The Role of Tight Junctions in Mammary Gland Function

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of mammary gland biology and neoplasia

• Publication date

  2014-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10911-013-9309-1PMID 24249583
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Concomitant lipopolysaccharide-induced transfer of blood-derived components including immunoglobulins into milk.

  2013cited by this paper
• Lipopolysaccharide Disrupts the Milk-Blood Barrier by Modulating Claudins in Mammary Alveolar Tight Junctions

  2013influential reference
• Claudins, dietary milk proteins, and intestinal barrier regulation.

  2013cited by this paper
• Concomitant LPS induced transfer of blood derived components including imunoglobulins into milk

  2013cited by this paper
• Effect of prolactin-release inhibition on milk production and mammary gland involution at drying-off in cows.

  2013cited by this paper
• Bovine Colostrum Increases Pore-Forming Claudin-2 Protein Expression but Paradoxically Not Ion Permeability Possibly by a Change of the Intestinal Cytokine Milieu

  2013cited by this paper
• Invited review: reduced milking frequency: milk production and management implications.

  2013cited by this paper
• Short communication: differential immunoglobulin transfer during mastitis challenge by pathogen-specific components.

  2013cited by this paper
• Occludin is required for apoptosis when claudin–claudin interactions are disrupted

  2012cited by this paper
• ZO‐2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis

  2012cited by this paper
• Serotonin as a homeostatic regulator of lactation.

  2012influential reference
• Distinct behavior of claudin-3 and -4 around lactation period in mammary alveolus in mice

  2011cited by this paper
• Suppression of lactation and acceleration of involution in the bovine mammary gland by a selective serotonin reuptake inhibitor.

  2011cited by this paper
• Altered expression of tight junction proteins in mammary epithelium after discontinued suckling in mice

  2011influential reference
• Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistance

  2009cited by this paper
• Tight Junctions: A Barrier to the Initiation and Progression of Breast Cancer?

  2009cited by this paper
• Short communication: Effect of estrogen supplemented at dry-off on temporal changes in concentrations of lactose in blood plasma of Holstein cows.

  2009cited by this paper
• Bovine Colostrum Supplementation During Running Training Increases Intestinal Permeability

  2009cited by this paper
• Immune components of bovine colostrum and milk.

  2009cited by this paper
• Structure-Activity Relationships of Antimicrobial and Lipoteichoic Acid-Sequestering Properties in Polyamine Sulfonamides

  2008cited by this paper
• Autocrine Production of Insulin-like Growth Factor-I (IGF-I) Affects Paracellular Transport Across Epithelial Cells In Vitro

  2007cited by this paper
• Impaired tight junction sealing and precocious involution in mammary glands of PKN1 transgenic mice

  2007cited by this paper
• Characterisation of host defence proteins in milk using a proteomic approach.

  2007cited by this paper
• Mammary gland homeostasis employs serotonergic regulation of epithelial tight junctions

  2007cited by this paper
• Immune Components of Colostrum and Milk—A Historical Perspective

  2007influential reference
• Major advances associated with hormone and growth factor regulation of mammary growth and lactation in dairy cows.

  2006influential reference
• Regulation of tight junction proteins during engorgement of the mammary gland : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Palmerston North, New Zealand

  2006cited by this paper
• Milk accumulation decreases expression of genes involved in cell–extracellular matrix communication and is associated with induction of apoptosis in the bovine mammary gland

  2005cited by this paper
• Decreased expression of β1‐integrin and focal adhesion kinase in epithelial cells may initiate involution of mammary glands

  2004cited by this paper
• The role of claudins in determining paracellular charge selectivity.

  2004influential reference
• Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders.

  2004cited by this paper
• Regulation of mammary tight junctions through parathyroid hormone-related peptide-induced activation of apical calcium channels.

  2003influential reference
• Infusions of casein hydrolyzates into the mammary gland disrupt tight junction integrity and induce involution in cows.

  2003cited by this paper
• Glucocorticoid Down-regulation of RhoA Is Required for the Steroid-induced Organization of the Junctional Complex and Tight Junction Formation in Rat Mammary Epithelial Tumor Cells*

  2003cited by this paper
• Signalling to and from tight junctions

  2003cited by this paper
• Claudins form ion-selective channels in the paracellular pathway. Focus on "Claudin extracellular domains determine paracellular charge selectively and resistance but not tight junction fibril architecture".

  2003cited by this paper
• Casein-derived phosphopeptides disrupt tight junction integrity, and precipitously dry up milk secretion in goats.

  2002cited by this paper
• Thrice-daily milking throughout lactation maintains epithelial integrity and thereby improves milk protein quality.

  2001cited by this paper
• Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability.

  2001cited by this paper
• Effect of Milking Frequency on Mammary Functioning and Shape of the Lactation Curve

  2001influential reference
• Prolactin, alone or in combination with glucocorticoids, enhances tight junction formation and expression of the tight junction protein occludin in mammary cells.

  1999cited by this paper
• Elevated plasma cortisol reduces permeability of mammary tight junctions in the lactating bovine mammary epithelium.

  1998cited by this paper
• The tight junction: morphology to molecules.

  1998cited by this paper
• The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton*

  1998cited by this paper
• Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

  1998cited by this paper
• An anti-inflammatory component derived from milk of hyperimmunised cows reduces tight junction permeability in vitro

  1998cited by this paper
• Time course of milk accumulation-induced opening of mammary tight junctions, and blood clearance of milk components.

  1997influential reference
• Cortisol and regulation of tight junctions in the mammary gland of the late-pregnant goat

  1996cited by this paper
• Defining the roles of parathyroid hormone-related protein in normal physiology.

  1996cited by this paper
• Antagonistic Regulation of Tight Junction Dynamics by Glucocorticoids and Transforming Growth Factor- in Mouse Mammary Epithelial Cells (*)

  1996cited by this paper
• Continuous versus single drainage of milk from the bovine mammary gland during a 24 hour period

  1996cited by this paper
• Fixed Y leld Responses to Increased Milking Frequency

  1995cited by this paper
• Morphologic observation of neutrophil diapedesis across bovine mammary gland epithelium in vitro.

  1995cited by this paper
• EGTA-induced disruption of epithelial cell tight junctions in the lactating caprine mammary gland.

  1995cited by this paper
• Effects of unilateral prepartum milking on concentrations of immunoglobulin G1 and prolactin in colostrum.

  1994cited by this paper
• Evidence that growth hormone stimulates milk synthesis by direct action on the mammary gland and that prolactin exerts effects on milk secretion by maintenance of mammary deoxyribonucleic acid content and tight junction status.

  1994cited by this paper
• Mammary epithelial cell tight junction integrity and mammary blood flow during an extended milking interval in goats.

  1994cited by this paper
• Relationship of serine/threonine phosphorylation/dephosphorylation signaling to glucocorticoid regulation of tight junction permeability and ZO-1 distribution in nontransformed mammary epithelial cells.

  1994cited by this paper
• Local control of parathyroid hormone-related protein secretion by the mammary gland of the goat.

  1994cited by this paper
• Occludin: a novel integral membrane protein localizing at tight junctions

  1993cited by this paper
• Structure, function, and regulation of cellular tight junctions.

  1992cited by this paper
• Glucocorticoid-induced formation of tight junctions in mouse mammary epithelial cells in vitro.

  1992cited by this paper
• Milk synthesis and secretion rates in cows with milk composition changed by oxytocin.

  1990cited by this paper
• Electrical potentials and cell-to-cell dye movement in mouse mammary gland during lactation.

  1984cited by this paper
• Effects of extracellular calcium depletion on membrane topography and occluding junctions of mammary epithelial cells in culture

  1983cited by this paper
• A freeze-fracture study of tight junction structure in sheep mammary gland epithelium during pregnancy and lactation

  1982cited by this paper
• Ionized calcium in milk and the integrity of the mammary epithelium in the goat.

  1981cited by this paper
• Absorption of colostral immunoglobulins in newborn calves.

  1980cited by this paper
• The effect of raised intramammary pressure on mammary function in the goat in relation to the cessation of lactation.

  1980cited by this paper
• Mammary function and its control at the cessation of lactation in the goat.

  1978cited by this paper
• Secretory activity of goat mammary glands during pregnancy and the onset of lactation.

  1975cited by this paper
• The effects of prolactin and oxytocin on milk secretion and on the permeability of the mammary epithelium in the rabbit.

  1975cited by this paper
• Changes in colostrum composition and in the permeability of the mammary epithelium at about the time of parturition in the goat

  1974cited by this paper
• CELL CONTACTS IN THE MOUSE MAMMARY GLAND

  1973cited by this paper
• The effects of oxytocin and milk removal on milk secretion in the goat

  1971cited by this paper
• Pregnancy

  1962cited by this paper

• Immune response in breastmilk of Black women to SARS-CoV-2 infection and vaccination against COVID-19

  2026cites this paper
• From rumen to milk: Dietary polyphenols in dairy cows—A critical review

  2026cites this paper
• Hormonal control of the mammary blood-milk barrier and its role in establishing and maintaining milk production

  2025cites this paper
• Influence of rutin on LPS-induced inflammation, oxidative stress, and autophagy in bovine mammary epithelial cells.

  2025cites this paper
• Modelling Cancer Pathophysiology: Mechanisms and Changes in the Extracellular Matrix During Cancer Initiation and Early Tumour Growth

  2025cites this paper
• Effects of automated short-term incomplete milking during peak- to mid-lactation on milk production, udder health, and selected metabolic parameters in dairy cows.

  2025cites this paper
• A novel, cost-effective approach to cell-cultured milk production: Progesterone and MMP inhibition promote lactogenic differentiation in bovine mammary epithelial cells

  2025cites this paper
• ALKBH5 Improves the Epithelial Cell Tight Junctions to Inhibit Escherichia coli-Induced Mastitis

  2025cites this paper
• Genome-wide study for signatures of selection identifies genomic regions and candidate genes associated with milk traits in sheep

  2025cites this paper
• Deciphering the colostral-immunity transfer: from mammary gland to neonates small intestine

  2025cites this paper
• Synergistic effects of heat stress and mastitis induced by K. pneumoniae on inflammation responses and blood-milk barrier in rats.

  2025cites this paper
• Human Milk Electrolytes as Nutritional Biomarkers of Mammary Gland Integrity: A Study Across Ductal Conditions and Donor Milk

  2025cites this paper
• High-grain feeding contributes to endotoxin contamination in dairy milk.

  2024cites this paper
• Mammary epithelium permeability during established lactation: associations with cytokine levels in human milk

  2024cites this paper
• Impact of nutrient restriction at dry-off on performance and metabolism.

  2024cites this paper
• Cellular characteristics and milk component productivity of primary bovine mammary cells for cell-cultured milk component production

  2024cites this paper
• Leptin on the apical surface inhibits casein production and STAT5 phosphorylation in mammary epithelial cells.

  2024cites this paper
• Hydroxy-selenomethionine helps cows to overcome heat stress by enhancing antioxidant capacity and alleviating blood-milk barrier damage

  2024cites this paper
• A review of extended lactation in dairy cows managed in high-input and pasture-based farming systems

  2024cites this paper
• Effects of subclinical mastitis on automatic milking system data, hematological and biochemical parameters, and milk composition in Holstein cows

  2024cites this paper
• Pharmacokinetics of carprofen in lactating dogs after intravenous treatment

  2024cites this paper
• Generation of Anti‐Mastitis Gene‐Edited Dairy Goats with Enhancing Lysozyme Expression by Inflammatory Regulatory Sequence using ISDra2‐TnpB System

  2024cites this paper
• Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse Mammary Gland Development During Pregnancy, Lactation, and Weaning.

  2024cites this paper
• Residents or Tourists: Is the Lactating Mammary Gland Colonized by Residential Microbiota?

  2024cites this paper
• Biomarker-based text messages to promote lactation success in mothers of critically Ill infants: a randomized controlled pilot study

  2024cites this paper
• Estimation of udder emptying based on milk constituents of strip samples after milking.

  2024cites this paper
• Effect and mechanism of Prunella vulgaris L. extract on alleviating lipopolysaccharide-induced acute mastitis in protecting the blood-milk barrier and reducing inflammation.

  2024cites this paper
• Colostrum Composition, Characteristics and Management for Buffalo Calves: A Review

  2023cites this paper
• Hexadecanamide alleviates Staphylococcus aureus-induced mastitis in mice by inhibiting inflammatory responses and restoring blood-milk barrier integrity

  2023cites this paper
• Butyrate Protects against γ-d-Glutamyl-meso-diaminopimelic Acid-Induced Inflammatory Response and Tight Junction Disruption through Histone Deacetylase 3 Inhibition in Bovine Mammary Epithelial Cells.

  2023cites this paper
• The impact of automated, constant incomplete milking on energy balance, udder health, and subsequent performance in early lactation of dairy cows.

  2023cites this paper
• Effects of 2-acetyl-4-tetrahydroxybutylimidazole exposure during gestation and lactation on maternity and offspring immune function in Balb/c mice.

  2023cites this paper
• Stem cell and Non-stem Cell Components of Breast Milk

  2023cites this paper
• Musashi2 binds TGFβR1 regulates mastitis via TGFβ/Smad signaling pathway in dairy cows

  2023cites this paper
• RNA binding protein Musashi2 regulates dairy cows' mastitis by activating the TGFβ signaling pathway.

  2023cites this paper
• Puerarin Alleviates H2O2-Induced Oxidative Stress and Blood–Milk Barrier Impairment in Dairy Cows

  2023cites this paper
• Lactational exposure to Deoxynivalenol causes mammary gland injury via inducing inflammatory response and impairing blood-milk barrier integrity in mice.

  2023cites this paper
• iE-DAP Induced Inflammatory Response and Tight Junction Disruption in Bovine Mammary Epithelial Cells via NOD1-Dependent NF-κB and MLCK Signaling Pathway

  2023cites this paper
• Sweet taste receptor subunit T1R3 regulates casein secretion and phosphorylation of STAT5 in mammary epithelial cells.

  2023cites this paper
• The Prevention Effect of Lactobacillus plantarum 17–5 on Escherichia coli-Induced Mastitis in Mice

  2023cites this paper
• High concentrate diet induced inflammatory response and tight junction disruption in the mammary gland of dairy cows.

  2023cites this paper
• Deoxynivalenol exposure inhibits biosynthesis of milk fat and protein by impairing tight junction in bovine mammary epithelial cells.

  2022cites this paper
• Traditional and emerging Fusarium mycotoxins disrupt homeostasis of bovine mammary cells by altering cell permeability and innate immune function

  2022cites this paper
• Novel organic selenium source hydroxy-selenomethionine counteracts the blood-milk barrier disruption and inflammatory response of mice under heat stress

  2022cites this paper
• Mechanism underlying the modulation of milk production by incomplete milking.

  2022cites this paper
• Sanguinarine Enhances the Integrity of the Blood–Milk Barrier and Inhibits Oxidative Stress in Lipopolysaccharide-Stimulated Mastitis

  2022cites this paper
• Pro-inflammatory cytokines and growth factors in human milk: Associations with increased mammary epithelium permeability during established lactation

  2022influential citation
• A cross-sectional study evidences regulations of leukocytes in the colostrum of mothers with obesity

  2022cites this paper
• Immune defenses of the mammary gland epithelium of dairy ruminants

  2022cites this paper
• Ochratoxin A and Citrinin Differentially Modulate Bovine Mammary Epithelial Cell Permeability and Innate Immune Function

  2022influential citation
• Nisin Z attenuates lipopolysaccharide-induced mastitis by inhibiting the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways.

  2022cites this paper
• Toll-like Receptor 2 Is Associated with the Immune Response, Apoptosis, and Angiogenesis in the Mammary Glands of Dairy Cows with Clinical Mastitis

  2022cites this paper
• Early effects of lipoteichoic acid from Staphylococcus aureus on milk production-related signaling pathways in mouse mammary epithelial cells.

  2022cites this paper
• Lactose on the basolateral side of mammary epithelial cells inhibits milk production concomitantly with signal transducer and activator of transcription 5 inactivation

  2022cites this paper
• Anesthesia and breastfeeding

  2022cites this paper
• Carry-over effects of dry period heat stress on the mammary gland proteome and phosphoproteome in the subsequent lactation of dairy cows

  2022cites this paper
• Tissue mechanics in stem cell fate, development, and cancer.

  2021cites this paper
• The relationship between milk somatic cell count and cheese production, quality and safety: A review

  2021cites this paper
• Milk on the Moo've.

  2021cites this paper
• Genetic correlations between fertility traits and milk composition and fatty acids in Holstein-Friesian, Brown Swiss, and Simmental cattle using recursive models.

  2021cites this paper
• Invited review: The role of the blood-milk barrier and its manipulation for the efficacy of the mammary immune response and milk production.

  2021cites this paper
• Uneven milking intervals are adequate to achieve the benefits of increased milking frequency in early lactation.

  2021cites this paper
• Expression of Grainyhead-like 2 in the Process of Ductal Development of Mouse Mammary Gland

  2021cites this paper
• Optimization of Pulsation Rate of the Milking System for the Mammary Gland Remodeling during Involution in Thai Crossbred Holstein Cows

  2021cites this paper
• Pathogen-specific changes in composition and quality traits of milk from goats affected by subclinical intramammary infections

  2021cites this paper
• Development of a Pig Mammary Epithelial Cell Culture Model as a Non-Clinical Tool for Studying Epithelial Barrier—A Contribution from the IMI-ConcePTION Project

  2021cites this paper
• Kynurenic acid protects against mastitis in mice by ameliorating inflammatory responses and enhancing blood-milk barrier integrity.

  2021cites this paper
• Ferulic acid inhibits LPS-induced apoptosis in bovine mammary epithelial cells by regulating the NF-κB and Nrf2 signalling pathways to restore mitochondrial dynamics and ROS generation

  2021cites this paper
• Exosomal miR-193b-5p as a regulator of LPS-induced inflammation in dairy cow mammary epithelial cells

  2021cites this paper
• Pedunculoside protects against LPS-induced mastitis in mice by inhibiting inflammation and maintaining the integrity of blood-milk barrier

  2021cites this paper
• Oxytocin and cortisol release during suckling, hand-milking and machine milking in camels

  2021cites this paper
• Oligosaccharides and Microbiota in Human Milk Are Interrelated at 3 Months Postpartum in a Cohort of Women with a High Prevalence of Gestational Impaired Glucose Tolerance

  2021cites this paper
• Taurine protects blood-milk barrier integrity via limiting inflammatory response in Streptococcus uberis infections.

  2021cites this paper
• IL-1β is a key inflammatory cytokine that weakens lactation-specific tight junctions of mammary epithelial cells.

  2021cites this paper
• Tartary buckwheat flavonoids relieve the tendency of mammary fibrosis induced by HFD during pregnancy and lactation

  2021cites this paper
• High-throughput analysis of CircRNA in cows with naturally infected Staphylococcus aureus mammary gland

  2021cites this paper
• Comparative analysis of the skim milk and milk fat globule membrane proteomes produced by Jersey cows grazing pastures with different plant species diversity

  2020cites this paper
• Changes in milk metabolome during the lactation of dairy cows based on 1H NMR and UHPLC–QToF/MS

  2020cites this paper
• Suppressive effects of curcumin on milk production without inflammatory responses in lactating mammary epithelial cells.

  2020cites this paper
• Application of an indirect MilA ELISA for the detection of Mycoplasma bovis antibodies in bovine milk

  2020cites this paper
• Structural equation modeling for investigating multi-trait genetic architecture of udder health in dairy cattle

  2020cites this paper
• Selenium biofortified alfalfa hay fed in low quantities improves selenium status and glutathione peroxidase activity in transition dairy cows and their calves.

  2020cites this paper
• Overview of Research Development on the Role of NF-κB Signaling in Mastitis

  2020cites this paper
• Dual effects of JNK activation in blood-milk barrier damage induced by zinc oxide nanoparticles.

  2020cites this paper
• Impact of Staphylococcus aureus infection on the late lactation goat milk proteome: New perspectives for monitoring and understanding mastitis in dairy goats.

  2020cites this paper
• Mammary gland cell’s tight junction permeability from dairy cows producing stable or unstable milk in the ethanol test

  2020cites this paper
• Occludin protects secretory cells from ER stress by facilitating SNARE-dependent apical protein exocytosis

  2020cites this paper
• Radial Profile Analysis of Epithelial Polarity in Breast Acini: A Tool for Primary (Breast) Cancer Prevention

  2020influential citation
• Raw Milk Physiology

  2019cites this paper
• Response of lactating dairy cows fed different supplemental zinc sources with and without evaporative cooling to intramammary lipopolysaccharide infusion: intake, milk yield and composition, and hematologic profile1.

  2019cites this paper
• Short communication: Mammary gland tight junction permeability after parturition is greater in dairy cows with elevated circulating serotonin concentrations.

  2019cites this paper
• Nicotine directly affects milk production in lactating mammary epithelial cells concurrently with inactivation of STAT5 and glucocorticoid receptor in vitro.

  2019cites this paper
• Morin alleviates LPS-induced mastitis by inhibiting the PI3K/AKT, MAPK, NF-κB and NLRP3 signaling pathway and protecting the integrity of blood-milk barrier.

  2019cites this paper
• Genetic mechanisms regulating the host response during mastitis.

  2019cites this paper
• Evaluation of 2 different treatment procedures after calving to improve harvesting of high-quantity and high-quality colostrum

  2019cites this paper
• Gestational and Lactational Exposure to an Environmentally-relevant Mixture of Brominated Flame Retardants Down-regulates Junctional Proteins, Thyroid Hormone Receptor α1 Expression and the Proliferation-Apoptosis Balance in Mammary Glands Post Puberty.

  2019cites this paper
• Evaluation of Casein Hydrolysate as an Alternative Dry-Off Treatment and Milk Quality Management Tool in Dairy Cows

  2019influential citation
• NMR metabolite profiles of dairy: A review

  2019cites this paper
• NMR-based metabolomics to evaluate the milk composition from Friesian and autochthonous cows of Northern Italy at different lactation times

  2019cites this paper
• Adaptation of dairy cows to increasing degrees of incomplete milk removal during a single milking interval.

  2018cites this paper