Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Sleep

• Publication date

  2012-09-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.5665/sleep.2080PMID 22942503PMCID PMC3413802
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Narcolepsy is strongly associated with the T-cell receptor alpha locus (vol 41, pg 708, 2009)

  2014cited by this paper
• Relationship between clinical characteristics of narcolepsy and CSF orexin‐A levels

  2011cited by this paper
• Clinical features of childhood narcolepsy. Can cataplexy be foretold?

  2011cited by this paper
• Advances in narcolepsy.

  2010cited by this paper
• P9-11 Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population

  2010cited by this paper
• Narcolepsy is strongly associated with the TCR alpha locus

  2009cited by this paper
• Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy.

  2009cited by this paper
• Symptomatic narcolepsy in patients with neuromyelitis optica and multiple sclerosis: new neurochemical and immunological implications.

  2009cited by this paper
• Multiple sleep latency measures in narcolepsy and behaviourally induced insufficient sleep syndrome.

  2009cited by this paper
• Does age at the onset of narcolepsy influence the course and severity of the disease?

  2009cited by this paper
• Narcolepsy in childhood.

  2009cited by this paper
• CSF hypocretin-1 assessment in sleep and neurological disorders.

  2008cited by this paper
• Prevalence of narcolepsy‐cataplexy in Korean adolescents

  2008cited by this paper
• Análisis comparativo de un grupo de pacientes con narcolepsia-cataplejía, narcolepsia sin cataplejía e hipersomnia idiopática

  2007cited by this paper
• CSF hypocretin-1 levels and clinical profiles in narcolepsy and idiopathic CNS hypersomnia in Norway.

  2007cited by this paper
• [Comparative analysis of patients with narcolepsy-cataplexy, narcolepsy without cataplexy and idiopathic hypersomnia].

  2007cited by this paper
• Brief introduction to second edition of International Classification of Sleep Disorders:Diagnostic and Coding Manual

  2007cited by this paper
• Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults.

  2006cited by this paper
• A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepiness.

  2006cited by this paper
• EFNS guidelines on management of narcolepsy

  2006cited by this paper
• The prevalence of multiple sleep-onset REM periods in a population-based sample.

  2006cited by this paper
• Narcolepsy without cataplexy: 2 subtypes based on CSF hypocretin-1/orexin-A findings.

  2006cited by this paper
• Hypocretin (orexin) deficiency predicts severe objective excessive daytime sleepiness in narcolepsy with cataplexy

  2005cited by this paper
• Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test.

  2005cited by this paper
• CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions

  2003cited by this paper
• Excessive daytime somnolence and increased rapid eye movement pressure in myotonic dystrophy

  2003cited by this paper
• Prevalence of narcolepsy symptomatology and diagnosis in the European general population

  2002cited by this paper
• The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias.

  2002cited by this paper
• Hypocretin (orexin) levels in cerebrospinal fluid of patients with narcolepsy: relationship to cataplexy and HLA DQB1*0602 status.

  2002cited by this paper
• Clinical aspects of narcolepsy-cataplexy across ethnic groups.

  2002cited by this paper
• Excessive daytime somnolence and increased rapid eye movement pressure in myotonic dystrophy.

  2002cited by this paper
• The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study.

  2002cited by this paper
• Age at onset of narcolepsy in two large populations of patients in France and Quebec

  2001cited by this paper
• Hypersomnia in the Prader Willi syndrome: clinical-electrophysiological features and underlying factors.

  2001cited by this paper
• Narcolepsy:Clinical Features, New Pathophysiologic Insights, and Future Perspectives

  2001cited by this paper
• Hypocretin (orexin) deficiency in human narcolepsy.

  2000cited by this paper
• Sleep onset REM periods during multiple sleep latency tests in patients evaluated for sleep apnea.

  2000cited by this paper
• Validation of a cataplexy questionnaire in 983 sleep-disorders patients.

  1999cited by this paper
• Value of the multiple sleep latency test (MSLT) for the diagnosis of narcolepsy.

  1997cited by this paper
• Survival Analysis: A Self-Learning Text

  1997cited by this paper
• HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients.

  1997cited by this paper
• Diagnostic and Statistical Manual of Mental Disorders, 4th Ed.

  1994cited by this paper
• The prevalence of narcolepsy: An epidemiological study of the Finnish Twin Cohort

  1994cited by this paper
• The International Classification of Sleep Disorders

  1992cited by this paper
• The International Classification of Sleep Disorders

  1991cited by this paper
• A new method for measuring daytime sleepiness: the Epworth sleepiness scale.

  1991cited by this paper
• Guidelines for the multiple sleep latency test (MSLT): a standard measure of sleepiness.

  1986cited by this paper
• Survival Analysis

  1981cited by this paper
• REM sleep episodes during the Multple Sleep Latency Test in narcoleptic patients.

  1979cited by this paper
• Excessive daytime sleepiness in man: multiple sleep latency measurement in narcoleptic and control subjects.

  1978cited by this paper

• Narcolepsy and metabolic disease: A meta-analytic synthesis.

  2026cites this paper
• Acquired narcolepsy secondary to a presumptive hypothalamic hamartoma in a young German wirehaired pointer dog

  2025cites this paper
• Narkolepsie

  2025cites this paper
• Present and Future of Central Disorders of Hypersomnolence

  2025cites this paper
• [Symptomatic narcolepsy type 2 in a patient with AQP4-positive neuromyelitis optica spectrum disorder].

  2025cites this paper
• Orexin Restoration in Narcolepsy: Breakthroughs in Cellular Therapy

  2025cites this paper
• HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity

  2025cites this paper
• 16-mer hypocretin-1/orexin-A in cerebrospinal fluid to diagnose narcolepsy.

  2025cites this paper
• Current knowledge on the pathophysiology of idiopathic hypersomnia and potential mechanisms of action for low-sodium oxybate treatment

  2025cites this paper
• HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity.

  2025cites this paper
• Narcolepsy: Beyond the Classic Pentad

  2025cites this paper
• Narcolepsy type 2 is an unstable diagnosis and idiopathic hypersomnia has the potential for remission - long-term and cross-sectional observations from the Bern Sleep ̶ Wake Registry.

  2025cites this paper
• Armodafinil as Monotherapy in Treating Narcolepsy with Cataplexy

  2024cites this paper
• Narcolepsy and rapid eye movement sleep

  2024cites this paper
• High‐resolution HLA sequencing and hypocretin receptor 2 autoantibodies in narcolepsy type 1 and type 2

  2024cites this paper
• SwinSleep: A Deep Learning Framework Advancing Overnight Sleep Staging Toward Clinical Practice

  2024cites this paper
• HypnoGPT: A Hypnogram Language Model for Sleep Staging Enhancement and Sleep Disorder Diagnosis

  2024cites this paper
• The Role of T Cells in the Pathogenesis of Narcolepsy Type 1: A Narrative Review

  2024cites this paper
• Narcolepsy Severity Scale-2 and Idiopathic Hypersomnia Severity Scale to better quantify symptoms severity and consequences in Narcolepsy type 2.

  2024cites this paper
• Narcolepsy secondary to anti-Ma2 encephalitis: two case reports

  2023cites this paper
• Altered reinforcement learning in Narcolepsy type I and other central disorders of hypersomnolence.

  2023cites this paper
• Orphan Drugs in Neurology—A Narrative Review

  2023cites this paper
• Exploring the Literature on Narcolepsy: Insights into the Sleep Disorder That Strikes during the Day

  2023cites this paper
• Orexin pathway in Parkinson’s disease: a review

  2023cites this paper
• Clinical Evaluation and Management of Narcolepsy in Children and Adolescents.

  2023cites this paper
• Pharmacological options for narcolepsy: are they the way forward?

  2023cites this paper
• A Turkish Validity and Reliability Study of the Swiss Narcolepsy Scale

  2023cites this paper
• Narcolepsy and Idiopathic Hypersomnia.

  2023cites this paper
• A series of 7 cases of patients with narcolepsy with hypocretin deficiency without the HLA DQB1*06:02 allele

  2023cites this paper
• Hypersomnies

  2023cites this paper
• Characteristics of hypersomnia due to inflammatory demyelinating diseases of the central nervous system

  2023cites this paper
• Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1.

  2023cites this paper
• Analysis of thyroid function and related factors in narcolepsy patients

  2023cites this paper
• Central Disorders of Hypersomnolence

  2023cites this paper
• The immunopathogenesis of narcolepsy type 1

  2023cites this paper
• MOG‐antibody‐associated disorder with hypothalamic lesions associated with hypersomnia and decrease of orexin in CSF: A case report

  2022cites this paper
• Daytime sleepiness in a neurologist's office

  2022cites this paper
• Repeated measures of hypocretin-1 in Danish and Italian patients with narcolepsy and in controls.

  2022cites this paper
• Prevalence, incidence, evolution and associated factors of sleep paralysis in a longitudinal study of the US general population.

  2022cites this paper
• The orexin story, sleep and sleep disturbances

  2022cites this paper
• The Impact of Sleep Pattern in School/Work Performance During the COVID-19 Home Quarantine in Patients With Narcolepsy

  2022cites this paper
• The REM-sleep-related characteristics of narcolepsy: a nation-wide multicenter study in Turkey, the REMCON study.

  2022cites this paper
• Cardiovascular Burden of Narcolepsy Disease (CV-BOND): a real-world evidence study

  2022influential citation
• Intermediate hypocretin-1 cerebrospinal fluid levels and typical cataplexy: their significance in the diagnosis of narcolepsy type 1

  2022cites this paper
• Orexin 2 receptor–selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients

  2022cites this paper
• Approach to a sleepy child: Diagnosis and treatment of excessive daytime sleepiness in children and adolescents.

  2022cites this paper
• Narcolepsia na Infância: A Atuação Multidisciplinar com a Psicologia do Sono do Diagnóstico ao Tratamento em um Relato de Caso

  2022cites this paper
• Metabolic-Syndrome-Related Comorbidities in Narcolepsy Spectrum Disorders: A Preliminary Cross-Sectional Study in Japan

  2022cites this paper
• Clinical considerations for the diagnosis of idiopathic hypersomnia.

  2022cites this paper
• Comorbid parasomnias in narcolepsy and idiopathic hypersomnia: more REM than NREM parasomnias

  2022cites this paper
• Temporal distribution of sleep onset REM periods and N3 sleep in the MSLT and night polysomnogram of narcolepsy type 1 and other hypersomnias.

  2022cites this paper
• Disrupted nighttime sleep and sleep instability in narcolepsy

  2021cites this paper
• Hypersomnolence – etiologies

  2021cites this paper
• Review of Select Sleep Medicine Pharmacology: Treatments of Hypersomnias and Parasomnia

  2021cites this paper
• Reviewing the Clinical Implications of Treating Narcolepsy as an Autoimmune Disorder

  2021cites this paper
• Disorders of Excessive Sleepiness

  2021cites this paper
• The Swiss Primary Hypersomnolence and Narcolepsy Cohort study (SPHYNCS): Study protocol for a prospective, multicentre cohort observational study

  2021cites this paper
• Vitamin B12 deficiency is associated with narcolepsy.

  2021cites this paper
• Case report: early onset narcolepsy initially misdiagnosed as obstructive sleep apnea syndrome.

  2021cites this paper
• Sleep Neurology: A Comprehensive Guide to Basic and Clinical Aspects

  2021influential citation
• Pitolisant for the treatment of cataplexy in adults with narcolepsy

  2021cites this paper
• Stability of Nocturnal Wake and Sleep Stages Defines CNS Disorders of Hypersomnolence.

  2021cites this paper
• Induction of narcolepsy-like symptoms by orexin receptor antagonists in mice.

  2021cites this paper
• Defining Disrupted Nighttime Sleep and Assessing its Diagnostic Utility for Pediatric Narcolepsy Type 1.

  2020cites this paper
• Diagnosis of central disorders of hypersomnolence: A reappraisal by European experts.

  2020cites this paper
• Narcolepsy: the impact of aging, hypocretin deficiency, and years of formal education in olfactory function and abdominal obesity

  2020cites this paper
• Physiopathology of Narcolepsy and Other Central Hypersomnias

  2020cites this paper
• Genetics of Sleep and Sleep Disorders

  2020cites this paper
• Nocturnal Sleep Onset Rapid Eye Movement Sleep Periods as a Predictor of the Severity of Narcolepsy in Korea

  2020cites this paper
• Schlafstörungen bei neurologischen Erkrankungen

  2020influential citation
• Treatment of narcolepsy with natalizumab.

  2020cites this paper
• Neuroimaging in Narcolepsy and Idiopathic Hypersomnia: from Neural Correlates to Clinical Practice

  2020cites this paper
• Narcolepsy and Central Nervous System Hypersomnias

  2020cites this paper
• Sleep-Wake Disorders in Childhood.

  2020cites this paper
• Immunotherapy in Narcolepsy

  2020cites this paper
• The evolution of the narcolepsy concept in Russia: A historical view

  2020cites this paper
• COMMENTARY on Lammers et al, Diagnosis of central disorders of hypersomnolence: Challenges in defining central disorders of hypersomnolence.

  2020cites this paper
• Central Disorders of Hypersomnolence.

  2020cites this paper
• Hypocretin (Orexin): What It Does and How It Links With Narcolepsy and Food Choices

  2020cites this paper
• Association of Inattention, Hyperactivity, and Hypersomnolence in Two Clinic-Based Adult Cohorts

  2020cites this paper
• Multiple Sleep Latency Test/Maintenance of Wakefulness Test and Central Hypersomnias: Evolving Diagnostic and Therapeutic Approaches

  2020cites this paper
• Proteomic biomarkers of sleep apnea.

  2020cites this paper
• To split or to lump? Classifying the central disorders of hypersomnolence

  2020cites this paper
• Reply to Maski K et al. commentary on diagnosis of central disorders of hypersomnolence: Challenges in defining central disorders of hypersomnolence.

  2020cites this paper
• The influence of narcolepsy on olfactory function: a review.

  2020cites this paper
• Comparison of the macro and microstructure of sleep in a sample of sleep clinic hypersomnia cases

  2019cites this paper
• Hypocretin-deficient narcolepsy patients have abnormal brain activation during humor processing.

  2019cites this paper
• Management Of Excessive Sleepiness In Patients With Narcolepsy And OSA: Current Challenges And Future Prospects

  2019cites this paper
• Demographic and nap-related variance of the MSLT: results from 2,498 suspected hypersomnia patients: Clinical MSLT variance.

  2019cites this paper
• HPLC analysis of CSF hypocretin-1 in type 1 and 2 narcolepsy

  2019cites this paper
• Narkolepsie – mit Beachtung der Kataplexie als Differenzialdiagnose epileptischer Anfälle

  2019cites this paper
• Genetics of narcolepsy

  2019cites this paper
• Treatment of Excessive Daytime Sleepiness in Patients with Narcolepsy

  2019cites this paper
• [Psychogenically induced narcolepsy].

  2019cites this paper
• NSS_A_218402 241..252

  2019cites this paper
• Narcolepsy — clinical spectrum, aetiopathophysiology, diagnosis and treatment

  2019cites this paper
• Clinical neurophysiology of CNS hypersomnias.

  2019cites this paper
• Coexisting narcolepsy (with and without cataplexy) and multiple sclerosis Six new cases and a literature review

  2019cites this paper
• Validation of Multiple Sleep Latency Test for the diagnosis of pediatric narcolepsy type 1

  2019cites this paper
• Hypersomnia

  2018cites this paper