Lead exposure during synaptogenesis alters NMDA receptor targeting via NMDA receptor inhibition.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Neurotoxicology

• Publication date

  2011-03-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.neuro.2010.12.013PMID 21192972PMCID PMC3049857
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metaplasticity at single glutamatergic synapses.

  2010influential reference
• Lead exposure during synaptogenesis alters vesicular proteins and impairs vesicular release: potential role of NMDA receptor-dependent BDNF signaling.

  2010influential reference
• Molecular determinants of Pb2+ interaction with NMDA receptor channels.

  2008cited by this paper
• Specific Targeting of Pro-Death NMDA Receptor Signals with Differing Reliance on the NR2B PDZ Ligand

  2008cited by this paper
• Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal‐regulated kinases (ERK) activity in cultured rat hippocampal neurons

  2006cited by this paper
• Synaptic targeting of N-methyl-D-aspartate receptor splice variants is regulated differentially by receptor activity.

  2005cited by this paper
• The Micromolar Zinc-Binding Domain on the NMDA Receptor Subunit NR2B

  2005cited by this paper
• Homeostatic plasticity and NMDA receptor trafficking.

  2005influential reference
• Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking.

  2005cited by this paper
• Calcium/calmodulin-dependent protein kinase II activity and expression are altered in the hippocampus of Pb2+-exposed rats.

  2005cited by this paper
• Lead neurotoxicity: from exposure to molecular effects.

  2005influential reference
• A molecular mechanism for stabilization of learning-induced synaptic modifications.

  2004cited by this paper
• Lead stimulates ERK1/2 and p38MAPK phosphorylation in the hippocampus of immature rats.

  2004cited by this paper
• Regulation of the NMDA Receptor Complex and Trafficking by Activity-Dependent Phosphorylation of the NR2B Subunit PDZ Ligand

  2004cited by this paper
• Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation.

  2003cited by this paper
• Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure

  2003cited by this paper
• Selective decrease in NR1 subunit splice variant mRNA in the hippocampus of Pb2+-exposed rats: implications for synaptic targeting and cell surface expression of NMDAR complexes.

  2003cited by this paper
• Lead exposure alters cyclic-AMP response element binding protein phosphorylation and binding activity in the developing rat brain.

  2003influential reference
• Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

  2002cited by this paper
• Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain.

  2002influential reference
• Subunit-specific NMDA receptor trafficking to synapses.

  2002cited by this paper
• Effect of developmental lead exposure on the expression of specific NMDA receptor subunit mRNAs in the hippocampus of neonatal rats by digoxigenin-labeled in situ hybridization histochemistry.

  2002influential reference
• N-methyl-D-aspartate receptor subunit changes are associated with lead-induced deficits of long-term potentiation and spatial learning.

  2000influential reference
• Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit.

  2000cited by this paper
• Turnover Analysis of Glutamate Receptors Identifies a Rapidly Degraded Pool of the N-Methyl-d-aspartate Receptor Subunit, NR1, in Cultured Cerebellar Granule Cells*

  1999cited by this paper
• NMDAR-2A subunit protein expression is reduced in the hippocampus of rats exposed to Pb2+ during development.

  1999cited by this paper
• The Incorporation of NMDA Receptors with a Distinct Subunit Composition at Nascent Hippocampal Synapses In Vitro

  1999cited by this paper
• Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure.

  1998cited by this paper
• Impairment of long-term potentiation and paired-pulse facilitation in rat hippocampal dentate gyrus following developmental lead exposure in vivo.

  1998cited by this paper
• Differential Surface Expression and Phosphorylation of the N-Methyl-D-aspartate Receptor Subunits NR1 and NR2 in Cultured Hippocampal Neurons*

  1997cited by this paper
• Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain.

  1997cited by this paper
• Lead inhibition of N-methyl-D-aspartate receptors containing NR2A, NR2C and NR2D subunits.

  1997cited by this paper
• Chronic developmental lead exposure increases the threshold for long-term potentiation in rat dentate gyrus in vivo.

  1996cited by this paper
• The sensitivity of N-methyl-D-aspartate receptors to lead inhibition is dependent on the receptor subunit composition.

  1996cited by this paper
• The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.

  1996cited by this paper
• Biochemical evidence of an interaction of lead at the zinc allosteric sites of the NMDA receptor complex: effects of neuronal development.

  1995cited by this paper
• Alternatively spliced isoforms of the NMDARI receptor subunit.

  1995cited by this paper
• Developmental and regional expression in the rat brain and functional properties of four NMDA receptors.

  1994cited by this paper
• Neurochemical aspects of hippocampal and cortical Pb2+ neurotoxicity.

  1994influential reference
• Synaptogenesis in hippocampal cultures: evidence indicating that axons and dendrites become competent to form synapses at different stages of neuronal development

  1994cited by this paper
• Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.

  1993cited by this paper
• Developmental change of the inhibition by lead of NMDA-activated currents in cultured hippocampal neurons.

  1992cited by this paper
• Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C.

  1992cited by this paper
• Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

  1992cited by this paper
• Selective blockade of NMDA‐activated channel currents may be implicated in learning deficits caused by lead

  1990cited by this paper
• Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites

  1983cited by this paper

• Lead-induced neurotoxic effects on the synaptic signalling pathways and its association with autism spectrum disorder: a systematic review.

  2026cites this paper
• Proteomic Mapping of Hippocampal Pathways Involved in Lead (Pb)-Induced Neurotoxicity.

  2026cites this paper
• Toxicoepigenomics: Epigenetic disruption by environmental exposures and implications for biomarker development.

  2026cites this paper
• Ameliorative role of bioactive compounds against lead-induced neurotoxicity.

  2025influential citation
• Proposed Key Characteristics of Neurotoxic Chemicals.

  2025cites this paper
• Glutamate-Mediated Neural Alterations in Lead Exposure: Mechanisms, Pathways, and Phenotypes

  2025cites this paper
• Lead exposure disrupts cytoskeletal arrangement and perturbs glucose metabolism in nerve cells through activation of the RhoA/ROCK signaling pathway.

  2025cites this paper
• Developmental toxicity in zebrafish embryos exposed to single, binary, and tertiary mixtures of Cd, Pb, and As

  2024cites this paper
• Lead exposure leads to premature neural differentiation via inhibiting Wnt signaling.

  2024cites this paper
• Prenatal and early life lead exposure induced neurotoxicity

  2024cites this paper
• Environmental pollution and extreme weather conditions: insights into the effect on mental health

  2024cites this paper
• Involvement of Nrf2 signaling in lead-induced toxicity.

  2023cites this paper
• Environmental exposures to cadmium and lead as potential causes of eye diseases.

  2023cites this paper
• Identification of novel NRF2-dependent genes as regulators of lead and arsenic toxicity in neural progenitor cells.

  2023cites this paper
• Gallic acid and neurodegenerative diseases

  2023cites this paper
• GRIN2B-related neurodevelopmental disorder: current understanding of pathophysiological mechanisms

  2023cites this paper
• Development of a physiologically based toxicokinetic model for lead in pregnant women: The role of bone tissue in the maternal and fetal internal exposure.

  2023cites this paper
• Potential of Quercetin to Protect Cadmium Induced Cognitive Deficits in Rats by Modulating NMDA-R Mediated Downstream Signaling and PI3K/AKT—Nrf2/ARE Signaling Pathways in Hippocampus

  2023cites this paper
• Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons

  2023influential citation
• Species and reproductive status influence element concentrations in bat fur.

  2023cites this paper
• Adverse Childhood Experiences (ACEs) and Environmental Exposures on Neurocognitive Outcomes in Children: Empirical Evidence, Potential Mechanisms, and Implications

  2023cites this paper
• Chronic early-life lead exposure sensitizes adolescent rats to cocaine: Role of the dopaminergic system

  2022cites this paper
• Effects of metallic elements on reproduction and development

  2022cites this paper
• Environmental Metal Exposure, Neurodevelopment, and the Role of Iron Status: a Review

  2022cites this paper
• The protective effect of C3G against Pb-induced learning and memory impairments through cAMP-PKA-CREB signaling pathway in rat hippocampus

  2022cites this paper
• A Comparative Analysis of Heavy Metal Effects on Medicinal Plants

  2022cites this paper
• Systemic review of genetic and epigenetic factors underlying differential toxicity to environmental lead (Pb) exposure

  2022cites this paper
• Heavy Metals and Human Health: Possible Exposure Pathways and the Competition for Protein Binding Sites

  2021cites this paper
• Molecular Mechanisms of Environmental Metal Neurotoxicity: A Focus on the Interactions of Metals with Synapse Structure and Function

  2021cites this paper
• Early-life lead exposure induces long-term toxicity in the central nervous system: From zebrafish larvae to juveniles and adults.

  2021cites this paper
• MOLECULAR MECHANISMS OF LEAD NEUROTOXICITY.

  2021cites this paper
• Effects of Co-exposure to Lead and Manganese on Learning and Memory De�cits

  2021cites this paper
• Early-life lead exposure and neurodevelopmental disorders.

  2021cites this paper
• Mitochondrial uncoupling protein 2 is regulated through heterogeneous nuclear ribonucleoprotein K in lead exposure models.

  2021cites this paper
• The Effect of Lead Exposure on Autism Development

  2021influential citation
• Lead and Excitotoxicity

  2021cites this paper
• Cognitive Impairment Induced by Lead Exposure during Lifespan: Mechanisms of Lead Neurotoxicity

  2021cites this paper
• Effects of co-exposure to lead and manganese on learning and memory deficits.

  2021cites this paper
• Persistent Effects on Cardiorespiratory and Nervous Systems Induced by Long-Term Lead Exposure: Results from a Longitudinal Study

  2020cites this paper
• D-serine reduces memory impairment and neuronal damage induced by chronic lead exposure

  2020cites this paper
• NMDA receptors in axons: there's no coincidence

  2020cites this paper
• Low-level developmental lead exposure does not predispose to adult alcohol self-administration, but does increase the risk of relapsing to alcohol seeking in mice: Contrasting role of GLT1 and xCT brain expression.

  2020cites this paper
• Effects of Gastrodin against Lead-Induced Brain Injury in Mice Associated with the Wnt/Nrf2 Pathway

  2020cites this paper
• Long-Term Lead Exposure Since Adolescence Causes Proteomic and Morphological Alterations in the Cerebellum Associated with Motor Deficits in Adult Rats

  2020cites this paper
• Sex-Dependent Effects of Developmental Lead Exposure in Wistar Rats: Evidence from Behavioral and Molecular Correlates

  2020cites this paper
• Long-term exposure to lead reduces antioxidant capacity and triggers motor neurons degeneration and demyelination in spinal cord of adult rats.

  2020cites this paper
• Kynurenine Pathway as a New Target of Cognitive Impairment Induced by Lead Toxicity During the Lactation

  2020cites this paper
• The role of neuroinflammation in developmental neurotoxicity, tackling complexity in children's exposures and outcomes

  2019cites this paper
• OECD Series on Adverse Outcome Pathways No . 5 Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D-aspartate receptors ( NMDARs ) during brain development induces impairment of learning and memory abilities

  2019cites this paper
• Mechanistic Effect of Heavy Metals in Neurological Disorder and Brain Cancer

  2019cites this paper
• Toxicological effects in children exposed to lead: A cross-sectional study at the Colombian Caribbean coast.

  2019cites this paper
• Mechanism and Health Effects of Heavy Metal Toxicity in Humans

  2019cites this paper
• Opioid receptor‐mediated changes in the NMDA receptor in developing rat and chicken

  2019cites this paper
• Epigenetic modifications associated with pathophysiological effects of lead exposure

  2019cites this paper
• Influence of clozapine on neurodevelopmental protein expression and behavioral patterns in animal model of psychiatric disorder induced by low-level of lead

  2019cites this paper
• Development of the Adverse Outcome Pathway (AOP): Chronic binding of antagonist to N-methyl-d-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities of children

  2018cites this paper
• Ascorbic Acid Attenuates Lead-Induced Alterations in the Synapses in the Developing Rat Cerebellum

  2018cites this paper
• Chelator combination as therapeutic strategy in mercury and lead poisonings

  2018cites this paper
• Genetic polymorphisms of GRIN2A and GRIN2B modify the neurobehavioral effects of low‐level lead exposure in children

  2018cites this paper
• Intermittent low‐level lead exposure provokes anxiety, hypertension, autonomic dysfunction and neuroinflammation

  2018cites this paper
• Effect of Pb Exposure on Synaptic Scaling Through Regulation of AMPA Receptor Surface Trafficking

  2018cites this paper
• Lead-induced changes of cytoskeletal protein is involved in the pathological basis in mice brain

  2018cites this paper
• Phytohormone Abscisic Acid Improves Spatial Memory and Synaptogenesis Involving NDR1/2 Kinase in Rats

  2018cites this paper
• Intraventricular infusion of quinolinic acid impairs spatial learning and memory in young rats: a novel mechanism of lead-induced neurotoxicity

  2018cites this paper
• Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors

  2018cites this paper
• Developmental Neurotoxicity of Endocrine Disruptor Chemicals: A Challenge for Behavioral Toxicology

  2018cites this paper
• The Regulation of GluN2A by Endogenous and Exogenous Regulators in the Central Nervous System

  2017cites this paper
• Elevated lead levels from e-waste exposure are linked to decreased olfactory memory in children.

  2017cites this paper
• Impact of long‐term dietary exposure to lead on some reproductive parameters of a female Common carp (Cyprinus carpio L.)

  2017cites this paper
• GRIN2A polymorphisms and expression levels are associated with lead-induced neurotoxicity

  2017influential citation
• RNA-Seq of Human Neural Progenitor Cells Exposed to Lead (Pb) Reveals Transcriptome Dynamics, Splicing Alterations and Disease Risk Associations

  2017cites this paper
• Pb(II) disruption of synaptic activity through Ca(II)- and Zn(II)-binding proteins

  2017cites this paper
• Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity

  2017cites this paper
• A Behavioral and Neuroimmune System Model of the Effects of Chronic Low-Level Lead Exposure in Young Male C57BL/6J Mice

  2017cites this paper
• Clinical and molecular aspects of lead toxicity: An update

  2017cites this paper
• Source apportionment of lead in the blood of women of reproductive age living near tailings in Taxco, Guerrero, Mexico: An isotopic study.

  2017cites this paper
• The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster

  2016cites this paper
• Animal models of gene-environment interaction in schizophrenia: A dimensional perspective.

  2016cites this paper
• Alterations of Synaptic Proteins in the Hippocampus of Mouse Offspring Induced by Developmental Lead Exposure

  2016cites this paper
• Early-Life Toxic Insults and Onset of Sporadic Neurodegenerative Diseases-an Overview of Experimental Studies.

  2016cites this paper
• In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children

  2016cites this paper
• Heavy metals (Pb, Cd, As and MeHg) as risk factors for cognitive dysfunction: A general review of metal mixture mechanism in brain.

  2016cites this paper
• Possible Alteration of Circadian Rhythms in Bats at a Heavy Metal Contaminated Site

  2016cites this paper
• Modeling Gene–Environment Interaction in Schizophrenia

  2016cites this paper
• Defining potential roles of Pb(2+) in neurotoxicity from a calciomics approach.

  2016cites this paper
• Maternal lead exposure decreases the levels of brain development and cognition-related proteins with concomitant upsurges of oxidative stress, inflammatory response and apoptosis in the offspring rats.

  2016cites this paper
• β-Asarone Rescues Pb-Induced Impairments of Spatial Memory and Synaptogenesis in Rats

  2016cites this paper
• The combined effects of developmental lead and ethanol exposure on hippocampus dependent spatial learning and memory in rats: Role of oxidative stress.

  2016cites this paper
• Summary of the AOP Molecular Initiating Event

  2015cites this paper
• Protective effects of lithium against lead-induced toxicities in multiple systems of adult mouse

  2015cites this paper
• Role of Wnt/β-catenin signaling in the protective effect of epigallocatechin-3-gallate on lead-induced impairments of spine formation in the hippocampus of rats

  2015cites this paper
• Timing in neural maturation: arrest, delay, precociousness, and temporal determination of malformations.

  2015cites this paper
• Multifactorial Origin of Neurodevelopmental Disorders: Approaches to Understanding Complex Etiologies

  2015cites this paper
• AOP Title Binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Short name: Binding of antagonist to NMDARs impairs cognition

  2015cites this paper
• Mechanisms of Heavy Metal Neurotoxicity: Lead and Manganese

  2015cites this paper
• Effects of curcumin and tannic acid on the aluminum- and lead-induced oxidative neurotoxicity and alterations in NMDA receptors

  2015cites this paper
• Sex- and tissue-specific methylome changes in brains of mice perinatally exposed to lead.

  2015cites this paper
• On the Role of Glutamate in Presynaptic Development: Possible Contributions of Presynaptic NMDA Receptors

  2015cites this paper
• Approaches to Understanding Mechanisms between Environmental Chemical Exposure and Brain Development

  2015cites this paper
• Lead Exposure Impairs Hippocampus Related Learning and Memory by Altering Synaptic Plasticity and Morphology During Juvenile Period

  2015cites this paper