Transcription Factor Nrg1 Mediates Capsule Formation, Stress Response, and Pathogenesis in Cryptococcus neoformans

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Eukaryotic Cell

• Publication date

  2006-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/EC.00145-06PMID 16835458PMCID PMC1489281
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Light Controls Growth and Development via a Conserved Pathway in the Fungal Kingdom

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• Aflatoxin conducive and non-conducive growth conditions reveal new gene associations with aflatoxin production.

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• Repressors Nrg1 and Nrg2 Regulate a Set of Stress-Responsive Genes in Saccharomyces cerevisiae

  2005cited by this paper
• Alternative Candida albicans lifestyles: growth on surfaces.

  2005cited by this paper
• Components of the ESCRT Pathway, DFG16, and YGR122w Are Required for Rim101 To Act as a Corepressor with Nrg1 at the Negative Regulatory Element of the DIT1 Gene of Saccharomyces cerevisiae

  2005cited by this paper
• Transcriptional Network of Multiple Capsule and Melanin Genes Governed by the Cryptococcus neoformans Cyclic AMP Cascade

  2005influential reference
• UGD1, Encoding the Cryptococcus neoformans UDP-Glucose Dehydrogenase, Is Essential for Growth at 37°C and for Capsule Biosynthesis

  2004influential reference
• Transcriptional Analysis of Biofilm Formation Processes in the Anaerobic, Hyperthermophilic Bacterium Thermotoga maritima

  2004cited by this paper
• Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates.

  2003cited by this paper
• Faculty Opinions recommendation of Carbohydrate-induced differential gene expression patterns in the hyperthermophilic bacterium Thermotoga maritima.

  2003cited by this paper
• Sexual Cycle of Cryptococcus neoformans var. grubii and Virulence of Congenic a and α Isolates

  2003cited by this paper
• A MAP kinase cascade composed of cell type specific and non‐specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans

  2003cited by this paper
• Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are encoded in subtelomeric clusters and subject to RAP1- and SIR-dependent transcriptional silencing.

  2003cited by this paper
• Mg2+ sensing by the Mg2+ sensor PhoQ of Salmonella enterica.

  2003cited by this paper
• The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function

  2003cited by this paper
• Snf1 Kinases with Different β-Subunit Isoforms Play Distinct Roles in Regulating Haploid Invasive Growth

  2003cited by this paper
• Carbohydrate-induced Differential Gene Expression Patterns in the Hyperthermophilic Bacterium Thermotoga maritima * 210

  2003cited by this paper
• Importance of a Developmentally Regulated Pheromone Receptor of Cryptococcus neoformans for Virulence

  2003cited by this paper
• Adenylyl Cyclase Functions Downstream of the Gα Protein Gpa1 and Controls Mating and Pathogenicity of Cryptococcus neoformans

  2002cited by this paper
• Snf1 Protein Kinase and the Repressors Nrg1 and Nrg2 Regulate FLO11, Haploid Invasive Growth, and Diploid Pseudohyphal Differentiation

  2002cited by this paper
• Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

  2002cited by this paper
• Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae.

  2001cited by this paper
• Cas1p is a membrane protein necessary for the O‐acetylation of the Cryptococcus neoformans capsular polysaccharide

  2001cited by this paper
• NRG1, a repressor of filamentous growth in C.albicans, is down‐regulated during filament induction

  2001cited by this paper
• Assessing Gene Significance from cDNA Microarray Expression Data via Mixed Models

  2001cited by this paper
• NRG1 represses yeast–hypha morphogenesis and hypha‐specific gene expression in Candida albicans

  2001cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Urease as a Virulence Factor in Experimental Cryptococcosis

  2000cited by this paper
• The G-Protein β Subunit GPB1 Is Required for Mating and Haploid Fruiting in Cryptococcus neoformans

  2000cited by this paper
• How does Cryptococcus get its coat?

  2000cited by this paper
• The Phosphatase Activity Is the Target for Mg2+Regulation of the Sensor Protein PhoQ in Salmonella*

  2000cited by this paper
• A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating.

  2000cited by this paper
• Nrg1 Is a Transcriptional Repressor for Glucose Repression of STA1 Gene Expression inSaccharomyces cerevisiae

  1999cited by this paper
• Characterization of the glyceraldehyde-3-phosphate dehydrogenase gene [correction of glyceraldehyde-3-phosphate gene] and the use of its promoter for heterologous expression in Cryptococcus neoformans, a human pathogen.

  1999cited by this paper
• Candida albicans ALS3 and insights into the nature of the ALS gene family

  1998cited by this paper
• Exploring the metabolic and genetic control of gene expression on a genomic scale.

  1997cited by this paper
• Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.

  1997cited by this paper
• The second capsule gene of cryptococcus neoformans, CAP64, is essential for virulence

  1996cited by this paper
• Warfarin: Mechanism of Action

  1995cited by this paper
• The actin gene from Cryptococcus neoformans: structure and phylogenetic analysis.

  1995cited by this paper
• Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence

  1994cited by this paper
• The alpha-mating type locus of Cryptococcus neoformans contains a peptide pheromone gene

  1993cited by this paper
• Inhibition of Cryptococcus neoformans replication by nitrogen oxides supports the role of these molecules as effectors of macrophage-mediated cytostasis

  1991cited by this paper
• Zinc fingers: gilt by association.

  1988cited by this paper
• Role of the capsule in phagocytosis of Cryptococcus neoformans.

  1988cited by this paper
• Zinc fingers: gilt by association.

  1988cited by this paper
• Laboratory course manual for methods in yeast genetics

  1986cited by this paper
• Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans

  1986cited by this paper
• Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide.

  1985influential reference
• Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice

  1982cited by this paper
• The capsule of cryptococcus neoformans passively inhibits phagocytosis of the yeast by macrophages.

  1982cited by this paper
• Involvement of a plasmid in the invasive ability of Shigella flexneri

  1982cited by this paper
• Chronic cryptococcal meningitis: a new experimental model in rabbits.

  1980influential reference
• Inhibition of phagocytosis by cryptococcal polysaccharide: dissociation of the attachment and ingestion phases of phagocytosis

  1976cited by this paper
• Morphogenesis of Filobasidiella neoformans, the sexual state of Cryptococcus neoformans.

  1976cited by this paper
• In Vitro Phagocytosis and Intracellular Fate of Variously Encapsulated Strains of Cryptococcus neoformans

  1972cited by this paper
• Medical Mycology

  1944cited by this paper

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  2026cites this paper
• MaNrg1, a transcriptional regulator, negatively regulates the UV-B tolerance and governs the microcycle conidiation in Metarhizium acridum.

  2026cites this paper
• Transcription Factors Fzc9 and Pdr802 Regulate ATP Levels and Metabolism in Cryptococcus neoformans

  2025cites this paper
• Peroxisomes regulate virulence and cell density sensing in Cryptococcus neoformans

  2025cites this paper
• Putative transcription factor Nrg1 is involved in the hyphal branching and the cell wall structure formation in the filamentous fungus Pleurotus ostreatus.

  2025cites this paper
• Cryptococcal nutrient acquisition and pathogenesis: dining on the host

  2025cites this paper
• Roles of Different Signaling Pathways in Cryptococcus neoformans Virulence

  2024influential citation
• Leveraging a new data resource to define the response of Cryptococcus neoformans to environmental signals

  2024cites this paper
• Alternative isoforms and phase separation of Ref1 repress morphogenesis in Cryptococcus

  2024cites this paper
• Measuring Stress Phenotypes in Cryptococcus neoformans.

  2024cites this paper
• Pleiotropic roles of LAMMER kinase, Lkh1 in stress responses and virulence of Cryptococcus neoformans

  2024cites this paper
• CryptoCEN: A Co-Expression Network for Cryptococcus neoformans reveals novel proteins involved in DNA damage repair

  2024cites this paper
• Leveraging a new data resource to define the response of C. neoformans to environmental signals

  2023cites this paper
• CryptoCEN: A Co-Expression Network for Cryptococcus neoformans reveals novel proteins involved in DNA damage repair

  2023cites this paper
• How host-like signals drive gene expression and gene expression drives capsule expansion in Cryptococcus neoformans

  2023cites this paper
• Influence of Pathogen Carbon Metabolism on Interactions With Host Immunity

  2022cites this paper
• Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen

  2022cites this paper
• RNAi machinery regulates nutrient metabolism and fluconazole resistance in the pathogenic fungus Cryptococcus deneoformans.

  2022cites this paper
• Glycans of the Pathogenic Yeast Cryptococcus neoformans and Related Opportunities for Therapeutic Advances

  2021cites this paper
• Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci

  2021cites this paper
• Acid pH Strategy Adaptation through NRG1 in Ustilago maydis

  2021cites this paper
• Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans

  2020cites this paper
• Environmental Factors That Contribute to the Maintenance of Cryptococcus neoformans Pathogenesis

  2020cites this paper
• Internalization of the host alkaline pH signal in a fungal pathogen

  2020cites this paper
• Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence

  2020cites this paper
• Coordinate genomic association of transcription factors controlled by an imported quorum sensing peptide in Cryptococcus neoformans

  2020cites this paper
• The cAMP/Protein Kinase A Pathway Regulates Virulence and Adaptation to Host Conditions in Cryptococcus neoformans

  2019cites this paper
• Cdk8 and Ssn801 Regulate Oxidative Stress Resistance and Virulence in Cryptococcus neoformans

  2019cites this paper
• Induction of signal transduction pathways related to the pathogenicity of Cryptococcus neoformans in the host environment.

  2019cites this paper
• Life Cycle of Cryptococcus neoformans.

  2019cites this paper
• Identifying a novel connection between the fungal plasma membrane and pH‐sensing

  2018cites this paper
• Cryptococcus neoformans, Unlike Candida albicans, Forms Aneuploid Clones Directly from Uninucleated Cells under Fluconazole Stress

  2018cites this paper
• Characterization of novel components of the environmental pH-sensing complex in Cryptococcus neoformans

  2018cites this paper
• Differences in Sirtuin Regulation in Response to Calorie Restriction in Cryptococcus neoformans

  2018cites this paper
• Characterization of additional components of the environmental pH-sensing complex in the pathogenic fungus Cryptococcus neoformans

  2018cites this paper
• Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi.

  2017cites this paper
• Comparative Ecology of Capsular Exophiala Species Causing Disseminated Infection in Humans

  2017cites this paper
• Disarming Fungal Pathogens: Bacillus safensis Inhibits Virulence Factor Production and Biofilm Formation by Cryptococcus neoformans and Candida albicans

  2017cites this paper
• Capsule Enlargement in Cryptococcus neoformans Is Dependent on Mitochondrial Activity

  2017cites this paper
• Discovery of a Novel Antifungal Agent in the Pathogen Box

  2017cites this paper
• Random mutagenesis analysis and identification of a novel C2H2-type transcription factor from the nematode-trapping fungus Arthrobotrys oligospora

  2017cites this paper
• Genotypic and phenotypic analyses of two model strains of Cryptococcus neoformans

  2017cites this paper
• Transcriptomic analysis of synergy between antifungal drugs and iron chelators for alternative antifungal therapies

  2016influential citation
• Candida species Rewired Hyphae Developmental Programs for Chlamydospore Formation

  2016cites this paper
• Magnesium Ion Acts as a Signal for Capsule Induction in Cryptococcus neoformans

  2016cites this paper
• A Genomic Safe Haven for Mutant Complementation in Cryptococcus neoformans

  2015cites this paper
• Exploiting Fungal Virulence-Regulating Transcription Factors As Novel Antifungal Drug Targets

  2015cites this paper
• Phylogenic analysis revealed an expanded C₂H₂-homeobox subfamily and expression profiles of C₂H₂ zinc finger gene family in Verticillium dahliae.

  2015cites this paper
• The cAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis

  2015cites this paper
• Strategies for increasing the applicability of biological network inference

  2015influential citation
• Fungal serotype-specific differences in bacterial-yeast interactions

  2015cites this paper
• Proteomic profiling of the pathogenic fungus Cryptococcus neoformans upon regulation of the cyclic-AMP/protein kinase A signaling pathway

  2015influential citation
• Network-assisted genetic dissection of pathogenicity and drug resistance in the opportunistic human pathogenic fungus Cryptococcus neoformans

  2015cites this paper
• Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation

  2015influential citation
• Systematic functional profiling of transcription factor networks in Cryptococcus neoformans

  2015cites this paper
• Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis.

  2014cites this paper
• Cryptococcus neoformans: historical curiosity to modern pathogen

  2014cites this paper
• Noncanonical Gβ Gib2 Is a Scaffolding Protein Promoting cAMP Signaling through Functions of Ras1 and Cac1 Proteins in Cryptococcus neoformans*

  2014cites this paper
• Regulation of vacuolar trafficking by Vps45p in the pathogenic fungus Cryptococcus neoformans

  2014influential citation
• Pathogenicity of Cryptococcus Stress Signaling Pathways for the

  2014cites this paper
• neoformans Cryptococcus AMP / Protein Kinase A Pathways in Cross Talk between the Cell Wall Integrity and Cyclic 2014

  2014cites this paper
• Cross Talk between the Cell Wall Integrity and Cyclic AMP/Protein Kinase A Pathways in Cryptococcus neoformans

  2014cites this paper
• Cross Talk between the Cell Wall Integrity and Cyclic AMP/Protein Kinase A Pathways in <named-content content-type='genus-species'>Cryptococcus neoformans</named-content>

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• Negative feedback regulation of calcineurin-dependent Prz1 transcription factor by the CaMKK-CaMK1 axis in fission yeast

  2014cites this paper
• Fungal morphogenesis.

  2014cites this paper
• Ras1 Acts through Duplicated Cdc42 and Rac Proteins to Regulate Morphogenesis and Pathogenesis in the Human Fungal Pathogen Cryptococcus neoformans

  2013cites this paper
• Sex and Virulence in Basidiomycete Pathogens

  2013cites this paper
• An encapsulation of iron homeostasis and virulence in Cryptococcus neoformans.

  2013cites this paper
• Two Rac paralogs regulate polarized growth in the human fungal pathogen Cryptococcus neoformans.

  2013cites this paper
• Level Size Is Mediated at the Polymer Cryptococcus neoformans Regulation of

  2013cites this paper
• The Cryptococcus neoformans Rim101 Transcription Factor Directly Regulates Genes Required for Adaptation to the Host

  2013cites this paper
• Cryptococcus neoformans transcriptional regulation of the host-pathogen interface

  2013influential citation
• Title: The Cryptococcus neoformans Rim101 transcription factor directly

  2013cites this paper
• Stress Signaling Pathways for the Pathogenicity of Cryptococcus

  2013cites this paper
• The Cryptococcus neoformans Capsule: a Sword and a Shield

  2012cites this paper
• Sword and a Shield The Cryptococcus neoformans Capsule: a

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• Cryptococcus neoformans Requires the ESCRT Protein Vps23 for Iron Acquisition from Heme, for Capsule Formation, and for Virulence

  2012cites this paper
• ‘Popping the Clutch’: Novel Mechanisms Regulating Sexual Development in Cryptococcus neoformans

  2012cites this paper
• Two cation transporters Ena1 and Nha1 cooperatively modulate ion homeostasis, antifungal drug resistance, and virulence of Cryptococcus neoformans via the HOG pathway.

  2012cites this paper
• Practical Approaches to Biological Network Discovery

  2012influential citation
• Cryptococcal Titan Cell Formation Is Regulated by G-Protein Signaling in Response to Multiple Stimuli

  2011cites this paper
• The Cryptococcus Genomes: Tools for Comparative Genomics and Expression Analysis

  2011cites this paper
• Emerging themes in cryptococcal capsule synthesis.

  2011cites this paper
• G-Protein Signaling Pathways: Regulating Morphogenesis and Virulence of Cryptococcus

  2011cites this paper
• Adaptation of Cryptococcus neoformans to Mammalian Hosts: Integrated Regulation of Metabolism and Virulence

  2011influential citation
• Toward an Integrated Model of Capsule Regulation in Cryptococcus neoformans

  2011influential citation
• Cryptococcus neoformans Requires a Functional Glycolytic Pathway for Disease but Not Persistence in the Host

  2011cites this paper
• Cryptococcus gattii Virulence Composite: Candidate Genes Revealed by Microarray Analysis of High and Less Virulent Vancouver Island Outbreak Strains

  2011influential citation
• Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease

  2011cites this paper
• The cAMP/Protein Kinase A Pathway and Virulence in Cryptococcus neoformans

  2011cites this paper
• Biochemical systems analysis of signaling pathways to understand fungal pathogenicity.

  2011cites this paper
• Análise funcional de genes de Cryptococcus neoformans envolvidos no processo de interação patógeno-hospedeiro

  2010cites this paper
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  2010cites this paper
• Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions

  2010cites this paper
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  2010cites this paper
• Cryptococcus neoformans Histone Acetyltransferase Gcn5 Regulates Fungal Adaptation to the Host

  2010cites this paper
• Environmental Stress-Sensing and Pathogenicity in Cryptococcus neoformans

  2010cites this paper
• How sweet it is! Cell wall biogenesis and polysaccharide capsule formation in Cryptococcus neoformans.

  2009cites this paper
• The Trehalose Synthesis Pathway Is an Integral Part of the Virulence Composite for Cryptococcus gattii

  2009cites this paper
• The capsule of the fungal pathogen Cryptococcus neoformans.

  2009cites this paper