TCR Comodulation of Nonengaged TCR Takes Place by a Protein Kinase C and CD3γ Di-Leucine-Based Motif-Dependent Mechanism 1

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Immunology

• Publication date

  2003-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.171.6.3003PMID 12960325
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000influential reference
• Dissection of the Role of CD3γ Chains in Profound but Reversible T‐Cell Receptor Down‐regulation

  2000cited by this paper
• Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe.

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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998influential reference
• Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells.

  1998cited by this paper
• A receptor/cytoskeletal movement triggered by costimulation during T cell activation.

  1998cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Indications for carotid artery stenting: a preview of the potential derived from early clinical experience.

  1996cited by this paper
• Evidence for multivalent structure of T-cell antigen receptor complex.

  1995cited by this paper
• Serial triggering of many T-cell receptors by a few peptide–MHC complexes

  1995influential reference
• CD3 gamma contains a phosphoserine‐dependent di‐leucine motif involved in down‐regulation of the T cell receptor.

  1994cited by this paper
• Structure of the T cell receptor in a Ti alpha V beta 2, alpha V beta 8-positive T cell line.

  1994cited by this paper
• Structure of the T cell receptor in a TiαVβ2,αVβ8‐positive T cell line

  1994influential reference
• Structure of the T‐Cell Receptor in a Tiαβ, Tiγδ Double Positive T‐Cell Line

  1993cited by this paper
• Transmembrane signalling through the T-cell-receptor-CD3 complex.

  1993cited by this paper
• Failure to synthesize the CD3-gamma chain. Consequences for T cell antigen receptor assembly, processing, and expression.

  1992cited by this paper
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  1992cited by this paper
• Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T‐cell antigen receptor.

  1991cited by this paper
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  1990cited by this paper
• Chapter 4 Architectural Editing: Regulating the Surface Expression of the Multicomponent T-Cell Antigen Receptor

  1990cited by this paper
• Structural mutation affecting intracellular transport and cell surface expression of murine class II molecules

  1988cited by this paper
• Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes

  1987cited by this paper
• Internalization and cycling of the T cell antigen receptor. Role of protein kinase C.

  1987cited by this paper
• Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes.

  1987cited by this paper
• Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes.

  1987cited by this paper
• Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation

  1987cited by this paper
• Transfer of specificity by murine α and β T-cell receptor genes

  1986cited by this paper
• Transfer of specificity by murine alpha and beta T-cell receptor genes.

  1986cited by this paper
• The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype

  1984cited by this paper
• The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody

  1983cited by this paper
• The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product

  1983cited by this paper

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  2022cites this paper
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  2020cites this paper
• Orchestration of Immunological Synapse Assembly by Vesicular Trafficking

  2019cites this paper
• On the role of receptor downregulation and costimulation in shaping the T cell response

  2018influential citation
• β‐arrestin‐1 mediates the TCR‐triggered re‐routing of distal receptors to the immunological synapse by a PKC‐mediated mechanism

  2014cites this paper
• The Serial Engagement Model 17 Years After: From TCR Triggering to Immunotherapy

  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
• TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

  2010cites this paper
• The SCHOOL of nature: I. Transmembrane signaling.

  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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