Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence

P. Kim,H. Nakano,Partha P. Das,Michael J. Chen,R. G. Rowe,Stephanie S. Chou,Samantha Ross,K. Sakamoto,L. Zon,T. Schlaeger,Stuart H. Orkin,A. Nakano,G. Daley

Published 2015 in Journal of Experimental Medicine

ABSTRACT

Kim et al. identify a novel shear stress–induced pathway involving protein kinase A, CREB, and bone morphogenetic protein that regulates hematopoietic stem cell generation in the embryonic aorta.

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