Activation of Stat3 signaling in AgRP neurons promotes locomotor activity.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cell Metabolism

• Publication date

  2008-03-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cmet.2008.01.007PMID 18316029
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Adipose tissue as an endocrine organ.

  2010cited by this paper
• [Obesity and insulin resistance].

  2009cited by this paper
• Mechanisms of leptin action and leptin resistance.

  2008cited by this paper
• Ontogeny of leptin and its receptor expression in mouse testis during the postnatal period

  2008cited by this paper
• Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.

  2008cited by this paper
• Appropriate Inhibition of Orexigenic Hypothalamic Arcuate Nucleus Neurons Independently of Leptin Receptor/STAT3 Signaling

  2007cited by this paper
• Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation.

  2007cited by this paper
• Neuropeptide Y-induced enhancement of the evoked release of newly synthesized dopamine in rat striatum: mediation by Y2 receptors.

  2007cited by this paper
• The Long Form of the Leptin Receptor Regulates STAT5 and Ribosomal Protein S6 via Alternate Mechanisms*

  2007cited by this paper
• Differential accessibility of circulating leptin to individual hypothalamic sites.

  2007cited by this paper
• Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function.

  2007cited by this paper
• Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding.

  2007cited by this paper
• Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

  2007cited by this paper
• Decreased Vesicular Somatodendritic Dopamine Stores in Leptin-Deficient Mice

  2007cited by this paper
• Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.

  2006cited by this paper
• Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting.

  2006cited by this paper
• Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid.

  2006cited by this paper
• Molecular disruption of hypothalamic nutrient sensing induces obesity

  2006cited by this paper
• The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis.

  2006cited by this paper
• Overview of endogenous and synthetic melanocortin peptides.

  2006cited by this paper
• Regulation of the insulin gene by glucose and fatty acids.

  2006cited by this paper
• Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus.

  2006cited by this paper
• Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.

  2006cited by this paper
• Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation.

  2006cited by this paper
• Role of brain insulin receptor in control of body weight and reproduction.

  2006cited by this paper
• Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

  2006cited by this paper
• Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

  2006cited by this paper
• Agouti-related protein-deficient mice display an age-related lean phenotype.

  2005cited by this paper
• Postembryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype

  2005cited by this paper
• IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW，Thompson RW，et al//Proc Natl Acad Sci U S A

  2005cited by this paper
• Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes.

  2005cited by this paper
• Diabetes, Obesity, and the Brain

  2005cited by this paper
• Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism

  2005cited by this paper
• The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

  2005cited by this paper
• Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis.

  2005cited by this paper
• Blockade of melanocortin transmission inhibits cocaine reward

  2005cited by this paper
• NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates

  2005cited by this paper
• Leptin receptor action and mechanisms of leptin resistance

  2005cited by this paper
• New advances in the genetics of early onset obesity

  2005cited by this paper
• Monogenic obesity in humans.

  2005cited by this paper
• Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3.

  2005cited by this paper
• Insulin determines leptin responses during a glucose challenge in fed and fasted rats

  2005cited by this paper
• Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance

  2005cited by this paper
• The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.

  2005cited by this paper
• Mesolimbic Dopamine Super-Sensitivity in Melanin-Concentrating Hormone-1 Receptor-Deficient Mice

  2005cited by this paper
• Agouti-related peptide–expressing neurons are mandatory for feeding

  2005cited by this paper
• LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin.

  2004cited by this paper
• Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults.

  2004cited by this paper
• Behavioral and physiologic responses to caloric restriction in mice.

  2004cited by this paper
• Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus

  2004cited by this paper
• Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism.

  2004cited by this paper
• Central nervous system mechanisms in blood pressure control

  2004cited by this paper
• Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice.

  2004cited by this paper
• Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis.

  2004cited by this paper
• Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice.

  2004cited by this paper
• Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

  2004cited by this paper
• Recombinant human leptin in women with hypothalamic amenorrhea.

  2004cited by this paper
• Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation.

  2004cited by this paper
• Ala67Thr polymorphism in the Agouti‐related peptide gene is associated with inherited leanness in humans

  2004cited by this paper
• Role of Hypothalamic Melanocortin 3/4-Receptors in Mediating Chronic Cardiovascular, Renal, and Metabolic Actions of Leptin

  2004cited by this paper
• FoxOs at the crossroads of cellular metabolism, differentiation, and transformation.

  2004cited by this paper
• Cardiovascular and metabolic responses to fasting and thermoneutrality in Ay mice.

  2003cited by this paper
• Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression

  2003cited by this paper
• The mouse brain in stereotaxic coordinates

  2003cited by this paper
• Basal and feeding-evoked dopamine release in the rat nucleus accumbens is depressed by leptin.

  2003cited by this paper
• Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin.

  2003cited by this paper
• Regulation of leptin secretion from white adipocytes by free fatty acids.

  2003cited by this paper
• Rapid generation of inducible mouse mutants.

  2003cited by this paper
• STAT3 signalling is required for leptin regulation of energy balance but not reproduction

  2003cited by this paper
• Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

  2002cited by this paper
• A Road Map for Those Who Don't Know JAK-STAT

  2002cited by this paper
• Dietary Modulation of Circulating Leptin Levels: Site-Specific Changes in Fat Deposition and Ob mRNA Expression

  2002cited by this paper
• A phosphatidylinositol 3-kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding

  2002cited by this paper
• Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion.

  2002cited by this paper
• Signalling: STATs: transcriptional control and biological impact

  2002cited by this paper
• Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

  2002cited by this paper
• Generation of Soluble Leptin Receptor by Ectodomain Shedding of Membrane-spanning Receptors in Vitro and in Vivo *

  2002cited by this paper
• The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins

  2002cited by this paper
• Validity of body mass index compared with other body-composition screening indexes for the assessment of body fatness in children and adolescents.

  2002cited by this paper
• Regulation of Jak Kinases by Intracellular Leptin Receptor Sequences*

  2002cited by this paper
• Central administration of oleic acid inhibits glucose production and food intake.

  2002cited by this paper
• Hypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice.

  2002cited by this paper
• Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake

  2002cited by this paper
• Cardiovascular and sympathetic effects of leptin

  2002cited by this paper
• Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

  2001cited by this paper
• Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene.

  2001cited by this paper
• Correlation of Increased Grooming Behavior and Motor Activity with Alterations in Nigrostriatal and Mesolimbic Catecholamines After α-Melanotropin and Neuropeptide Glutamine–Isoleucine Injection in the Rat Ventral Tegmental Area

  2001cited by this paper
• Increased Expression of the Sterol Regulatory Element-binding Protein-1 Gene in Insulin Receptor Substrate-2−/−Mouse Liver*

  2001cited by this paper
• Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors*

  2001cited by this paper
• Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling.

  2001cited by this paper
• Intracellular signalling: Key enzyme in leptin-induced anorexia

  2001cited by this paper
• Neuropeptide Y Has a Central Inhibitory Action on the Hypothalamic-Pituitary-Thyroid Axis.

  2001cited by this paper
• The gene structure and minimal promoter of the human agouti related protein.

  2001cited by this paper
• The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation.

  2001cited by this paper
• Selective deletion of leptin receptor in neurons leads to obesity.

  2001cited by this paper
• Genetics of body-weight regulation

  2000cited by this paper
• Dual regulation of leptin secretion: intracellular energy and calcium dependence of regulated pathway.

  2000cited by this paper
• Dynamic regulation of leptin entry into brain by the blood-brain barrier.

  2000cited by this paper
• Regulation of the fatty acid synthase promoter by insulin.

  2000cited by this paper
• SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985 *

  2000cited by this paper

• Central leptin pathways in metabolic homeostasis

  2025cites this paper
• Fam163a knockdown and mitochondrial stress in the arcuate nucleus of hypothalamus reduce AgRP neuron activity and differentially regulate mitochondrial dynamics in mice

  2025cites this paper
• Models for T-large granular lymphocytic leukemia: how to mimic the cellular interplays in malignant autoimmunity

  2025cites this paper
• IGF-1 and insulin receptors in LepRb neurons jointly regulate body growth, bone mass, reproduction, and metabolism

  2024cites this paper
• d‐Amphetamine and Feeding States Cohesively Affect Locomotion and Motor Neuron Response in Zebrafish Larvae

  2024cites this paper
• The potential role of targeting the leptin receptor as a treatment for breast cancer in the context of hyperleptinemia: a literature review

  2024cites this paper
• Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.

  2024cites this paper
• Hypothalamic Grb10 enhances leptin signalling and promotes weight loss

  2023cites this paper
• Astrocytic insulin receptor controls circadian behavior via dopamine signaling in a sexually dimorphic manner

  2023cites this paper
• Hypothalamic control of energy expenditure and thermogenesis

  2022cites this paper
• Effects of maternal high-fat diet on the hypothalamic components related to food intake and energy expenditure in mice offspring.

  2022cites this paper
• Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior

  2022cites this paper
• Targeting STAT3 Signaling in COL1+ Fibroblasts Controls Colitis-Associated Cancer in Mice

  2022cites this paper
• Leptin signaling and leptin resistance

  2022cites this paper
• Appetite Control Mechanisms and Obesity

  2022cites this paper
• Amylin Pharmacology in Alzheimer’s Disease Pathogenesis and Treatment

  2021cites this paper
• Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus

  2021cites this paper
• Hypothalamic long noncoding RNA AK044061 is involved in the development of dietary obesity in mice

  2021cites this paper
• Neuropeptide Y and Metabolism Syndrome: An Update on Perspectives of Clinical Therapeutic Intervention Strategies

  2021cites this paper
• Aurora A and AKT Kinase Signaling Associated with Primary Cilia

  2021cites this paper
• Exercise Increases NPY/AgRP and TH Neuron Activity in the Hypothalamus of Female Mice.

  2021cites this paper
• The Diagnostic and Therapeutic Role of Leptin and Its Receptor ObR in Glioblastoma Multiforme

  2020cites this paper
• PGC-1β-expressing POMC neurons mediate the effect of leptin on thermoregulation in the mouse

  2020cites this paper
• Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network

  2020cites this paper
• Malnourishment during early lactation disrupts the ontogenetic distribution of the CART and α-MSH anorexigenic molecules in the arcuate/paraventricular pathway and lateral hypothalamus in male rats.

  2020cites this paper
• Suprachiasmatic Nucleus–Arcuate Nucleus Axis: Interaction Between Time and Metabolism Essential for Health

  2020cites this paper
• Bisphenol A Induces Agrp Gene Expression in Hypothalamic Neurons through a Mechanism Involving ATF3

  2020cites this paper
• Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer

  2020cites this paper
• LRP1 regulates food intake and energy balance in GABAergic neurons independently of leptin action.

  2020cites this paper
• Perinatal free‐choice of a high‐calorie low‐protein diet affects leptin signaling through IRS1 and AMPK dephosphorylation in the hypothalami of female rat offspring in adulthood

  2019cites this paper
• Raspberry ketone and Garcinia Cambogia rebalanced disrupted insulin resistance and leptin signaling in rats fed high fat fructose diet.

  2019cites this paper
• DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice

  2019cites this paper
• Transcriptional and physiological roles for STAT proteins in leptin action

  2019cites this paper
• STAT5 ablation in AgRP neurons increases female adiposity and blunts food restriction adaptations.

  2019cites this paper
• STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis

  2019cites this paper
• Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons

  2018cites this paper
• Primary Cilia as Signaling Hubs in Health and Disease

  2018cites this paper
• Investigation of hypothalamic regulatory mechanisms during spontaneous daily torpor and fasting-induced torpor in the Djungarian hamster (Phodopus sungorus)

  2018cites this paper
• A review of brain insulin signaling in mood disorders: From biomarker to clinical target

  2018cites this paper
• The Paraventricular Nucleus of the Hypothalamus: Development, Function, and Human Diseases.

  2018cites this paper
• Electrophysiological Mechanism of Peripheral Hormones and Nutrients Regulating Energy Homeostasis.

  2018cites this paper
• The Leptin Signaling.

  2018cites this paper
• The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF

  2018cites this paper
• Pharmacological characterization and functional rescue of the giant panda and human melanocortin-4 receptors

  2017cites this paper
• Hypothalamic inflammation in obesity and metabolic disease

  2017cites this paper
• The Suprachiasmatic Nucleus of the Dromedary Camel (Camelus dromedarius): Cytoarchitecture and Neurochemical Anatomy

  2017cites this paper
• Anorexia–cachexia syndrome-like hypothalamic neuroendocrine dysfunction in a patient with a papillary craniopharyngioma

  2017cites this paper
• Differential effects of early-life NMDA receptor antagonism on aspartame-impaired insulin tolerance and behavior.

  2016cites this paper
• PGC-1α expression in murine AgRP neurons regulates food intake and energy balance

  2016cites this paper
• Kinase Inactive Tyrosine Kinase (Tyk2) Supports Differentiation of Brown Fat Cells

  2016cites this paper
• Sustained Treatment with Insulin Detemir in Mice Alters Brain Activity and Locomotion

  2016cites this paper
• IL-27 suppresses type 2 immune responses in vivo via direct effects on group 2 innate lymphoid cells

  2016cites this paper
• The brain renin-angiotensin system in metabolic and cardiovascular regulation

  2016cites this paper
• miceof ambulatory activity and wheel running in Identification of a physiological role for leptin in the

  2016cites this paper
• Leptin and Obesity

  2016cites this paper
• CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting

  2016cites this paper
• Foxa1 is essential for development and functional integrity of the subthalamic nucleus

  2016cites this paper
• Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling

  2016cites this paper
• Imbalanced insulin action in chronic over nutrition: Clinical harm, molecular mechanisms, and a way forward.

  2016influential citation
• Enhancement of Hypothalamic STAT3 Acetylation by Nuclear Receptor Nur77 Dictates Leptin Sensitivity

  2015cites this paper
• A talk between fat tissue, gut, pancreas and brain to control body weight.

  2015influential citation
• Fuel homeostasis and locomotor behavior: role of leptin and melanocortin pathways

  2015cites this paper
• Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients.

  2015cites this paper
• Metabolic regulation and energy homeostasis through the primary Cilium.

  2015cites this paper
• The role of VGF and its derived peptides in the regulation of energy homeostasis

  2015cites this paper
• A Physiological Role for Hypothalamic Proopiomelanocortin in the Intrinsic Regulation of Locomotor Activity and Stress.

  2015cites this paper
• The role of the hypothalamus in the maintenance of energy balance and peripheral glucose control

  2015cites this paper
• Maternal Brain Adaptations in Pregnancy

  2015cites this paper
• Hypothalamic KLF4 mediates leptin's effects on food intake via AgRP

  2014cites this paper
• The impact of leptin on perinatal development and psychopathology.

  2014cites this paper
• 20 years of leptin: connecting leptin signaling to biological function.

  2014cites this paper
• The Hunger Hormone Ghrelin Dynamically Tunes Phasic Mesolimbic Signals Underlying Food-Directed Behaviors

  2014cites this paper
• Decoding insulin resistance and metabolic syndrome for promising therapeutic intervention.

  2014cites this paper
• Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain.

  2014cites this paper
• Erythropoietin, a Novel Versatile Player Regulating Energy Metabolism beyond the Erythroid System

  2014cites this paper
• Role of PTPRT in obesity and its substrate paxillin tyrosine-88 in colorectal cancer

  2014cites this paper
• Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system

  2014cites this paper
• Neuroendocrine control of satiation

  2014cites this paper
• Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance.

  2014cites this paper
• Metabolic influences on neuroendocrine regulation of reproduction

  2013cites this paper
• 4 INSULIN – LEPTIN SIGNALING IN THE BRAIN

  2013cites this paper
• Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from Kiss1 cells.

  2013cites this paper
• CNS insulin signaling in the control of energy homeostasis and glucose metabolism - from embryo to old age.

  2013cites this paper
• Sucrose feeding in mouse pregnancy leads to hypertension, and sex-linked obesity and insulin resistance in female offspring

  2013cites this paper
• Environment, Leptin Sensitivity, and Hypothalamic Plasticity

  2013cites this paper
• Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity

  2013cites this paper
• ROCK1 in AgRP neurons regulates energy expenditure and locomotor activity in male mice.

  2013cites this paper
• Insulin–Leptin Signaling in the Brain

  2013cites this paper
• Kiss1 neurons and Metabolic Sensing

  2013cites this paper
• Hypothalamic Control of Appetite and Energy Metabolism

  2013cites this paper
• TXNIP in Agrp Neurons Regulates Adiposity, Energy Expenditure, and Central Leptin Sensitivity

  2012cites this paper
• Effects of leptin treatment and Western diet on wheel running in selectively bred high runner mice.

  2012cites this paper
• Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.

  2012influential citation
• Neuronal overexpression of insulin receptor substrate 2 leads to increased fat mass, insulin resistance, and glucose intolerance during aging

  2012cites this paper
• FoxO1 target Gpr17 activates AgRP neurons to regulate food intake.

  2012cites this paper
• Rho-kinase Regulates Energy Balance by Targeting Hypothalamic Leptin Receptor Signaling

  2012cites this paper
• Topiramate treatment improves hypothalamic insulin and leptin signaling and action and reduces obesity in mice.

  2012cites this paper
• Hypothalamic AgRP‐neurons control peripheral substrate utilization and nutrient partitioning

  2012cites this paper
• Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

  2012influential citation
• Acutely Decreased Thermoregulatory Energy Expenditure or Decreased Activity Energy Expenditure Both Acutely Reduce Food Intake in Mice

  2012cites this paper