A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Molecular Biology of the Cell

• Publication date

  2007-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/MBC.E07-06-0581PMID 17804815PMCID PMC2043575
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differential susceptibility of mitogen‐activated protein kinase pathway mutants to oxidative‐mediated killing by phagocytes in the fungal pathogen Candida albicans

  2007influential reference
• The Cek1 and Hog1 Mitogen-Activated Protein Kinases Play Complementary Roles in Cell Wall Biogenesis and Chlamydospore Formation in the Fungal Pathogen Candida albicans

  2006cited by this paper
• Role of the Hog 1 Stress-activated Protein Kinase in the Global Transcriptional Response to Stress in the Fungal Pathogen Candida albicans

  2006influential reference
• Adaptor protein Ste50p links the Ste11p MEKK to the HOG pathway through plasma membrane association.

  2006cited by this paper
• The role of the sakA (Hog1) and tcsB (sln1) genes in the oxidant adaptation of Aspergillus fumigatus.

  2006influential reference
• A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans.

  2006influential reference
• Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway

  2006influential reference
• Functional studies of the Ssk1p response regulator protein of Candida albicans as determined by phenotypic analysis of receiver domain point mutants

  2006cited by this paper
• The Pbs2 MAP kinase kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans.

  2005influential reference
• Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans.

  2005influential reference
• Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans.

  2005influential reference
• The Sho1 Adaptor Protein Links Oxidative Stress to Morphogenesis and Cell Wall Biosynthesis in the Fungal Pathogen Candida albicans

  2005influential reference
• Aspergillus nidulans HOG pathway is activated only by two‐component signalling pathway in response to osmotic stress

  2005cited by this paper
• Gene disruption in Candida albicans using a synthetic, codon-optimised Cre-loxP system.

  2005cited by this paper
• A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans.

  2004influential reference
• Sho1 and Pbs2 act as coscaffolds linking components in the yeast high osmolarity MAP kinase pathway.

  2004cited by this paper
• A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast.

  2004cited by this paper
• Regulation of the osmoregulatory HOG MAPK cascade in yeast.

  2004cited by this paper
• Studies on the regulation of the two-component histidine kinase gene CHK1 in Candida albicans using the heterologous lacZ reporter gene.

  2004influential reference
• A Mitogen-Activated Protein Kinase That Senses Nitrogen Regulates Conidial Germination and Growth in Aspergillus fumigatus

  2004influential reference
• Candida albicans Response Regulator Gene SSK1 Regulates a Subset of Genes Whose Functions Are Associated with Cell Wall Biosynthesis and Adaptation to Oxidative Stress

  2003influential reference
• Global transcriptional responses of fission yeast to environmental stress.

  2003cited by this paper
• Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis.

  2003influential reference
• A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway

  2003influential reference
• Protein A‐tagging for purification of native macromolecular complexes from Candida albicans

  2003cited by this paper
• The Hog1 Mitogen-Activated Protein Kinase Is Essential in the Oxidative Stress Response and Chlamydospore Formation in Candidaalbicans

  2003influential reference
• Distinct regulatory proteins control the graded transcriptional response to increasing H(2)O(2) levels in fission yeast Schizosaccharomyces pombe.

  2002cited by this paper
• Deletion of the Two-Component Histidine Kinase Gene (CHK1) of Candida albicans Contributes to Enhanced Growth Inhibition and Killing by Human Neutrophils In Vitro

  2002cited by this paper
• A Third Osmosensing Branch in Saccharomyces cerevisiae Requires the Msb2 Protein and Functions in Parallel with the Sho1 Branch

  2002cited by this paper
• Osmotic Stress Signaling and Osmoadaptation in Yeasts

  2002cited by this paper
• Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway.

  2001cited by this paper
• Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.

  2001cited by this paper
• Cassettes for PCR‐mediated construction of green, yellow, and cyan fluorescent protein fusions in Candida albicans

  2001cited by this paper
• Remodeling of yeast genome expression in response to environmental changes.

  2001cited by this paper
• Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42

  2000cited by this paper
• Defects in protein glycosylation cause SHO1-dependent activation of a STE12 signaling pathway in yeast.

  2000cited by this paper
• Response of Saccharomyces cerevisiae to severe osmotic stress: evidence for a novel activation mechanism of the HOG MAP kinase pathway

  2000influential reference
• Yeast Cdc42 GTPase and Ste20 PAK‐like kinase regulate Sho1‐dependent activation of the Hog1 MAPK pathway

  2000cited by this paper
• Genomic expression programs in the response of yeast cells to environmental changes.

  2000cited by this paper
• CIp10, an efficient and convenient integrating vector for Candida albicans.

  2000influential reference
• The MET3 promoter: a new tool for Candida albicans molecular genetics

  1999influential reference
• Rapid Hypothesis Testing with Candida albicans through Gene Disruption with Short Homology Regions

  1999influential reference
• Role of the Mitogen-Activated Protein Kinase Hog1p in Morphogenesis and Virulence of Candida albicans

  1999influential reference
• Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two‐component response regulator

  1998cited by this paper
• Heat stress activates fission yeast Spc1/StyI MAPK by a MEKK-independent mechanism.

  1998cited by this paper
• Requirement of STE50 for Osmostress-Induced Activation of the STE11 Mitogen-Activated Protein Kinase Kinase Kinase in the High-Osmolarity Glycerol Response Pathway

  1998cited by this paper
• The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae.

  1998cited by this paper
• Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.

  1997influential reference
• The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans

  1996cited by this paper
• Active and inactive protein kinases: structural basis for regulation.

  1996influential reference
• Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor.

  1996cited by this paper
• Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.

  1995influential reference
• Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast.

  1995influential reference
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994cited by this paper
• Getting started with yeast.

  1991cited by this paper

• Proteomics and physiologic analysis reveal different response strategies to cadmium stress in Lentinula edodes.

  2025cites this paper
• Invasive Gastric Candidiasis With Concurrent Clostridioides difficile Colitis: A Case Report and Review of the Literature

  2025cites this paper
• Identification of the ADH gene family in Trichosporon asahii and the role of TaADH_like in pathogenicity and fluconazole resistance

  2025cites this paper
• PPI network identifies interacting pathogenic signaling pathways in Candida albicans.

  2025cites this paper
• The HOG signal pathway contributes to survival strategies of the piezo-tolerant fungus Aspergillus sydowii DM1 in hadal sediments

  2025cites this paper
• AoChk1 Is Required for Sporulation, Trap Formation, and Metabolic Process in Arthrobotrys oligospora

  2025cites this paper
• A screen to identify antifungal antagonists reveals a variety of pharmacotherapies that induce echinocandin tolerance in Candida albicans

  2025cites this paper
• A screen to identify antifungal antagonists reveals a variety of pharmacotherapies induce echinocandin tolerance in Candida albicans

  2025cites this paper
• The StuA Transcription Factor and Alternative Splicing Mechanisms Drive the Levels of MAPK Hog1 Transcripts in the Dermatophyte Trichophyton rubrum

  2024cites this paper
• Role of Hog1-mediated stress tolerance in biofilm formation by the pathogenic fungus Trichosporon asahii

  2024cites this paper
• Stress contingent changes in Hog1 pathway architecture and regulation in Candida albicans

  2024cites this paper
• Fungal plant pathogen “mutagenomics” reveals tagged and untagged mutations in Zymoseptoria tritici and identifies SSK2 as key morphogenesis and stress-responsive virulence factor

  2023influential citation
• Hog1-mediated stress tolerance in the pathogenic fungus Trichosporon asahii

  2023cites this paper
• Caffeine activates HOG-signalling and inhibits pseudohyphal growth in Saccharomyces cerevisiae

  2023cites this paper
• An insight into the role of protein kinases as virulent factors, regulating pathogenic attributes in Candida albicans.

  2022cites this paper
• AoSsk1, a Response Regulator Required for Mycelial Growth and Development, Stress Responses, Trap Formation, and the Secondary Metabolism in Arthrobotrys oligospora

  2022cites this paper
• Adaptation to Endoplasmic Reticulum Stress in Candida albicans Relies on the Activity of the Hog1 Mitogen-Activated Protein Kinase

  2022cites this paper
• Kinase Hog1 and Adr1 Opposingly Regulate Haploid Cell Morphology by Controlling Vacuole Size in Sporisorium scitamineum

  2022cites this paper
• Antifungal activity and potential mechanism of berberine hydrochloride against fluconazole-resistant Candida albicans.

  2022cites this paper
• The high osmolarity glycerol (HOG) pathway in fungi†

  2021cites this paper
• Inhibitory effect of berberine hydrochloride against Candida albicans and the role of the HOG-MAPK pathway

  2021cites this paper
• The zinc cluster transcription factor Czf1 regulates cell wall architecture and integrity in Candida albicans

  2021cites this paper
• Host lung environment limits Aspergillus fumigatus germination through a SskA-dependent signaling response

  2021cites this paper
• A Target-Based In Vivo Test System to Identify Novel Fungicides with Mode of Action in the HOG Pathway.

  2021cites this paper
• Host Lung Environment Limits Aspergillus fumigatus Germination through an SskA-Dependent Signaling Response

  2021cites this paper
• The two-component signal transduction system and its regulation in Candida albicans

  2021cites this paper
• The regulation of hyphae growth in Candida albicans

  2020cites this paper
• Sho1p Connects Glycolysis to Ras1-cAMP Signaling and Is Required for Microcolony Formation in Candida albicans

  2020cites this paper
• The Two-Component Response Regulator Ssk1 and the Mitogen-Activated Protein Kinase Hog1 Control Antifungal Drug Resistance and Cell Wall Architecture of Candida auris

  2020cites this paper
• Inhibiting roles of farnesol and HOG in morphological switching of Candida albicans.

  2020cites this paper
• Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance.

  2019cites this paper
• The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway

  2019cites this paper
• Cross-talk between the Ras GTPase and the Hog1 survival pathways in response to nitrosative stress in Paracoccidioides brasiliensis.

  2019cites this paper
• PGPBS, a mitogen-activated protein kinase kinase, is required for vegetative differentiation, cell wall integrity, and pathogenicity of the barley leaf stripe fungus Pyrenophora graminea.

  2019cites this paper
• Removing the Mask:Regulation of Cell Wall β (1,3)-Glucan Unmasking in Candida albicans

  2019cites this paper
• Protein-Protein Interactions in Candida albicans

  2019cites this paper
• Stress-Activated Protein Kinases in Human Fungal Pathogens

  2019cites this paper
• Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen

  2019cites this paper
• Hypoxia Promotes Immune Evasion by Triggering β-Glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase A Signaling

  2018cites this paper
• The antimicrobial photodynamic inactivation resistance of Candida albicans is modulated by the Hog1 pathway and the Cap1 transcription factor.

  2018cites this paper
• Influence of ylHog1 MAPK kinase on Yarrowia lipolytica stress response and erythritol production

  2018cites this paper
• High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis

  2018cites this paper
• PbsB Regulates Morphogenesis, Aflatoxin B1 Biosynthesis, and Pathogenicity of Aspergillus flavus

  2018cites this paper
• Functions of Candida albicans cell wall glycosidases Dfg5p and Dcw1p in biofilm formation and HOG MAPK pathway

  2018cites this paper
• Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space

  2018cites this paper
• Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation

  2017cites this paper
• Stress Adaptation

  2017cites this paper
• The Fungal Cell Wall: Structure, Biosynthesis, and Function

  2017cites this paper
• The phosphorelay signal transduction system in Candida glabrata: an in silico analysis

  2017cites this paper
• Signalling mucin Msb2 Regulates adaptation to thermal stress in Candida albicans

  2016cites this paper
• An investigation into the stress response mechanisms and virulence of the human fungal pathogen, Candida albicans

  2016influential citation
• The conserved dual phosphorylation sites of the Candida albicans Hog1 protein are crucial for white-opaque switching, mating, and pheromone-stimulated cell adhesion.

  2016cites this paper
• The MAP Kinase Network As the Nervous System of Fungi

  2016cites this paper
• Identification and characterization of transcription factors involved in morphogenesis in the human fungal pathogen Candida albicans

  2016cites this paper
• Complementary roles of the Cek1 and Cek2 MAP kinases in Candida albicans cell-wall biogenesis.

  2016cites this paper
• Two-Component Signaling Regulates Osmotic Stress Adaptation via SskA and the High-Osmolarity Glycerol MAPK Pathway in the Human Pathogen Talaromyces marneffei

  2016cites this paper
• Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis

  2016cites this paper
• Genome-Wide Identification of Mitogen-Activated Protein Kinase Gene Family across Fungal Lineage Shows Presence of Novel and Diverse Activation Loop Motifs

  2016cites this paper
• Oxidative Stress Responses in the Human Fungal Pathogen, Candida albicans

  2015cites this paper
• The Pho4 transcription factor mediates the response to arsenate and arsenite in Candida albicans

  2015cites this paper
• Peroxide sensing and signaling in the Sporothrix schenckii complex: an in silico analysis to uncover putative mechanisms regulating the Hog1 and AP-1 like signaling pathways.

  2015cites this paper
• The transmembrane protein Sho1 cooperates with the mucin Msb2 to regulate invasive growth and plant infection in Fusarium oxysporum.

  2015cites this paper
• The Mkk2 MAPKK Regulates Cell Wall Biogenesis in Cooperation with the Cek1-Pathway in Candida albicans

  2015cites this paper
• Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans

  2015cites this paper
• Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance

  2015cites this paper
• Oxidative stress response pathways: Fission yeast as archetype

  2015cites this paper
• Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight

  2015cites this paper
• Fungal Quorum Sensing Inhibitors

  2015cites this paper
• Ineffective Phosphorylation of Mitogen-Activated Protein Kinase Hog1p in Response to High Osmotic Stress in the Yeast Kluyveromyces lactis

  2015cites this paper
• Activation of stress signalling pathways enhances tolerance of fungi to chemical fungicides and antifungal proteins

  2014cites this paper
• Stress adaptation in a pathogenic fungus

  2014influential citation
• The lack of upstream elements of the Cek1 and Hog1 mediated pathways leads to a synthetic lethal phenotype upon osmotic stress in Candida albicans.

  2014cites this paper
• Phagocytes Stress That Enhances the Potent Fungicidal Activity of to Combinatorial Cationic and Oxidative Candida albicans Mechanisms Underlying the Exquisite Sensitivity of 2014

  2014cites this paper
• Mechanisms Underlying the Exquisite Sensitivity of Candida albicans to Combinatorial Cationic and Oxidative Stress That Enhances the Potent Fungicidal Activity of Phagocytes

  2014cites this paper
• A Novel Function for Hog1 Stress-Activated Protein Kinase in Controlling White-Opaque Switching and Mating in Candida albicans

  2014cites this paper
• The CEK1-mediated mitogen-activated protein kinase pathway in the fungal pathogen Candida albicans

  2013cites this paper
• A modeling perspective on Candida albicans' interactions with its human host

  2013cites this paper
• Stk2, a Mitogen-Activated Protein Kinase from ＂Setosphaeria turcica＂, Specifically Complements the Functions of the Fus3 and Kss1 of ＂Saccharomyces cerevisiae＂ in Filamentation, Invasive Growth, and Mating Behavior

  2013cites this paper
• University of Birmingham Stress adaptation in a pathogenic fungus

  2013influential citation
• Aquaporins in Magnaporthe oryzae

  2013influential citation
• The CEK 1-mediated mitogen-activated protein kinase pathway in the fungal pathogen Candida albicans

  2013cites this paper
• The transmembrane protein Opy2 mediates activation of the Cek1 MAP kinase in Candida albicans.

  2013cites this paper
• Genetic Networks Inducing Invasive Growth in Saccharomyces cerevisiae Identified Through Systematic Genome-Wide Overexpression

  2013cites this paper
• Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen

  2012cites this paper
• Current Understanding of HOG-MAPK Pathway in Aspergillus fumigatus

  2012cites this paper
• A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi

  2012influential citation
• Combinatorial stresses kill pathogenic Candida species

  2012cites this paper
• Msb2 Shedding Protects Candida albicans against Antimicrobial Peptides

  2012cites this paper
• Stress Responses in Candida

  2012cites this paper
• The role of redox-sensitive antioxidants in oxidative stress signalling in Candida albicans

  2011cites this paper
• The metabolic basis of Candida albicans morphogenesis and quorum sensing.

  2011cites this paper
• The two‐component histidine kinases DrkA and SlnA are required for in vivo growth in the human pathogen Penicillium marneffei

  2011cites this paper
• Identification and characterization of putative osmosensors, HwSho1A and HwSho1B, from the extremely halotolerant black yeast Hortaea werneckii.

  2011cites this paper
• Ste50 adaptor protein governs sexual differentiation of Cryptococcus neoformans via the pheromone-response MAPK signaling pathway.

  2011cites this paper
• MAPKKK-independent Regulation of the Hog1 Stress-activated Protein Kinase in Candida albicans

  2011cites this paper
• Stress signalling to fungal stress-activated protein kinase pathways

  2010cites this paper
• Heat Shock Response

  2010cites this paper
• Thioredoxin Regulates Multiple Hydrogen Peroxide-Induced Signaling Pathways in Candida albicans

  2010cites this paper
• Interaction between the Candida albicans High-Osmolarity Glycerol (HOG) Pathway and the Response to Human β-Defensins 2 and 3

  2010cites this paper
• The MAP kinase-activated protein kinase Rck2p regulates cellular responses to cell wall stresses, filamentation and virulence in the human fungal pathogen Candida albicans.

  2010cites this paper