Serotonin receptors of type 6 (5-HT6): what can we expect from them?

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Current Medicinal Chemistry

• Publication date

  2011-05-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/092986711796011283PMID 21649582
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats

  2011cited by this paper
• E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat

  2011cited by this paper
• Physical Interaction of Jab1 with Human Serotonin 6 G-protein-coupled Receptor and Their Possible Roles in Cell Survival*

  2010cited by this paper
• Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

  2010cited by this paper
• 5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists.

  2010cited by this paper
• 5-HT6 receptor antagonists as potential therapeutics for cognitive impairment.

  2010cited by this paper
• Serotonin, genetic variability, behaviour, and psychiatric disorders - a review

  2010cited by this paper
• Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis.

  2010cited by this paper
• Signalling pathways associated with 5-HT6 receptors: relevance for cognitive effects.

  2010cited by this paper
• 5-HT6 antagonism attenuates cue-induced relapse to cocaine seeking without affecting cocaine reinforcement.

  2010cited by this paper
• The medicinal chemistry of 5-HT6 receptor ligands with a focus on arylsulfonyltryptamine analogs.

  2010cited by this paper
• Synthesis and SAR of tolylamine 5-HT6 antagonists.

  2009cited by this paper
• Role of peripheral and spinal 5-HT6 receptors according to the rat formalin test.

  2009cited by this paper
• The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer’s disease

  2009cited by this paper
• Advances in the design of 5-HT6 receptor ligands with therapeutic potential.

  2009cited by this paper
• Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists.

  2009cited by this paper
• 1-Sulfonylindazoles as potent and selective 5-HT6 ligands.

  2009cited by this paper
• Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists.

  2009cited by this paper
• Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6

  2009cited by this paper
• Pharmacological targeting of the serotonergic system for the treatment of obesity

  2009cited by this paper
• Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved

  2009cited by this paper
• Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts.

  2009cited by this paper
• Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists.

  2009cited by this paper
• Selective 5-HT6 Receptor Blockade Improves Spatial Recognition Memory and Reverses Age-Related Deficits in Spatial Recognition Memory in the Mouse

  2009cited by this paper
• Identification of a series of benzoxazoles as potent 5-HT6 ligands.

  2009cited by this paper
• Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer's disease.

  2009cited by this paper
• Male specific association between the 5-HTR6 gene 267C/T SNP and suicide in the Portuguese population.

  2009cited by this paper
• Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands.

  2009cited by this paper
• 5‐HT6 antagonists as potential treatment for cognitive dysfunction

  2009cited by this paper
• Reinforcing, rewarding and dopamine-stimulant properties of the 5-HT6 receptor agonist ST1936: the first member of a new class of psychostimulant?

  2009cited by this paper
• 5-HT1A/1B, 5-HT6, and 5-HT7 serotonergic receptors recruitment in tonic-clonic seizure-induced antinociception: role of dorsal raphe nucleus.

  2009cited by this paper
• Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus.

  2009cited by this paper
• A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands.

  2008cited by this paper
• Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht6 receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task

  2008cited by this paper
• Tricyclic azepine derivatives as selective brain penetrant 5-HT6 receptor antagonists.

  2008cited by this paper
• 5-HT6/7 Receptor Antagonists Facilitate Dopamine Release in the Cochlea via a GABAergic Disinhibitory Mechanism

  2008cited by this paper
• Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats.

  2008cited by this paper
• The selective 5-HT(6) receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats.

  2008cited by this paper
• Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease.

  2008cited by this paper
• 5-HT6 receptor antagonist reversal of emotional learning and prepulse inhibition deficits induced by apomorphine or scopolamine.

  2008cited by this paper
• Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466

  2008cited by this paper
• Functional interaction between 5-HT(6) receptors and hypothalamic-pituitary-adrenal axis: cognitive implications.

  2008cited by this paper
• Prefrontal executive function and D1, D3, 5-HT2A and 5-HT6 receptor gene variations in healthy adults.

  2008cited by this paper
• Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease.

  2008cited by this paper
• Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders.

  2008cited by this paper
• A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory

  2008cited by this paper
• Functional human 5-HT6 receptor assay for high throughput screening of chemical ligands and binding proteins.

  2008cited by this paper
• Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies.

  2008cited by this paper
• Design, synthesis and preliminary screening of novel 3-(2-N,N-dimethylaminoethylthio) indole derivatives as potential 5-HT6 receptor ligands

  2008cited by this paper
• Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor.

  2008cited by this paper
• Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.

  2008cited by this paper
• 5-HT6 receptor antagonists: prospects for the treatment of cognitive disorders including dementia.

  2008cited by this paper
• An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function.

  2008cited by this paper
• Actions of novel agonists, antagonists and antipsychotic agents at recombinant rat 5-HT6 receptors: a comparative study of coupling to G alpha s.

  2008cited by this paper
• Synthesis of 3-(2-N,N-diethylaminoethoxy)indoles as potential 5-HT6 receptor ligands.

  2008cited by this paper
• The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801.

  2008cited by this paper
• 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer’s disease

  2008cited by this paper
• Effects of 5‐HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat

  2008cited by this paper
• Indene-based scaffolds. Design and synthesis of novel serotonin 5-HT6 receptor ligands.

  2008cited by this paper
• The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats.

  2008cited by this paper
• Increased expression of 5-HT6 receptors in the nucleus accumbens blocks the rewarding but not psychomotor activating properties of cocaine.

  2008cited by this paper
• A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning and memory.

  2008cited by this paper
• New Serotonin 5-HT6 Ligands from Common Feature Pharmacophore Hypotheses

  2008cited by this paper
• Reversal of Subchronic PCP-Induced Deficits in Attentional Set Shifting in Rats by Sertindole and a 5-HT6 Receptor Antagonist: Comparison Among Antipsychotics

  2008cited by this paper
• Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression.

  2007cited by this paper
• 5-HT6 receptor antagonist SB-399885 potentiates haloperidol and risperidone-induced dopamine efflux in the medial prefrontal cortex or hippocampus.

  2007cited by this paper
• Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats

  2007cited by this paper
• Study into a possible mechanism responsible for the antidepressant-like activity of the selective 5-HT6 receptor antagonist SB-399885 in rats.

  2007cited by this paper
• Biochemical and Behavioral Evidence for Antidepressant-Like Effects of 5-HT6 Receptor Stimulation

  2007cited by this paper
• Acute onset by 5-HT(6)-receptor activation on rat brain brain-derived neurotrophic factor and activity-regulated cytoskeletal-associated protein mRNA expression.

  2007cited by this paper
• Pro-cognitive effects of 5-HT6 receptor antagonists in the social recognition procedure in rats: implication of the frontal cortex

  2007cited by this paper
• Endogenous Serotonin Excites Striatal Cholinergic Interneurons via the Activation of 5-HT 2C, 5-HT6, and 5-HT7 Serotonin Receptors: Implications for Extrapyramidal Side Effects of Serotonin Reuptake Inhibitors

  2007cited by this paper
• Memory consolidation and amnesia modify 5-HT6 receptors expression in rat brain: an autoradiographic study.

  2007cited by this paper
• Social isolation and expression of serotonergic neurotransmission‐related genes in several brain areas of male mice

  2007cited by this paper
• Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist.

  2007cited by this paper
• Increased Expression of 5-HT6 Receptors in the Rat Dorsomedial Striatum Impairs Instrumental Learning

  2007cited by this paper
• Effects of the novel 5-HT(6) receptor antagonist RO4368554 in rat models for cognition and sensorimotor gating.

  2007cited by this paper
• The Novel Cellular Mechanism of Human 5-HT6 Receptor through an Interaction with Fyn*

  2007cited by this paper
• Efficacy of selective 5‐HT6 receptor ligands determined by monitoring 5‐HT6 receptor‐mediated cAMP signaling pathways

  2006cited by this paper
• Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors.

  2006cited by this paper
• Quantitative mapping shows that serotonin rather than dopamine receptor mRNA expressions are affected after repeated intermittent administration of MDMA in rat brain.

  2006cited by this paper
• SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.

  2006cited by this paper
• Physical Characterization of Anhydrous and Hydrous Forms of the Hydrochloride Salt of BVT.5182 A Novel 5-HT6 Receptor Antagonist

  2006cited by this paper
• Lack of localization of 5‐HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5‐HT6 receptor‐mediated acetylcholine release

  2006cited by this paper
• Structure-brain exposure relationships.

  2006cited by this paper
• Medicinal chemistry strategies to 5-HT(6) receptor ligands as potential cognitive enhancers and antiobesity agents.

  2006cited by this paper
• Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients

  2006cited by this paper
• Chronic 5‐HT6 receptor modulation by E‐6837 induces hypophagia and sustained weight loss in diet‐induced obese rats

  2006cited by this paper
• Expression of mRNA for multiple serotonin (5-HT) receptor types/subtypes by the peripheral blood mononuclear cells of rhesus macaques.

  2006cited by this paper
• A Null Mutation of the Serotonin 6 Receptor Alters Acute Responses to Ethanol

  2006cited by this paper
• Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity

  2005cited by this paper
• The Selective 5-HT6 Receptor Antagonist Ro4368554 Restores Memory Performance in Cholinergic and Serotonergic Models of Memory Deficiency in the Rat

  2005cited by this paper
• Molecular analysis of the interaction between the intracellular loops of the human serotonin receptor type 6 (5-HT6) and the alpha subunit of GS protein.

  2005cited by this paper
• Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.

  2005cited by this paper
• Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.

  2005cited by this paper
• 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.

  2005cited by this paper
• Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists.

  2005cited by this paper
• 5-HT6 receptor antagonists improve performance in an attentional set shifting task in rats

  2005cited by this paper
• Association between the 5‐HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder

  2005cited by this paper
• Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task.

  2005cited by this paper

• Unraveling the Involvement of Serotonergic 5-Hydroxytryptamine Receptor-6 Activation in Chronic Pain: A Narrative Review

  2025cites this paper
• Distribution of 5-HT receptors in the central nervous system: an update

  2020cites this paper
• Effects of 5-hydroxytryptamine Receptor on the Reaction of the Lower Esophageal Sphincter Under the Electrical Field Stimulation

  2020cites this paper
• Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry

  2018cites this paper
• SNX14 is a bifunctional negative regulator for neuronal 5‐HT6 receptor signaling

  2015cites this paper
• Effects of ST1936, a selective serotonin-6 agonist, on electrical activity of putative mesencephalic dopaminergic neurons in the rat brain

  2015cites this paper
• Antagonists of Serotonin 5-HT6 Receptors. VI. Substituted 3-(Phenylsulfonyl)Quinolines, Synthesis and Structure–Activity Relationships

  2015cites this paper
• Sulfonyl-containing modulators of serotonin receptors and their pharmacophore models

  2014cites this paper
• Expression of serotonin receptors in human lower esophageal sphincter

  2014cites this paper
• Neurotransmitters and Memory

  2014cites this paper
• Direct Interaction and Functional Coupling between Human 5-HT6 Receptor and the Light Chain 1 Subunit of the Microtubule-Associated Protein 1B (MAP1B-LC1)

  2014cites this paper
• Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-НТ6 receptors.

  2013cites this paper
• Withdrawal Symptoms and Rebound Syndromes Associated with Switching and Discontinuing Atypical Antipsychotics: Theoretical Background and Practical Recommendations

  2013cites this paper
• 5-HT6 receptors and Alzheimer's disease

  2013cites this paper
• Serotonin receptor of type 6 (5-HT6) in human prefrontal cortex and hippocampus post-mortem: an immunohistochemical and immunofluorescence study.

  2013cites this paper
• Serotonin receptors of type 6 (5-HT6): from neuroscience to clinical pharmacology.

  2013cites this paper
• 5HT6 receptor antagonists: a patent update. Part 1. Sulfonyl derivatives

  2012cites this paper
• Translational Evaluation of JNJ-18038683, a 5-Hydroxytryptamine Type 7 Receptor Antagonist, on Rapid Eye Movement Sleep and in Major Depressive Disorder

  2012cites this paper
• Distribution of Serotonin Receptor of Type 6 (5-HT6) in Human Brain Post-mortem. A Pharmacology, Autoradiography and Immunohistochemistry Study

  2012cites this paper
• Serotonergic mechanisms as targets for existing and novel antipsychotics.

  2012cites this paper
• REM sleep and in major depressive disorder

  2012cites this paper
• Benzenesulfonyl and Benzenesulfonamide as Modulators of the 5-HT6 Receptor: Patent Highlight.

  2012cites this paper
• Translational evaluation of JNJ-18038683, a 5-HT7 receptor antagonist, on REM sleep and in major depressive disorder

  2012cites this paper
• The Serotonin-6 Receptor as a Novel Therapeutic Target

  2011cites this paper