AFRICAN TRYPANOSOME INTERACTIONS WITH AN IN VITRO MODEL OF THE HUMAN BLOOD–BRAIN BARRIER

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Parasitology

• Publication date

  2004-10-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1645/GE-287RPMID 15562595
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Immunofluorescence microscopy of cultured cells.

  2006cited by this paper
• Flagellum-mediated adhesion ofTrypanosoma congolense to bovine aorta endothelial cells

  2004cited by this paper
• African trypanosomiasis: Haematogenic brain parasitism early in experimental infection through bypassing the blood-brain barrier, with considerations on brain trypanosomiasis in man

  2004cited by this paper
• The pathogenesis of trypanosomiasis of the CNS

  2004cited by this paper
• Functional analysis of tight junctions.

  2003cited by this paper
• Neurological diseases: Pathogenesis of bacterial meningitis: from bacteraemia to neuronal injury

  2003cited by this paper
• The trans-sialidase from the african trypanosome Trypanosoma brucei.

  2002cited by this paper
• Characteristic gene expression profile of primary human cerebral endothelial cells

  2002cited by this paper
• Trypanosome hydrolases and the blood-brain barrier.

  2002cited by this paper
• Effective gene transfer into Trypanosoma brucei bloodstream forms by particle bombardment.

  2002cited by this paper
• Bacterial invasion and transcytosis in transfected human brain microvascular endothelial cells.

  2001cited by this paper
• Trypanosoma brucei brucei crosses the blood–brain barrier while tight junction proteins are preserved in a rat chronic disease model

  2001cited by this paper
• Traversal of Candida albicans across Human Blood-Brain Barrier In Vitro

  2001cited by this paper
• Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes.

  2001cited by this paper
• Blood—Brain Barrier Genomics

  2001cited by this paper
• Molecular physiology and pathophysiology of tight junctions in the blood–brain barrier

  2001cited by this paper
• Characterisation of the growth and differentiation in vivo and in vitro-of bloodstream-form Trypanosoma brucei strain TREU 927.

  2001cited by this paper
• E. coli invasion of brain microvascular endothelial cells as a pathogenetic basis of meningitis.

  2000cited by this paper
• Involvement of Focal Adhesion Kinase inEscherichia coli Invasion of Human Brain Microvascular Endothelial Cells

  2000cited by this paper
• Analysis of tight junctions during neutrophil transendothelial migration.

  2000cited by this paper
• Escherichia coli K 1 aslA Contributes to Invasion of Brain Microvascular Endothelial Cells In Vitro and In Vivo

  2000cited by this paper
• Bacterial penetration across the blood-brain barrier during the development of neonatal meningitis.

  2000cited by this paper
• beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.

  2000cited by this paper
• Escherichia coli K1 aslAContributes to Invasion of Brain Microvascular Endothelial Cells In Vitro and In Vivo

  2000cited by this paper
• Expression and localization of serum resistance associated protein in Trypanosoma brucei rhodesiense.

  1999cited by this paper
• P-Glycoprotein, a gatekeeper in the blood-brain barrier.

  1999cited by this paper
• Molecular and cellular mechanisms for microbial entry into the CNS.

  1999cited by this paper
• Chemically, mechanically, and hyperosmolarity-induced calcium responses of rat cortical capillary endothelial cells in culture

  1999cited by this paper
• Invasion of brain microvascular endothelial cells by group B streptococci

  1997cited by this paper
• Bovine brain microvascular endothelial cells transfected with SV40-large T antigen: Development of an immortalized cell line to study pathophysiology of CNS disease

  1997cited by this paper
• Nonfilamentous C. albicans mutants are avirulent.

  1997cited by this paper
• TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier.

  1997cited by this paper
• [Current status of trypanosomiasis].

  1997cited by this paper
• A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis.

  1997cited by this paper
• Selective expression of adhesion molecules on human brain microvascular endothelial cells.

  1997cited by this paper
• TNF-α Opens a Paracellular Route for HIV-1 Invasion across the Blood-Brain Barrier

  1997cited by this paper
• vaccine in The Netherlands . persons vaccinated with inactivated poliovirus Poliovirus-specific immunoglobulin A in

  1997cited by this paper
• Entry of pathogens into the central nervous system.

  1996influential reference
• Migration of the fungal pathogen Candida albicans across endothelial monolayers

  1996cited by this paper
• Escherichia coli invasion of brain microvascular endothelial cells in vitro and in vivo: molecular cloning and characterization of invasion gene ibe10

  1995cited by this paper
• Immunoelectron microscopic studies on the specific adhesion of Trypanosoma congolense to cultured vascular endothelial cells.

  1994cited by this paper
• The interaction of Trypanosoma congolense with endothelial cells

  1994cited by this paper
• Altered intracellular polyamines in bloodstream form Trypanosoma brucei brucei: transformation to procyclic trypomastigotes.

  1993cited by this paper
• Chemotherapy of Trypanosoma brucei infection of the central nervous system: the use of a rapid chemotherapeutic regimen and the development of post-treatment encephalopathies.

  1993cited by this paper
• Monitoring trypanosomiasis in space and time

  1993cited by this paper
• Adhesion and Migration of Human Polymorphonuclear Leukocytes Across Cultured Bovine Brain Microvessel Endothelial Cells

  1992cited by this paper
• Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers.

  1989cited by this paper
• Trypanosomiasis and encephalitis: possible aetiology and treatment.

  1989cited by this paper
• Spread of Trypanosoma brucei to the nervous system: Early attack on circumventricular organs and sensory ganglia

  1988cited by this paper
• Cerebral trypanosomiasis in cattle with mixed Trypanosoma congolense and T. brucei brucei infections.

  1984cited by this paper
• Relapsed parasitaemia following chemotherapy of chronic T. brucei infections in mice and its relation to cerebral trypanosomes.

  1983cited by this paper
• Pathology of infection with Trypanosoma brucei: disease syndromes in dogs and cattle resulting from severe tissue damage.

  1983cited by this paper
• Relapsed parasitaemia following chemotherapy of chronic T. brucei infections in mice and its relation to cerebral trypanosomes.

  1983cited by this paper
• Injury induced by Trypanosoma congolense adhesion to cell membranes.

  1980cited by this paper
• In vitro binding of Trypanosoma congolense to erythrocytes.

  1979cited by this paper
• The brain as a source of relapsing Trypanosoma brucei infection in mice after chemotherapy.

  1979cited by this paper
• Meningoencephalitis in chronic Trypanosoma brucei rhodesiense infection of the white mouse.

  1979cited by this paper
• Binding of Trypanosoma congolense to the walls of small blood vessels.

  1978cited by this paper
• Trypanosoma rhodesiense encephalitis

  1965cited by this paper
• Two autopsies on rhodesiense sleeping sickness; Visceral lesions and significance of changes in cerebrospinal fluid

  1941cited by this paper
• The pathology of the brain in rhodesian trypanosomiasis

  1937cited by this paper
• Some clinical aspects of trypanosomiasis rhodesiensis

  1929cited by this paper

• Engineered In Vitro Models to Improve the Mechanistic Understanding and Treatment of Neglected Tropical Diseases Caused by Protozoan Parasites

  2024cites this paper
• Effects of Trypanosoma brucei on thyroid hormones in albino rats

  2024cites this paper
• The Evolving Spectrum of Human African Trypanosomiasis.

  2023cites this paper
• Bradykinin produced during Plasmodium falciparum erythrocytic cycle drives monocyte adhesion to human brain microvascular endothelial cells.

  2023cites this paper
• Targeting Cysteine Proteases and their Inhibitors to Combat Trypanosomiasis.

  2023cites this paper
• The Pathogenesis of African Trypanosomiasis.

  2022cites this paper
• Transmigration of Trypanosoma brucei across an in vitro blood-cerebrospinal fluid barrier

  2022cites this paper
• Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response

  2022cites this paper
• The monoterpene 1,8-cineole prevents cerebral edema in a murine model of severe malaria

  2022cites this paper
• Microarray profiling predicts early neurological and immune phenotypic traits in advance of CNS disease during disease progression in Trypanosoma. b. brucei infected CD1 mouse brains

  2021cites this paper
• Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host

  2021cites this paper
• Circulating MicroRNAs and Blood-Brain-Barrier Function in Breast Cancer Metastasis

  2020cites this paper
• Early Blood Brain Barrier Traversal by Trypanosoma Brucei Brucei Strains: A Phenomenon of Laboratory Strains or Field Strains as Well?

  2020cites this paper
• Generation of neuroinflammation in human African trypanosomiasis

  2019cites this paper
• Proteome characterization in various biological fluids of Trypanosoma brucei gambiense-infected subjects.

  2019cites this paper
• Intravital microscopy: Imaging host–parasite interactions in the brain

  2019cites this paper
• Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis

  2019cites this paper
• Transmigration of Trypanosoma cruzi trypomastigotes through 3D cultures resembling a physiological environment

  2019cites this paper
• A novel laminin-binding protein mediates microbial-endothelial cell interactions and facilitates dissemination of Lyme disease pathogens.

  2019cites this paper
• Crossing the Blood-Brain Barrier by Neuroinvasive Pathogens

  2018cites this paper
• Description of an Intracellular Stage in the Experimental Infections of Albino Mice with a Venezuelan Isolate of Trypanosoma Evansi Using Scanning and Transmission Electron Microscopy Techniques

  2018cites this paper
• A multigene family encoding surface glycoproteins in Trypanosoma congolense

  2017cites this paper
• Trypanosoma brucei brucei traverses different biological barriers differently and may modify the host plasma membrane in the process.

  2017cites this paper
• Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis

  2017cites this paper
• African trypanosomes and brain infection – the unsolved question

  2017cites this paper
• CD44-mediated monocyte transmigration across Cryptococcus neoformans-infected brain microvascular endothelial cells is enhanced by HIV-1 gp41-I90 ectodomain

  2016cites this paper
• Immunology of the Brain

  2016cites this paper
• Trypanosomal Cysteine Peptidases: Target Validation and Drug Design Strategies

  2016cites this paper
• Exploiting genetic variation to discover genes involved in important disease phenotypes.

  2015cites this paper
• Neglected Tropical Diseases and Conditions of the Nervous System

  2014cites this paper
• Neurobiology of African Trypanosomiasis

  2014cites this paper
• African Trypanosome-Induced Blood–Brain Barrier Dysfunction under Shear Stress May Not Require ERK Activation

  2014cites this paper
• Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis

  2013cites this paper
• Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood–brain barrier model for drug permeability studies

  2013influential citation
• Imaging African trypanosomes

  2013cites this paper
• Claudin-5 Controls Intercellular Barriers of Human Dermal Microvascular but Not Human Umbilical Vein Endothelial Cells

  2013cites this paper
• Microglial TNF-α-Dependent Elevation of MHC Class I Expression on Brain Endothelium Induced by Amyloid-Beta Promotes T Cell Transendothelial Migration

  2013cites this paper
• Identification of Trans-Sialidases as a Common Mediator of Endothelial Cell Activation by African Trypanosomes

  2013influential citation
• Establishment of a simplified in vitro porcine blood–brain barrier model with high transendothelial electrical resistance

  2013cites this paper
• CXCL1 Contributes to β-Amyloid-Induced Transendothelial Migration of Monocytes in Alzheimer’s Disease

  2013cites this paper
• Mechanisms of CNS invasion and damage by parasites.

  2013cites this paper
• Synthetic and natural protease inhibitors provide insights into parasite development, virulence and pathogenesis.

  2013cites this paper
• Concepts and mechanisms: crossing host barriers.

  2013influential citation
• Virulence in African Trypanosomes: Genetic and Molecular Approaches

  2013cites this paper
• Pathogenesis of haematogenous spread in Acanthamoeba castellanii infections

  2013cites this paper
• Tsetse fly saliva: Could it be useful in fly infection when feeding in chronically aparasitemic mammalian hosts

  2012cites this paper
• Early Invasion of Brain Parenchyma by African Trypanosomes

  2012cites this paper
• Toxoplasma gondii and the blood-brain barrier

  2012cites this paper
• Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system

  2012cites this paper
• Passage of parasites across the blood-brain barrier

  2012cites this paper
• Trypanosoma brucei brucei oligopeptidase B null mutants display increased prolyl oligopeptidase-like activity.

  2012cites this paper
• [Sleeping sickness: end of the epidemic outbreak?].

  2012cites this paper
• © 2012 Landes Bioscience. Do not distribute. © 2012 Landes Bioscience. Do not distribute. Toxoplasma gondii and the blood-brain barrier

  2012cites this paper
• The Distribution of Nifurtimox Across the Healthy and Trypanosome-Infected Murine Blood-Brain and Blood-Cerebrospinal Fluid Barriers

  2011cites this paper
• Traversal of human and animal trypanosomes across the blood-brain barrier

  2011influential citation
• Gene disruption of TcoCATL (Congopain) and oligopeptidase B, pathogenic factors of African trypanosomes.

  2011cites this paper
• Trypanosome genetics: populations, phenotypes and diversity.

  2011cites this paper
• Melarsoprol cyclodextrin inclusion complexes for the treatment for human African trypanosomiasis

  2011cites this paper
• Parasite-driven pathogenesis in Trypanosoma brucei infections

  2011cites this paper
• An insight into the ligand-receptor interactions involved in the translocation of pathogens across blood-brain barrier.

  2011influential citation
• Magnetic Resonance Imaging to Assess Blood–Brain Barrier Damage in Murine Trypanosomiasis

  2011cites this paper
• An optimized in vitro blood-brain barrier model reveals bidirectional transmigration of African trypanosome strains.

  2011influential citation
• In-vitro- und in-vivo-Untersuchungen zur Neuroinvasion durch Toxoplasma gondii

  2010cites this paper
• Protozoa traversal of the blood-brain barrier to invade the central nervous system.

  2010cites this paper
• Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-alpha-dependent.

  2010cites this paper
• Human brain microvascular endothelial cell traversal by Borrelia burgdorferi requires calcium signaling.

  2009cites this paper
• Neuropathology of Naturally Occurring Trypanosoma evansi Infection of Horses

  2009cites this paper
• Protease Activated Receptor Signaling Is Required for African Trypanosome Traversal of Human Brain Microvascular Endothelial Cells

  2009cites this paper
• The gut immune barrier and the blood-brain barrier: are they so different?

  2009cites this paper
• Trypanosomiasis and the brain

  2009cites this paper
• Virulence in Cryptococcus species.

  2009cites this paper
• Human African trypanosomiasis, chemotherapy and CNS disease.

  2009cites this paper
• Pathogen translocation across the blood-brain barrier.

  2009cites this paper
• Acanthamoeba affects the integrity of human brain microvascular endothelial cells and degrades the tight junction proteins.

  2009cites this paper
• Amyloid β Interaction with Receptor for Advanced Glycation End Products Up-Regulates Brain Endothelial CCR5 Expression and Promotes T Cells Crossing the Blood-Brain Barrier1

  2009cites this paper
• Studies in Blood-Brain Barrier Disruption in Anthrax Meningitis

  2009cites this paper
• RNA Interference of Trypanosoma brucei Cathepsin B and L Affects Disease Progression in a Mouse Model

  2008cites this paper
• Apports diagnostiques au cours de la trypanosomose humaine africaine

  2008cites this paper
• Thèse en co-tutelle Pour obtenir le grade de DOCTEUR DE L'UNIVERSITE DE LIMOGES Discipline : Biologie-Science-Santé Spécialité : Parasitologie

  2008cites this paper
• Blood–brain barrier impairment with enhanced SP, NK‐1R, GFAP and Claudin‐5 expressions in experimental cerebral toxocariasis

  2008cites this paper
• Mechanisms of microbial traversal of the blood–brain barrier

  2008cites this paper
• Characterization of 3-hydroxyacyl-ACP dehydratase of mitochondrial fatty acid synthesis in yeast, humans and trypanosomes

  2007cites this paper
• Cysteine protease function in Trypanosoma brucei

  2007cites this paper
• Isolierung und Identifizierung der hauptaktiven antitrypanosomalen Komponente des Viperngiftes von Eristocophis macmahoni und ihre Effekte auf Trypanosoma brucei

  2007cites this paper
• Anaplasma phagocytophilum-Borrelia burgdorferi Coinfection Enhances Chemokine, Cytokine, and Matrix Metalloprotease Expression by Human Brain Microvascular Endothelial Cells

  2007cites this paper
• Flagella Promote Escherichia coli K1 Association with and Invasion of Human Brain Microvascular Endothelial Cells

  2007cites this paper
• Le vaccin antivariolique historique Lister : séquence génomique, diversité phénotypique et neuropathogénicité : perspectives vaccinales

  2007cites this paper
• A fatty-acid synthesis mechanism specialized for parasitism

  2007cites this paper
• microvascular endothelial cells is enhanced with Anaplasma phagocytophilum

  2007cites this paper
• Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease.

  2007cites this paper
• Entry of Trypanosoma brucei gambiense into microvascular endothelial cells of the human blood-brain barrier.

  2006cites this paper
• UNIVERSIDADE FEDERAL DE SANTA MARIA CENTRO DE CIÊNCIAS RURAIS PROGRAMA DE PÓS-GRADUAÇÃO EM MEDICINA VETERINÁRIA INFECÇÃO NATURAL POR Trypanosoma evansi EM EQÜINOS

  2006cites this paper
• Plasmodium falciparum-infected erythrocytes increase intercellular adhesion molecule 1 expression on brain endothelium through NF-kappaB.

  2006cites this paper
• Distinct Genes Encode Type II Topoisomerases for the Nucleus and Mitochondrion in the Protozoan Parasite Trypanosoma brucei*

  2006cites this paper
• Anaplasma phagocytophilum-infected neutrophils enhance transmigration of Borrelia burgdorferi across the human blood brain barrier in vitro.

  2006cites this paper
• Plasmodium falciparum-Infected Erythrocytes Increase Intercellular Adhesion Molecule 1 Expression on Brain Endothelium through NF-κB

  2006cites this paper
• Microbial translocation of the blood-brain barrier.

  2006cites this paper
• Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease.

  2006cites this paper
• Harbouring in the brain: A focus on immune evasion mechanisms and their deleterious effects in malaria and human African trypanosomiasis.

  2006cites this paper
• Borrelia burgdorferi, Host-Derived Proteases, and the Blood-Brain Barrier

  2005cites this paper