Negative regulation of cytokine signaling

Cytokines use complex signaling cascades to elicit their biological effects, many of which involve phosphorylation as a mechanism of activation. Rapid and efficient attenuation of cytokine signals is crucial to maintaining regulation of these processes and to preventing toxic side effects. Phosphatases have been shown to be involved in these regulatory processes, but more recent research has seen the discovery of two new families of negative regulators, the suppressor of cytokine signaling (SOCS) and protein inhibitors of signal transducer and activator of transcription (STAT) (PIAS) protein families. SOCS proteins are induced by and inhibit many cytokine‐signaling systems in a classic negative‐feedback loop, and the generation of transgenic and knockout models has greatly increased our understanding of their physiological functions. PIAS proteins interact with the transcriptional mediators of cytokine action, the STATs, to suppress their DNA‐binding activity. These three classes of molecules form what is now emerging as an integrated system for deactivating cytokine signaling at a number of levels, from the receptor to the transcription factor.

• Publication year

  2001

• Venue

  Journal of Leukocyte Biology

• Publication date

  2001-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1189/jlb.70.3.348PMID 11527983
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Arginine Methylation of STAT1 Modulates IFNα/β-Induced Transcription

  2001cited by this paper
• Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3).

  2001cited by this paper
• Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling.

  2001cited by this paper
• Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription.

  2001cited by this paper
• CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

  2001cited by this paper
• Signal Transducer and Activator of Transcription (Stat)-Induced Stat Inhibitor 1 (Ssi-1)/Suppressor of Cytokine Signaling 1 (Socs1) Inhibits Insulin Signal Transduction Pathway through Modulating Insulin Receptor Substrate 1 (Irs-1) Phosphorylation

  2001cited by this paper
• Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor.

  2000influential reference
• The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function.

  2000cited by this paper
• Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction.

  2000cited by this paper
• Defective Thymocyte Development and Perturbed Homeostasis of T cells in STAT-Induced STAT Inhibitor-1/Suppressors of Cytokine Signaling-1 Transgenic Mice1

  2000cited by this paper
• Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor

  2000cited by this paper
• CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2*

  2000cited by this paper
• SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling*

  2000cited by this paper
• Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines.

  2000cited by this paper
• Role of the Cytokine-inducible SH2 Protein CIS in Desensitization of STAT5b Signaling by Continuous Growth Hormone*

  2000cited by this paper
• Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling.

  2000cited by this paper
• Role of the Suppressor of Cytokine Signaling-3 in Mediating the Inhibitory Effects of Interleukin-1β on the Growth Hormone-dependent Transcription of the Acid-labile Subunit Gene in Liver Cells*

  2000influential reference
• IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3.

  2000influential reference
• Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130.

  2000cited by this paper
• Interferon-alpha directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1.

  2000cited by this paper
• Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts.

  2000cited by this paper
• Gigantism in mice lacking suppressor of cytokine signalling-2

  2000cited by this paper
• Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and SOCS-3 in FRTL-5 thyroid cells.

  2000cited by this paper
• IL‐10 attenuates IFN‐α‐activated STAT1 in the liver: involvement of SOCS2 and SOCS3

  2000cited by this paper
• A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer

  2000cited by this paper
• SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

  1999cited by this paper
• Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL‐6 signal transduction

  1999influential reference
• The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.

  1999cited by this paper
• Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction.

  1999cited by this paper
• SOCS-3 Is Tyrosine Phosphorylated in Response to Interleukin-2 and Suppresses STAT5 Phosphorylation and Lymphocyte Proliferation

  1999influential reference
• SOCS-1, -2, -3: selective targets and functions downstream of the prolactin receptor.

  1999cited by this paper
• Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.

  1999cited by this paper
• Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo.

  1999cited by this paper
• SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.

  1999cited by this paper
• SOCS3 is essential in the regulation of fetal liver erythropoiesis.

  1999cited by this paper
• SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

  1999cited by this paper
• Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma.

  1999cited by this paper
• Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice.

  1999influential reference
• Growth hormone regulation of SOCS-2, SOCS-3, and CIS messenger ribonucleic acid expression in the rat.

  1999cited by this paper
• Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues

  1999cited by this paper
• SOCS/CIS Protein Inhibition of Growth Hormone-stimulated STAT5 Signaling by Multiple Mechanisms*

  1999cited by this paper
• Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation.

  1999influential reference
• CIS Associates with the Interleukin-2 Receptor β Chain and Inhibits Interleukin-2-dependent Signaling*

  1999cited by this paper
• Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice

  1999cited by this paper
• Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins.

  1999cited by this paper
• Inhibition and Restoration of Prolactin Signal Transduction by Suppressors of Cytokine Signaling*

  1999cited by this paper
• The Role of SOCS-3 in Leptin Signaling and Leptin Resistance*

  1999cited by this paper
• Endotoxin-Induced Inhibition of Growth Hormone Receptor Signaling in Rat Liver in Vivo1.

  1999cited by this paper
• Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis.

  1999cited by this paper
• Normal growth and development in the absence of hepatic insulin-like growth factor I.

  1999influential reference
• Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor.

  1999influential reference
• Cis desensitizes GH induced Stat5 signaling in rat liver cells.

  1999cited by this paper
• Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction.

  1999cited by this paper
• Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1

  1999cited by this paper
• Activation of SOCS-3 Messenger Ribonucleic Acid in the Hypothalamus by Ciliary Neurotrophic Factor.

  1999cited by this paper
• The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.

  1998cited by this paper
• Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice.

  1998cited by this paper
• Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.

  1998cited by this paper
• Signaling by the Cytokine Receptor Superfamily a

  1998cited by this paper
• Interaction of Human Suppressor of Cytokine Signaling (SOCS)-2 with the Insulin-like Growth Factor-I Receptor*

  1998influential reference
• Twenty proteins containing a C-terminal SOCS box form five structural classes.

  1998cited by this paper
• Growth Hormone Preferentially Induces the Rapid, Transient Expression of SOCS-3, a Novel Inhibitor of Cytokine Receptor Signaling*

  1998influential reference
• Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling.

  1998cited by this paper
• Inhibition of Stat1-mediated gene activation by PIAS1.

  1998cited by this paper
• Identification of SOCS-3 as a potential mediator of central leptin resistance.

  1998cited by this paper
• Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

  1998cited by this paper
• The Suppressor of Cytokine Signaling (SOCS) 1 and SOCS3 but Not SOCS2 Proteins Inhibit Interferon-mediated Antiviral and Antiproliferative Activities*

  1998influential reference
• Cloning and characterization of novel CIS family genes.

  1997influential reference
• Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction.

  1997cited by this paper
• Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.

  1997cited by this paper
• CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation.

  1997cited by this paper
• Stat5a is mandatory for adult mammary gland development and lactogenesis.

  1997cited by this paper
• Specific inhibition of Stat3 signal transduction by PIAS3.

  1997cited by this paper
• A new protein containing an SH2 domain that inhibits JAK kinases

  1997cited by this paper
• A family of cytokine-inducible inhibitors of signalling

  1997influential reference
• DNA-binding antibodies from viable motheaten mutant mice: implications for B cell tolerance.

  1997cited by this paper
• Structure and function of a new STAT-induced STAT inhibitor

  1997influential reference
• A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs.

  1997cited by this paper
• Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression.

  1997cited by this paper
• Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1

  1996cited by this paper
• Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1

  1996cited by this paper
• Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding proteins by tumor necrosis factor.

  1995cited by this paper
• Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites.

  1995cited by this paper
• A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors.

  1995influential reference
• Alterations in hepatic production and peripheral clearance of IGF-I after endotoxin.

  1995cited by this paper
• Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1

  1995cited by this paper
• Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis.

  1995cited by this paper
• Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.

  1995influential reference
• The viable motheaten (mev) mouse--a new model for arthritis.

  1994cited by this paper
• Negative regulation of early B lymphopoiesis by interleukin 3 and interleukin 1 alpha.

  1994cited by this paper
• Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

  1993cited by this paper
• Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.

  1993cited by this paper
• Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis.

  1993cited by this paper
• Interleukin-10.

  1993cited by this paper
• IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

  1992cited by this paper
• Secretory rhythm of growth hormone regulates sexual differentiation of mouse liver.

  1984cited by this paper
• Can interferon induce disease?

  1982cited by this paper
• Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice.

  1981cited by this paper

• Exposure to Bisphenol-A increases susceptibility to Trypanosoma cruzi infection.

  2025cites this paper
• Exploring retinoic acid-induced skin irritation: Pathological and mechanistic insights from an ex vivo porcine skin model

  2025cites this paper
• Syringic Acid in Canarium odontophyllum for Diabetes and Obesity – A Review

  2025cites this paper
• The anti-inflammatory effect of ferulic acid is via the modulation of NFκB-TNF-α-IL-6 and STAT1-PIAS1 signaling pathways in 2-methoxyethanol-induced testicular inflammation in rats

  2023cites this paper
• The Role of the JAK/STAT Signaling Pathway in the Pathogenesis of Alzheimer’s Disease: New Potential Treatment Target

  2023cites this paper
• Antheraea pernyi Suppressor of Cytokine Signaling 2 Negatively Modulates the JAK/STAT Pathway to Attenuate Microbial Infection

  2022cites this paper
• Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus

  2021cites this paper
• Antimigratory effect of pyrazole derivatives through the induction of STAT1 phosphorylation in A549 cancer cells.

  2021cites this paper
• Docosahexaenoic acid ameliorates autoimmune inflammation by activating GPR120 signaling pathway in dendritic cells.

  2021cites this paper
• Lipid Metabolism in Tumor-Associated Fibroblasts.

  2021cites this paper
• A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response

  2020cites this paper
• Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges

  2020cites this paper
• JAKs to STATs: A tantalizing therapeutic target in acute myeloid leukemia.

  2020cites this paper
• Targeting the JAK/STAT pathway in solid tumors

  2020cites this paper
• A Novel Anti-Inflammatory d-Peptide Inhibits Disease Phenotype Progression in an ALS Mouse Model

  2020cites this paper
• A Novel Anti-in ammatory D-peptide Halts Disease Phenotype Progression in an ALS Mouse Model

  2020cites this paper
• The JAK/STAT Pathway in Skeletal Muscle Pathophysiology

  2019cites this paper
• Targeting steroid resistance in T-cell acute lymphoblastic leukemia.

  2019cites this paper
• Attenuated Responses To Inflammatory Cytokines In Mouse Embryonic Stem Cells: Biological Implications And The Molecular Basis

  2019cites this paper
• Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications.

  2019cites this paper
• Characterisation of metabotropic glutamate receptor 4 as a therapeutic target in Parkinson's disease

  2019cites this paper
• Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes

  2018cites this paper
• Towards a personalised medicine strategy to reduce prostate cancer risk in men

  2018cites this paper
• Suppression of STAT3 NH2‐terminal domain chemosensitizes medulloblastoma cells by activation of protein inhibitor of activated STAT3 via de‐repression by microRNA‐21

  2018cites this paper
• Suppressor of cytokine signaling 2 (Socs2) deletion protects bone health of mice with DSS-induced inflammatory bowel disease

  2018cites this paper
• Aberrant DNA Methylation in Chronic Myeloid Leukemia: Cell Fate Control, Prognosis, and Therapeutic Response

  2018cites this paper
• miRNA as viral transcription tuners in HPV-mediated cervical carcinogenesis.

  2018cites this paper
• The role of the JAK/STAT signal pathway in rheumatoid arthritis

  2018cites this paper
• Characterisation of immune responses to mycobacterial infections in a murine model of type 2 diabetes

  2018cites this paper
• PCSK9 AND INFLAMMATION: IN VITRO STUDY ON HEPATOCYTES AND MACROPHAGES

  2018cites this paper
• Elucidating the role of JAK/STAT signalling in polycythaemia vera and essential thrombocythaemia using proteomics

  2018cites this paper
• Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL‐12 subunit p40 to form the IL‐23 complex

  2017cites this paper
• JAK-STAT signaling regulation of chicken embryonic stem cell differentiation into male germ cells

  2017cites this paper
• Molecular cloning of chicken interleukin‐17B, which induces proinflammatory cytokines through activation of the NF‐&kgr;B signaling pathway

  2017cites this paper
• Modeling the Dynamics of the Immune Response

  2017cites this paper
• Increased expression of negative regulators of cytokine signaling during chronic HIV disease cause functionally exhausted state of dendritic cells

  2017cites this paper
• (Putative) sex differences in neuroimmune modulation of memory

  2017cites this paper
• Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway.

  2017cites this paper
• Negative Regulators of JAK/STAT Signaling in Rheumatoid Arthritis and Osteoarthritis

  2017cites this paper
• Investigation of the role of alpha-casein and downstream signalling in breast cancer initiation and progression

  2017cites this paper
• Upregulation of SOCS1 and SOCS3 mRNA levels in pediatric patients with henoch-schoenlein purpura

  2017cites this paper
• Isoliquiritigenin attenuates MiR-21 expression via induction of PIAS3 in breast cancer cells

  2017cites this paper
• Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation

  2017cites this paper
• Upregulation of SOCS1 and SOCS3 in pediatric patients with Henoch-Schoenlein purpura

  2017cites this paper
• STAT5-Interacting Proteins: A Synopsis of Proteins that Regulate STAT5 Activity

  2017cites this paper
• Suppressor of cytokine signaling 2 (SOCS2) negatively regulates the expression of antimicrobial peptides by affecting the Stat transcriptional activity in shrimp Marsupenaeus japonicus.

  2016cites this paper
• Protective effect of curcumin on TNBS-induced intestinal inflammation is mediated through the JAK/STAT pathway

  2016cites this paper
• A de novo transcriptome analysis shows that modulation of the JAK-STAT signaling pathway by salmonid alphavirus subtype 3 favors virus replication in macrophage/dendritic-like TO-cells

  2016cites this paper
• The role of IL-11 in immunity and cancer.

  2016cites this paper
• Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice

  2016influential citation
• Increased copy number of SOCS2 gene in Chinese gamecocks

  2016cites this paper
• Cinnamic Acid Derivatives as Inhibitors of Oncogenic Protein Kinases--Structure, Mechanisms and Biomedical Effects.

  2016cites this paper
• The Expression of Aryl Hydrocarbon Receptor in RAW 264.7 Macrophages in the Presence of SOCS1 Peptide and SOCS3 Peptide Mimetic and Cells Infected with HSV-1

  2016influential citation
• Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling

  2016cites this paper
• Leptin-Induced JAK/STAT Signaling and Cancer Growth

  2016influential citation
• Novel role for Gas6 as a positive regulator of myelination

  2016cites this paper
• Potential therapeutic targets for inflammation in toll-like receptor 4 (TLR4)-mediated signaling pathways.

  2016cites this paper
• Expressão de stat3 em tumor odontogênico queratocístico e ameloblastoma

  2016cites this paper
• Suppressor of cytokine signaling and rheumatoid arthritis

  2016cites this paper
• Identification and expression analysis of suppressors of cytokine signaling (SOCS) of Japanese flounder Paralichthys olivaceus.

  2016cites this paper
• The Role of Tumour Necrosis Factor in Pulmonary Viral Infections

  2016cites this paper
• Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung

  2016cites this paper
• Differential regulation of Janus kinase 3 (JAK3) in bovine preovulatory follicles and identification of JAK3 interacting proteins in granulosa cells

  2016cites this paper
• Growth hormone (GH) modulation of Epidermal growth factor (EGF) signalling in human mammary epithelial cells

  2015cites this paper
• Ocular Inflammatory Diseases: Molecular Pathogenesis and Immunotherapy.

  2015cites this paper
• A Point Mutation in Suppressor of Cytokine Signalling 2 (Socs2) Increases the Susceptibility to Inflammation of the Mammary Gland while Associated with Higher Body Weight and Size and Higher Milk Production in a Sheep Model

  2015cites this paper
• Type I Vs. Type II Cytokine Levels as a Function of SOD1 G93A Mouse Amyotrophic Lateral Sclerosis Disease Progression

  2015cites this paper
• Avalle L, Regis G, Poli V. Universal and Specific Functions of STAT3in Solid Tumours

  2015cites this paper
• ReviewStat 3 : linking inflammation to epithelial cancer-more than a " gut " feeling ?

  2015cites this paper
• Die Immunantwort durch Lymphocyten

  2015cites this paper
• The Impact of HSV-1 Infection on Cell Viability, Morphology, and CD Markers Expression by Unpolarized and Cytokine-Polarized J774A.1 Mouse Macrophages

  2015cites this paper
• In Vivo Role of JAK2 in the Pathogenesis of Obesity and the Metabolic Syndrome

  2015cites this paper
• Functional Impairment of Myeloid Dendritic Cells during Advanced Stage of HIV-1 Infection: Role of Factors Regulating Cytokine Signaling

  2015cites this paper
• The logic of communication: roles for mobile transcription factors in plants.

  2015cites this paper
• Signaling Mechanisms that Control Ciliated Cell Differentiation

  2015cites this paper
• Development of New Cellular Models for Step-by-Step Analysis of Astrogliogenic Pathways

  2015cites this paper
• Lipid Metabolism, Apoptosis and Cancer Therapy

  2015cites this paper
• Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells.

  2014cites this paper
• Direct interaction of natural and synthetic catechins with signal transducer activator of transcription 1 affects both its phosphorylation and activity

  2014cites this paper
• A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress

  2014cites this paper
• Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors.

  2014cites this paper
• Role of Prolactin and Its Receptor in Colorectal Cancer

  2014cites this paper
• Uncovering the pathogenesis of large granular lymphocytic leukemia—novel STAT3 and STAT5b mutations

  2014cites this paper
• IL-6 and related cytokines as the critical lynchpins between inflammation and cancer.

  2014cites this paper
• The Stat3 paradox: a killer and an oncogene.

  2014cites this paper
• Role of Prolactin and Prolactin Receptor Signaling in Colorectal Tumorigenesis

  2014cites this paper
• Labda‐8(17),12,14‐trien‐19‐oic Acid Contained in Fruits of Cupressus sempervirens Suppresses Benign Prostatic Hyperplasia in Rat and In Vitro Human Models Through Inhibition of Androgen and STAT‐3 Signaling

  2014cites this paper
• Current aspects of leukemia inhibitory factor (LIF) and its signaling pathways in choriocarcinoma cell lines

  2014cites this paper
• Taenia crassiceps infection and its excreted/secreted products inhibit STAT1 activation in response to IFN-γ.

  2014cites this paper
• DNA methyltransferase 1(DNMT1) induced the expression of suppressors of cytokine signaling3 (Socs3) in a mouse model of asthma

  2014cites this paper
• SOCS genes expression during physiological and perturbed implantation in bovine endometrium.

  2014cites this paper
• STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy

  2014cites this paper
• Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity

  2014cites this paper
• Statistical modelling of masked gene regulatory pathway changes across microarray studies of interferon gamma activated macrophages

  2014cites this paper
• Universidade de São Paulo FCF/FEA/FSP Programa de Pós-graduação Interunidades em Nutrição Humana Aplicada- PRONUT Efeito da suplementação de simbióticos sobre a inflamação sistêmica de idosos.

  2014cites this paper
• Phosphotyrosine phosphatases in GH-stimulated skin fibroblasts from children with idiopathic short stature

  2013cites this paper
• Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases.

  2013cites this paper
• Human Airway Eosinophils Exhibit Preferential Reduction in STAT Signaling Capacity and Increased CISH Expression

  2013influential citation
• STAT signaling in glioma cells.

  2013cites this paper
• Molecular components of JAK/STAT signaling pathway and its interaction with transcription machinery

  2013cites this paper