particular, the suppression of the HHA-axis is clearly reduced. From the chronobiological point of view, 400 μg budesonide given in the morning and 400 μg budesonide given in the evening are not the same, so the difference between the study groups may be explained by the morning administration, not just by the dose itself. An interesting question would be: do twice-daily morning/evening doses produce the same results as a oncedaily morning dose or twice-daily morning/afternoon doses? For practical reasons, one should strive for a single morning dose, because such a regimen is easier for the patient, particularly elderly asthmatics who often have to take five or more drugs. Anything that simplifies dosage schedules is an advantage. We encourage the authors to investigate such therapeutic dosage schedules

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-9 of 9 references · Page 1 of 1

CITED BY

Showing 1-100 of 284 citing papers · Page 1 of 3

123
Next