Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Biochemistry

• Publication date

  2011-07-05

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/bi200107nPMID 21630672PMCID PMC3658134
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differing views of the role of selenium in thioredoxin reductase

  2011cited by this paper
• Linked Thioredoxin-Glutathione Systems in Platyhelminth Parasites

  2010cited by this paper
• Mapping the Catalytic Cycle of Schistosoma mansoni Thioredoxin Glutathione Reductase by X-ray Crystallography*

  2010cited by this paper
• Thiol-disulfide exchange between glutaredoxin and glutathione.

  2010cited by this paper
• Focus on mammalian thioredoxin reductases--important selenoproteins with versatile functions.

  2009cited by this paper
• Mechanistic and Kinetic Details of Catalysis of Thiol-Disulfide Exchange by Glutaredoxins and Potential Mechanisms of Regulation

  2009cited by this paper
• Selenoproteins*

  2009cited by this paper
• Comparative modeling of thioredoxin glutathione reductase from Schistosoma mansoni: a multifunctional target for antischistosomal therapy.

  2009cited by this paper
• CUG Start Codon Generates Thioredoxin/Glutathione Reductase Isoforms in Mouse Testes*♦

  2009cited by this paper
• No selenium required: reactions catalyzed by mammalian thioredoxin reductase that are independent of a selenocysteine residue.

  2009cited by this paper
• Inhibition of Schistosoma mansoni Thioredoxin-glutathione Reductase by Auranofin

  2009cited by this paper
• Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.

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• Protein S-glutathionylation: a regulatory device from bacteria to humans.

  2009cited by this paper
• Structural aspects of the distinct biochemical properties of glutaredoxin 1 and glutaredoxin 2 from Saccharomyces cerevisiae.

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• Identification of oxadiazoles as new drug leads for the control of schistosomiasis

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  2008cited by this paper
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  2008cited by this paper
• Platyhelminth Mitochondrial and Cytosolic Redox Homeostasis Is Controlled by a Single Thioredoxin Glutathione Reductase and Dependent on Selenium and Glutathione*

  2008cited by this paper
• Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade

  2008cited by this paper
• Glutathione reductase and thioredoxin reductase at the crossroad: The structure of Schistosoma mansoni thioredoxin glutathione reductase

  2008cited by this paper
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  2008cited by this paper
• Acid-base catalysis in the mechanism of thioredoxin reductase from Drosophila melanogaster.

  2008cited by this paper
• Function of Glu-469' in the acid-base catalysis of thioredoxin reductase from Drosophila melanogaster.

  2008cited by this paper
• A study of the activity of 2-(alkylamino)-1-phenyl-1-ethanethiosulfuric acids against infection by Schistosoma mansoni in a murine model.

  2007cited by this paper
• Schistosomiasis Mansoni: Novel Chemotherapy Using a Cysteine Protease Inhibitor

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• Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

  2007cited by this paper
• Selenium in chemistry and biochemistry in comparison to sulfur

  2007cited by this paper
• Artemisinins for schistosomiasis and beyond.

  2007cited by this paper
• Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

  2007cited by this paper
• Identification of Acid-Base Catalytic Residues of High-Mr Thioredoxin Reductase from Plasmodium falciparum*

  2006cited by this paper
• Redox Balance Mechanisms in Schistosoma mansoni Rely on Peroxiredoxins and Albumin and Implicate Peroxiredoxins as Novel Drug Targets*

  2006cited by this paper
• Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds.

  2005cited by this paper
• Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase.

  2005cited by this paper
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  2004cited by this paper
• The thioredoxin system—From science to clinic

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• Biochemical Characterization of 2-Cys Peroxiredoxins from Schistosoma mansoni*

  2004cited by this paper
• Purification, characterization and kinetic properties of the multifunctional thioredoxin-glutathione reductase from Taenia crassiceps metacestode (cysticerci).

  2004cited by this paper
• The Mammalian Cytosolic Selenoenzyme Thioredoxin Reductase Reduces Ubiquinone

  2003cited by this paper
• The Mechanism of High Mr Thioredoxin Reductase from Drosophila melanogaster*

  2003cited by this paper
• Active sites of thioredoxin reductases: Why selenoproteins?

  2003cited by this paper
• The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase.

  2002cited by this paper
• Molecular and enzymatic characterisation of Schistosoma mansoni thioredoxin.

  2002cited by this paper
• Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems

  2001cited by this paper
• Thioredoxin reductase two modes of catalysis have evolved.

  2000cited by this paper
• Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence.

  2000cited by this paper
• Essential Role of Selenium in the Catalytic Activities of Mammalian Thioredoxin Reductase Revealed by Characterization of Recombinant Enzymes with Selenocysteine Mutations*

  2000cited by this paper
• Thioredoxin-thioredoxin reductase--a system that has come of age.

  2000cited by this paper
• Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5' untranslated region.

  2000cited by this paper
• Mixed disulfide with glutathione as an intermediate in the reaction catalyzed by glutathione reductase from yeast and as a major form of the enzyme in the cell.

  2000cited by this paper
• AhpF and other NADH:peroxiredoxin oxidoreductases, homologues of low Mr thioredoxin reductase.

  2000cited by this paper
• Aurothioglucose inhibits murine thioredoxin reductase activity in vivo.

  1999cited by this paper
• High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes.

  1999cited by this paper
• Thioredoxin reductase from Plasmodium falciparum: evidence for interaction between the C-terminal cysteine residues and the active site disulfide-dithiol.

  1999cited by this paper
• Preparation and assay of mammalian thioredoxin and thioredoxin reductase.

  1999cited by this paper
• Human Placenta Thioredoxin Reductase

  1998cited by this paper
• Reactivity of the human thioltransferase (glutaredoxin) C7S, C25S, C78S, C82S mutant and NMR solution structure of its glutathionyl mixed disulfide intermediate reflect catalytic specificity.

  1998cited by this paper
• The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli.

  1997cited by this paper
• Glutaredoxin.

  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• Drug resistance in schistosomes.

  1993cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1983cited by this paper
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  1981cited by this paper

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  2023cites this paper
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