Emerging roles for orphan G-protein-coupled receptors in the cardiovascular system.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  TIPS - Trends in Pharmacological Sciences

• Publication date

  2002-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0165-6147(02)00007-XPMID 12498728
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Proteomics in drug discovery.

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  2000cited by this paper
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  2000cited by this paper
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• Identification and Characterization of Two Neuromedin U Receptors Differentially Expressed in Peripheral Tissues and the Central Nervous System*

  2000influential reference
• TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus

  1999cited by this paper
• Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.

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• Receptor for motilin identified in the human gastrointestinal system.

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  1999influential reference
• Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14

  1999influential reference
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• Proteomics in drug discovery.

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• A prolactin-releasing peptide in the brain

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• Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

  1998influential reference
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  1997influential reference
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  1995influential reference
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  1995cited by this paper
• Epigenesis: The Missing Beat in Biotechnology?

  1994cited by this paper
• Release of motilin by oral and intravenous nutrients in man.

  1979influential reference
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  1975cited by this paper

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