Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

No abstract is available for this paper.

• Publication year

  2003

• Venue

  EMBO Journal

• Publication date

  2003-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/emboj/cdg599PMID 14633986PMCID PMC291840
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sclerostin Is a Novel Secreted Osteoclast-derived Bone Morphogenetic Protein Antagonist with Unique Ligand Specificity*

  2003cited by this paper
• Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.

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• Lack of association between the SOST gene and bone mineral density in perimenopausal women: analysis of five polymorphisms.

  2002cited by this paper
• Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A.

  2002cited by this paper
• Bone Morphogenetic Proteins Stimulate Angiogenesis through Osteoblast-Derived Vascular Endothelial Growth Factor A.

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• A Role for the BMP Antagonist Chordin in Endochondral Ossification

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• Bone Morphogenetic Protein Signals Are Required for Cartilage Formation and Differently Regulate Joint Development During Skeletogenesis

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• Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

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• CRYSTAL STRUCTURE OF THE HUMAN TBR2 ECTODOMAIN-TGF-B3 COMPLEX

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• Do Bone Cells Behave Like a Neuronal Network?

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• Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures.

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• Differentiation of murine preosteoblastic KS483 cells depends on autocrine bone morphogenetic protein signaling during all phases of osteoblast formation.

  2002cited by this paper
• A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.

  2002cited by this paper
• Crystal structure of the human TβR2 ectodomain–TGF-β3 complex

  2002cited by this paper
• Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein.

  2001cited by this paper
• Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST).

  2001cited by this paper
• LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.

  2001cited by this paper
• Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice.

  2001cited by this paper
• Bone Morphogenetic Proteins Induce Gremlin, a Protein That Limits Their Activity in Osteoblasts1

  2000cited by this paper
• Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts.

  2000cited by this paper
• Molecular events caused by mechanical stress in bone.

  2000cited by this paper
• Crystal structure of the BMP-2–BRIA ectodomain complex

  2000cited by this paper
• Essential Requirement of BMPs‐2/4 for Both Osteoblast and Osteoclast Formation in Murine Bone Marrow Cultures from Adult Mice: Antagonism by Noggin

  2000cited by this paper
• Overexpression of DAN causes a growth suppression in p53-deficient SAOS-2 cells.

  2000cited by this paper
• The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb.

  1999cited by this paper
• Human bone marrow osteoprogenitors express estrogen receptor‐alpha and bone morphogenetic proteins 2 and 4 mRNA during osteoblastic differentiation

  1999cited by this paper
• Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.

  1999cited by this paper
• Extracellular matrix-associated bone morphogenetic proteins are essential for differentiation of murine osteoblastic cells in vitro.

  1999cited by this paper
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• Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts.

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• The negative charge of glutamic acid-820 in the gastric H+,K+-ATPase alpha-subunit is essential for K+ activation of the enzyme activity.

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• Mutational Analysis of Putative SCH 28080 Binding Sites of the Gastric H+,K+-ATPase*

  1997cited by this paper
• Identification of Asp804 and Asp808 as Na+ and K+ coordinating residues in α‐subunit of renal Na,K‐ATPase

  1997cited by this paper
• Functional Consequences of Mutations in the Transmembrane Core Region for Cation Translocation and Energy Transduction in the Na+, K+‐ATPase and the SR Ca2+‐ATPase a

  1997cited by this paper
• The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.

  1996cited by this paper
• Asp804 and Asp808 in the Transmembrane Domain of the Na,K-ATPase α Subunit Are Cation Coordinating Residues*

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• Scanning Mutagenesis Reveals a Similar Pattern of Mutation Sensitivity in Transmembrane Sequences M4, M5, and M6, but Not in M8, of the Ca2+-ATPase of Sarcoplasmic Reticulum (SERCA1a)*

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  1996cited by this paper
• Role of Negatively Charged Residues in the Fifth and Sixth Transmembrane Domains of the Catalytic Subunit of Gastric H+,K+-ATPase*

  1996cited by this paper
• Functional Expression of Gastric H+,K+-ATPase and Site-directed Mutagenesis of the Putative Cation Binding Site and the Catalytic Center (*)

  1996cited by this paper
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  1996cited by this paper
• Two Residues That May Ligate Ca2+ in Transmembrane Domain Six of the Plasma Membrane Ca2+-ATPase (*)

  1995cited by this paper
• Mutant Glu781-->Ala of the rat kidney Na+,K(+)-ATPase displays low cation affinity and catalyzes ATP hydrolysis at a high rate in the absence of potassium ions.

  1995cited by this paper
• Sodium Acts as a Potassium Analog on Gastric H,K-ATPase (*)

  1995cited by this paper
• Ethanol stimulates expression of functional H+,K(+)-ATPase in SF9 cells.

  1995cited by this paper
• The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression.

  1994cited by this paper
• Gastric H+/K+-ATPase

  1994cited by this paper
• Tertiary amines as antagonists of both the luminal and cytosolic K(+)-site of gastric H,K-ATPase.

  1994cited by this paper
• Na+,K(+)-ATPase.

  1994cited by this paper
• Rubidium occlusion within tryptic peptides of the H,K-ATPase.

  1993cited by this paper
• Functional expression of gastric H,K‐ATPase using the baculovirus expression system

  1993cited by this paper
• Kinetics of transient pump currents generated by the (H,K)-ATPase after an ATP concentration jump

  1993cited by this paper
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  1993cited by this paper
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  1992cited by this paper
• Isolation and characterization of a cDNA encoding the putative distal colon H+,K(+)-ATPase. Similarity of deduced amino acid sequence to gastric H+,K(+)-ATPase and Na+,K(+)-ATPase and mRNA expression in distal colon, kidney, and uterus.

  1992cited by this paper
• Extensive digestion of Na+,K(+)-ATPase by specific and nonspecific proteases with preservation of cation occlusion sites.

  1992cited by this paper
• Identification of an extracytoplasmic region of H+,K(+)-ATPase labeled by a K(+)-competitive photoaffinity inhibitor.

  1991cited by this paper
• Phosphorylation of H+/K(+)-ATPase by inorganic phosphate. The role of K+ and SCH 28080.

  1991cited by this paper
• Determination of the epitope for the inhibitory monoclonal antibody 5-B6 on the catalytic subunit of gastric Mg(2+)-dependent H(+)-transporting and K(+)-stimulated ATPase.

  1991cited by this paper
• A monoclonal antibody against pig gastric H+/K(+)-ATPase, which binds to the cytosolic E1.K+ form.

  1990cited by this paper
• Demonstration of the electrogenicity of proton translocation during the phosphorylation step in gastric H+K+-ATPase

  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper
• Role of water in the energy of hydrolysis of phosphate compounds--energy transduction in biological membranes.

  1989cited by this paper
• The binding of a K+ competitive ligand, 2-methyl,8-(phenylmethoxy)imidazo(1,2-a)pyridine 3-acetonitrile, to the gastric (H+ + K+)-ATPase.

  1989cited by this paper
• Sclerosteosis.

  1988cited by this paper
• Complete primary structure of a human plasma membrane Ca2+ pump.

  1988cited by this paper
• Conformational states of (K+ + H+)-ATPase studied using tryptic digestion as a tool.

  1987cited by this paper
• Conformational states of (K+ + H+)-ATPase studied using tryptic digestion as a tool.

  1987cited by this paper
• Inhibition of gastric H+,K+-ATPase and acid secretion by SCH 28080, a substituted pyridyl(1,2a)imidazole.

  1987cited by this paper
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  1987cited by this paper
• Eosin, a fluorescent marker for the high-affinity ATP site of (K++H+)-ATPase

  1986cited by this paper
• Cranial CT findings in sclerosteosis.

  1986cited by this paper
• Eosin, a fluorescent marker for the high-affinity ATP site of (K+ + H+)-ATPase.

  1986cited by this paper
• Molecular cloning of the rat stomach (H+ + K+)-ATPase.

  1986cited by this paper
• Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA

  1985cited by this paper
• Amino-acid sequence of a Ca2+ + Mg2+ -dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

  1985cited by this paper
• Membranes: A variety of calcium channels

  1985cited by this paper
• Direct evidence for an ADP-sensitive phosphointermediate of (K+ + H+)-ATPase.

  1985cited by this paper
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  1985cited by this paper
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  1983cited by this paper
• Sclerosteosis

  1983cited by this paper
• Determination of total protein.

  1983cited by this paper
• Interaction of fluorescein isothiocyanate with the (H+ + K+)-ATPase.

  1983cited by this paper
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  1979cited by this paper
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  1976cited by this paper
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  1958cited by this paper
• Osteopetrosis with syndactyly; a morphological variant of Albers-Schönberg's disease.

  1958cited by this paper

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