Protective mechanisms of helminths against reactive oxygen species are highly promising drug targets.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Current Medicinal Chemistry

• Publication date

  2014-05-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.2174/0929867320666131119122907PMID 24251574
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Natural Products as a Source for Treating Neglected Parasitic Diseases

  2013cited by this paper
• Glutathione peroxidases.

  2013cited by this paper
• Characterization and comparative analysis of the complete Haemonchus contortus β-tubulin gene family and implications for benzimidazole resistance in strongylid nematodes.

  2013cited by this paper
• A selective inhibitor of heme biosynthesis in endosymbiotic bacteria elicits antifilarial activity in vitro.

  2013cited by this paper
• An Update on Redox Biology of Parasites

  2013cited by this paper
• Systematic Review and Meta-Analysis of Artemisinin Based Therapies for the Treatment and Prevention of Schistosomiasis

  2012cited by this paper
• Neurocysticercosis: Neglected but Not Forgotten

  2012cited by this paper
• Immunopathogenesis of lymphatic filarial disease

  2012cited by this paper
• Schistosomiasis and bladder cancer: similarities and differences from urothelial cancer

  2012cited by this paper
• Neglected tropical diseases: diagnosis, clinical management, treatment and control.

  2012cited by this paper
• Ups and downs of RNA interference in parasitic nematodes.

  2012cited by this paper
• The redox biology of schistosome parasites and applications for drug development.

  2012cited by this paper
• The biological roles of glutaredoxins.

  2012cited by this paper
• Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen.

  2012cited by this paper
• Future prospects and challenges of vaccines against filariasis

  2012cited by this paper
• The onchocerciasis chronicle: from the beginning to the end?

  2012cited by this paper
• Neurocysticercosis: A Review

  2012cited by this paper
• Oxidative Stress and Antioxidant Defense

  2012cited by this paper
• An inconvenient truth: global worming and anthelmintic resistance.

  2012cited by this paper
• Concurrence of dermatological and ophthalmological morbidity in onchocerciasis.

  2012cited by this paper
• The development of RNA interference (RNAi) in gastrointestinal nematodes

  2012cited by this paper
• Functional characterization and immune recognition of the extracellular superoxide dismutase from the human pathogenic parasite Onchocerca volvulus (OvEC-SOD).

  2012cited by this paper
• A Research Agenda for Helminth Diseases of Humans: Intervention for Control and Elimination

  2012cited by this paper
• Immunomodulatory activity of diethylcarbamazine on humoral, cellular cytokine response and respiratory burst in BALB/c mice

  2012cited by this paper
• Medicinal Plants: A Source of Anti-Parasitic Secondary Metabolites

  2012cited by this paper
• Current status of food-borne trematode infections

  2012cited by this paper
• A Research Agenda for Helminth Diseases of Humans: The Problem of Helminthiases

  2012cited by this paper
• An eye on RNAi in nematode parasites.

  2011cited by this paper
• Advances in helminth immunology: optimism for future vaccine design?

  2011cited by this paper
• Nucleic acid transfection and transgenesis in parasitic nematodes

  2011cited by this paper
• Structural and functional characterization of Schistosoma mansoni Thioredoxin

  2011cited by this paper
• TRP channels in parasites.

  2011cited by this paper
• Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans

  2011cited by this paper
• Establishing Transgenic Schistosomes

  2011cited by this paper
• Crystal structure of Cu / Zn superoxide dismutase from Taenia solium reveals metal‐mediated self‐assembly

  2011cited by this paper
• Expression and characterization of Cu/Zn superoxide dismutase from Wuchereria bancrofti

  2011cited by this paper
• Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni.

  2011cited by this paper
• Novel inhibitors to Taenia solium Cu/Zn superoxide dismutase identified by virtual screening

  2011cited by this paper
• Unresolved issues in anthelmintic pharmacology for helminthiases of humans.

  2010cited by this paper
• Elimination of lymphatic filariasis: do we have the drugs to complete the job?

  2010cited by this paper
• A High-Throughput 1,536-Well Luminescence Assay for Glutathione S-Transferase Activity

  2010cited by this paper
• Redox compartmentalization and cellular stress

  2010cited by this paper
• Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon

  2010cited by this paper
• Thioredoxin and thioredoxin reductase: current research with special reference to human disease.

  2010cited by this paper
• Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: randomized, exploratory open-label trial.

  2010cited by this paper
• In vitro activity of Cameroonian and Ghanaian medicinal plants on parasitic (Onchocerca ochengi) and free-living (Caenorhabditis elegans) nematodes

  2010cited by this paper
• Peroxiredoxin: a central player in immune modulation

  2010cited by this paper
• The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells.

  2010cited by this paper
• Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi

  2010cited by this paper
• Lymphatic filariasis and onchocerciasis.

  2010cited by this paper
• Peroxiredoxin-1 from Schistosoma japonicum functions as a scavenger against hydrogen peroxide but not nitric oxide.

  2009cited by this paper
• A Novel Biological Activity of Praziquantel Requiring Voltage-Operated Ca2+ Channel β Subunits: Subversion of Flatworm Regenerative Polarity

  2009cited by this paper
• Is the oxidative stress theory of aging dead?

  2009cited by this paper
• Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology.

  2009cited by this paper
• Enzymatic antioxidant systems in helminth parasites

  2009cited by this paper
• Identifying sub-optimal responses to ivermectin in the treatment of River Blindness

  2009cited by this paper
• Increased expression of ABC transport proteins is associated with ivermectin resistance in the model nematode Caenorhabditis elegans.

  2009cited by this paper
• Proteolytic degradation of hemoglobin in the intestine of the human hookworm Necator americanus.

  2009cited by this paper
• Redox-based regulation of signal transduction: principles, pitfalls, and promises.

  2008cited by this paper
• Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus.

  2008cited by this paper
• The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products.

  2008cited by this paper
• Stage- and Gender-Specific Proteomic Analysis of Brugia malayi Excretory-Secretory Products

  2008cited by this paper
• The Global Programme to Eliminate Lymphatic Filariasis: Health Impact after 8 Years

  2008cited by this paper
• Helminth 2‐Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages

  2008cited by this paper
• The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms

  2008cited by this paper
• Helminth infections: the great neglected tropical diseases.

  2008cited by this paper
• Oxidative stress in Caenorhabditis elegans: protective effects of the Omega class glutathione transferase (GSTO‐1)

  2008cited by this paper
• Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis.

  2008cited by this paper
• Redox Regulation of Cell Survival

  2008cited by this paper
• Multivalent anthelminthic vaccine to prevent hookworm and schistosomiasis

  2008cited by this paper
• Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis.

  2008cited by this paper
• Identification of oxadiazoles as new drug leads for the control of schistosomiasis

  2008cited by this paper
• Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

  2007cited by this paper
• Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

  2007cited by this paper
• Free radicals and antioxidants in normal physiological functions and human disease.

  2007cited by this paper
• Markers for benzimidazole resistance in human parasitic nematodes?

  2007cited by this paper
• Foreword: Towards markers for anthelmintic resistance in helminths of importance in animal and human health

  2007cited by this paper
• Target assessment for antiparasitic drug discovery.

  2007cited by this paper
• Drug discovery and development for neglected parasitic diseases

  2006cited by this paper
• Using Caenorhabditis elegans for functional analysis of genes of parasitic nematodes.

  2006cited by this paper
• Design of potent inhibitors for Schistosoma japonica glutathione S-transferase.

  2006cited by this paper
• A modified larval migration assay for detection of resistance to macrocyclic lactones in Haemonchus contortus, and drug screening with Trichostrongylidae parasites.

  2006cited by this paper
• Glutathione transferases in the genomics era: new insights and perspectives.

  2006cited by this paper
• Activation of superoxide dismutases: putting the metal to the pedal.

  2006cited by this paper
• Role of Thioredoxin in Cell Growth Through Interactions with Signaling Molecules

  2006cited by this paper
• MOLECULAR CLONING AND CHARACTERIZATION OF A 2-CYS PEROXIREDOXIN FROM TAENIA SOLIUM

  2006cited by this paper
• Opportunities and Challenges in Antiparasitic Drug Discovery

  2005cited by this paper
• Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling.

  2005cited by this paper
• Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate.

  2005cited by this paper
• Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics

  2005cited by this paper
• Mammalian Selenoprotein Thioredoxin-glutathione Reductase

  2005cited by this paper
• Glutathione transferases.

  2005cited by this paper
• X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site.

  2005cited by this paper
• Structure of the Major Cytosolic Glutathione S-Transferase from the Parasitic Nematode Onchocerca volvulus*

  2005cited by this paper
• Control of Taenia solium taeniasis/cysticercosis: from research towards implementation.

  2005cited by this paper
• Functional Expression of a Recombinant Copper/Zinc Superoxide Dismutase of Filarial Nematode, Brugia malayi

  2005cited by this paper
• The changing landscape of antiparasitic drug discovery for veterinary medicine.

  2004cited by this paper
• Nucleic Acid Vaccination with Schistosoma mansoni Antioxidant Enzyme Cytosolic Superoxide Dismutase and the Structural Protein Filamin Confers Protection against the Adult Worm Stage

  2004cited by this paper
• Biochemical Characterization of 2-Cys Peroxiredoxins from Schistosoma mansoni*

  2004cited by this paper
• Structure of the cytosolic Cu,Zn superoxide dismutase from Schistosoma mansoni.

  2004cited by this paper

• Moniezia benedeni infected Zaraibi (Egyptian Nubian) goats: Insights into serum biochemical changes, redox imbalance, and molecular mechanisms of oxidative-inflammatory cascades mediated intestinal injury.

  2025cites this paper
• Helminth-derived molecules: Pathogenic and pharmacopeial roles

  2024cites this paper
• Taenia solium cysticerci's extracellular vesicles Attenuate the AKT/mTORC1 pathway for Alleviating DSS‐induced colitis in a murine model

  2024cites this paper
• Recent Advances in Anti-Schistosomiasis Drug Discovery

  2023cites this paper
• Immunological and Biochemical Interplay between Cytokines, Oxidative Stress and Schistosomiasis

  2021cites this paper
• The Untapped Pharmacopeic Potential of Helminths.

  2018cites this paper
• Role of Polyamines in Parasite Cell Architecture and Function.

  2017cites this paper
• Comparative proteomics of hydatid fluids from two Echinococcus multilocularis isolates.

  2017cites this paper
• Evaluation of false positive results in microbial inhibitor tests for screening antibiotics in goat milk

  2016cites this paper
• Harnessing the Helminth Secretome for Therapeutic Immunomodulators

  2014cites this paper