Healing Bone Using Recombinant Human Bone Morphogenetic Protein 2 and Copolymer

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Clinical Orthopaedics and Related Research

• Publication date

  1998-04-01

• Fields of study

  Medicine, Materials Science

• Identifiers
  DOI 10.1097/00003086-199804000-00026PMID 9584385
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intraosseous cellular response to biodegradable fracture fixation screws made of polyglycolide or polylactide

  2004cited by this paper
• A new animal model for maxillary sinus floor augmentation: evaluation parameters.

  1997cited by this paper
• Ectopic induction of cartilage and bone by bovine bone morphogenetic protein using a biodegradable polymeric reservoir.

  1996cited by this paper
• Bone morphogenetic protein encapsulated with a biodegradable and biocompatible polymer.

  1996cited by this paper
• Long-term evaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system.

  1996cited by this paper
• Use of Bone Morphogenetic Protein-2 in the Rabbit Ulnar Nonunion Model

  1996cited by this paper
• Periodontal repair in dogs: recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration.

  1995cited by this paper
• Long-term healing of bone using recombinant human bone morphogenetic protein 2.

  1995cited by this paper
• Osseous regeneration in preclinical models using bioabsorbable delivery technology for recombinant human bone morphogenetic protein 2 (rhBMP-2)

  1995cited by this paper
• Recombinant bone morphogenetic proteins: novel substances for enhancing bone healing.

  1995cited by this paper
• Recombinant bone morphogenetic protein-2 enhances bone healing, guided by osteopromotive e-PTFE membranes: An experimental study in rats

  1995cited by this paper
• Evaluation of rhBMP‐2 With an OPLA Carrier in a Canine Posterolateral (Transverse Process) Spinal Fusion Model

  1995cited by this paper
• Healing of large segmental defects in rat femurs is aided by RhBMP-2 in PLGA matrix.

  1994cited by this paper
• Evaluation of Human Bone Morphogenetic Protein 2 in a Canine Spinal Fusion Model

  1994cited by this paper
• Effect of polylactic acid on osteoinduction of demineralized bone: preliminary study of the usefulness of polylactic acid as a carrier of bone morphogenetic protein.

  1994cited by this paper
• Effect of poly DL-lactide--co-glycolide implants and xenogeneic bone matrix-derived growth factors on calvarial bone repair in the rabbit.

  1994cited by this paper
• Osseous regeneration in the rat calvarium using novel delivery systems for recombinant human bone morphogenetic protein-2 (rhBMP-2).

  1994cited by this paper
• Polylactic acid-polyethylene glycol block copolymer. A new biodegradable synthetic carrier for bone morphogenetic protein.

  1993cited by this paper
• Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein.

  1993cited by this paper
• Incorporation of polylactide-polyglycolide in a cortical defect: neoosteogenesis in a bone chamber.

  1993cited by this paper
• Bone-derived growth factor release from poly(alpha-hydroxy acid) implants in vitro.

  1993cited by this paper
• Bone-derived growth factor release from poly(α-hydroxy acid) implants in vitro

  1993cited by this paper
• A Multiphase System Bone Implant for Regenerating the Calvaria

  1993cited by this paper
• Bone induction and bone repair by composites of bone morphogenetic protein and biodegradable synthetic polymers.

  1993cited by this paper
• Degradation and tissue replacement of an absorbable polyglycolide screw in the fixation of rabbit femoral osteotomies.

  1992cited by this paper
• Polymeric debris from absorbable polyglycolide screws and pins. Intraosseous migration studied in rabbits.

  1992cited by this paper
• Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro.

  1992cited by this paper
• Advances in osteogenin and related bone morphogenetic proteins in bone induction and repair.

  1992cited by this paper
• Discussion: The Ultrastructural Architecture of the Tissue/Hard-Tissue Replacement Interface

  1992cited by this paper
• Clinical Applications of Recombinant Gene Technology: Bone and Cartilage Repair

  1992cited by this paper
• Foreign-body reactions to polyglycolide screws. Observations in 24/216 malleolar fracture cases.

  1992cited by this paper
• Resistant nonunions and partial or complete segmental defects of long bones. Treatment with implants of a composite of human bone morphogenetic protein (BMP) and autolyzed, antigen-extracted, allogeneic (AAA) bone.

  1992cited by this paper
• Evaluation of polylactic acid homopolymers as carriers for bone morphogenetic protein.

  1992cited by this paper
• The ultrastructural architecture of the tissue/hard-tissue replacement interface.

  1992cited by this paper
• Telopeptide‐depleted bovine skin collagen as a carrier for bone morphogenetic protein

  1991cited by this paper
• Murine osteogenic protein (OP-1): high levels of mRNA in kidney.

  1991cited by this paper
• Ultramicroscopic aspects of the conversion of fibroblasts to chondrocytes in the mouse dorsal subfascia induced by bone morphogenetic protein (BMP).

  1991cited by this paper
• The use of bone morphogenetic protein in the treatment of non-union in a canine model.

  1991cited by this paper
• Foreign-body reactions to fracture fixation implants of biodegradable synthetic polymers.

  1990cited by this paper
• Osseous wound healing with xenogeneic bone implants with a biodegradable carrier.

  1990cited by this paper
• Immunohistochemical observations on bone morphogenetic protein in normal and abnormal conditions.

  1990cited by this paper
• Recombinant human bone morphogenetic protein induces bone formation.

  1990cited by this paper
• Bone morphogenetic protein augmentation grafting of resistant femoral nonunions. A preliminary report.

  1988cited by this paper
• Repair of segmental defects of the tibia with cancellous bone grafts augmented with human bone morphogenetic protein. A preliminary report.

  1988cited by this paper
• Novel regulators of bone formation: molecular clones and activities.

  1988cited by this paper
• Purification and characterization of other distinct bone-inducing factors.

  1988cited by this paper
• Bovine Bone Morphogenetic Protein (bBMP) Fraction‐induced Repair of Craniotomy Defects in the Rhesus Monkey (Macaca speciosa)

  1987cited by this paper
• Osteogenesis induced by bone matrix is inhibited by inflammation.

  1986cited by this paper
• The critical size defect as an experimental model for craniomandibulofacial nonunions.

  1986cited by this paper
• Correlations of radiographic analysis of healing fractures with strength: A statistical analysis of experimental osteotomies

  1985cited by this paper

• Systematic Review of the Preclinical Technology Readiness of Orthopedic Gene Therapy and Outlook for Clinical Translation

  2021cites this paper
• Segmental long bone regeneration guided by degradable synthetic polymeric scaffolds

  2020cites this paper
• Growth Factors, Carrier Materials, and Bone Repair.

  2020cites this paper
• Bone Substitutes in Orthopedic and Trauma Surgery

  2019cites this paper
• Associations between variants of bone morphogenetic protein 7 gene and growth traits in chickens

  2018cites this paper
• 7.16 Materials in Fracture Fixation

  2017cites this paper
• Biomimetic Calcium Phosphate/PEM Coatings For Sequential Multifactor Delivery

  2016cites this paper
• AWARD NUMBER: W81XWH-13-1-0501 TITLE: Novel Therapy for Bone Regeneration in Large Segmental Defects PRINCIPAL INVESTIGATOR: Tien-Min Chu CONTRACTING ORGANIZATION: NDIANA UNIVERSITY INDIANAPOLIS IN 46202-5130

  2016cites this paper
• Photo-immobilization of bone morphogenetic protein-2 using azidophenyl gelatin on a collagen sheet enhances osteogenesis in a rat calvarial defect model

  2016cites this paper
• Stem cell therapy: is there a future for reconstruction of large bone defects?

  2016cites this paper
• How does the pathophysiological context influence delivery of bone growth factors?

  2015cites this paper
• Surgical Fixation Hardware for Regeneration of Long Bone Segmental Defects: Translating Large Animal Model and Human Experiences

  2015cites this paper
• Novel Therapy for Bone Regeneration in Large Segmental Defects

  2015cites this paper
• Use of Native Bovine Bone Morphogenetic Protein Extract in Healing Segmental Tibial Bone Defects in Goats

  2015cites this paper
• BMP delivery complements the guiding effect of scaffold architecture without altering bone microstructure in critical-sized long bone defects: A multiscale analysis.

  2015cites this paper
• Tissue engineered bone using select growth factors: A comprehensive review of animal studies and clinical translation studies in man.

  2014cites this paper
• Recent research on the growth plate: Mechanisms for growth plate injury repair and potential cell-based therapies for regeneration.

  2014cites this paper
• Animal Models for Orthopedic Applications of Tissue Engineering

  2014cites this paper
• The effect of immunonutrition (glutamine, alanine) on fracture healing

  2014cites this paper
• Fracture Repair

  2013cites this paper
• Use of Perfusion Bioreactors and Large Animal Models for Long Bone Tissue Engineering

  2013cites this paper
• Comparative study of Chinese hamster ovary cell versus Escherichia coli-derived bone morphogenetic protein-2 using the critical-size supraalveolar peri-implant defect model.

  2013cites this paper
• Polycaprolactone scaffold and reduced rhBMP-7 dose for the regeneration of critical-sized defects in sheep tibiae.

  2013cites this paper
• Autologous bone tissue engineering strategies envisioning the regeneration of critical size defects using cell-seeded scaffolds and a newly developed perfusion bioreactor

  2013cites this paper
• Bone grafts and bone replacements

  2012cites this paper
• Porous scaffold architecture guides tissue formation

  2012cites this paper
• Bone Substitute Materials in Trauma and Orthopedic Surgery – Properties and Use in Clinic

  2012cites this paper
• R-S2.4 The effect of immunonutrition (Glutamine, Alanine) on fracture healing

  2012cites this paper
• THE EFFECT OF BONE MARROW AUTOGRAFT ON FRACTURE HEALING WITH DESTRUCTION OF PERIOSTEUM AND ENDOSTEUM IN RABBITS *

  2012cites this paper
• Osteogenic Protein-1 Delivered by Hydroxyapatite-coated Implants Improves Bone Ingrowth in Extracortical Bone Bridging

  2011cites this paper
• Preclinical Animal Models for Segmental Bone Defect Research and Tissue Engineering

  2011cites this paper
• A novel cell-based therapy in segmental bone defect: using adipose derived stromal cells.

  2011cites this paper
• Reindeer-derived bone protein extract in the healing of bone defects : evaluation of various carrier materials and delivery systems

  2011cites this paper
• 6.616 – Materials in Fracture Fixation

  2011cites this paper
• The influence of Bone Morphogenic Protein-2 on the consolidation phase in a distraction osteogenesis model.

  2011cites this paper
• Successful transplant of mesenchymal stem cells in induced osteonecrosis of the ovine femoral head: preliminary results.

  2010cites this paper
• Exaggerated Inflammatory Response After Use of Recombinant Bone Morphogenetic Protein in Recurrent Unicameral Bone Cysts

  2010cites this paper
• Long Bone Defect Models for Tissue Engineering Applications: Criteria for Choice

  2010cites this paper
• Rh-BMP-2 in distraction osteogenesis: dose effect and premature consolidation.

  2010cites this paper
• Maxillary sinus floor elevation using a tissue-engineered bone complex with beta-TCP and BMP-2 gene-modified bMSCs in rabbits.

  2009cites this paper
• Evaluation of an injectable, photopolymerizable three-dimensional scaffold based on d,l-lactide and ɛ-caprolactone in a tibial goat model

  2008cites this paper
• The effects of extracorporeal shockwave on acute high-energy long bone fractures of the lower extremity

  2007cites this paper
• (iv) The use of bone morphogenetic proteins (BMPs) in long-bone non-unions

  2007cites this paper
• The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres.

  2007cites this paper
• Material design of bioabsorbable inorganic/organic composites for bone regeneration.

  2007cites this paper
• Use of bone morphogenetic proteins for augmentation of bone regeneration.

  2007cites this paper
• Use of a composite pedicled muscle flap and rhBMP-7 for mandibular reconstruction.

  2007cites this paper
• Fracture Repair 23 Reparative Phase

  2007cites this paper
• Contour and volume assessment of repairing mandibular osteoperiosteal continuity defects in sheep using recombinant human osteogenic protein 1.

  2006cites this paper
• Unexpected Absence of Effect of rhBMP-7 on Distraction Osteogenesis

  2006cites this paper
• Developing bioactive composite scaffolds for bone tissue engineering

  2006cites this paper
• Chapter 82 – Bone Grafts and Bone Replacements

  2006cites this paper
• Biodegradable polymeric scaffolds. Improvements in bone tissue engineering through controlled drug delivery.

  2006cites this paper
• Manipulations in Hydrogel Degradation Behavior Enhance Osteoblast Function and Mineralized Tissue Formation

  2006cites this paper
• Effect of BMP-2 gene transfer on bone healing in sheep

  2006cites this paper
• Treatment of Fractures and Bone Defects Bone Morphogenetic Proteins. Development and Clinical Efficacy in the

  2006cites this paper
• Acceleration of bone formation in distraction osteogenesis by bone morphogenetic protein-7

  2006cites this paper
• Mesenchymal stem cells and bone regeneration.

  2006cites this paper
• Mechanical and radiological assessment of the influence of rhTGFβ‐3 on bone regeneration in a segmental defect in the ovine tibia: Pilot study

  2006cites this paper
• Development and application of bone morphogenetic proteins for the enhancement of bone healing

  2005cites this paper
• Review: Biodegradable Polymeric Scaffolds. Improvements in Bone Tissue Engineering through Controlled Drug Delivery

  2005cites this paper
• Healing of Critically Sized Femoral Defects, Using Genetically Modified Mesenchymal Stem Cells from Human Adipose Tissue

  2005cites this paper
• Bone Morphogenetic Proteins and Other Growth Factors to Enhance Fracture Healing and Treatment of Nonunions

  2005cites this paper
• Bone morphogenetic proteins. Development and clinical efficacy in the treatment of fractures and bone defects.

  2005cites this paper
• Sheep mandibular animal models for dental implantology research

  2005cites this paper
• Healing of a critical-sized defect in the rat femur with use of a vascularized periosteal flap, a biodegradable matrix, and bone morphogenetic protein.

  2005cites this paper
• Bone Metastasis and Pathological Fractures

  2005cites this paper
• Delivery of bone morphogenetic proteins for orthopedic tissue regeneration.

  2005cites this paper
• Repairing of goat Tibial Bone Defects with BMP-2 Gene–Modified Tissue-Engineered Bone

  2005cites this paper
• Histological assessment of bioengineered new bone in repairing osteoperiosteal mandibular defects in sheep using recombinant human bone morphogenetic protein-7.

  2004cites this paper
• Delivery systems for bone growth factors — the new players in skeletal regeneration

  2004cites this paper
• Shock wave treatment shows dose-dependent enhancement of bone mass and bone strength after fracture of the femur.

  2004cites this paper
• Local and controlled release of growth factors (combination of IGF-I and TGF-beta I, and BMP-2 alone) from a polylactide coating of titanium implants does not lead to ectopic bone formation in sheep muscle.

  2004cites this paper
• O uso do aspirado de medula óssea de ilíaco em falhas ósseas de fêmures de camundongos: estudo experimental

  2004cites this paper
• The use of inhaled bone marrow of ileum in bone failures of femurs of rats – Experimental study

  2004cites this paper
• Results of Bone Morphogenetic Proteins in Animal Models

  2003cites this paper
• Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician?

  2003cites this paper
• A new animal model of femoral head necrosis induced by intraosseous injection of ethanol

  2002cites this paper
• Bone induction in clinical orthodontics: a review.

  2002cites this paper
• Critical size defect model on the femur in rabbits

  2002cites this paper
• Osteogenic protein-1 (OP-1, BMP-7) for stimulation of healing of closed fractures: evidence based medicine and pre-clinical experience

  2002cites this paper
• Delivery of osteoinductive growth factors from degradable PEG hydrogels influences osteoblast differentiation and mineralization.

  2002cites this paper
• Bone induction in clinical orthodontics: a review.

  2002cites this paper
• Preclinical models of recombinant BMP induced healing of orthopedic defects

  2002cites this paper
• Modern issues in bone graft substitutes and advances in bone tissue technology.

  2002cites this paper
• In situ forming lactic acid based orthopaedic biomaterials: Influence of oligomer chemistry on osteoblast attachment and function

  2001cites this paper
• Composite implant composed of hydroxyapatite and bone morphogenetic protein in the healing of a canine ulnar defect.

  2001cites this paper
• The effect of recombinant human bone morphogenetic protein‐2 on femoral reconstruction with an intercalary allograft in a dog model

  2001cites this paper
• Native bovine bone morphogenetic protein in the healing of segmental long bone defects

  2001cites this paper
• Recombinant Human Bone Morphogenetic Protein-2 Accelerates Healing in a Rabbit Ulnar Osteotomy Model

  2001cites this paper
• Histomorphometric description of allograft bone remodeling and union in a canine segmental femoral defect model: A comparison of rhBMP‐2, cancellous bone graft, and absorbable collagen sponge

  2001cites this paper
• Bone morphogenetic proteins in the development and healing of synovial joints.

  2001cites this paper
• NATIVE BOVINE BONE MORPHOGENETIC PROTEIN IN THE HEALING OF SEGMENTAL LONG BONE DEFECTS

  2001cites this paper
• Analysis of Ti-6Al-4V implants placed with fibroblast growth factor 1 in rat tibiae.

  2001cites this paper
• Combination of Growth Factors Inhibits Bone Ingrowth in the Bone Harvest Chamber

  2001cites this paper
• Sheep model in orthopedic research: a literature review.

  2001cites this paper
• Critical aspects of tissue-engineered therapy for bone regeneration.

  2001cites this paper
• Biomechanical and histological aspects of fracture healing, stimulated with osteogenic protein-1.

  2001cites this paper
• Delivering on the promise of bone morphogenetic proteins.

  2001cites this paper
• Native bovine bone morphogenetic protein improves the potential of biocoral to heal segmental canine ulnar defects

  2000cites this paper