Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Neurochemistry

• Publication date

  2009-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1471-4159.2009.05882.xPMID 19183272PMCID PMC2676439
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease.

  2008cited by this paper
• Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

  2008cited by this paper
• Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies.

  2008cited by this paper
• Site‐specific effects of tau phosphorylation on its microtubule assembly activity and self‐aggregation

  2007cited by this paper
• Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

  2007cited by this paper
• Glycogen synthase kinase-3 in neurodegeneration and neuroprotection: lessons from lithium.

  2007cited by this paper
• Signal Transduction Cascades Associated with Oxidative Stress in Alzheimer's Disease

  2007cited by this paper
• Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.

  2006cited by this paper
• Tau phosphorylation and aggregation in Alzheimer's disease pathology

  2006cited by this paper
• GSK-3 is essential in the pathogenesis of Alzheimer's disease

  2006cited by this paper
• Dysregulation of Protein Phosphorylation/Dephosphorylation in Alzheimer's Disease: A Therapeutic Target

  2006cited by this paper
• Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies.

  2005influential reference
• Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

  2005cited by this paper
• Pseudophosphorylation of tau protein alters its ability for self‐aggregation

  2004cited by this paper
• Phosphorylation of microtubule‐associated protein tau by isoforms of c‐Jun N‐terminal kinase (JNK)

  2004cited by this paper
• Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain.

  2004cited by this paper
• Tau Becomes a More Favorable Substrate for GSK-3 When It Is Prephosphorylated by PKA in Rat Brain*

  2004cited by this paper
• Isoforms changes of tau protein during development in various species.

  2003cited by this paper
• Cdk5: One of the links between senile plaques and neurofibrillary tangles?

  2003cited by this paper
• β-Amyloid Induces Paired Helical Filament-like Tau Filaments in Tissue Culture*

  2003cited by this paper
• Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease.

  2002cited by this paper
• The Role of Mitogen-Activated Protein Kinase Pathways in Alzheimer’s Disease

  2002cited by this paper
• Role of Serine/Threonine Protein Phosphatase in Alzheimer’s Disease

  2002cited by this paper
• Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

  2001cited by this paper
• Localization of protein Ser/Thr phosphatase 5 in rat brain.

  2001cited by this paper
• C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease.

  2000cited by this paper
• Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry

  2000cited by this paper
• cAMP-Dependent Protein Kinase Phosphorylations on Tau in Alzheimer’s Disease

  1999cited by this paper
• Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning.

  1998cited by this paper
• The interrelationship between selective tau phosphorylation and microtubule association.

  1998cited by this paper
• Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.

  1998cited by this paper
• Subcellular distribution of protein phosphatases and abnormally phosphorylated τ in the temporal cortex from Alzheimer's disease and control brains

  1998cited by this paper
• Stress‐Activated Protein Kinase/c‐Jun N‐Terminal Kinase Phosphorylates τ Protein

  1997cited by this paper
• Distribution, Levels, and Activity of Glycogen Synthase Kinase‐3 in the Alzheimer Disease Brain

  1997cited by this paper
• Further evidence that the inhibition of glycogen synthase kinase‐3β by IGF‐1 is mediated by PDK1/PKB‐induced phosphorylation of Ser‐9 and not by dephosphorylation of Tyr‐216

  1997cited by this paper
• Calcium/calmodulin‐dependent protein kinase II phosphorylates tau at Ser‐262 but only partially inhibits its binding to microtubules

  1996cited by this paper
• Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

  1995influential reference
• Hyperphosphorylation of tau in PHF.

  1995cited by this paper
• Microtubule-associated Protein/Microtubule Affinity-regulating Kinase (p110mark)

  1995influential reference
• Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons.

  1994cited by this paper
• Altered microtubule organization in small-calibre axons of mice lacking tau protein

  1994cited by this paper
• Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease.

  1994cited by this paper
• Tau in paired helical filaments is functionally distinct from fetal tau: assembly incompetence of paired helical filament-tau.

  1993influential reference
• Developmental Changes in τ Phosphorylation: Fetal τ Is Transiently Phosphorylated in a Manner Similar to Paired Helical Filament‐τ Characteristic of Alzheimer's Disease

  1993influential reference
• Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

  1993influential reference
• The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

  1993cited by this paper
• τ in Paired Helical Filaments Is Functionally Distinct from Fetal τ: Assembly Incompetence of Paired Helical Filament‐τ

  1993cited by this paper
• Tau Protein and the Neurofibrillary Pathology of Alzheimer's Disease

  1993cited by this paper
• Modulation of the glycogen synthase kinase‐3 family by tyrosine phosphorylation.

  1993cited by this paper
• The extent of phosphorylation of fetal tau is comparable to that of PHF-tau from Alzheimer paired helical filaments.

  1993cited by this paper
• Glycogen synthase kinase-3: functions in oncogenesis and development.

  1992cited by this paper
• Regulation of tubulin, Tau and microtubule associated protein 2 expression during mouse brain development.

  1992cited by this paper
• Tubulin gene expression during synaptogenesis in rat, mouse and chick brain

  1991cited by this paper
• A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

  1991cited by this paper
• Differential Distribution of Tau Proteins in Developing Cat Cerebral Cortex and Corpus Callosum

  1991cited by this paper
• Calcium/calmodulin-dependent protein kinase II.

  1989cited by this paper
• Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease.

  1989cited by this paper
• MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS

  1989influential reference
• Cloning and sequencing of the cDNA encoding an isoform of microtubule‐associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

  1989cited by this paper
• Developmentally regulated expression of specific tau sequences.

  1989cited by this paper
• Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids.

  1987cited by this paper
• Defective brain microtubule assembly in Alzheimer's disease.

  1986cited by this paper
• Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

  1986cited by this paper
• Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

  1986cited by this paper
• Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease.

  1986cited by this paper
• Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease.

  1986cited by this paper
• MAP5: A novel brain microtubule-associated protein under strong developmental regulation

  1986cited by this paper
• Phosphorylation affects the ability of tau protein to promote microtubule assembly.

  1984cited by this paper
• Assay of proteins in the presence of interfering materials.

  1976cited by this paper
• INTERNATIONAL SOCIETY FOR NEUROCHEMISTRY

  1976cited by this paper
• STAPHYLOCOCCI RESISTANT TO NEOMYCIN AND BACITRACIN.

  1965cited by this paper

• The Role and Pathogenesis of Tau Protein in Alzheimer’s Disease

  2025cites this paper
• Neuroplasticity After Hypoxic-Ischemic Brain Injury in Neonatal Pigs Based on Time-Dependent Behavior of 1H-MRS-Tau Protein and Synaptic Associated Proteins and Synaptic Structure Analysis

  2025cites this paper
• Large-scale single-molecule analysis of tau proteoforms

  2025cites this paper
• Tau aggregation results in an impaired ability to counteract microtubule destabilization via specific combinatorial tau phosphorylation patterns

  2025cites this paper
• Melatonin Supplementation in Alzheimer’s disease: The Potential Role in Neurogenesis

  2025cites this paper
• Tau–Mitochondria Interactions in Neurodegeneration: Mechanisms and Therapeutic Potential

  2025cites this paper
• Tau Hypophosphorylation at Ser416 as the Early Molecular Imprint of Maternal Immune Activation: Insights from Female Mice Offspring

  2025cites this paper
• Alleviation of Neurological Disorders by Targeting Neurodegenerative-Associated Enzymes: Natural and Synthetic Molecules

  2025cites this paper
• Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy

  2025cites this paper
• The Unified Theory of Neurodegeneration Pathogenesis Based on Axon Deamidation

  2025cites this paper
• A pathological phosphorylation pattern enhances tau cooperativity on microtubules and facilitates tau filament assembly

  2025cites this paper
• Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission

  2025cites this paper
• Excessive Alcohol Use as a Risk Factor for Alzheimer's Disease: Epidemiological and Preclinical Evidence.

  2025cites this paper
• Porphyromonas gingivalis outer membrane vesicles alter cortical neurons and Tau phosphorylation in the embryonic mouse brain

  2025cites this paper
• A pathological phosphorylation pattern enhances tau cooperativity on microtubules and facilitates tau filament assembly

  2025cites this paper
• Structural insights into the role of the proline rich region in tau function.

  2025cites this paper
• Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission

  2025cites this paper
• Tauopathies: Emerging discoveries on tau protein, with a special focus on Alzheimer's disease.

  2025cites this paper
• Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease

  2024cites this paper
• Structural Insights into the Role of the Proline Rich Region in Tau Function

  2024cites this paper
• Role of O-GlcNAcylation in Alzheimer’s Disease: Insights and Perspectives

  2024cites this paper
• Oligodendrocyte Dysfunction in Tauopathy: A Less Explored Area in Tau-Mediated Neurodegeneration

  2024cites this paper
• Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation

  2024cites this paper
• TauP301L disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability

  2024cites this paper
• Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission

  2024cites this paper
• Neuronal Excitation Induces Tau Protein Dephosphorylation via Protein Phosphatase 1 Activation to Promote Its Binding with Stable Microtubules

  2024cites this paper
• Diverse Efficacy of Dimethyl Fumarate in Alleviating the Late Streptozotocin-Induced Cognitive Impairment and Neuropathological Features in Rat

  2024cites this paper
• Alzheimer's disease and related tauopathies: disorders of disrupted neuronal identity.

  2023cites this paper
• Tau, microtubule dynamics, and axonal transport: New paradigms for neurodegenerative disease

  2023cites this paper
• Structures of AT8 and PHF1 Phospho-Mimetic Tau: Insights Into the Posttranslational Modification Code of Tau Amyloid Formation

  2023cites this paper
• Gain-of-function MARK4 variant associates with pediatric neurodevelopmental disorder and dysmorphism

  2023cites this paper
• Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins

  2023cites this paper
• Phosphorylation of Tau R2 Repeat Destabilizes Its Binding to Microtubules: A Molecular Dynamics Simulation Study

  2023cites this paper
• Bacopa monnieri reduces Tau aggregation and Tau-mediated toxicity in cells.

  2023cites this paper
• Tau; One Protein, So Many Diseases

  2023influential citation
• The Adult Neurogenesis Theory of Alzheimer’s Disease

  2023cites this paper
• Activation of β2-adrenergic receptor ameliorates amyloid-β-induced mitophagy defects and tau pathology in mice.

  2022cites this paper
• Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins

  2022cites this paper
• Mouse and Human Tau Expression in Different Brain Areas

  2022cites this paper
• Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons

  2022cites this paper
• Targeting Microtubule-Associated Protein Tau in Chemotherapy-Resistant Models of High-Grade Serous Ovarian Carcinoma

  2022cites this paper
• Ethanol sustains phosphorylated tau protein in the cultured neonatal rat hippocampus: Implications for fetal alcohol spectrum disorders.

  2022cites this paper
• Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice

  2022cites this paper
• Long-Term Depression-Inducing Low Frequency Stimulation Enhances p-Tau181 and p-Tau217 in an Age-Dependent Manner in Live Rats

  2022cites this paper
• Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome

  2022cites this paper
• A single closed head injury in mice induces chronic, progressive white matter atrophy and increased phospho-tau expressing oligodendrocytes

  2022cites this paper
• PP2A-associated tau hyperphosphorylation was involved in sevoflurane induced neonatal neurotoxicity

  2022cites this paper
• In vivo analysis of the phosphorylation of tau and the tau protein kinases Cdk5-p35 and GSK3β by using Phos-tag SDS-PAGE.

  2022cites this paper
• LTD-inducing low frequency stimulation enhances p-Tau181 and p-Tau217 in an age-dependent manner in live rats

  2022cites this paper
• Kai-Xin-San Inhibits Tau Pathology and Neuronal Apoptosis in Aged SAMP8 Mice

  2022cites this paper
• Tau Pathology, Metal Dyshomeostasis and Repetitive Mild Traumatic Brain Injury: An Unexplored Link Paving the Way for Neurodegeneration

  2022cites this paper
• Early-Life Environment Influence on Late-Onset Alzheimer’s Disease

  2022cites this paper
• Unravelling the Selectivity of 6,7‐Dimethyl Quinoxaline Analogs for Kinase Inhibition: An Insight towards the Development of Alzheimer's Therapeutics

  2021cites this paper
• Defined Tau Phosphospecies Differentially Inhibit Fast Axonal Transport Through Activation of Two Independent Signaling Pathways

  2021cites this paper
• Retromer dysfunction at the nexus of tauopathies

  2021cites this paper
• Mass spectrometry analysis of tau and amyloid‐beta in iPSC‐derived models of Alzheimer’s disease and dementia

  2021cites this paper
• Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

  2021cites this paper
• Similarities and Differences in the Pattern of Tau Hyperphosphorylation in Physiological and Pathological Conditions: Impacts on the Elaboration of Therapies to Prevent Tau Pathology

  2021cites this paper
• Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia

  2021cites this paper
• Immature Persimmon Suppresses Amyloid Beta (Aβ) Mediated Cognitive Dysfunction via Tau Pathology in ICR Mice

  2021cites this paper
• Rats Display Sexual Dimorphism in Phosphorylation of Brain Tau with Age

  2021cites this paper
• “Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies

  2021cites this paper
• Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer’s disease

  2021cites this paper
• Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration

  2021cites this paper
• A current view on Tau protein phosphorylation in Alzheimer's disease.

  2021cites this paper
• Alzheimer’s Disease: A Molecular View of β-Amyloid Induced Morbific Events

  2021cites this paper
• A critical appraisal of tau‐targeting therapies for primary and secondary tauopathies

  2021cites this paper
• Functional Interactions of Tau Phosphorylation Sites That Mediate Toxicity and Deficient Learning in Drosophila melanogaster

  2020cites this paper
• Developmental Pathogenicity of 4-Repeat Human Tau Is Lost with the P301L Mutation in Genetically Matched Tau-Transgenic Mice

  2020cites this paper
• Interaction of Tau, IL-6 and mitochondria on synapse and cognition following sevoflurane anesthesia in young mice

  2020cites this paper
• Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer's disease-like pathology?

  2020cites this paper
• SETD7-mediated lysine monomethylation is abundant on non-hyperphosphorylated nuclear Tau

  2020cites this paper
• Recent advances in tau-directed immunotherapy against Alzheimer’s disease: an overview of pre-clinical and clinical development

  2020cites this paper
• Overexpression of GSK-3β in Adult Tet-OFF GSK-3β Transgenic Mice, and Not During Embryonic or Postnatal Development, Induces Tau Phosphorylation, Neurodegeneration and Learning Deficits

  2020cites this paper
• Modelling Frontotemporal Dementia using patient-derived induced pluripotent stem cells.

  2020cites this paper
• Methionine-Mediated Protein Phosphatase 2A Catalytic Subunit (PP2Ac) Methylation Ameliorates the Tauopathy Induced by Manganese in Cell and Animal Models

  2020cites this paper
• Retromer regulates the lysosomal clearance of MAPT/tau

  2020cites this paper
• Vaccinium bracteatum Improves Spatial Learning and Memory by Regulating N-methyl-D-aspartate Receptors and Tau Phosphorylation in Chronic Restraint Stress-Induced Memory Impaired Mice.

  2020cites this paper
• Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice

  2019cites this paper
• LITHUANIAN UNIVERSITY OF HEALTH SCIENCES

  2019cites this paper
• Tau pathology reduction with SM07883, a novel, potent, and selective oral DYRK1A inhibitor: A potential therapeutic for Alzheimer's disease

  2019cites this paper
• Tau: It's Not What You Think.

  2019cites this paper
• Tau isoform expression and phosphorylation in marmoset brains

  2019cites this paper
• Tau Phosphorylation and Aggregation in the Developing Human Brain.

  2019cites this paper
• What is strain in neurodegenerative diseases?

  2019cites this paper
• 25 Ubiquitination and SUMOylation of Amyloid and Amyloid-like Proteins in Health and Disease

  2019cites this paper
• GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease

  2019cites this paper
• TAUOPATHIES, NOVEL OPTOGENETIC TOOLS, AND THE FUTURE OF ARTIFICIAL INTELLIENCE IN MEDICINE.

  2019cites this paper
• Modeling Sporadic Alzheimer’s Disease by Efficient Direct Reprogramming of the Elderly Derived Disease Dermal Fibroblasts into Neural Stem Cells

  2019cites this paper
• Diagnostic and prognostic biomarkers for HAND

  2019cites this paper
• Neurofibromatosis type 2 tumor suppressor protein is expressed in oligodendrocytes and regulates cell proliferation and process formation

  2018cites this paper
• Mechanisms of Hydrogen Sulfide against the Progression of Severe Alzheimer’s Disease in Transgenic Mice at Different Ages

  2018cites this paper
• Rbfox3/NeuN Regulates Alternative Splicing of Tau Exon 10

  2018cites this paper
• Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead

  2018cites this paper
• Phosphorylation, Dephosphorylation, and Multiprotein Assemblies Regulate Dynamic Behavior of Neuronal Cytoskeleton: A Mini-Review

  2018cites this paper
• Bilateral Implantation of Shear Stress Modifier in ApoE Knockout Mouse Induces Cognitive Impairment and Tau Abnormalities

  2018cites this paper
• Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport

  2018cites this paper
• The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic–ischemic near-term lamb

  2018cites this paper
• High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development

  2018cites this paper
• Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases.

  2018cites this paper