Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Clinical Investigation

• Publication date

  2001-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI12214PMID 11518728PMCID PMC209398
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999cited by this paper
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  1999cited by this paper
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  1999influential reference
• Effect of C-C chemokine receptor 2 (CCR2) knockout on type-2 (schistosomal antigen-elicited) pulmonary granuloma formation: analysis of cellular recruitment and cytokine responses.

  1999cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997influential reference
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  1997cited by this paper
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  1997cited by this paper
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  1996influential reference
• Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group.

  1996cited by this paper
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  1993influential reference
• Expression of monocyte chemoattractant protein 1 mRNA in human idiopathic pulmonary fibrosis.

  1992cited by this paper
• [Lung transplantation].

  1991influential reference
• HLA-class II antigen expression in human heart-lung allografts.

  1990cited by this paper

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