Age-related changes in midbrain dopaminergic regulation of the human reward system

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2008-09-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.0802127105PMID 18794529PMCID PMC2567500
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory

  2007cited by this paper
• Regulation of firing of dopaminergic neurons and control of goal-directed behaviors.

  2007cited by this paper
• Multiple dopamine functions at different time courses.

  2007cited by this paper
• Anticipation of monetary gain but not loss in healthy older adults

  2007cited by this paper
• Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans

  2006cited by this paper
• Reward-based decision-making and aging.

  2005cited by this paper
• Age-related changes in human D1 dopamine receptors measured by positron emission tomography

  2005cited by this paper
• Pathological gambling is linked to reduced activation of the mesolimbic reward system

  2005cited by this paper
• Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: implications for intracranial self-stimulation.

  2005cited by this paper
• Region-specific changes in prefrontal function with age: a review of PET and fMRI studies on working and episodic memory.

  2005cited by this paper
• Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype

  2005cited by this paper
• PET Studies of Net Blood—Brain Clearance of FDOPA to Human Brain: Age-Dependent Decline of [18F]Fluorodopamine Storage Capacity

  2005cited by this paper
• Cerebral Cortex doi:10.1093/cercor/bhj004 Neural Coding of Distinct Statistical Properties of Reward Information in Humans

  2005cited by this paper
• The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies.

  2004cited by this paper
• Amphetamine modulates human incentive processing.

  2004cited by this paper
• A technique for standardized central analysis of 6-(18)F-fluoro-L-DOPA PET data from a multicenter study.

  2004cited by this paper
• Subsecond dopamine release promotes cocaine seeking

  2003cited by this paper
• Functional deactivations: Change with age and dementia of the Alzheimer type

  2003cited by this paper
• Discrete Coding of Reward Probability and Uncertainty by Dopamine Neurons

  2003cited by this paper
• Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging

  2003cited by this paper
• Hemispheric asymmetry reduction in older adults: the HAROLD model.

  2002cited by this paper
• A Model of Prefrontal Cortex Dopaminergic Modulation during the Delayed Alternation Task

  2002cited by this paper
• Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

  2002cited by this paper
• Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET.

  2002cited by this paper
• The effects of aging upon the hemodynamic response measured by functional MRI.

  2001cited by this paper
• Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens

  2001cited by this paper
• Dissociation of reward anticipation and outcome with event-related fMRI

  2001cited by this paper
• Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain.

  2000cited by this paper
• Chemical neuromodulation of frontal-executive functions in humans and other animals

  2000cited by this paper
• Neuronal coding of prediction errors.

  2000cited by this paper
• Multiple reward signals in the brain

  2000cited by this paper
• Age Differences in the Frontal Lateralization of Verbal and Spatial Working Memory Revealed by PET

  2000cited by this paper
• Isolating the neural mechanisms of age-related changes in human working memory

  2000cited by this paper
• Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism.

  2000cited by this paper
• Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation

  1999cited by this paper
• FluoroDOPA PET shows the nondopaminergic as well as dopaminergic destinations of levodopa

  1999cited by this paper
• The effect of normal aging on the coupling of neural activity to the bold hemodynamic response.

  1999cited by this paper
• Aging and Recognition Memory: Changes in Regional Cerebral Blood Flow Associated with Components of Reaction Time Distributions

  1999cited by this paper
• Noise stress impairs prefrontal cortical cognitive function in monkeys: evidence for a hyperdopaminergic mechanism.

  1998cited by this paper
• Age-related shift in brain region activity during successful memory performance.

  1998cited by this paper
• Prolonged and Extrasynaptic Excitatory Action of Dopamine Mediated by D1 Receptors in the Rat Striatum In Vivo

  1997cited by this paper
• Dopamine transporters decrease with age.

  1996cited by this paper
• Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol.

  1996cited by this paper
• Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys

  1994cited by this paper
• Age-related changes in multiple neurotransmitter systems in the monkey brain.

  1989cited by this paper
• Dr. Volkow and Colleagues Reply

  1987cited by this paper
• Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

  1983cited by this paper
• Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys.

  1981cited by this paper

• Interaction Between the VNTR of the DAT1 Gene and DAT1 Methylation in Relation to Impulsivity in Combat Sports Athletes

  2025cites this paper
• Exploring longitudinal associations of appetitive traits with thinness-oriented eating disorder symptomatology in Chinese older adults.

  2025cites this paper
• Impact of Obesity on Appetite‐Related Behaviors and Biomarkers in Older Adults: A Cross‐Sectional Study

  2025cites this paper
• Sentencing for Youthful Offenders: The Impact of Youthfulness on the Sentencing Decisions

  2025cites this paper
• Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake.

  2025cites this paper
• Visually Appealing iEat® Food Products Enhance Visual Cortex Activity in Patients with Dysphagia: A Functional MRI (fMRI) Study

  2025cites this paper
• Effect of ninjin'yoeito on age-related decline in responsiveness of the brain reward system in mice.

  2025cites this paper
• Serum tyrosine associates with increased CSF Aβ42, reduced Aβ deposition, and cognitive improvement in MCI: modulation by confounding factors

  2025cites this paper
• Compensatory Mechanisms in Prefrontal and Reward Systems Reveal Delayed Brain Aging in Musicians

  2025cites this paper
• Food Inhibitory Control and Reward Responsiveness in Healthy Aging

  2025cites this paper
• Harnessing BDNF Signaling to Promote Resilience in Aging

  2024cites this paper
• Lauric acid with or without levodopa ameliorates Parkinsonism in genetically modified model of Drosophila melanogaster via the oxidative–inflammatory–apoptotic pathway

  2024cites this paper
• Financial and prosocial rewards differentially enhance cognition in younger and older healthy adults

  2024cites this paper
• The extraordinary "ordinary magic" of resilience.

  2024cites this paper
• Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake

  2024cites this paper
• Age- and sex-driven alterations in alcohol consumption patterns: Role of brain ethanol metabolism and the opioidergic system in the nucleus accumbens.

  2024cites this paper
• Memory and automatic processing of valuable information in younger and older adults

  2024cites this paper
• Slow-wave sleep is associated with nucleus accumbens volume in elderly adults

  2024cites this paper
• JMJD3 deficiency disturbs dopamine biosynthesis in midbrain and aggravates chronic inflammatory pain

  2024cites this paper
• Sex as a Determinant of Age-Related Changes in the Brain

  2024cites this paper
• Slowing of Movements in Healthy Aging as a Rational Economic Response to an Elevated Effort Landscape

  2024cites this paper
• The effect of loss incentives on prospective memory in healthy older adults: study protocol of a randomized controlled trial using ultra-high field fMRI

  2023cites this paper
• Dopamine and Alcohol: A Review of in vivo PET and SPECT Studies

  2023cites this paper
• The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates

  2023cites this paper
• Effects of Adult Age and Functioning of the Locus Coeruleus Norepinephrinergic System on Reward-Based Learning

  2023cites this paper
• Gambling and Aging: An Overview of a Risky Behavior

  2023cites this paper
• Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat

  2023cites this paper
• Effort cost of reaching prompts vigor reduction in older adults

  2023cites this paper
• Fleeting Effects of Incentives: Adult Age Differences in ERP Measures of Motivated Attention

  2022cites this paper
• Bi-phasic patterns of age-related differences in dopamine D1 receptors across the adult lifespan

  2022cites this paper
• Carving the senescent phenotype by the chemical reactivity of catecholamines: An integrative review.

  2022cites this paper
• Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters

  2022cites this paper
• Age-related differences in ERP correlates of value-based decision making.

  2022cites this paper
• Reward System Dysfunction and the Motoric-Cognitive Risk Syndrome in Older Persons

  2022cites this paper
• Risk‐taking in the human brain: An activation likelihood estimation meta‐analysis of the balloon analog risk task (BART)

  2022cites this paper
• Reward Processing as an Indicator of Vulnerability or Compensatory Resilience in Psychoses? Results From a Twin Study

  2022cites this paper
• The Acute Effects of Breakfast Drinks with Varying Protein and Energy Contents on Appetite and Free-Living Energy Intake in UK Older Adults

  2022cites this paper
• Spatial profiles provide sensitive MRI measures of the midbrain micro- and macrostructure

  2022cites this paper
• Effects of baclofen on insular gain anticipation in alcohol-dependent patients — a randomized, placebo-controlled, pharmaco-fMRI pilot trial

  2022cites this paper
• Topographic organization of the human caudate functional connectivity and age-related changes with resting-state fMRI

  2022cites this paper
• A bias toward the unknown: individual and environmental factors influencing exploratory behavior

  2022cites this paper
• Aging in nucleus accumbens and its impact on alcohol use disorders

  2022cites this paper
• Older Barbary macaques show limited capacity for self-regulation to avoid hazardous social interactions

  2022cites this paper
• Longitudinal Cerebral Blood Flow Changes in Normal Aging and the Alzheimer’s Disease Continuum Identified by Arterial Spin Labeling MRI

  2021cites this paper
• Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson’s disease

  2021cites this paper
• The Effect of Sound in VR Exergame to Adult Player: A Primary Investigation

  2021cites this paper
• Human aging alters social inference about others' changing intentions.

  2021cites this paper
• Reconsidering delay discounting in bulimia nervosa.

  2021cites this paper
• Brain activations associated with anticipation and delivery of monetary reward: A systematic review and meta-analysis of fMRI studies

  2021cites this paper
• The impact of dietary macronutrient intake on cognitive function and the brain.

  2021cites this paper
• The Biology and Pathobiology of Glutamatergic, Cholinergic, and Dopaminergic Signaling in the Aging Brain

  2021cites this paper
• Sex-Specific Functional Connectivity in the Reward Network Related to Distinct Gender Roles

  2021cites this paper
• Ageing is associated with disrupted reinforcement learning whilst learning to help others is preserved

  2021cites this paper
• The Brain Reward System

  2021cites this paper
• Age-Related Changes in the Role of Social Motivation: Implications for Healthy Aging.

  2021cites this paper
• Effects of aging on the cholinergic innervation of the rat ventral tegmental area: A stereological study.

  2021cites this paper
• Dysfonctionnements du système de récompense et biais cognitifs chez les joueurs pathologiques

  2021cites this paper
• Low-grade inflammation and cognitive functioning: Emotion recognition, reinforcement learning, and attention

  2020cites this paper
• Temporal discounting in adolescents and adults with Tourette syndrome

  2020cites this paper
• Appetite Control across the Lifecourse: The Acute Impact of Breakfast Drink Quantity and Protein Content. The Full4Health Project

  2020cites this paper
• The Role of the Striatum in Learning to Orthogonalize Action and Valence: A Combined PET and 7 T MRI Aging Study.

  2020cites this paper
• Loss of Sensitivity to Rewards by Dopamine Neurons May Underlie Age-Related Increased Probability Discounting

  2020cites this paper
• Ageing disrupts reinforcement learning whilst learning to help others is preserved

  2020cites this paper
• THE RELATIONSHIP OF TIME PERCEPTION AND IMPULSIVENESS OF UKRAINIAN STUDENTS

  2020cites this paper
• Motivation and sensitivity to monetary reward in late-life insomnia: moderating role of sex and the inflammatory marker CRP

  2020cites this paper
• Age-differential relationships among dopamine D1 binding potential, fusiform BOLD signal, and face-recognition performance

  2020cites this paper
• Telomerase and telomeres in aging theory and chronographic aging theory

  2020cites this paper
• Polycystic ovary syndrome and brain: An update on structural and functional studies.

  2020cites this paper
• Positron Emission Tomography of the

  2020cites this paper
• The interaction of curiosity and reward on long-term memory in younger and older adults

  2020cites this paper
• Interaction of Cannabis Use and Aging: From Molecule to Mind

  2020cites this paper
• Dopaminergic Modulation of Working Memory and Cognitive Flexibility in a Zebrafish Model of Aging-Related Cognitive Decline

  2020cites this paper
• PET and SPECT Imaging of the Central Dopamine System in Humans

  2020cites this paper
• Neurobiology of Wisdom

  2019cites this paper
• Dopaminergic Mechanisms Underlying Normal Variation in Trait Anxiety

  2019cites this paper
• A comparison of implicit and explicit reward learning in low risk alcohol users versus people who binge drink and people with alcohol dependence

  2019cites this paper
• An EEG investigation of pain processing in Parkinson's disease

  2019cites this paper
• The effects of age on reward magnitude processing in the monetary incentive delay task

  2019cites this paper
• Resilience and the brain: a key role for regulatory circuits linked to social stress and support

  2019cites this paper
• How does decisional capacity evolve with normal cognitive aging: systematic review of the literature

  2019cites this paper
• Advanced Mass Spectrometry Imaging in Neuropharmacology

  2019cites this paper
• Determinants of Gambling Disorders in Elderly People—A Systematic Review

  2019influential citation
• Neural mechanisms of decision-making in aging.

  2019cites this paper
• The emergence of neuromarketing investigated through online public communications (2002–2008)

  2019cites this paper
• Examining the Effects of Stress and Age on Neural Reward Processing: Considerations for the Role of Individual Differences in Autonomic Reactivity

  2019influential citation
• Clinical Course, Neurobiology and Therapeutic Approaches to Treatment Resistant Schizophrenia. Toward an Integrated View

  2019cites this paper
• Influence of aging on the behavioral phenotypes of C57BL/6J mice after social defeat

  2019cites this paper
• The Emerging Empirical Science of Wisdom: Definition, Measurement, Neurobiology, Longevity, and Interventions

  2019cites this paper
• Introductory Chapter: The Chemical Basis of Neural Function and Dysfunction

  2019cites this paper
• On the Interactions of Reward, Time, and Effort in Human Movement

  2018cites this paper
• Individual differences in dopamine D2 receptor availability correlate with reward valuation

  2018cites this paper
• Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults

  2018cites this paper
• Effects of aging on executive functioning and mesocorticolimbic dopamine markers in male Fischer 344 × brown Norway rats.

  2018cites this paper
• Age-related variability in decision-making: Insights from neurochemistry

  2018cites this paper
• Age-related differences in striatal, medial temporal, and frontal involvement during value-based decision processing.

  2018cites this paper
• Neuro-Cognitive Effects of Acute Tyrosine Administration on Reactive and Proactive Response Inhibition in Healthy Older Adults

  2018influential citation
• Dopamine Transporter and Reward Anticipation in a Dimensional Perspective: A Multimodal Brain Imaging Study

  2018cites this paper
• Evaluation of the Social Motivation Hypothesis of Autism: A Systematic Review and Meta-analysis

  2018cites this paper
• Independent effects of age and levodopa on reversal learning in healthy volunteers.

  2018cites this paper
• Resilience and White Matter Integrity in Geriatric Depression.

  2018cites this paper