Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse

Compared with T-ALL diagnosis samples, samples obtained at relapse or after xenograft into immunodeficient mice exhibit additional genomic lesions in oncogenes and/or tumor suppressor genes; these lesions contribute to leukemia-initiating activity.

• Publication year

  2011

• Venue

  Journal of Experimental Medicine

• Publication date

  2011-04-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20110105PMID 21464223PMCID 3135355
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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