Changes in Gene Expression during Pegylated Interferon and Ribavirin Therapy of Chronic Hepatitis C Virus Distinguish Responders from Nonresponders to Antiviral Therapy

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Virology

• Publication date

  2007-01-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.02640-06PMID 17267482PMCID PMC1866036
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1.

  2006cited by this paper
• The Prevalence of Hepatitis C Virus Infection in the United States, 1999 through 2002

  2006cited by this paper
• Global transcriptional response to interferon is a determinant of HCV treatment outcome and is modified by race

  2006influential reference
• Effects of filtering by Present call on analysis of microarray experiments

  2006cited by this paper
• Genomic response to interferon‐α in chimpanzees: Implications of rapid downregulation for hepatitis C kinetics

  2006cited by this paper
• Type 1 Interferons and the Virus-Host Relationship: A Lesson in Détente

  2006influential reference
• Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector

  2005influential reference
• Global Transcriptional Profiling Demonstrates the Combination of Type I and Type II Interferon Enhances Antiviral and Immune Responses at Clinically Relevant Doses

  2005cited by this paper
• Upregulation of Protein Phosphatase 2Ac by Hepatitis C Virus Modulates NS3 Helicase Activity through Inhibition of Protein Arginine Methyltransferase 1

  2005cited by this paper
• Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling.

  2005influential reference
• Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.

  2005influential reference
• Evasion of intracellular host defence by hepatitis C virus

  2005influential reference
• Impairments of the 2-5A synthetase/RNase L pathway in chronic fatigue syndrome.

  2005cited by this paper
• Diagnosis, management, and treatment of hepatitis C

  2004cited by this paper
• Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications

  2004cited by this paper
• Intrahepatic Gene Expression during Chronic Hepatitis C Virus Infection in Chimpanzees

  2004cited by this paper
• Peginterferon alfa‐2a (40 kd) and ribavirin for black American patients with chronic HCV genotype 1

  2004cited by this paper
• Hepatocellular carcinoma: recent trends in the United States.

  2004cited by this paper
• Global effect of PEG-IFN-alpha and ribavirin on gene expression in PBMC in vitro.

  2004influential reference
• Peginterferon alfa-2b and ribavirin for the treatment of chronic hepatitis C in blacks and non-Hispanic whites.

  2004influential reference
• Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose.

  2004influential reference
• Global Effect of PEG-IFN-α and Ribavirin on Gene Expression in PBMC In Vitro

  2004cited by this paper
• Implications for RNase L in prostate cancer biology.

  2003cited by this paper
• Peginterferon Alfa-2a Plus Ribavirin for Chronic Hepatitis C Virus Infection

  2003influential reference
• Genomic analysis of the host response to hepatitis C virus infection

  2002cited by this paper
• Induction of IL-1Ra in Resistant and Responsive Hepatitis C Patients Following Treatment with IFN-con1

  2002cited by this paper
• Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection.

  2002cited by this paper
• Antiviral Actions of Interferons

  2001cited by this paper
• Hepatitis C in African Americans: summary of a workshop.

  2000influential reference
• Prevalence of hepatitis C virus infection in the United States.

  1999cited by this paper
• The International Union of Biochemistry and Molecular Biology

  1999cited by this paper
• Racial differences in responses to therapy with interferon in chronic hepatitis C

  1999cited by this paper
• Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils.

  1999influential reference
• The international union of biochemistry and molecular biology

  1998cited by this paper
• How cells respond to interferons.

  1998cited by this paper
• Regulated production of the interferon-gamma-inducible protein-10 (IP-10) chemokine by human neutrophils.

  1997cited by this paper
• Regulated production of the interferon‐γ‐inducible protein−10 (IP‐10) chemokine by human neutrophils

  1997cited by this paper
• For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group

  year unknowninfluential reference
• Identification and handling of artifactual gene expression profiles emerging in microarray hybridization experiments

  year unknowncited by this paper

• Differential Impact of Interferon-Based and Direct-Acting Antiviral Therapies on Bone Metabolism in Chronic Hepatitis C: Insights from Transcriptomic and Clinical Analyses

  2025cites this paper
• Homogeneity Tests for High-dimensional Mean Vectors and Covariance Matrices

  2024cites this paper
• GeTeSEPdb: A comprehensive database and online tool for the identification and analysis of gene profiles with temporal-specific expression patterns

  2024cites this paper
• IFNT stimulates lysosomal function via type I IFN signaling pathway in pregnant bovine leukocytes.

  2023cites this paper
• Bayesian approach for predicting responses to therapy from high-dimensional time-course gene expression profiles

  2021cites this paper
• Nuclear AIM2‐Like Receptors Drive Genotoxic Tissue Injury by Inhibiting DNA Repair

  2021cites this paper
• Relationships Between Vitamin D Status and Cytokine: Results from Interferon-Based Therapy in Non-Cirrhotic, Treatment-Naïve Patients with Chronic Hepatitis C Infection

  2020cites this paper
• Homogeneity tests of covariance matrices with high-dimensional longitudinal data.

  2019cites this paper
• Toll-like Receptor 7 Expression and Gene Polymorphism in Patients with Hepatitis C and Hepatocellular Carcinoma

  2019cites this paper
• Impact of Interferon Lambda 4 Genotype on Interferon‐Stimulated Gene Expression During Direct‐Acting Antiviral Therapy for Hepatitis C

  2018cites this paper
• Down regulation of TRIF, TLR3, and MAVS in HCV infected liver correlates with the outcome of infection

  2017cites this paper
• Study of inhibition of interferon inducible genes by dephosphorylation of E2 envelope gene of HCV genotype 1a

  2017cites this paper
• HCV drives increased type I IFN-associated impairments associated to fibrosis severity in ART-treated HIV-1-HCV coinfected individuals.

  2017cites this paper
• β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development

  2017cites this paper
• Role of zinc in dendritic cell activation and the regulation of complement protein interactions

  2017cites this paper
• Regulation of protein synthesis and autophagy in activated dendritic cells: implications for antigen processing and presentation

  2016cites this paper
• Transcriptional Dysregulation of Upstream Signaling of IFN Pathway in Chronic HCV Type 4 Induced Liver Fibrosis

  2016cites this paper
• Large-scale gene co-expression network as a source of functional annotation for cattle genes

  2016cites this paper
• Trisomy 21 consistently activates the interferon response

  2016influential citation
• Effect of Drug Resistance Mutations on Antiviral Agents in HCV Patients

  2016influential citation
• Toll-like receptors 7 and 8 mRNA in monocytes of Egyptian children with chronic hepatitis C infection genotype 4 as predictor to “response” interferon and ribavirin treatment

  2016cites this paper
• IFI16, an amplifier of DNA-damage response: Role in cellular senescence and aging-associated inflammatory diseases.

  2016cites this paper
• Causal Compression

  2016cites this paper
• Impacts of pegylated interferon-related neutropenia and thrombocytopenia on treatment of incessant HBV contamination

  2015cites this paper
• T cell exhaustion, costimulation and clinical outcome in autoimmunity and infection

  2015cites this paper
• Dissecting mechanisms underlying increased TLR7-mediated IFNα production in pDCs in physiological and pathophysiological settings : between sex differences and HIV-1-HCV co-infection

  2015cites this paper
• Down-regulation of suppressor of cytokine signaling 3 by miR-122 enhances interferon-mediated suppression of hepatitis B virus.

  2015cites this paper
• Improving treatment predictors of HCV therapy and the impact of steatosis on the hepatocyte transcriptome and anti-HCV action of interferon

  2015cites this paper
• Ménage à trois: an evolutionary interplay between human papillomavirus, a tumor, and a woman.

  2014cites this paper
• Differential expression of Toll-like receptors 7 & 8 mRNA in monocytes of patients with chronic hepatitis C infection: correlation with interferon and ribavirin treatment.

  2014cites this paper
• Prediction of dynamical drug sensitivity and resistance by module network rewiring-analysis based on transcriptional profiling.

  2014cites this paper
• Gene Expression Profiling To Predict and Assess the Consequences of Therapy-Induced Virus Eradication in Chronic Hepatitis C Virus Infection

  2014cites this paper
• A Derived Network-Based Interferon-Related Signature of Human Macrophages Responding to Mycobacterium tuberculosis

  2014cites this paper
• In vitro blood cell responsiveness to IFN-α predicts clinical response independently of IL28B in hepatitis C virus genotype 1 infected patients

  2014cites this paper
• Study of toll-like receptor 7 expression and interferon α in Egyptian patients with chronic hepatitis C Infection and Hepatocellular Carcinoma

  2014cites this paper
• Prognostic biomarkers for prediction of recurrence of hepatocellular carcinoma: current status and future prospects.

  2014cites this paper
• Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer

  2013cites this paper
• Biomarqueurs pour patients infectés par le hcv

  2013cites this paper
• Progesterone suppresses interferon signaling by repressing TLR-7 and MxA expression in peripheral blood mononuclear cells of patients infected with hepatitis C virus

  2013cites this paper
• Innate immune responses to hepatitis C virus.

  2013cites this paper
• Chapter 99 – Viral Hepatitis

  2013cites this paper
• High-throughput gene expression profiling identified a novel signalling pathway involved in hepatitis virus resistance to interferon-based therapy

  2013cites this paper
• A study of novel biomarkers of hepatitis C related liver injury

  2013cites this paper
• Analysis of surrogate gene expression markers in peripheral blood of melanoma patients to predict treatment outcome of adjuvant pegylated interferon alpha 2b (EORTC 18991 side study)

  2013influential citation
• Frequência do polimorfismo rs12979860, no gene da IL28B, em pacientes portadores de hepatite C crônica e em controles sadios: nova metodologia de baixo custo e menor tempo para genotipagem

  2013cites this paper
• The Blood Transcriptional Signature of Chronic Hepatitis C Virus Is Consistent with an Ongoing Interferon-Mediated Antiviral Response

  2013cites this paper
• Temperature rise after peginterferon alfa-2a injection in patients with chronic hepatitis C is associated with virological response and is modulated by IL28B genotype.

  2013cites this paper
• ChIP-PED enhances the analysis of ChIP-seq and ChIP-chip data

  2013cites this paper
• Interferon-stimulated genes are associated with peginterferon/ribavirin treatment response regardless of IL28B alleles in hepatitis C virus/HIV-coinfected patients

  2013cites this paper
• Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C

  2013cites this paper
• Hepatitis C Virus: From Molecular Virology to Antiviral Therapy

  2013cites this paper
• Replication of hepatitis C virus in peripheral blood mononuclear cells in patients with chronic hepatitis C treated with pegylated interferon alpha and ribavirin.

  2013cites this paper
• Quantitative set analysis for gene expression: a method to quantify gene set differential expression including gene-gene correlations

  2013influential citation
• Analysis of Time-Resolved Gene Expression Measurements across Individuals

  2013influential citation
• Endogenous IFNγ in chronic HCV genotype 4 patients treated with PEG-IFNα and ribavirin.

  2013cites this paper
• Interferon-α as Antiviral and Antitumor Vaccine Adjuvants: Mechanisms of Action and Response Signature

  2012cites this paper
• The interferon signaling pathway genes as biomarkers of hepatitis C virus disease progression and response to treatment.

  2012cites this paper
• Novel insights in the physiological function of sialoadhesin as a downregulator of macrophage phagocytosis and its implications for viral infection

  2012cites this paper
• Studying and modelling dynamic biological processes using time-series gene expression data

  2012influential citation
• Suppression of ribosomal protein synthesis and protein translation factors by Peg-interferon alpha/ribavirin in HCV patients blood mononuclear cells (PBMC)

  2012cites this paper
• Effects of pegylated interferon-related neutropenia and thrombocytopenia on treatment of chronic HBV infection

  2012cites this paper
• Analysis of human liver disease using a cluster of differentiation (CD) antibody microarray

  2012cites this paper
• Interference with ERK and STAT signaling pathways and inhibition of hepatitis C virus replication by ribavirin.

  2012cites this paper
• Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon Alfa-2a.

  2012cites this paper
• Hepatitis C virus' initial encounters: mechanisms of innate immunity.

  2012cites this paper
• Quantitation of pretreatment serum interferon‐γ–inducible protein‐10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response

  2011cites this paper
• Decreased IFNγ production correlates with diminished production of cytokines by dendritic cells in patients infected with hepatitis C virus and receiving therapy

  2011cites this paper
• Genetic variation in interleukin-28B predicts SVR in hepatitis C genotype 1 Argentine patients treated with PEG IFN and ribavirin.

  2011cites this paper
• Cell subset prediction for blood genomic studies

  2011cites this paper
• The long and the short of interferon‐gamma–inducible protein 10 in hepatitis C virus infection

  2011cites this paper
• Identifying differentially regulated genes

  2011cites this paper
• Ribavirin potentiates interferon action by augmenting interferon‐stimulated gene induction in hepatitis C virus cell culture models

  2011cites this paper
• Concomitant detection of IFNα signature and activated monocyte/dendritic cell precursors in the peripheral blood of IFNα-treated subjects at early times after repeated local cytokine treatments

  2011influential citation
• Toll-like receptor 3 gene expression in Egyptian patients with glomerulonephritis and hepatitis C virus infection

  2011cites this paper
• Boceprevir (Victrelis) for HCV: V is for victory and very complex

  2011cites this paper
• Transcriptional Response of MxA, PKR and SOCS3 to Interferon-Based Therapy in HCV Genotype 4-Infected Patients and Contribution of p53 to Host Antiviral Response

  2011cites this paper
• Exhausted or just sleeping: Awakening virus‐specific responses in chronic hepatitis C virus infection

  2011cites this paper
• IL28B genetic variations are associated with high sustained virological response (SVR) of interferon-α plus ribavirin therapy in Taiwanese chronic HCV infection

  2011cites this paper
• Transfer learning for molecular systems biology

  2011cites this paper
• NK inhibitory receptor expression associated with treatment failure and IL-28 B genotype in patients with chronic hepatitis C

  2011cites this paper
• Mechanisms of action of antiviral drugs: the interferons

  2011cites this paper
• Natural killer inhibitory receptor expression associated with treatment failure and interleukin‐28B genotype in patients with chronic hepatitis C

  2011cites this paper
• S-adenosyl methionine improves early viral responses and interferon-stimulated gene induction in hepatitis C nonresponders.

  2011cites this paper
• Quantitation of Pretreatment Serum IP-10 Improves the Predictive Value of an IL28B Gene Polymorphism for Hepatitis C Treatment Response

  2011cites this paper
• Application of interferon response-related gene array to the antiviral treatment outcome in chronic hepatitis C.

  2010cites this paper
• Impairment of TLR7-Dependent Signaling in Dendritic Cells from Chronic Hepatitis C Virus (HCV)-Infected Non-responders to Interferon/Ribavirin Therapy

  2010cites this paper
• Genomics and the Management of Hepatitis

  2010cites this paper
• Differential expression of interferon-induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha

  2010cites this paper
• Early viral and peripheral blood mononuclear cell responses to pegylated interferon and ribavirin treatment: the first 24 h

  2010cites this paper
• Mitteilungen der Gastroenterologischen Arbeitsgemeinschaft Rheinland-Pfalz/Saarland (GARPS)

  2010cites this paper
• Reduction in Neutrophil Count During Hepatitis C Treatment: Drug Toxicity or Predictor of Good Response?

  2010cites this paper
• Innate immunity and chronic immune activation in HCV/HIV-1 co-infection.

  2010cites this paper
• Low‐ and standard‐dose peginterferon alfa‐2a for chronic hepatitis C, genotype 2 or 3: efficacy, tolerability, viral kinetics and cytokine response

  2010cites this paper
• Ribavirin improves early responses to peginterferon through improved interferon signaling.

  2010cites this paper
• Impaired expression and function of toll‐like receptor 7 in hepatitis C virus infection in human hepatoma cells

  2010cites this paper
• Decline in male sexual desire, function, and satisfaction during and after antiviral therapy for chronic hepatitis C.

  2009cites this paper
• Gene transcript abundance profiles distinguish Kawasaki disease from adenovirus infection.

  2009cites this paper
• The Induction of Type I Interferon Production in Hepatitis C–Infected Patients

  2009cites this paper
• Early changes in hepatitis C virus (HCV) levels in response to peginterferon and ribavirin treatment in patients with chronic HCV genotype 1 infection.

  2009cites this paper
• Blood-based transcriptomics: leukemias and beyond

  2009cites this paper