Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer's disease (APP/PS1) transgenic mice.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Neurobiology of Learning and Memory

• Publication date

  2015-02-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.nlm.2014.12.005PMID 25543023
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Shape abnormalities of subcortical and ventricular structures in mild cognitive impairment and Alzheimer's disease: Detecting, quantifying, and predicting

  2014cited by this paper
• 2013 Alzheimer's disease facts and figures

  2013cited by this paper
• Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice.

  2013cited by this paper
• Biomarker modeling of Alzheimer's disease.

  2013cited by this paper
• Different types of exercise induce differential effects on neuronal adaptations and memory performance.

  2012cited by this paper
• Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer's disease.

  2012cited by this paper
• Total daily physical activity and the risk of AD and cognitive decline in older adults

  2012cited by this paper
• Truncated TrkB: beyond a dominant negative receptor.

  2012cited by this paper
• Voluntary wheel running enhances contextual but not trace fear conditioning.

  2012cited by this paper
• Influence of Emotional Content and Context on Memory in Mild Alzheimer's Disease

  2012cited by this paper
• Alemtuzumab more effective than interferon β-1a at 5-year follow-up of CAMMS223 clinical trial

  2012cited by this paper
• Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice.

  2012cited by this paper
• Chronic circadian disturbance by a shortened light-dark cycle increases mortality.

  2012cited by this paper
• Volume reduction in subcortical regions according to severity of Alzheimer’s disease

  2011cited by this paper
• Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease.

  2011cited by this paper
• Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation.

  2011cited by this paper
• The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

  2011cited by this paper
• Selective improvement of cognitive function in adult and aged APP/PS1 transgenic mice by continuous non-shock treadmill exercise.

  2011cited by this paper
• The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

  2011cited by this paper
• Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity.

  2011cited by this paper
• Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease.

  2010cited by this paper
• CSF Biomarkers in Prediction of Cerebral and Clinical Change in Mild Cognitive Impairment and Alzheimer's Disease

  2010cited by this paper
• Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease

  2010cited by this paper
• Exercise and Alzheimer's disease biomarkers in cognitively normal older adults

  2010cited by this paper
• Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: evidence for a dual-process memory model.

  2009cited by this paper
• Exercise and the brain: something to chew on.

  2009cited by this paper
• Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain‐derived neurotrophic factor and synaptotagmin I

  2009cited by this paper
• Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition.

  2008cited by this paper
• Be smart, exercise your heart: exercise effects on brain and cognition

  2008cited by this paper
• Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence

  2008cited by this paper
• Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice.

  2008cited by this paper
• Glucocorticoid signaling and exercise-induced downregulation of the mineralocorticoid receptor in the induction of adult mouse dentate neurogenesis by treadmill running.

  2008cited by this paper
• Exercise training acts as a therapeutic strategy for reduction of the pathogenic phenotypes for Alzheimer's disease in an NSE/APPsw-transgenic model.

  2008cited by this paper
• Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease

  2008cited by this paper
• Brain serotonin depletion impairs short-term memory, but not long-term memory in rats.

  2007cited by this paper
• Journal of Applied Physiology publishes original papers that deal with diverse area of research in applied

  2007cited by this paper
• Exercise Program for Nursing Home Residents with Alzheimer's Disease: A 1‐Year Randomized, Controlled Trial

  2007cited by this paper
• Treadmill exercise counteracts the suppressive effects of peripheral lipopolysaccharide on hippocampal neurogenesis and learning and memory

  2007cited by this paper
• Predictors of progression from mild cognitive impairment to Alzheimer disease

  2007cited by this paper
• Exercise builds brain health: key roles of growth factor cascades and inflammation.

  2007cited by this paper
• Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people.

  2006cited by this paper
• Neurobiology of exercise

  2006cited by this paper
• The Different Effects on Recognition Memory of Perirhinal Kainate and NMDA Glutamate Receptor Antagonism: Implications for Underlying Plasticity Mechanisms

  2006cited by this paper
• Prolonged behavioral stress enhances synaptic connectivity in the basolateral amygdala.

  2006cited by this paper
• Neuropathologic substrate of mild cognitive impairment.

  2006cited by this paper
• Neurobiology of Exercise

  2006cited by this paper
• Cognitive neuroscience of emotional memory

  2006cited by this paper
• Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease.

  2006cited by this paper
• Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala.

  2005cited by this paper
• Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.

  2004cited by this paper
• Effects of exercise on Pavlovian fear conditioning.

  2004cited by this paper
• Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

  2004cited by this paper
• Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B Involvement in Amygdala-Dependent Fear Conditioning

  2004cited by this paper
• RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

  2003cited by this paper
• Exercise: a behavioral intervention to enhance brain health and plasticity.

  2002cited by this paper
• From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning.

  2002cited by this paper
• Alzheimer's disease and Aβ toxicity: from top to bottom

  2001cited by this paper
• Alzheimer's disease and Abeta toxicity: from top to bottom.

  2001cited by this paper
• Cognitive and neural mechanisms of emotional memory.

  2001cited by this paper
• Trk receptors: mediators of neurotrophin action.

  2001cited by this paper
• Beyond the hippocampus

  2001cited by this paper
• Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.

  2000cited by this paper
• Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth

  2000cited by this paper
• Medial temporal atrophy and memory impairment in early stage of Alzheimer's disease: an MRI volumetric and memory assessment study.

  2000cited by this paper
• Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice.

  1999cited by this paper
• Relative Contribution of Endogenous Neurotrophins in Hippocampal Long-Term Potentiation

  1999cited by this paper
• Destabilization of cortical dendrites and spines by BDNF.

  1999cited by this paper
• Short- and long-term memory are differentially regulated by monoaminergic systems in the rat brain.

  1998cited by this paper
• Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease.

  1998cited by this paper
• Amygdala-hippocampal atrophy and memory performance in dementia of Alzheimer type.

  1997cited by this paper
• Rapidly progressing atrophy of medial temporal lobe in Alzheimer's disease.

  1994cited by this paper
• Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

  1992cited by this paper

• Targeting the Gut-Brain Axis: The Therapeutic Potential of Exercise in Age-Related Multimorbidity

  2026cites this paper
• Running exercise mitigates amyloidosis in 5xFAD mice by improving the structure and function of the meningeal lymphatic system.

  2026cites this paper
• Precision exercise in older adults with early Alzheimer’s disease: The study protocol of the FIT-AD Sequential, Multiple Assignment, Randomized Trial (SMART)

  2025cites this paper
• High intensity interval training and its impact on brain-derived neurotrophic factor: a potential mechanism to reduce early onset dementia

  2025cites this paper
• Effect of happiness and positive emotions on dementia.

  2025cites this paper
• Microecologics and Exercise: Targeting the Microbiota–Gut–Brain Axis for Central Nervous System Disease Intervention

  2025cites this paper
• Aerobic Exercise Ameliorates Alzheimer's Disease-Like Pathology by Regulating Hepatic Phagocytosis of Aβ.

  2025cites this paper
• Exercise-Induced Neuroplasticity: Adaptive Mechanisms and Preventive Potential in Neurodegenerative Disorders

  2025cites this paper
• Impact of Exercise on the Course of Parkinson’s Disease: A Systematic Review

  2025cites this paper
• The effects of an acute Tai Chi on emotional memory and prefrontal cortex activation: a fNIRS study

  2025cites this paper
• Current Strategies for Healthy Aging: The Interplay Between Nutrition, Metabolism, and Exercise

  2025cites this paper
• Understanding the mechanisms of disease modifying effects of aerobic exercise in people with Alzheimer's disease.

  2024cites this paper
• Role of the amygdala and possible biomarkers in psychiatric disorders

  2024cites this paper
• Voluntary wheel running decreases amyloidogenic pathway and rescues cognition and mitochondrial energy metabolism in middle-aged female 3xTg-AD mouse model of Alzheimer's disease

  2024cites this paper
• Physical Exercise and Mechanism Related to Alzheimer’s Disease: Is Gut–Brain Axis Involved?

  2024cites this paper
• Treadmill Exercise Facilitates Synaptic Plasticity in APP/PS1 Mice by Regulating Hippocampal AMPAR Activity

  2024influential citation
• Beneficial effects of physical exercise on cognitive-behavioral impairments and brain-derived neurotrophic factor alteration in the limbic system induced by neurodegeneration.

  2024cites this paper
• BDNF-Regulated Modulation of Striatal Circuits and Implications for Parkinson’s Disease and Dystonia

  2024cites this paper
• Exercise leads to sex-specific recovery of behavior and pathological AD markers following adolescent ethanol exposure in the TgF344-AD model

  2024cites this paper
• Effects of exercise on brain-derived neurotrophic factor in Alzheimer's disease models: A systematic review and meta-analysis.

  2024cites this paper
• 10 weeks low intensity treadmill exercise intervention ameliorates motor deficits and sustains muscle mass via decreasing oxidative damage and increasing mitochondria function in a rat model of Parkinson's disease.

  2024cites this paper
• Unveiling the Interplay of AMPK/SIRT1/PGC-1α axis in Brain Health: Promising Targets Against Aging and NDDs.

  2024cites this paper
• Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease.

  2024cites this paper
• The effect of tennis batting sound on anxiety: a randomized controlled trial and basic acoustic analysis

  2023cites this paper
• Neuroprotective mechanisms of physical activity

  2023cites this paper
• Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse line

  2023cites this paper
• Levels of Physical Activity at Age 10 Years and Brain Morphology Changes From Ages 10 to 14 Years

  2023cites this paper
• Aerobic exercise attenuates abnormal myelination and oligodendrocyte differentiation in 3xTg-AD mice.

  2023cites this paper
• Exercise therapy to prevent and treat Alzheimer’s disease

  2023influential citation
• Mid-Adulthood Cognitive Training Improves Performance in a Spatial Task but Does Not Ameliorate Hippocampal Pathology in a Mouse Model of Alzheimer’s Disease

  2023cites this paper
• Maresin1 can be a potential therapeutic target for nerve injury.

  2023cites this paper
• Long-term voluntary exercise inhibited AGE/RAGE and microglial activation and reduced the loss of dendritic spines in the hippocampi of APP/PS1 transgenic mice.

  2023cites this paper
• The effects of endurance exercise and metformin on memory impairment caused by diabetes

  2023cites this paper
• Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry

  2022cites this paper
• Exercise Normalized the Hippocampal Renin-Angiotensin System and Restored Spatial Memory Function, Neurogenesis, and Blood-Brain Barrier Permeability in the 2K1C-Hypertensive Mouse

  2022cites this paper
• Alteration of Neural Pathways and Its Implications in Alzheimer’s Disease

  2022cites this paper
• Trauma-like exposure alters neuronal apoptosis, Bin1, Fkbp5 and NR2B expression in an amyloid-beta (1-42) rat model of Alzheimer's disease.

  2022cites this paper
• Changes in Hippocampus and Amygdala Volume with Hypoxic Stress Related to Cardiorespiratory Fitness under a High-Altitude Environment

  2022cites this paper
• Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice

  2022cites this paper
• Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential

  2022cites this paper
• c-Fos protein shRNA blockade in the central amygdala nucleus interfere with rats emotional reactivity on behavioral and autonomic level

  2022cites this paper
• The impact of physical activity on blood inflammatory cytokines and neuroprotective factors in individuals with mild cognitive impairment: a systematic review and meta-analysis of randomized-controlled trials

  2022cites this paper
• Dramatic impacts on brain pathology, anxiety, and cognitive function in the knock-in APPNL-G-F mouse model of Alzheimer disease following long-term voluntary exercise

  2022cites this paper
• Activity‐Dependent Induction of Younger Biological Phenotypes

  2022cites this paper
• The Effects of Physical Activity on the Gut Microbiota and the Gut–Brain Axis in Preclinical and Human Models: A Narrative Review

  2022cites this paper
• An overview on microglial origin, distribution, and phenotype in Alzheimer's disease

  2022cites this paper
• Can Control Infections Slow Down the Progression of Alzheimer’s Disease? Talking About the Role of Infections in Alzheimer’s Disease

  2021influential citation
• Long-term running exercise alleviates cognitive dysfunction in APP/PSEN1 transgenic mice via enhancing brain lysosomal function

  2021cites this paper
• Maintenance of the Amygdala-Hippocampal Circuit Function with Safe and Feasible Shaking Exercise Therapy in SAMP-10 Mice

  2021cites this paper
• Pioglitazone rescues high-fat diet-induced depression-like phenotypes and hippocampal astrocytic deficits in mice.

  2021cites this paper
• Differential paraventricular nucleus activation and behavioral responses to social isolation in prairie voles following environmental enrichment with and without physical exercise

  2021cites this paper
• Neuroprotective mechanisms of chronic physical exercise via reduction of β-amyloid protein in experimental models of Alzheimer's disease: A systematic review.

  2021cites this paper
• Running and Swimming Differently Adapt the BDNF/TrkB Pathway to a Slow Molecular Pattern at the NMJ

  2021cites this paper
• The Effect of 4 Weeks Aerobic Exercise on Gene Expression of Glial Cell_Derived Neurotrophic Factor, TNF-α and Cognition in Rat’s Hippocampus with Alzheimer's Disease Induced by Amyloid Beta 1

  2021cites this paper
• The effect of 4-Week rehabilitation by aerobic exercise on hippocampus BDNF and TGF-β1 gene expressions inAβ 1-42-induced rat model of Alzheimer's disease.

  2021cites this paper
• Effect of 4 Weeks Aerobic Training on Trk-B, PKC and AKT in Hippocampus of Male rats with Alzheimer’s Disease

  2021cites this paper
• Exercise-Mediated Autophagy and Alzheimer’s Disease

  2021cites this paper
• All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer's disease

  2021cites this paper
• Simultaneous Effect of Interval Training and Octopamine Extract on NLRP-1 and NLRP-3 in Brain Tissue of Alzheimer's Rats

  2021cites this paper
• The Effect of Physical Exercise on Cognitive Impairment in Neurodegenerative Disease: From Pathophysiology to Clinical and Rehabilitative Aspects

  2021cites this paper
• Physical and Cognitive Exercise for Patients with Dementia

  2021cites this paper
• Glymphatic imaging and modulation of the optic nerve

  2021influential citation
• The Beneficial Role of Exercise on Treating Alzheimer’s Disease by Inhibiting β-Amyloid Peptide

  2021cites this paper
• Effect of involuntary chronic physical exercise on beta-amyloid protein in experimental models of Alzheimer's disease: Systematic review and meta-analysis.

  2021cites this paper
• Multiple bouts of high-intensity interval exercise reverse age-related functional connectivity disruptions without affecting motor learning in older adults

  2021cites this paper
• Editorial: Physical Activity: Epigenetic and Metabolic Regulation of Brain Aging

  2020cites this paper
• Exercise effects on brain and behavior in healthy mice, Alzheimer's disease and Parkinson's disease model - a systematic review and meta-analysis.

  2020cites this paper
• The therapeutic potential of exercise for neuropsychiatric diseases: A review.

  2020cites this paper
• Hypothesized Mechanisms Through Which Exercise May Attenuate Memory Interference

  2020cites this paper
• Descriptive Study of Role Played by Exercise and Diet on Brain Plasticity

  2020cites this paper
• Maternal Treadmill Exercise Reduces the Neurotoxicity of Prenatal Sevoflurane Exposure in Rats via Activation of p300 Histone Acetyltransferase

  2020cites this paper
• Exercise and Dementia.

  2020cites this paper
• Effects of Physical Activity on Brain Energy Biomarkers in Alzheimer’s Diseases

  2020cites this paper
• Amygdala: Neuroanatomical and Morphophysiological Features in Terms of Neurological and Neurodegenerative Diseases

  2020cites this paper
• Osteocalcin, Ovarian senescence, and Brain health.

  2020cites this paper
• Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration

  2020influential citation
• Comparing prophylactic effect of exercise and metformin on cognitive brain functions in rats with type 3 diabetes mellitus

  2020cites this paper
• Amyloid-beta clearance in Alzheimer’s disease: Does exercise play a role?

  2020cites this paper
• Effects of Swimming Training and Royal Jelly on BDNF and NGF Gene Expression in Hippocampus Tissue of Rats with Alzheimer’s Disease

  2020cites this paper
• Elevated neurofilament light chain in plasma is associated with reduced right hippocampal and amygdala volume in Alzheimer's patients

  2020cites this paper
• Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR.

  2019cites this paper
• Treadmill Exercise Decreases Aβ Deposition and Counteracts Cognitive Decline in APP/PS1 Mice, Possibly via Hippocampal Microglia Modifications

  2019cites this paper
• Exercise, spinogenesis and cognitive functions.

  2019cites this paper
• Acute and long-term treadmill running differentially induce c-Fos expression in region- and time-dependent manners in mouse brain

  2019cites this paper
• University of Groningen Effects of long-term moderate intensity exercise on cognitive behaviors and cholinergic forebrain in the aging rat Teglas,

  2019cites this paper
• Differential effects of adolescent and adult‐initiated voluntary exercise on context and cued fear conditioning

  2019cites this paper
• Can Healthy Diets, Regular Exercise, and Better Lifestyle Delay the Progression of Dementia in Elderly Individuals?

  2019cites this paper
• Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease

  2019cites this paper
• Protective neuroendocrine effects of environmental enrichment and voluntary exercise against social isolation: evidence for mediation by limbic structures

  2019cites this paper
• Effects of Long-Term Moderate Intensity Exercise on Cognitive Behaviors and Cholinergic Forebrain in the Aging Rat.

  2019cites this paper
• Prevention and Treatment of Alzheimer’s Disease: Biological Mechanisms of Exercise

  2019cites this paper
• Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea

  2019cites this paper
• Exercise and Hippocampal Memory Systems.

  2019cites this paper
• Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours

  2019cites this paper
• Short-time high-intensity exercise increases peripheral BDNF in a physical fitness-dependent way in healthy men

  2019cites this paper
• The effects of aerobic training before and after the induction of Alzheimer’s disease on ABCA1 and APOE mRNA expression and the level of soluble Aβ1-42 in the hippocampus of male Wistar rats

  2019cites this paper
• Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway

  2019cites this paper
• Exercise-Induced Modulation of Neuroinflammation in Models of Alzheimer’s Disease

  2018cites this paper
• Beneficial contribution of health behaviors to learning and related brain mechanisms in older adults

  2018cites this paper
• تأثیر 4 هفته پیش آماده سازی ورزشی بر سطح آمیلوئیدبتای محلول و اختلال حافظه در رتهای مبتلا به بیماری آلزایمر القاء شده با تزریق Aβ1-42

  2018cites this paper