Aplastic Anemia

Treatments of aplastic anemia are comprised of supportive therapy and aplastic anemia-specific therapy aimed at restoring hematopoiesis. Supportive therapies include transfusion, G-CSF, and the administration of iron chelation agents, as well as dealing specifically with individual symptoms. Aplastic anemia-specific treatments given with the aim of achieving hematopoietic recovery include immunosuppressive therapy, allogeneic hematopoietic stem cell transplantation, and anabolic hormone therapy. Although transplantation provides complete recovery of hematopoiesis (cure), there is a risk of death due to transplant-related complications. The most effective immunosuppressive therapy is a combination of anti-thymocyte globulin and cyclosporine. This treatment is also effective against the secondary, drug-induced and hepatitis-associated forms of aplastic anemia. In the management of aplastic anemia, a treatment is selected from among these options depending on the disease severity and the age of the individual case. The thrombopoietin receptor agonist eltrombopag appears to be effective and to provide tri-lineage recovery of hematopoiesis in some cases. Indications for its use are expected to expand in Japan.

• Publication year

  2020

• Venue

  Haematology and Blood Transfusion / Hämatologie und Bluttransfusion

• Publication date

  2020-02-08

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/978-3-642-67483-9PMID 27725585
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Myelotoxicity of gold.

  1976cited by this paper
• Aplastic anemia.

  1972cited by this paper
• Statewide study of chloramphenicol therapy and fatal aplastic anemia.

  1969cited by this paper
• Aplastic Anaemia

  1965cited by this paper
• APLASTIC ANEMIA FOLLOWING EXPOSURE TO BENZENE HEXACHLORIDE (LINDANE).

  1965cited by this paper
• Refractory anemia occurring in survivors of the atomic bombing in Nagasaki, Japan.

  1955cited by this paper

• Hetrombopag Added to Cyclosporine as the First‐Line Treatment for Patients With Non‐Severe Aplastic Anemia: A Phase 2 Multicenter Trial

  2026influential citation
• Adsorptive removal of chloramphenicol antibiotics from aqueous solutions using functionalised biochar developed from animal-waste.

  2026cites this paper
• Stem cells and secretome in aplastic anaemia: a bibliometric analysis of global research trends (2018–2023) and future directions for regenerative therapies

  2026cites this paper
• Luspatercept for the treatment of transfusion-dependent non-severe aplastic anemia

  2026cites this paper
• Cyclosporine related adverse events in aplastic anemia patients treated with immunosuppressive therapy

  2026cites this paper
• Assessment of characteristics and treatment patterns of adult patients with acquired aplastic anemia in Turkiye (PLANE-TR)

  2026cites this paper
• The Role of Human Microbiota in Autoimmune Diseases: Exploring Dysbiosis and Mechanisms

  2026cites this paper
• DNA methylation variability in pediatric aplastic anaemia contributes to T‐cell differentiation

  2026cites this paper
• Mendelian randomization analysis of immune cell subsets and inflammatory cytokines in aplastic anaemia

  2026cites this paper
• Anti-thymocyte globulin-based treatment frequently leads to enduring treatment success in both old and young adult patients with aplastic anaemia: a real-world analysis from the Dutch aplastic anaemia registry

  2026cites this paper
• Factors Related To The Incidence Of Anemia Among Pregnant Women In The Working Area Of Kedokanbunder Public Health Center, Indramayu Regency

  2026cites this paper
• A Rare Case of Atezolizumab-Induced Very Severe Aplastic Anemia

  2025cites this paper
• The efficacy of immunosuppressive therapy with or without thrombopoietin receptor agonist in elderly patients with severe aplastic anemia

  2025cites this paper
• Spinal Extramedullary Hematopoiesis Causing Spinal Cord Compression in Radiation-induced Bone Marrow Aplasia: A Case Report

  2025cites this paper
• Advanced electrochemical platform based on graphitic carbon nitride for monitoring chloramphenicol in complex matrices

  2025cites this paper
• Severe, refractory paraneoplastic aplastic anemia secondary to primary peritoneal carcinoma: a case report

  2025cites this paper
• Modified Guilu Erxian Glue regulates Treg immune function to suppress bone marrow failure in aplastic anemia mice

  2025cites this paper
• A decade of acquired aplastic anemia: insights from a Central South African Center

  2025influential citation
• Targeting interleukin-2-inducible T cell kinase ameliorates immune-mediated aplastic anemia

  2025cites this paper
• Effect of major ABO blood group mismatched HSCT on blood transfusion and clinical outcomes in AA patients

  2025cites this paper
• Refractory severe aplastic anemia in a child: treatment failure and access barriers in a low-resource setting

  2025cites this paper
• Beyond the Bone Marrow: A Comprehensive Clinical Overview OF Acquired Aplastic Anemia in Children

  2025cites this paper
• The haematopoietic cell transplantation comorbidity index predicts clinical outcomes for severe aplastic anaemia patients after haploidentical haematopoietic stem cell transplantation

  2025cites this paper
• Up-front alternative donor HCT in severe aplastic anemia: gaps and opportunities to translate evidence into practice

  2025cites this paper
• Donor impact on allogeneic transplant outcomes with PTCy for severe aplastic anemia: a study of the SAAWP EBMT

  2025cites this paper
• Efficacy of Poloxamer 188 in Carboplatin-Induced Aplastic Anemia Model in CBA Mice

  2025cites this paper
• The outcomes of second haploidentical donor transplantation for graft failure in patients with severe aplastic anaemia

  2025cites this paper
• Protective factors, management and prognosis of mixed chimerism after allogeneic hematopoietic stem cell transplantation for severe aplastic anemia in children

  2025cites this paper
• Efficacy of Poloxamer 188 in Experimental Myelosuppression Model Induced by Carboplatin in CBA Mice

  2025cites this paper
• Efficacy and safety of immunosuppressive therapy versus cyclosporine combined with avatrombopag in older adults with severe aplastic anemia: a multicenter prospective study

  2025cites this paper
• 造血干细胞移植50年——从拓荒到领航，中国方案重塑全球格局

  2025cites this paper
• Efficacy and safety of rabbit ATLG and ATG in allogeneic hematopoietic stem cell transplantation for children with acquired severe aplastic anemia

  2025cites this paper
• Development of Interactive Nomograms for Predicting Short-Term Survival in ICU Patients with Aplastic Anemia

  2025cites this paper
• Acute hepatitis A-associated aplastic anemia in a pediatric: a case report from Syria

  2025cites this paper
• From severe aplastic anemia with TERT variant to Wilson disease - associations or not

  2025cites this paper
• IFN‐γ Synergizes with TNF‐α to Induce RIPK1‐Independent Necroptosis of Mesenchymal Stem/Stromal Cells

  2025cites this paper
• Aplastic Anaemia Disease Burden From the Patient Perspective and Quality of Life in Zimbabwe by A. Maramba and J. Mupini

  2025cites this paper
• Effect of Haplo-Allogeneic Hematopoietic Stem Cell Transplantation Timing on Patients with Severe Aplastic Anemia Without Histocompatible Matched Sibling Donor

  2025cites this paper
• Traditional Chinese medicine for intractable and rare diseases: Research progress and future strategies.

  2025cites this paper
• Early withdrawal immunosuppression improved mixed chimerism in stem cell transplantation for pediatric aplastic anemia

  2025cites this paper
• Cost utility analysis of adult patients with severe aplastic anemia: a single-center study

  2025cites this paper
• Interferon-γ-mediated selective inhibition of hematopoiesis and the clonal advantage of HLA-lacking hematopoietic stem progenitor cells in aplastic anemia

  2025cites this paper
• Pharmacovigilance assessment of drug-induced aplastic anemia: analysis of the FDA adverse event reporting system

  2025cites this paper
• A Forgotten Foe Returns: The Diagnostic Odyssey of Kala‐Azar Masquerading as Myelodysplastic Syndrome in a Post‐Elimination Era

  2025cites this paper
• Doxycycline-associated agranulocytosis : a rare hematologic complication

  2025cites this paper
• Human autoimmunity at single cell resolution in aplastic anemia before and after effective immunotherapy

  2025cites this paper
• Combining immunosuppressive therapy with low dosage eltrombopag in Chinese patients with severe aplastic anemia: mild aggravation of hepatic injury

  2025cites this paper
• Outcomes after Immunosuppressive Therapy for Aplastic Anemia: A Single Centre Experience from Northern India

  2024cites this paper
• Adding eltrombopag to intensive immunosuppressive therapy for severe aplastic anaemia may help adult patients achieve outcomes similar to paediatric patients

  2024cites this paper
• Frequent loss of HLA‐B*40:02 from leucocytes in male patients with hepatitis‐associated aplastic anaemia

  2024cites this paper
• Deciphering bone marrow engraftment after allogeneic stem cell transplantation in humans using single-cell analyses

  2024cites this paper
• Approach to pancytopenia: From blood tests to the bedside

  2024cites this paper
• Comprehensive mapping of immune perturbations associated with aplastic anemia

  2024cites this paper
• Utilizing Natural Resources in Dentistry Practice to Enhance Holistic Oral Well- Being

  2024cites this paper
• Causal role of immune cells in aplastic anemia: Mendelian randomization (MR) study

  2024cites this paper
• Haematopoietic regeneration by HLA‐A*0206‐deficient clones in severe aplastic anaemia without definitive immunosuppressive treatment

  2024cites this paper
• Risk assessment and genetic counseling for hematologic malignancies—Practice resource of the National Society of Genetic Counselors

  2024cites this paper
• Multidisciplinary approaches to study anaemia with special mention on aplastic anaemia (Review)

  2024influential citation
• Telomere length and clonal chromosomal alterations in peripheral blood of patients with severe aplastic anaemia

  2024cites this paper
• First-line treatment of severe aplastic anemia: immunosuppressive therapy plus eltrombopag versus haploidentical hematopoietic stem cell transplantation, a multicenter prospective study

  2024cites this paper
• A comprehensive analysis of the major specificities of anti-human T lymphocyte porcine immunoglobulin (p-ATG)

  2024cites this paper
• Feasibility and effectiveness of the prolonged use of eltrombopag in addition to immunosuppression in patients with acquired aplastic anemia: a single-center real-life experience

  2024cites this paper
• Oral Presentation of Haematological Disease: Part I – Diseases of Bone Marrow Failure

  2024influential citation
• Safety and efficacy of immunosuppressive therapy for elderly patients with severe aplastic anaemia

  2024cites this paper
• Long-Term Follow-Up of Eltrombopag Treatment for Patients with Cyclosporin A Refractory/Relapsed Transfusion-Dependent Non-Severe Aplastic Anemia: A Report from a Single Center in China

  2024cites this paper
• Exploring the potential mechanism of Chinese herbal medicine Fuzi on aplastic anemia based on UHPLC-MS/MS method combined with network pharmacology and molecular docking

  2024cites this paper
• Successful Treatment of Severe Aplastic Anemia with Hematopoietic Stem Cell Transplantation in the Setting of Active Mucormycosis

  2024cites this paper
• Clinical Study of Related Complications of Severe Aplastic Anemia Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

  2024cites this paper
• Donor-type bone marrow aplasia following hematopoietic stem cell transplantation in a child with a novel SAMD9L variant

  2024cites this paper
• Aplastic anemia & homeopathic for children's: Observational studies

  2024cites this paper
• Dioscin alleviates aplastic anemia through regulatory T cells promotion

  2024cites this paper
• Guidelines for the diagnosis and management of adult aplastic anaemia: A British Society for Haematology Guideline

  2024cites this paper
• Mendelian randomization of circulating proteome identifies IFN-γ as a druggable target in aplastic anemia

  2024cites this paper
• The ouroboros of autoimmunity

  2024cites this paper
• Effective treatment of refractory aplastic anemia with romiplostim after failure of multiple thrombopoietin receptor agonists: a single-center retrospective study

  2024cites this paper
• Severe aplastic anemia with acquired X chromosome clonality as a sole abnormality

  2024cites this paper
• Effects of Acceptance and Commitment Care in the Treatment of Aplastic Anemia Patients with Recombinant Human Thrombopoietin

  2024cites this paper
• Aplastic Anemia: A literature Review

  2024cites this paper
• Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway

  2024cites this paper
• Relapse and transformation to myelodysplastic syndrome and acute myeloid leukemia following immunosuppressive therapy for aplastic anemia is more common as compared to allogeneic stem cell transplantation with a negative impact on survival

  2024cites this paper
• Clinical impact and characteristics of erythroid dysplasia in adult aplastic anaemia: Results from a multicentre registry

  2024cites this paper
• Aplastic anaemia following antibiotic use for urinary tract infection

  2024cites this paper
• Outpatient subcutaneous alemtuzumab is feasible and safe for aplastic anemia and is associated with high response rates

  2024cites this paper
• The role of TIM3+ NK and TIM3- NK cells in the immune pathogenesis of severe aplastic anemia

  2024cites this paper
• Efficacy and safety of immunosuppressive therapy combined with eltrombopag for severe aplastic anemia: a systematic review and meta-analysis

  2024cites this paper
• Quality of life after immune suppressive therapy in aplastic anemia

  2024cites this paper
• A Study of Correlation between Sociodemographic Data and Anaemia Proxies among Women and Children

  2023cites this paper
• Meta-analysis of the results of haploidentical transplantation in the treatment of aplastic anemia

  2023cites this paper
• Low risk of relapse in aplastic anemia patients after SARS‐CoV‐2 omicron infection: A prospective NICHE cohort

  2023cites this paper
• GATA1-defective immune-megakaryocytes as possible drivers of idiopathic pulmonary fibrosis

  2023cites this paper
• Multidirectional pharmacological effects of saponins in light of clinical trials: a systematic review of literature

  2023cites this paper
• Pancitopenia como apresentação inicial de anemia perniciosa: relato de caso de uma abordagem minimamente invasiva

  2023cites this paper
• Hypoplastic form of myelodysplastic neoplasm.

  2023cites this paper
• Conditional survival and standardized mortality ratios of patients with severe aplastic anemia surviving at least one year after hematopoietic cell transplantation or immunosuppressive therapy

  2023cites this paper
• System-level immune monitoring reveals new pathophysiological features in hepatitis-associated aplastic anemia

  2023cites this paper
• Comparison of haploidentical–allogeneic hematopoietic stem cell transplantation and intensive immunosuppressive therapy for patients with severe aplastic anemia with an absolute neutrophil count of zero: a retrospective study

  2023cites this paper
• Malignant clonal evolution from high proportion of monocytes in patients with aplastic anemia: a case report

  2023cites this paper
• Research progress on the hematopoietic microenvironment in aplastic anemia

  2023cites this paper
• Avatrombopag, a promising novel thrombopoietin receptor agonist for refractory/relapsed/intolerant non-severe aplastic anemia: a phase 2 single-arm clinical trial

  2023cites this paper
• New onset of hypomegakaryocytic thrombocytopenia with the potential for progression to aplastic anemia after BNT162b2 mRNA COVID-19 vaccination

  2023cites this paper