Impaired tight junction sealing and precocious involution in mammary glands of PKN1 transgenic mice

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Cell Science

• Publication date

  2007-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.03467PMID 17591691
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell contacts in the mouse mammary gland

  2009cited by this paper
• Selective glucocorticoid control of Rho kinase isoforms regulate cell-cell interactions.

  2007cited by this paper
• Conversion

  2006cited by this paper
• Analysis of the murine 5‐HT1A receptor gene promoter in vitro and in vivo

  2004cited by this paper
• An Atlas of Mouse Mammary Gland Development

  2004cited by this paper
• The Mammary Gland: A Model for Development

  2004cited by this paper
• Apoptosis and mammary gland involution: reviewing the process

  2004cited by this paper
• The tight junction: a multifunctional complex.

  2004cited by this paper
• Signalling to and from tight junctions

  2003influential reference
• Glucocorticoid Down-regulation of RhoA Is Required for the Steroid-induced Organization of the Junctional Complex and Tight Junction Formation in Rat Mammary Epithelial Tumor Cells*

  2003cited by this paper
• Transcription factor AP-2gamma stimulates proliferation and apoptosis and impairs differentiation in a transgenic model.

  2003cited by this paper
• Potential role of MCP-1 in endothelial cell tight junction `opening': signaling via Rho and Rho kinase

  2003cited by this paper
• Transduction of the Mammary Epithelium with Adenovirus Vectors In Vivo

  2003cited by this paper
• Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function

  2003cited by this paper
• The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC.

  2003influential reference
• The Organization of Tight Junctions in Epithelia: Implications for Mammary Gland Biology and Breast Tumorigenesis

  2003cited by this paper
• Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation Published, JLR Papers in Press, April 16, 2003. DOI 10.1194/jlr.M300045-JLR200

  2003cited by this paper
• Mammary physiology and milk secretion.

  2003cited by this paper
• Molecular Dissection of the Interaction between the Small G Proteins Rac1 and RhoA and Protein Kinase C-related Kinase 1 (PRK1)*

  2003cited by this paper
• A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer

  2003cited by this paper
• Transcription Factor AP-2γ Stimulates Proliferation and Apoptosis and Impairs Differentiation in a Transgenic Model11Grants from Deutsche Forschungsgemeinschaft (Scho 503) and HGF (SGF01SF9808) to H.S. supported this work. Note: Data deposition: The transgenic mice are registered with MGD as Tg(Tcfa

  2003cited by this paper
• Functional Development of the Mammary Gland: Use of Expression Profiling and Trajectory Clustering to Reveal Changes in Gene Expression During Pregnancy, Lactation, and Involution

  2003cited by this paper
• Rho GTPases in cell biology

  2002influential reference
• Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma

  2002cited by this paper
• Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia.

  2001cited by this paper
• Regulation of Tight Junction Permeability in the Mammary Gland

  2001influential reference
• Generation of a constitutively active fragment of PKN in microglia/macrophages after middle cerebral artery occlusion in rats

  2001cited by this paper
• Regulation of gene expression by the small GTPase Rho through the ERK6 (p38γ) MAP kinase pathway

  2001cited by this paper
• Rho and Rac but not Cdc42 regulate endothelial cell permeability.

  2001cited by this paper
• Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.

  2001cited by this paper
• Perturbation of the tight junction permeability barrier by occludin loop peptides activates β‐catenin/TCF/LEF‐mediated transcription

  2001cited by this paper
• Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice

  2001influential reference
• Intraductal Injection into the Mouse Mammary Gland

  2000cited by this paper
• Specificity and mechanism of action of some commonly used protein kinase inhibitors.

  2000cited by this paper
• The Rho effector, PKN, regulates ANF gene transcription in cardiomyocytes through a serum response element.

  2000cited by this paper
• Molecular decipherment of Rho effector pathways regulating tight-junction permeability.

  2000cited by this paper
• Methods in Mammary Gland Biology and Breast Cancer Research

  2000cited by this paper
• Rho GTPases and their effector proteins.

  2000cited by this paper
• Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution.

  2000cited by this paper
• Mutational analysis of the regulatory mechanism of PKN: the regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain.

  1999cited by this paper
• Requirement for Ras and Phosphatidylinositol 3-Kinase Signaling Uncouples the Glucocorticoid-induced Junctional Organization and Transepithelial Electrical Resistance in Mammary Tumor Cells*

  1999influential reference
• RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation

  1998cited by this paper
• Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases

  1998influential reference
• Tight Junction Regulation in the Mammary Gland

  1998cited by this paper
• The role of PKN in the regulation of alphaB-crystallin expression via heat shock transcription factor 1.

  1998cited by this paper
• Active transport of nitrofurantoin across a mouse mammary epithelial monolayer.

  1997cited by this paper
• The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions

  1996cited by this paper
• Epithelial proliferation and differentiation in the mammary gland do not correlate with cFABP gene expression during early pregnancy.

  1995cited by this paper
• Glucocorticoid-induced formation of tight junctions in mouse mammary epithelial cells in vitro.

  1992cited by this paper
• Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion.

  1992cited by this paper
• Tumorigenesis and eye abnormalities in transgenic mice expressing MSV-SV40 large T-antigen.

  1990cited by this paper
• CELL CONTACTS IN T H E MOUSE MAMMARY GLAND I. Normal Gland in Postnatal Development and the Secretory Cycle

  1973cited by this paper
• CELL CONTACTS IN THE MOUSE MAMMARY GLAND

  1973cited by this paper
• Pregnancy

  1962influential reference
• Printed in U.S.A. Copyright © 1997 by The Endocrine Society Hormonal Control of Insulin-Like Growth Factor- Binding Protein-5 Production in the Involuting Mammary Gland of the Rat*

  year unknowncited by this paper

• Aim for Evidence Based Pathology

  2025cites this paper
• Functions of RhoA in the female reproductive system

  2025cites this paper
• Hormonal control of the mammary blood-milk barrier and its role in establishing and maintaining milk production

  2025cites this paper
• The structure and function of protein kinase C-related kinases (PRKs)

  2021cites this paper
• Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse

  2020cites this paper
• Hormone Signaling Pathways in the Postnatal Mammary Gland

  2020cites this paper
• Tissue-Specific Cell Signaling

  2020cites this paper
• Occludin protects secretory cells from ER stress by facilitating SNARE-dependent apical protein exocytosis

  2020cites this paper
• PKN1 controls the aggregation, spheroid formation, and viability of mouse embryonic fibroblasts in suspension culture.

  2019cites this paper
• PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes

  2019cites this paper
• Milk lipid regulation at the maternal-offspring interface.

  2018cites this paper
• eview ilk lipid regulation at the maternal-offspring interface

  2017influential citation
• A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

  2017cites this paper
• Developmental Expression of Claudins in the Mammary Gland

  2017cites this paper
• Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis.

  2016cites this paper
• Lactation and Its Hormonal Control

  2015cites this paper
• The Role of Tight Junctions in Mammary Gland Function

  2014cites this paper
• Glucocorticoids regulate barrier function and claudin expression in intestinal epithelial cells via MKP-1.

  2014cites this paper
• Male stem Cell Niche and Spermatogenesis in the Drosophila testis — A Tale of Germline-Soma Communication

  2014cites this paper
• Glucocorticoid alternative effects on proliferating and differentiated mammary epithelium are associated to opposite regulation of cell‐cycle inhibitor expression

  2012cites this paper
• Tumor suppressor genes

  2012cites this paper
• Refining the role of Lgl, Dlg and Scrib in Tumor Suppression and Beyond: Learning from the Old Time Classics

  2012cites this paper
• Site recognition and substrate screens for PKN family proteins.

  2011cites this paper
• The RhoA-Rok-Myosin II Pathway is Involved in Extracellular Matrix-Mediated Regulation of Prolactin Signaling in Mammary Epithelial Cells

  2011cites this paper
• Analysis of the mammary gland specific effect of endothelin-1 in transgenic mice

  2011cites this paper
• Asymmetric Expression/ Distribution of Connexins is Essential for Contractile Function in the Mammary Gland

  2011cites this paper
• Tissue Polarity-Dependent Control of Mammary Epithelial Homeostasis and Cancer Development: an Epigenetic Perspective

  2010cites this paper
• Development of an intracellularly acting inhibitory peptide selective for PKN.

  2010cites this paper
• Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?

  2010cites this paper
• Activation of PKN Mediates Survival of Cardiac Myocytes in the Heart During Ischemia/Reperfusion

  2010cites this paper
• Milk Secretion and Ejection Are Impaired in the Mammary Gland of Mice Harboring a Cx43 Mutant While Expression and Localization of Tight and Adherens Junction Proteins Remain Unchanged1

  2010cites this paper
• Lactation performance and milk composition studies in transgenic goats expressing recombinant proteins in the milk

  2009influential citation
• Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression.

  2009cites this paper
• Introduction: Tight Junctions and Secretory Activation in the Mammary Gland

  2009cites this paper
• Lactation failure in Src knockout mice is due to impaired secretory activation

  2008cites this paper
• The Role of Glucocorticoids in Secretory Activation and Milk Secretion, a Historical Perspective

  2007influential citation
• Funktionelle Charakterisierung des Rho-Effektormoleküls PKN in einem transgenen Mausmodell

  2007cites this paper