Recombinant soluble form of PSGL-1 accelerates thrombolysis and prevents reocclusion in a porcine model.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Circulation

• Publication date

  1999-03-16

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.CIR.99.10.1363PMID 10077522
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Time as an adjunctive agent to thrombolytic therapy

  2005cited by this paper
• Abciximab (ReoPro) potentiates thrombolysis in ST elevation myocardial infarction: results of TIMI 14 trials

  1998cited by this paper
• Anti-P-selectin antibody decreases inflammation and thrombus formation in venous thrombosis.

  1997cited by this paper
• GPIIb/IIIa Antagonists: Pathophysiologic and Therapeutic Insights from Studies of c7E3 Fab

  1997cited by this paper
• Specific accumulation of circulating monocytes and polymorphonuclear leukocytes on platelet thrombi in a vascular injury model.

  1997cited by this paper
• Remodeling and neointimal formation in the carotid artery of normal and P-selectin-deficient mice.

  1997cited by this paper
• Conjunctive Use of Platelet Glycoprotein IIb/IIIa Antagonists and Thrombolytic Therapy for Acute Myocardial Infarction

  1997cited by this paper
• Core2 beta-1,6-N-acetylglucosaminyltransferase enzyme activity is critical for P-selectin glycoprotein ligand-1 binding to P-selectin.

  1996cited by this paper
• Neutrophil and platelet activation at balloon-injured coronary artery plaque in patients undergoing angioplasty.

  1996cited by this paper
• Increased neutrophil-platelet adhesion in patients with unstable angina.

  1996cited by this paper
• Thrombolytic Therapy in Acute Myocardial Infarction

  1996cited by this paper
• Leukocyte activation with platelet adhesion after coronary angioplasty: a mechanism for recurrent disease?

  1995cited by this paper
• Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary artery model.

  1995cited by this paper
• A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding.

  1995cited by this paper
• Pretreatment with a blocking monoclonal antibody to P-selectin accelerates pharmacological thrombolysis in a primate model of arterial thrombosis.

  1995cited by this paper
• Induction of tissue factor on monocytes by adhesion to endothelial cells.

  1995cited by this paper
• P-selectin induces the expression of tissue factor on monocytes.

  1994cited by this paper
• Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.

  1994cited by this paper
• The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction.

  1993cited by this paper
• In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury.

  1993cited by this paper
• Illusion of Reperfusion Does Anyone Achieve Optimal Reperfusion During Acute Myocardial Infarction?

  1993cited by this paper
• Expression cloning of a functional glycoprotein ligand for P-selectin.

  1993cited by this paper
• The pathogenesis of coronary artery disease and the acute coronary syndromes (1).

  1992cited by this paper
• Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets

  1992cited by this paper
• A Randomized Trial of Late Reperfusion Therapy for Acute Myocardial Infarction

  1992cited by this paper
• Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells

  1992cited by this paper
• The pathogenesis of coronary artery disease and the acute coronary syndromes (2).

  1992cited by this paper
• Platelet-neutrophil interactions. Possible relevance in the pathogenesis of thrombosis and inflammation.

  1991cited by this paper
• Coupling of the adhesive receptor CD11b/CD18 to functional enhancement of effector macrophage tissue factor response.

  1991cited by this paper
• The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region

  1991cited by this paper
• GMP-140 mediates adhesion of stimulated platelets to neutrophils.

  1990cited by this paper
• PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells.

  1989cited by this paper
• Prevention of reoccluding platelet-rich thrombi in canine femoral arteries with a novel peptide antagonist of platelet glycoprotein IIb/IIIa receptors.

  1989cited by this paper
• PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes.

  1989cited by this paper
• GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies.

  1989cited by this paper
• Rapid and sustained coronary artery recanalization with combined bolus injection of recombinant tissue-type plasminogen activator and monoclonal antiplatelet GPIIb/IIIa antibody in a canine preparation.

  1988cited by this paper
• Antithrombotic therapy after myocardial reperfusion in acute myocardial infarction.

  1988cited by this paper
• Thrombolysis in myocardial infarction (TIMI) trial: Phase I. A comparison between intravenous tissue plasminogen activator and intravenous streptokinase

  1988cited by this paper
• Thrombolysis inMyocardial Infarction (TIMI) Trial, Phase I:acomparison between intravenous tissue plasminogen activator andintravenous streptokinase*

  1987cited by this paper
• Effect of intravenous streptokinase on left ventricular function and early survival after acute myocardial infarction.

  1987cited by this paper
• Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.

  1987cited by this paper
• A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein.

  1986cited by this paper
• A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation

  1985cited by this paper
• Neutrophil Depletion Suppresses 111In-Labeled Platelet Accumulation in Infarcted Myocardium

  1985cited by this paper

• Opportunities for the treatment of atherosclerosis: selectins.

  2025cites this paper
• Targeting the P-selectin/PSGL-1 pathway: discovery of disease-modifying therapeutics for disorders of thromboinflammation

  2024cites this paper
• Biomarkers of in vivo platelet activation in thoroughbreds during their first long-term training

  2024cites this paper
• Mechanistic and Therapeutic Implications of Protein and Lipid Sialylation in Human Diseases

  2024cites this paper
• Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood

  2022cites this paper
• P‐ and E‐ selectin in venous thrombosis and non‐venous pathologies

  2022cites this paper
• A Combined Activity of Thrombin and P-Selectin Is Essential for Platelet Activation by Pancreatic Cancer Cells

  2021cites this paper
• The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans

  2021cites this paper
• Novel Antiplatelet Therapies

  2019cites this paper
• Development of a Translatable Ultrasound Molecular Imaging Agent for Inflammation.

  2019cites this paper
• P‐ and E‐selectin receptor antagonism prevents human leukocyte adhesion to activated porcine endothelial monolayers and attenuates porcine endothelial damage

  2018cites this paper
• Targeting P‐selectin glycoprotein ligand‐1/P‐selectin interactions as a novel therapy for metabolic syndrome

  2017cites this paper
• Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies

  2016cites this paper
• valuation of Cardioprotective Effects f Recombinant Soluble P-Selectin lycoprotein Ligand-Immunoglobulin in yocardial Ischemia-Reperfusion Injury by eal-Time Myocardial Contrast Echocardiography

  2016cites this paper
• Novel anti-inflammatory therapies for the treatment of atherosclerosis.

  2015cites this paper
• The role of platelets in the recruitment of leukocytes during vascular disease

  2015cites this paper
• Primitive Erythroblast Cell Autonomously Regulates the Timing of Blood Circulation Onset via a Control of Adherence to Endothelium

  2014cites this paper
• New Principles in Developmental Processes

  2014cites this paper
• Novel adjunctive treatments of myocardial infarction.

  2014cites this paper
• Cellular adhesion and the endothelium: P-selectin.

  2014cites this paper
• Platelets as Therapeutic Targets of Atherosclerosis

  2013cites this paper
• Chapter 58 – Novel Antiplatelet Therapies

  2013cites this paper
• A Thought Experiment in Contemporary Drug Development: Informed Bench‐to‐Bedside Strategies

  2013cites this paper
• Potential therapeutic targeting of platelet-mediated cellular interactions in atherosclerosis and inflammation.

  2012cites this paper
• The Potential of Monoclonal Antibodies to Reduce Reperfusion Injury in Myocardial Infarction

  2012cites this paper
• Cell Adhesion Antagonists

  2012cites this paper
• Recent Insights into the Molecular and Cellular Contributions to Venous Thrombosis

  2012cites this paper
• Selectin Antagonists

  2012cites this paper
• Inflammation and Immunity as Targets for Drug Therapy in Acute Coronary Syndrome

  2011cites this paper
• Role of Platelets in Primary Hemostasis and Atherothrombosis

  2011cites this paper
• Anticorps anti-p-sélectine et leurs procédés d'utilisation et d'identification

  2011cites this paper
• Aspirin: Pharmacology and Clinical Applications

  2011cites this paper
• P-selectin antagonism in inflammatory disease.

  2010cites this paper
• Metalloprotease-dependent onset of blood circulation in zebrafish.

  2010cites this paper
• Contribution of SELP and PSGL-1 genotypes and haplotypes to the presence of coronary heart disease in Tunisians

  2010cites this paper
• Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.

  2010cites this paper
• Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis

  2010cites this paper
• Antiplatelet therapies for the treatment of cardiovascular disease

  2010cites this paper
• Significant association between neutrophil aggregation in aspirated thrombus and myocardial damage in patients with ST-segment elevation acute myocardial infarction.

  2009cites this paper
• PSGL‐1 function in immunity and steady state homeostasis

  2009cites this paper
• Identification of Novel Isoforms of Mouse L-selectin with Different Carboxyl-terminal Tails*

  2008cites this paper
• Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease.

  2008cites this paper
• Prophylactic P-selectin inhibition with PSI-421 promotes resolution of venous thrombosis without anticoagulation

  2008cites this paper
• Characterization of the Novel P-Selectin Inhibitor PSI-697 [2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] Quinoline-4-carboxylic acid] in Vitro and in Rodent Models of Vascular Inflammation and Thrombosis

  2008cites this paper
• CHAPTER 12 – P-Selectin/PSGL-1 and Other Interactions between Platelets, Leukocytes, and Endothelium

  2007cites this paper
• Fundamental Mechanisms in Venous Thrombosis

  2007cites this paper
• Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation

  2007cites this paper
• Etablierung eines Modells zur Untersuchung der Thrombozyten-Endothelzell-Interaktion und zur Analyse von P-Selektin in der synovialen Mikrozirkulation bei der Antigen-induzierten-Arthritis der Maus mittels Fluoreszenzmikroskopie in vivo

  2007cites this paper
• Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists.

  2007cites this paper
• Evolutionary conservation of P-selectin glycoprotein ligand-1 primary structure and function

  2007cites this paper
• 2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.

  2007cites this paper
• P-selectin

  2007cites this paper
• Monocyte-platelet aggregates in patients with ischemic heart disease

  2006cites this paper
• Biomechanics of P-selectin PSGL-1 bonds: shear threshold and integrin-independent cell adhesion.

  2006cites this paper
• Recombinant P‐selectin glycoprotein‐ligand‐1 delays thrombin‐induced platelet aggregation: a new role for P‐selectin in early aggregation

  2006cites this paper
• Selectins--potential pharmacological targets?

  2006cites this paper
• Recombinant P-selectin glycoprotein ligand-immunoglobulin, a P-selectin antagonist, as an adjunct to thrombolysis in acute myocardial infarction. The P-Selectin Antagonist Limiting Myonecrosis (PSALM) trial.

  2006cites this paper
• P-selectin glycoprotein ligand (PSGL)-1 and β 2-integrins cooperate in adhesion of leukocytes to von Willebrand factor

  2006cites this paper
• P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor.

  2006cites this paper
• A high affinity human antibody antagonist of P-selectin mediated rolling.

  2006cites this paper
• Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation.

  2005cites this paper
• Classification of venous thromboembolism (VTE)

  2005cites this paper
• Isolation and engineering of a high affinity antibody against P-selectin glycoprotein ligand-1 (PSGL-1)

  2005cites this paper
• Regulation of PSGL-1 Interactions with L-selectin, P-selectin, and E-selectin

  2005cites this paper
• L-selectin in inflammation, infection and immunity

  2005cites this paper
• Antiplatelet agents: current drugs and future trends.

  2005cites this paper
• Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular Injury

  2005cites this paper
• Preferential binding of platelets to monocytes over neutrophils under flow.

  2005cites this paper
• Classification of venous thromboembolism (VTE)

  2005cites this paper
• Overview of novel therapeutic targets for asthma and chronic obstructive pulmonary disease

  2005cites this paper
• Diferenças na resposta inflamatória e implante eletivo de stent coronário entre pacientes com e sem diabetes mellitus

  2005cites this paper
• Inhibitors of membrane receptors involved with leukocyte extravasation.

  2005cites this paper
• The P‐selectin, tissue factor, coagulation triad

  2005cites this paper
• Platelet Function Under Flow

  2005cites this paper
• Selectins-an emerging target for drug delivery.

  2004cites this paper
• Serum concentrations of soluble P-selectin glycoprotein ligand-1 are increased in patients with systemic sclerosis: association with lower frequency of pulmonary fibrosis

  2004cites this paper
• Deep venous thrombosis.

  2004cites this paper
• Key References: Basic Fibrinolysis and Thrombolysis Selected References: 1987–1997

  2004cites this paper
• Short alleles of P-selectin glycoprotein ligand-1 protect against premature myocardial infarction.

  2004cites this paper
• P-selectin in arterial thrombosis

  2004cites this paper
• Prevention of in-stent restenosis via reduction of thrombo-inflammatory reactions with recombinant P-selectin glycoprotein ligand-1

  2004cites this paper
• A new role in hemostasis for the adhesion receptor P-selectin.

  2004cites this paper
• Human P-selectin Glycoprotein Ligand-1 (PSGL-1) Interacts with the Skin-associated Chemokine CCL27 via Sulfated Tyrosines at the PSGL-1 Amino Terminus*

  2004cites this paper
• P‐selectin in haemostasis

  2004cites this paper
• P‐selectin glycoprotein ligand‐1 is required for the development of cutaneous vasculitis induced by immune complex deposition

  2004cites this paper
• Development of cell adhesion molecule antagonists as therapeutics for asthma and COPD.

  2004cites this paper
• Antibody cross-linking of human platelet P-selectin induces calcium entry by a mechanism dependent upon Fcγ receptor IIA

  2004cites this paper
• PSGL-1 as a novel therapeutic target.

  2004cites this paper
• Prospective evaluation of the relationship between platelet–leukocyte conjugate formation and recurrent myocardial ischemia in patients with acute coronary syndromes

  2004cites this paper
• Evaluation of cardioprotective effects of recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in myocardial ischemia-reperfusion injury by real-time myocardial contrast echocardiography.

  2004cites this paper
• hort alleles of P-selectin glycoprotein ligand-1 rotect against premature myocardial infarction

  2004cites this paper
• Recombinant P-selectin glycoprotein ligand-1 directly inhibits leukocyte rolling by all 3 selectins in vivo: complete inhibition of rolling is not required for anti-inflammatory effect.

  2003cites this paper
• T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules : a critical role for P-selectin glycoprotein ligand-1

  2003cites this paper
• Hemostasis, Thrombosis, and Vascular Biology

  2003cites this paper
• Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes ☆: A TACTICS-TIMI 18 substudy

  2003cites this paper
• Thrombolytics: prospects for new agents

  2003cites this paper
• Platelets in Inflammation and Thrombosis

  2003cites this paper
• Decrease in fibrin content of venous thrombi in selectin-deficient mice.

  2003cites this paper
• Arterial thrombosis for the interventional cardiologist: From adhesion molecules and coagulation factors to clinical therapeutics

  2003cites this paper
• SELPLG Gene Polymorphisms in Relation to Plasma SELPLG Levels and Coronary Artery Disease

  2003cites this paper