Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor

The chemokine beta family is comprised of at least six distinct cytokines that regulate trafficking of phagocytes and lymphocytes in mammalian species; at least one of these, macrophage inflammatory protein 1 alpha (MIP-1 alpha), also regulates the growth of hematopoietic stem cells. We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor. Moreover, we have now cloned both the cDNA and the gene for this receptor, functionally expressed the receptor in Xenopus oocytes, and mapped the gene to human chromosome 3p21. Transcripts for the receptor were found in mature and immature myeloid cells as well as B cells. The receptor is a member of the G protein-coupled receptor superfamily. It has approximately 33% amino acid identity with receptors for the alpha chemokine, interleukin 8, and may be the human homologue of the product of US28, an open reading frame of human cytomegalovirus.

• Publication year

  1993

• Venue

  Journal of Experimental Medicine

• Publication date

  1993-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.177.5.1421PMID 7683036PMCID 2191019
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of two high affinity human interleukin-8 receptors.

  1992cited by this paper
• Molecular evolution of the human interleukin–8 receptor gene cluster

  1992cited by this paper
• A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family.

  1992cited by this paper
• Virus proteins that counteract host immune defenses.

  1992cited by this paper
• Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils

  1992cited by this paper
• Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family

  1992cited by this paper
• Erratum: Molecular cloning of the fMet-Leu-Phe receptor from neutrophils (Journal of Biological Chemistry (1990) 265 (20061-20064))

  1992cited by this paper
• Employment of antipeptide antisera to distinguish two closely related cytokines induced in human T cells.

  1992cited by this paper
• Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP1 alpha in vivo.

  1992cited by this paper
• Structure and functional expression of a human interleukin-8 receptor.

  1991cited by this paper
• Model systems for the study of seven-transmembrane-segment receptors.

  1991cited by this paper
• Biology of the RANTES/SIS cytokine family.

  1991cited by this paper
• Properties of the novel proinflammatory supergene "intercrine" cytokine family.

  1991cited by this paper
• Macrophage inflammatory protein (MIP)-1 beta abrogates the capacity of MIP-1 alpha to suppress myeloid progenitor cell growth.

  1991cited by this paper
• Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 near Egf.

  1991cited by this paper
• Cloning of complementary DNA encoding a functional human interleukin-8 receptor.

  1991influential reference
• Molecular cloning of the fMet-Leu-Phe receptor from neutrophils.

  1990cited by this paper
• Identification and characterization of an inhibitor of haemopoietic stem cell proliferation

  1990cited by this paper
• Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES

  1990cited by this paper
• Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells.

  1990cited by this paper
• Human cytomegalovirus encodes three G protein-coupled receptor homologues

  1990cited by this paper
• Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines

  1989cited by this paper
• Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL 1 and TNF.

  1989cited by this paper
• Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties

  1988cited by this paper
• Genes for synapsin I, a neuronal phosphoprotein, map to conserved regions of human and murine X chromosomes.

  1986cited by this paper
• A new generation of Ca2+ indicators with greatly improved fluorescence properties.

  1985cited by this paper
• Detection of human cytomegalovirus in peripheral blood lymphocytes in a natural infection.

  1985cited by this paper
• Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.

  1984cited by this paper

• Hub genes and common pathogenic mechanisms between COPD and H. pylori infection

  2025cites this paper
• A bipartite bacterial virulence factor targets the complement system and neutrophil activation

  2025cites this paper
• CMV-encoded GPCRs in infection, disease, and pathogenesis.

  2024cites this paper
• The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA

  2023cites this paper
• CCR1 mediates Müller cell activation and photoreceptor cell death in macular and retinal degeneration

  2023cites this paper
• Molecular Docking Analysis of Phytochemical Thymoquinone as a Therapeutic Agent on SARS-Cov-2 Envelope Protein

  2020cites this paper
• Disruption of CCR1-mediated myeloid cell accumulation suppresses colorectal cancer progression in mice.

  2020cites this paper
• Significance of RANTES‐CCR5 axis and linked downstream immunomodulation in Dengue pathogenesis: A study from Guwahati, India

  2019cites this paper
• Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1

  2019cites this paper
• Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1

  2018cites this paper
• Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1

  2018cites this paper
• Chemokine and chemokine receptors in autoimmunity: the case of primary biliary cholangitis

  2016cites this paper
• Cytokines and Chemokines in Mycobacterium tuberculosis Infection

  2016cites this paper
• Biased agonism at chemokine receptors: obstacles or opportunities for drug discovery?

  2016cites this paper
• Chapter 64 – Hypercalcemia of Malignancy

  2016cites this paper
• Vibrio cholerae porin OmpU mediates M1-polarization of macrophages/monocytes via TLR1/TLR2 activation.

  2015cites this paper
• Dengue virus requires the CC‐chemokine receptor CCR5 for replication and infection development

  2015cites this paper
• Viral Chemokine Receptors

  2015cites this paper
• Pharmacological intervention at CCR1 and CCR5 as an approach for cancer: help or hindrance.

  2014cites this paper
• Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease

  2014cites this paper
• Experimental Studies on Platelet-Regulated Lymphocyte Adhesion and CD 4 + T Cell Activation

  2014cites this paper
• Leukocyte trafficking during infection with modified vaccinia virus Ankara

  2014cites this paper
• Aspergillus pneumonia in adult patients with acute leukemia.

  2014cites this paper
• PLATELET-LYMPHOCYTE CROSS-TALK IN ATHEROGENESIS Experimental Studies on Platelet-Regulated Lymphocyte Adhesion and CD4 + T Cell Activation

  2014cites this paper
• Leukocyte trafficking during infection with Modified Vaccinia virus Ankara: the role of chemokine receptor 1 and complement activation

  2014cites this paper
• Atorvastatin Inhibits the 5-Lipoxygenase Pathway and Expression of CCL3 to Alleviate Atherosclerotic Lesions in Atherosclerotic ApoE Knockout Mice

  2013cites this paper
• Functioning as a Death Receptor for B Cells CCR3 Expression Induced by IL-2 and IL-4

  2013cites this paper
• CC Chemokine Receptors and Chronic Inflammation—Therapeutic Opportunities and Pharmacological Challenges

  2013influential citation
• in Human Neutrophils γ by IFN- Induction of Chemotaxis to CC Chemokines Up-Regulation of CCR1 and CCR3 and

  2013cites this paper
• Rapid Publication Chemokine Receptor Usage by Human Eosinophils The Importance of CCR 3 Demonstrated Using an Antagonistic Monoclonal Antibody

  2013cites this paper
• Increased expression of chemokine receptors CCR1 and CCR3 in nasal polyps: molecular basis for recruitment of the granulocyte infiltrate

  2012cites this paper
• Analysis of minocycline as a countermeasure against acute radiation syndrome.

  2012cites this paper
• CCR1-Mediated STAT3 Tyrosine Phosphorylation and CXCL8 Expression in THP-1 Macrophage-like Cells Involve Pertussis Toxin-Insensitive Gα14/16 Signaling and IL-6 Release

  2012cites this paper
• Pertussis Toxin-Insensitive G THP-1 Macrophage-like Cells Involve Phosphorylation and CXCL 8 Expression in CCR 1-Mediated STAT 3 Tyrosine

  2012cites this paper
• Chemokine receptor CCR1 disruption limits renal damage in a murine model of hemolytic uremic syndrome.

  2012cites this paper
• Immunotherapy for acute kidney injury.

  2012cites this paper
• A Cannabigerol Quinone Alleviates Neuroinflammation in a Chronic Model of Multiple Sclerosis

  2012cites this paper
• The RANTES Chemokine

  2012cites this paper
• A case of myeloma with hypercalcemia caused by high serum concentrations of both parathyroid hormone-related peptide (PTHrP) and macrophage inflammatory protein-1α (MIP-1α).

  2011cites this paper
• Proteomic-Based Identification of CD4-Interacting Proteins in Human Primary Macrophages

  2011cites this paper
• Chemokine research moves on.

  2011cites this paper
• Therapeutic potential of CCR1 antagonists for multiple myeloma.

  2011cites this paper
• Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

  2011cites this paper
• 14. Targeting CCR1

  2011cites this paper
• Monocyte recruitment during infection and inflammation

  2011cites this paper
• Fibroblast-recruited , tumor-infiltrating CD 4 + T cells stimulate mammary cancer metastasis through RANKL-RANK signaling

  2011cites this paper
• Overcoming hurdles in developing successful drugs targeting chemokine receptors

  2011cites this paper
• Resequencing of the CCL5 and CCR5 genes and investigation of variants for association with diabetic nephropathy

  2010cites this paper
• CCL5 as an adjuvant for cancer immunotherapy

  2010cites this paper
• Small molecule antagonists of the chemokine receptor CCR5.

  2010cites this paper
• Anti-chemokine small molecule drugs: a promising future?

  2010cites this paper
• Small molecule antagonists of chemokine receptors--is promiscuity a virtue?

  2010cites this paper
• CCR1 knockdown suppresses human non-small cell lung cancer cell invasion

  2009cites this paper
• Chemokine receptor CCR1

  2009cites this paper
• Signaling and regulation of the human cytomegalovirus G-protein coupled receptor US28 in HCMV infected cells.

  2009influential citation
• Chemokine receptor antagonists: Part 1

  2009cites this paper
• CC Chemokine Receptor-1 Activates Intimal Smooth Muscle-Like Cells in Graft Arterial Disease

  2009cites this paper
• NK cell and dendritic cell interactions in innate immune responses

  2009cites this paper
• Differential involvement of Galpha16 in CC chemokine-induced stimulation of phospholipase Cbeta, ERK, and chemotaxis.

  2008cites this paper
• The role of chemokine receptor CCR1-dependent macrophage recruitment for the progression of chronic kidney disease in murine Alport syndrome or type 2 diabetes

  2008cites this paper
• Chemokines and chemokine receptors: the key to understanding AIDS.

  2008cites this paper
• CCR1 Chemokine Receptor

  2008cites this paper
• Platelet-derived chemokines in vascular biology

  2007cites this paper
• Aus der Deutschen Diabetes-Klinik des Deutschen Diabetes Zentrum -Leibniz-Institut- an der Heinrich- Heine- Universität Düsseldorf

  2007cites this paper
• Chemokine Receptors and Neutrophil Trafficking

  2007cites this paper
• Analysis of the immune-related transcriptome of a lophotrochozoan model, the marine annelid Platynereis dumerilii

  2007cites this paper
• The Birth and Maturation of Chemokines and Their Receptors

  2007cites this paper
• CCR1 Deficiency Increases Susceptibility to Fatal Coronavirus Infection of the Central Nervous System

  2007influential citation
• Chemokine receptors in tissue cells and angiogenesis

  2006cites this paper
• Human Cytomegalovirus Subverts the Functions of Monocytes, Impairing Chemokine-Mediated Migration and Leukocyte Recruitment

  2006cites this paper
• Ligand up-regulation does not correlate with a role for CCR1 in pathogenesis in a mouse model of non-lymphocyte-mediated neurological disease

  2006cites this paper
• Predictions of CCR1 Chemokine Receptor Structure and BX 471 Antagonist Binding Followed by Experimental Validation*

  2006cites this paper
• Asthma, allergy and chemokines.

  2006cites this paper
• CHEMOKINES AND THEIR ASSOCIATION WITH PAEDIATRIC DISEASES

  2006cites this paper
• Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human osteoclasts differentiated with RANKL and osteoclast like cells differentiated by MCP‐1 and RANTES

  2006cites this paper
• Expression of interleukin-8 receptors in endometriosis

  2005cites this paper
• S100A9 deficiency alters adenosine-5'-triphosphate induced calcium signalling but does not generally interfere with calcium and zinc homeostasis in murine neutrophils.

  2005cites this paper
• Cloning, expression, and functional characterization of cynomolgus monkey (Macaca fascicularis) CC chemokine receptor 1

  2005cites this paper
• Transendothelial migration of monocytes: the underlying molecular mechanisms and consequences of HIV-1 infection.

  2005cites this paper
• CCR1 antagonists in clinical development

  2005cites this paper
• Site-directed Mutagenesis of CC Chemokine Receptor 1 Reveals the Mechanism of Action of UCB 35625, a Small Molecule Chemokine Receptor Antagonist*

  2005cites this paper
• BX471: a CCR1 antagonist with anti-inflammatory activity in man.

  2005cites this paper
• Overview and History of Chemokines and Their Receptors

  2005cites this paper
• MIP‐1α[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF‐α and LTB4

  2005cites this paper
• MIP-1alpha[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4.

  2005cites this paper
• The human cytomegalovirus UL78 gene is highly conserved among clinical isolates, but is dispensable for replication in fibroblasts and a renal artery organ-culture system.

  2005cites this paper
• CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells.

  2004cites this paper
• Chemokines and viral diseases of the central nervous system

  2004cites this paper
• CCL3/MIP-1α Is a Potent Immunostimulator When Coexpressed with Interleukin-2 or Granulocyte-Macrophage Colony-Stimulating Factor in a Leukemia/Lymphoma Vaccine

  2004cites this paper
• MIP-1γ Promotes Receptor Activator of NF-κB Ligand-Induced Osteoclast Formation and Survival1

  2004cites this paper
• Neutrophil recruitment in mast cell-dependent inflammation: inhibitory mechanisms of glucocorticoids

  2004cites this paper
• MIP-1 gamma promotes receptor-activator-of-NF-kappa-B-ligand-induced osteoclast formation and survival.

  2004cites this paper
• Chemotactic peptides encoded by hiv-1 nef gene

  2004cites this paper
• PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells.

  2004cites this paper
• The chemokine receptor CCR1 is strongly up‐regulated after skin injury but dispensable for wound healing

  2004cites this paper
• Down‐regulation of connective tissue growth factor and type I collagen mRNA expression by connective tissue growth factor antisense oligonucleotide during experimental liver fibrosis

  2004cites this paper
• Study of selected molecular and cellular aspects of autoimmunity

  2004cites this paper
• Endocrine‐Immune Interactions in Human Endometrium

  2004cites this paper
• Expression of interleukin-8 receptors in endometriosis.

  2004cites this paper
• CCR1 chemokine receptor antagonist.

  2003cites this paper