Beetroot juice supplementation reduces whole body oxygen consumption but does not improve indices of mitochondrial efficiency in human skeletal muscle

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Physiology

• Publication date

  2016-01-15

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1113/JP270844PMID 26457670PMCID PMC4713742
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dietary nitrate supplementation in COPD: an acute, double-blind, randomized, placebo-controlled, crossover trial.

  2015cited by this paper
• Short-Term Intravenous Sodium Nitrite Infusion Improves Cardiac and Pulmonary Hemodynamics in Heart Failure Patients

  2015cited by this paper
• Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.

  2015cited by this paper
• Beetroot Juice Improves On-Water 500 M Time-Trial Performance, and Laboratory-Based Paddling Economy in National and International-Level Kayak Athletes.

  2015cited by this paper
• Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure With Preserved Ejection Fraction

  2015cited by this paper
• Omega‐3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle

  2014cited by this paper
• Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans.

  2014cited by this paper
• Nitrate supplementation enhances the contractile properties of human skeletal muscle.

  2014cited by this paper
• Beetroot juice supplementation does not improve performance of elite 1500-m runners.

  2014cited by this paper
• Dietary nitrate supplementation

  2014cited by this paper
• Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis

  2014cited by this paper
• Both linoleic and α-linolenic acid prevent insulin resistance but have divergent impacts on skeletal muscle mitochondrial bioenergetics in obese Zucker rats.

  2014cited by this paper
• Dietary nitrate supplementation improves team sport-specific intense intermittent exercise performance

  2013cited by this paper
• Beetroot juice and exercise: pharmacodynamic and dose-response relationships.

  2013cited by this paper
• Multiscale measurement of cardiac energetics

  2013cited by this paper
• ffects of nitrate supplementation via beetroot juice on contracting rat skeletal uscle microvascular oxygen pressure dynamics

  2013cited by this paper
• Co-Expression of SERCA Isoforms, Phospholamban and Sarcolipin in Human Skeletal Muscle Fibers

  2013cited by this paper
• Over-Expressing Mitofusin-2 in Healthy Mature Mammalian Skeletal Muscle Does Not Alter Mitochondrial Bioenergetics

  2013cited by this paper
• Influence of dietary nitrate supplementation on human skeletal muscle metabolism and force production during maximum voluntary contractions

  2013cited by this paper
• Submaximal ADP‐stimulated respiration is impaired in ZDF rats and recovered by resveratrol

  2013cited by this paper
• Influence of nitrate supplementation on VO2 kinetics and endurance of elite cyclists

  2013cited by this paper
• Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle

  2012cited by this paper
• Dietary nitrate supplementation improves rowing performance in well-trained rowers.

  2012cited by this paper
• Inorganic nitrite stimulates pancreatic islet blood flow and insulin secretion.

  2012cited by this paper
• Sodium nitrate supplementation does not enhance performance of endurance athletes.

  2012cited by this paper
• Opposing effects of nitric oxide and prostaglandin inhibition on muscle mitochondrial Vo(2) during exercise.

  2012cited by this paper
• Dietary nitrate does not enhance running performance in elite cross-country skiers.

  2012cited by this paper
• Dietary nitrate increases tetanic [Ca2+]i and contractile force in mouse fast‐twitch muscle

  2012cited by this paper
• Nitrate supplementation's improvement of 10-km time-trial performance in trained cyclists.

  2012influential reference
• Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study.

  2011influential reference
• Acute dietary nitrate supplementation improves cycling time trial performance.

  2011influential reference
• Dietary inorganic nitrate improves mitochondrial efficiency in humans.

  2011influential reference
• Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle.

  2011cited by this paper
• Oxidative stress and heart failure.

  2011cited by this paper
• Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans.

  2010influential reference
• Subsarcolemmal and intermyofibrillar mitochondria proteome differences disclose functional specializations in skeletal muscle

  2010influential reference
• Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans

  2010influential reference
• Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice

  2010cited by this paper
• Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise.

  2010influential reference
• Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans.

  2009cited by this paper
• Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans.

  2009influential reference
• Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production.

  2008cited by this paper
• Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite

  2008cited by this paper
• The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash.

  2008cited by this paper
• Nitric oxide increases oxidative phosphorylation efficiency

  2007influential reference
• Effects of dietary nitrate on oxygen cost during exercise

  2007cited by this paper
• The activity‐induced reduction of myofibrillar Ca2+ sensitivity in mouse skeletal muscle is reversed by dithiothreitol

  2006cited by this paper
• [Oxidative stress and heart failure].

  2006cited by this paper
• Reactive oxygen species reduce myofibrillar Ca2+ sensitivity in fatiguing mouse skeletal muscle at 37 degrees C.

  2005cited by this paper
• Reactive oxygen species reduce myofibrillar Ca2+ sensitivity in fatiguing mouse skeletal muscle at 37°C

  2005cited by this paper
• The basal proton conductance of mitochondria depends on adenine nucleotide translocase content.

  2005cited by this paper
• A Novel Function for Fatty Acid Translocase (FAT)/CD36

  2004cited by this paper
• Inorganic nitrate is a possible source for systemic generation of nitric oxide.

  2004cited by this paper
• Nitric oxide and physiologic vasodilation in human limbs: where do we go from here?

  2003cited by this paper
• Influence of chronic aerobic exercise on microcirculatory flow and nitric oxide in humans.

  2003cited by this paper
• Contractile response of skeletal muscle to low peroxide concentrations: myofibrillar calcium sensitivity as a likely target for redox-modulation.

  2001cited by this paper
• Reaction of nitric oxide with the turnover intermediates of cytochrome c oxidase: reaction pathway and functional effects.

  2000influential reference
• Contractile response to low peroxide concentrations: myofibrillar calcium sensitivity as a likely target for redox‐modulation of skeletal muscle function

  2000cited by this paper
• Inhibition of skeletal muscle sarcoplasmic reticulum Ca2+‐ATPase by nitric oxide

  1998cited by this paper
• Effect of nitric oxide on single skeletal muscle fibres from the mouse

  1998influential reference
• Contribution of nitric oxide to exercise‐induced changes in healthy volunteers: effects of acute exercise and long‐term physical training

  1997cited by this paper
• Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

  1994cited by this paper
• Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

  1994cited by this paper
• Nitric Oxide‐Mediated Inhibition of the Mitochondrial Respiratory Chain in Cultured Astrocytes

  1994influential reference
• The L-arginine-nitric oxide pathway.

  1993cited by this paper
• The L-arginine: nitric oxide pathway.

  1993cited by this paper
• Endurance training in humans: aerobic capacity and structure of skeletal muscle.

  1985influential reference
• Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds.

  1976cited by this paper
• Percutaneous needle biopsy of skeletal muscle in physiological and clinical research.

  1975cited by this paper

• Acute Effects of Beetroot Supplementation on Resistance Exercise Performance in Physically Active Men

  2026cites this paper
• Synergistic Actions of Natural Compounds for Enhancing Cognitive and Physical Performance: A Narrative Review.

  2026cites this paper
• A Decade of Beetroot (Beta vulgaris) Research 2015–2025: Phytoconstituents, Mechanisms, Preclinical and Clinical Insights

  2025cites this paper
• Nitric oxide in exercise physiology: past and present perspectives

  2025cites this paper
• UCI Sports Nutrition Project: Considerations and Applications for the Use of Sports Foods and Supplements to Improve Performance in Cycling.

  2025cites this paper
• Relationships between nitric oxide biomarkers and physiological outcomes following dietary nitrate supplementation.

  2024cites this paper
• Influence of acute dietary nitrate supplementation on oxygen delivery/consumption and limit of tolerance during progressive forearm exercise in men: a randomized crossover trial.

  2024cites this paper
• Sodium Nitrate Improves Oxidative Energy Contribution and Reduces Phosphocreatine Contribution During High-Intensity Intermittent Exercise

  2024cites this paper
• "Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance": Evidence-based sports supplements: a redox analysis.

  2024cites this paper
• Higher plant-derived nitrate intake is associated with lower odds of frailty in a cross-sectional study of community-dwelling older women

  2024cites this paper
• Influence of acute dietary nitrate supplementation on oxygen delivery/consumption and critical impulse during maximal effort forearm exercise in males: a randomized crossover trial.

  2024cites this paper
• Nitric oxide as a mediator of exercise performance: NO pain NO gain.

  2023cites this paper
• Food for Thought: Physiological Considerations for Nutritional Ergogenic Efficacy.

  2023cites this paper
• Sex Differences in the Effects of Inorganic Nitrate Supplementation On Exercise Economy and Endurance Capacity in Healthy Young Adults.

  2023cites this paper
• Effects of Short-Term Sodium Nitrate versus Sodium Chloride Supplementation on Energy and Lipid Metabolism during High-Intensity Intermittent Exercise in Athletes

  2023cites this paper
• Dietary nitrate preserves mitochondrial bioenergetics and mitochondrial protein synthesis rates during short‐term immobilization in mice

  2023cites this paper
• Effects of Dietary Nitrate Supplementation on Performance during Single and Repeated Bouts of Short-Duration High-Intensity Exercise: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

  2023cites this paper
• Positive feedback loop between dietary nitrate intake and oral health.

  2023cites this paper
• The Effect of a Hydroxytyrosol-Rich, Olive-Derived Phytocomplex on Aerobic Exercise and Acute Recovery

  2023cites this paper
• Dietary nitrate increases submaximal SERCA activity and ADP-transfer to mitochondria in slow-twitch muscle of female mice.

  2022cites this paper
• The Effects of Dietary Nitrate Supplementation on Explosive Exercise Performance: A Systematic Review

  2022cites this paper
• Nitric oxide regulation of cellular metabolism: Adaptive tuning of cellular energy.

  2022cites this paper
• Effects of Dietary Nitrate Supplementation on Performance and Muscle Oxygenation during Resistance Exercise in Men

  2022cites this paper
• Nitrite lowers the oxygen cost of ATP supply in cultured skeletal muscle cells by stimulating the rate of glycolytic ATP synthesis

  2022cites this paper
• Effects of dietary nitrate on the O2 cost of submaximal exercise: Accounting for “noise” in pulmonary gas exchange measurements

  2022cites this paper
• Influence of Sex and Acute Beetroot Juice Supplementation on 2 KM Running Performance

  2021cites this paper
• Contextualizing the biological relevance of standardized high‐resolution respirometry to assess mitochondrial function in permeabilized human skeletal muscle

  2021cites this paper
• Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis.

  2021cites this paper
• Effect of beetroot supplementation on 10 km time trial performance of distance runners

  2021cites this paper
• The effect of endurance, resistance training, and supplements on mitochondria and bioenergetics of muscle cells

  2021cites this paper
• Beetroot as a functional food with huge health benefits: Antioxidant, antitumor, physical function, and chronic metabolomics activity

  2021cites this paper
• Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis PERSPECTIVE FOR PROGRESS

  2021cites this paper
• Effect of dietary nitrate on human muscle power: a systematic review and individual participant data meta-analysis

  2021cites this paper
• Nitrate‐rich beetroot juice ingestion reduces skeletal muscle O2 uptake and blood flow during exercise in sedentary men

  2021cites this paper
• Effects of Nitrate Supplementation on Muscle Strength and Mass: A Systematic Review

  2021cites this paper
• Neither Beetroot Juice Supplementation nor Increased Carbohydrate Oxidation Enhance Economy of Prolonged Exercise in Elite Race Walkers

  2021cites this paper
• Effects of Beetroot Supplementation on Recovery After Exercise-Induced Muscle Damage: A Systematic Review

  2021cites this paper
• Dietary nitrate and population health: a narrative review of the translational potential of existing laboratory studies

  2021cites this paper
• Possible Effects of Beetroot Supplementation on Physical Performance Through Metabolic, Neuroendocrine, and Antioxidant Mechanisms: A Narrative Review of the Literature

  2021cites this paper
• Boosting nitric oxide in stress and respiratory infection: Potential relevance for asthma and COVID-19

  2021cites this paper
• Acute Beetroot Juice Supplementation Does Not Improve Match-Play Activity in Professional Tennis Players.

  2020cites this paper
• Montmorency cherry supplement does not affect aerobic exercise performance in healthy men.

  2020cites this paper
• Effects of Citrulline Malate and Beetroot Juice Supplementation on Energy Metabolism and Blood Flow During Submaximal Resistance Exercise

  2020cites this paper
• Subpopulation-specific Differences in Skeletal Muscle Mitochondria in Humans with Obesity Insights from Studies Employing Acute Nutritional and Exercise Stimuli.

  2020cites this paper
• Dietary nitrate and mitochondrial efficiency in humans.

  2020cites this paper
• Reply to TA Schiffer et al.

  2020cites this paper
• Could intramuscular storage of dietary nitrate contribute to its ergogenic effect? A mini-review.

  2020cites this paper
• The benefits and risks of beetroot juice consumption: a systematic review

  2020cites this paper
• Reviews on New Drug Targets in Age-Related Disorders

  2020cites this paper
• Skeletal Muscle Aging Atrophy: Assessment and Exercise-Based Treatment.

  2020cites this paper
• Synergetic Effect of NO Precursor Supplementation and Exercise Training

  2020cites this paper
• Effect of acute nitrite infusion on contractile economy and metabolism in isolated skeletal muscle in situ during hypoxia

  2020influential citation
• Skeletal muscle energy metabolism during exercise

  2020cites this paper
• The impact of beetroot juice intake on muscle oxygenation and performance during rhythmic handgrip exercise

  2020cites this paper
• A Pilot Study of Dietary Nitrate Supplementation in Anaemic Patients.

  2020cites this paper
• BESİNSEL NİTRAT TAKVİYESİNİN ANAEROBİK PERFORMANS ÜZERİNE ETKİLERİ

  2020cites this paper
• Title Dietary nitrate supplementation enhances high-intensity running performance in moderate normobaric hypoxia , independent of aerobic fitness

  2019cites this paper
• No longer beeting around the bush: a review of potential sex differences with dietary nitrate supplementation 1.

  2019cites this paper
• Beetroot Juice Does Not Enhance Supramaximal Intermittent Exercise Performance in Elite Endurance Athletes

  2019cites this paper
• Potential benefits of dietary nitrate ingestion in healthy and clinical populations: A brief review

  2019cites this paper
• An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions

  2019cites this paper
• No effect of beetroot juice supplementation on exercise economy and performance in recreationally active females despite increased torque production

  2019cites this paper
• Effect of Acute Dietary Nitrate Supplementation on the Post-Exercise Ambulatory Blood Pressure in Obese Males: A Randomized, Controlled, Crossover Trial.

  2019cites this paper
• Effects of chronic beetroot juice supplementation on maximum oxygen uptake, velocity associated with maximum oxygen uptake, and peak velocity in recreational runners: a double-blinded, randomized and crossover study

  2019cites this paper
• Inorganic nitrate and nitrite supplementation fails to improve skeletal muscle mitochondrial efficiency in mice and humans

  2019influential citation
• BEET-HF: The Effects of Dietary Inorganic Nitrate Supplementation on Aerobic Exercise Performance, Vascular Function, Cardiac Performance and Mitochondrial Respiration in Patients with Heart Failure with Reduced Ejection Fraction

  2019cites this paper
• Incubation with sodium nitrite attenuates fatigue development in intact single mouse fibres at physiological PO2

  2019influential citation
• Effects of Dietary Supplements on Adaptations to Endurance Training

  2019cites this paper
• Treatment with Nitrate, but Not Nitrite, Lowers the Oxygen Cost of Exercise and Decreases Glycolytic Intermediates While Increasing Fatty Acid Metabolites in Exercised Zebrafish

  2019cites this paper
• Exploring the mechanisms by which nitrate supplementation improves skeletal muscle contractile function: one fibre at a time

  2019cites this paper
• Factors influencing the effects of dietary nitrate supplementation on nitric oxide biomarkers and blood pressure

  2018cites this paper
• Effects of beetroot juice supplementation on intermittent high-intensity exercise efforts

  2018cites this paper
• Beetroot supplementation improves the physiological responses to incline walking

  2018cites this paper
• Acute beetroot juice administration improves peak isometric force production in adolescent males.

  2018cites this paper
• Sodium nitrate supplementation alters mitochondrial H2O2 emission but does not improve mitochondrial oxidative metabolism in the heart of healthy rats.

  2018cites this paper
• The effects of two different doses of ultraviolet-A light exposure on nitric oxide metabolites and cardiorespiratory outcomes

  2018cites this paper
• No individual or combined effects of caffeine and beetroot-juice supplementation during submaximal or maximal running.

  2018cites this paper
• Dietary Nitrate and Muscle Function in Humans: Acute versus Chronic Mechanisms Response

  2018cites this paper
• Metabolic adaptations to endurance training and nutrition strategies influencing performance

  2018influential citation
• Effects of Beetroot Juice Supplementation on Performance and Fatigue in a 30-s All-Out Sprint Exercise: A Randomized, Double-Blind Cross-Over Study

  2018cites this paper
• Dietary Nitrate and Physical Performance.

  2018cites this paper
• Comparison of Mitochondrial Incubation Media for Measurement of Respiration and Hydrogen Peroxide Production.

  2018cites this paper
• Effects of Single-Dose Dietary Nitrate on Oxygen Consumption During and After Maximal and Submaximal Exercise in Healthy Humans: A Pilot Study

  2018cites this paper
• Beetroot juice ingestion during prolonged moderate-intensity exercise attenuates progressive rise in O2 uptake.

  2018influential citation
• Beetroot Increases Muscle Performance and Oxygenation During Sustained Isometric Exercise, but Does Not Alter Muscle Oxidative Efficiency and Microvascular Reactivity at Rest

  2018influential citation
• The Effect of Nitrate Supplementation on Cycling Performance

  2018cites this paper
• Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy.

  2017cites this paper
• NUTRITIONAL STRATEGIES TO IMPROVE MUSCLE MITOCHONDRIAL CONTENT AND FUNCTION

  2017cites this paper
• “Beet-ing” the Mountain: A Review of the Physiological and Performance Effects of Dietary Nitrate Supplementation at Simulated and Terrestrial Altitude

  2017cites this paper
• Effects of Dietary Nitrate Supplementation on Physiological Responses, Cognitive Function, and Exercise Performance at Moderate and Very-High Simulated Altitude

  2017cites this paper
• Characterising and evaluating the efficacy of metabolic therapies for the treatment of Duchenne Muscular Dystrophy

  2017cites this paper
• Nitrate and Exercise Performance

  2017cites this paper
• Dietary nitrate as an ergogenic aid in sprint exercise performance and as an adjunct to sprint training

  2017cites this paper
• Effects of Beetroot Juice Supplementation on a 30-s High-Intensity Inertial Cycle Ergometer Test

  2017influential citation
• Influence of dietary nitrate supplementation on physiological and muscle metabolic adaptations to sprint interval training.

  2017cites this paper
• Therapeutic strategies to address neuronal nitric oxide synthase deficiency and the loss of nitric oxide bioavailability in Duchenne Muscular Dystrophy

  2017cites this paper
• Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise.

  2017cites this paper
• Dietary nitrate as modulator of physical performance and cardiovascular health

  2017cites this paper
• Beetroot Juice Increases Human Muscle Force without Changing Ca2+-Handling Proteins

  2017cites this paper
• Dietary nitrate supplementation and exercise tolerance in patients with heart failure with reduced ejection fraction.

  2017cites this paper