SUMO: regulating the regulator

Post-translational modifiers of the SUMO (S mall U biquitin-related M odifier) family have emerged as key regulators of protein function and fate. While the past few years have seen an enormous increase in knowledge on SUMO enzymes, substrates, and consequences of modification, regulation of SUMO conjugation is far from being understood. This brief review will provide an overview on recent advances concerning (i) the interplay between sumoylation and other post-translational modifications at the level of individual targets and (ii) global regulation of SUMO conjugation and deconjugation.

• Publication year

  2006

• Venue

  Cell Division

• Publication date

  2006-06-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/1747-1028-1-13PMID 16805918PMCID 1524954
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PDSM, a motif for phosphorylation-dependent SUMO modification.

  2006influential reference
• Characterization of a Family of Nucleolar SUMO-specific Proteases with Preference for SUMO-2 or SUMO-3*

  2006cited by this paper
• Sumoylation of PCNA: Wrestling with recombination at stalled replication forks.

  2006cited by this paper
• Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity

  2006cited by this paper
• Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes.

  2006influential reference
• A Calcium-Regulated MEF2 Sumoylation Switch Controls Postsynaptic Differentiation

  2006cited by this paper
• Control of MEF2 Transcriptional Activity by Coordinated Phosphorylation and Sumoylation*

  2006cited by this paper
• Circadian Clock Control by SUMOylation of BMAL1

  2005cited by this paper
• Regulation of MEF2 by Histone Deacetylase 4- and SIRT1 Deacetylase-Mediated Lysine Modifications

  2005cited by this paper
• SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

  2005cited by this paper
• Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins.

  2005influential reference
• Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor

  2005cited by this paper
• SUMO: a history of modification.

  2005cited by this paper
• The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice.

  2005cited by this paper
• Mutual interactions between the SUMO and ubiquitin systems: a plea of no contest.

  2005cited by this paper
• Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p.

  2005cited by this paper
• SIRT1 Deacetylation and Repression of p300 Involves Lysine Residues 1020/1024 within the Cell Cycle Regulatory Domain 1*

  2005cited by this paper
• SUMO Wrestles Its Way to Prominence in the Cell

  2005cited by this paper
• Something about SUMO inhibits transcription.

  2005cited by this paper
• Down-Regulation of c-Fos/c-Jun AP-1 Dimer Activity by Sumoylation

  2005cited by this paper
• A mechanism for inhibiting the SUMO pathway.

  2004influential reference
• Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53

  2004cited by this paper
• Global Analyses of Sumoylated Proteins in Saccharomyces cerevisiae

  2004cited by this paper
• Modifying NEMO.

  2004cited by this paper
• NOX enzymes and the biology of reactive oxygen

  2004cited by this paper
• Characterization of the Localization and Proteolytic Activity of the SUMO-specific Protease, SENP1*

  2004cited by this paper
• Protein modification by SUMO.

  2004cited by this paper
• Global shifts in protein sumoylation in response to electrophile and oxidative stress.

  2004cited by this paper
• Phosphorylation of Serine 303 Is a Prerequisite for the Stress-Inducible SUMO Modification of Heat Shock Factor 1

  2003cited by this paper
• SUMO-2/3 regulates topoisomerase II in mitosis

  2003cited by this paper
• Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress.

  2003cited by this paper
• SUMO: ligases, isopeptidases and nuclear pores.

  2003influential reference
• The Small Ubiquitin-like Modifier (SUMO) Protein Modification System in Arabidopsis

  2003cited by this paper
• Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity.

  2003cited by this paper
• NEDP1, a Highly Conserved Cysteine Protease That deNEDDylates Cullins*

  2003cited by this paper
• DEN1 Is a Dual Function Protease Capable of Processing the C Terminus of Nedd8 and Deconjugating Hyper-neddylated CUL1*

  2003cited by this paper
• Identification and Characterization of DEN1, a Deneddylase of the ULP Family*

  2003cited by this paper
• Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling.

  2002cited by this paper
• Desumoylation Activity of Axam, a Novel Axin-Binding Protein, Is Involved in Downregulation of β-Catenin

  2002cited by this paper
• SUMO-1 protease-1 regulates gene transcription through PML.

  2002cited by this paper
• Transcription factor Sp3 is silenced through SUMO modification by PIAS1

  2002influential reference
• An E3-like factor that promotes SUMO conjugation to the yeast septins.

  2001cited by this paper
• Regulation of Heat Shock Transcription Factor 1 by Stress-induced SUMO-1 Modification*

  2001cited by this paper
• Characterization of a Novel Mammalian SUMO-1/Smt3-specific Isopeptidase, a Homologue of Rat Axam, Which Is an Axin-binding Protein Promoting β-Catenin Degradation*

  2001cited by this paper
• Functional Heterogeneity of Small Ubiquitin-related Protein Modifiers SUMO-1 versus SUMO-2/3*

  2000cited by this paper
• c-Jun and p53 Activity Is Modulated by SUMO-1 Modification*

  2000cited by this paper
• A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase.

  2000cited by this paper
• A New SUMO-1-specific Protease, SUSP1, That Is Highly Expressed in Reproductive Organs*

  2000cited by this paper
• Alphaherpesvirus Proteins Related to Herpes Simplex Virus Type 1 ICP0 Affect Cellular Structures and Proteins

  2000cited by this paper
• Cell Cycle–Regulated Attachment of the Ubiquitin-Related Protein Sumo to the Yeast Septins

  1999cited by this paper
• Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1.

  1999cited by this paper
• Viral Immediate-Early Proteins Abrogate the Modification by SUMO-1 of PML and Sp100 Proteins, Correlating with Nuclear Body Disruption

  1999cited by this paper
• Cell cycle regulation of PML modification and ND10 composition.

  1999cited by this paper
• The Nuclear Dot Protein Sp100, Characterization of Domains Necessary for Dimerization, Subcellular Localization, and Modification by Small Ubiquitin-like Modifiers*

  1999cited by this paper
• SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.

  1998cited by this paper
• Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins

  1995cited by this paper

• APP SUMOylation prevents BACE1 cleavage of APP and increases BACE1 degradation to promote the nonamyloidogenic pathway

  2025influential citation
• Post-translational modifications: emerging directors of cell-fate decisions during endoplasmic reticulum stress in Arabidopsis thaliana

  2024cites this paper
• Guanosine increases global SUMO1‐ylation in the hippocampus of young and aged mice and improves the short‐term memory of young mice

  2023influential citation
• Sumoylation of Cas9 at lysine 848 regulates protein stability and DNA binding

  2022cites this paper
• Basic fibroblast growth factor induces matrix metalloproteinase-13 via ERK MAP kinase-altered phospohorylation and sumoylation of Elk-1 in human adult articular chondrocytes

  2022cites this paper
• The Interface between Cell Signaling Pathways and Pregnane X Receptor

  2021cites this paper
• Irilone, a Red Clover Isoflavone, Combined with Progesterone Enhances PR Signaling through the Estrogen and Glucocorticoid Receptors.

  2021cites this paper
• DROUGHT STRESS TOLERANCE MECHANISMS AND BREEDING EFFORT IN SUGARCANE: A REVIEW OF PROGRESS AND CONSTRAINTS IN SOUTH AFRICA

  2021cites this paper
• Sumoylation of the Carboxy-Terminal of Human Cytomegalovirus DNA Polymerase Processivity Factor UL44 Attenuates Viral DNA Replication

  2021influential citation
• A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis

  2021cites this paper
• SUMO1 SUMOylates and SENP3 deSUMOylates NLRP3 to orchestrate the inflammasome activation

  2020cites this paper
• Regulating the regulator: nitric oxide control of post-translational modifications.

  2020cites this paper
• Viral DNA Binding Protein SUMOylation Promotes PML Nuclear Body Localization Next to Viral Replication Centers

  2020cites this paper
• SUMOylation and deacetylation affect NF-κB p65 activity induced by high glucose in human lens epithelial cells.

  2019cites this paper
• The Molecular Regulation and Functional Roles of NOX5.

  2019cites this paper
• NADPH Oxidases: Methods and Protocols

  2019cites this paper
• Fish SUMO3 functions as a critical antiviral molecule against iridovirus and nodavirus

  2019cites this paper
• Expression, distribution, and trafficking of pore-forming and auxiliary subunits of kainate receptors

  2019cites this paper
• Sumoylation of nucleoprotein (NP) mediated by activation of NADPH oxidase complex is a consequence of oxidative cellular stress during infection by Infectious salmon anemia (ISA) virus necessary to viral progeny.

  2019cites this paper
• A role for S-nitrosylation of the SUMO-conjugating enzyme SCE1 in plant immunity

  2019cites this paper
• TGF-β synergizes with ML264 to block IL-1β-induced matrix degradation mediated by Krüppel-like factor 5 in the nucleus pulposus.

  2018cites this paper
• Activation of NADPH Oxidase Complex by ISA Virus Nucleoprotein Overexpression: Alteration of SUMO-1 Protein Levels a Consequence of Cellular Oxidative Stress

  2018cites this paper
• The role of SUMOylation in cerebral hypoxia and ischemia

  2017cites this paper
• Investigating the mechanisms by which histone deacetylase inhibitors induce apoptosis in cancer cells

  2017cites this paper
• SENP2 suppresses epithelial‐mesenchymal transition of bladder cancer cells through deSUMOylation of TGF‐βRI

  2017cites this paper
• SUMOylation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Increases Surface Expression and the Maximal Conductance of the Hyperpolarization-Activated Current

  2017cites this paper
• SUMOylation regulates focal adhesions in cancer cell migration

  2017cites this paper
• Organization and Regulation of Soybean SUMOylation System under Abiotic Stress Conditions

  2017cites this paper
• Ion Channel SUMOylation: a Novel Role for SUMO in Homeostatic Regulation of Multiple Ionic Conductances

  2017cites this paper
• Fish TRIM32 functions as a critical antiviral molecule against iridovirus and nodavirus

  2017cites this paper
• The Effects of SUMO modification of the Tumour Suppressor p53

  2016cites this paper
• SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells.

  2016cites this paper
• Oxidative Modification and Its Implications for the Neurodegeneration of Parkinson’s Disease

  2016cites this paper
• Detection of Sumo Modification of Endogenous Histone Deacetylase 2 (HDAC2) in Mammalian Cells.

  2016cites this paper
• The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors

  2016cites this paper
• LMP1-Induced Sumoylation Influences the Maintenance of Epstein-Barr Virus Latency through KAP1

  2015cites this paper
• Enzymatic regulation and functional relevance of NOX5.

  2015cites this paper
• Implication of SUMO E3 ligases in nucleotide excision repair

  2015cites this paper
• LMP 1-Induced Sumoylation Influences the Maintenance of Epstein-Barr Virus Latency through KAP 1

  2015cites this paper
• SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation

  2015cites this paper
• Knockdown of SUMO-activating enzyme subunit 2 (SAE2) suppresses cancer malignancy and enhances chemotherapy sensitivity in small cell lung cancer

  2015cites this paper
• RETRACTED ARTICLE: SUMO-specific protease 6 promotes gastric cancer cell growth via deSUMOylation of FoxM1

  2015cites this paper
• Molecular mechanisms of oncogénesis mediated by the BTB transcription factor Pipsqueak. Impact of sumoylation and proteolytic processing

  2015cites this paper
• Estudio sobre la interacción planta geminivirus.

  2015cites this paper
• A MicroRNA Processing Defect in Smokers' Macrophages Is Linked to SUMOylation of the Endonuclease DICER*

  2014cites this paper
• Tight regulation of a timed nuclear import wave of EKLF by PKCθ and FOE during Pro-E to Baso-E transition.

  2014cites this paper
• SUMOylation regulates AKT1 activity

  2014cites this paper
• Sumoylation modulates oxidative stress relevant to the viability and functionality of pancreatic beta cells.

  2014cites this paper
• SUMOylation of the Endonuclease DICER Smokers ' Macrophages Is Linked to A MicroRNA Processing Defect in Molecular Bases of Disease

  2014cites this paper
• Structural insights into the SENP6 Loop1 structure in complex with SUMO2

  2014cites this paper
• Selective modulation of PML nuclear bodies by Adenovirus regulatory proteins

  2014cites this paper
• Cross-talk between phosphorylation and SUMOylation regulates transforming activities of an adenoviral oncoprotein

  2013cites this paper
• Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily.

  2013cites this paper
• Essential Role of SIRT1 Signaling in the Nucleus Accumbens in Cocaine and Morphine Action

  2013cites this paper
• Identification of SUMO targets by a novel proteomic approach in plants(F).

  2013cites this paper
• Diversity oriented approach to triazole based peptidomimetics as mammalian sterile 20 kinase inhibitors

  2013cites this paper
• Physical and Genetic Interactions Between Uls1 and the Slx5–Slx8 SUMO-Targeted Ubiquitin Ligase

  2013cites this paper
• Targeted Identification of SUMOylation Sites in Human Proteins Using Affinity Enrichment and Paralog-specific Reporter Ions*

  2013cites this paper
• SUMO Tasks in Chromatin Remodeling

  2013cites this paper
• SUMO: a (Oxidative) Stressed Protein

  2013influential citation
• and synergistically induce in prostate cells

  2013cites this paper
• The Hydra small ubiquitin‐like modifier

  2013cites this paper
• Localization of SUMOylation factors and Osterix in odontoblast lineage cells during dentin formation and regeneration

  2013cites this paper
• Modification and movement

  2012cites this paper
• Salicylic acid-induced components of oligomeric protein complexes

  2012cites this paper
• SUMO-1 of mud crab (Scylla paramamosain) in gametogenesis.

  2012cites this paper
• Phosphorylation-Dependent SUMOylation of the Transcription Factor NF-E2

  2012cites this paper
• © 2012 Landes Bioscience. Do not distribute. Modification and movement Phosphorylation and SUMOylation regulate endocytosis of GluK2-containing kainate receptors

  2012cites this paper
• Protein SUMOylation in spine structure and function.

  2012cites this paper
• SUMOylation in Giardia lamblia: A Conserved Post-Translational Modification in One of the Earliest Divergent Eukaryotes

  2012cites this paper
• SUMO, a heavyweight player in plant abiotic stress responses

  2012influential citation
• Heterologous SUMO-2/3-Ubiquitin Chains Optimize IκBα Degradation and NF-κB Activity

  2012cites this paper
• A differential requirement for SUMOylation in proliferating and non-proliferating cells during Drosophila development

  2012cites this paper
• HTLV-1 Rex: the courier of viral messages making use of the host vehicle

  2012influential citation
• The role of microRNAs in modulating sirtuin 1 expression

  2011cites this paper
• Sumoylation inhibits α-synuclein aggregation and toxicity

  2011cites this paper
• [Mechanism of regulating deacetylase SIRT1 expression and activity.].

  2011influential citation
• OsSIZ1 Regulates the Vegetative Growth and Reproductive Development in Rice

  2011cites this paper
• Post-translational modification of pregnane x receptor.

  2011cites this paper
• SUMO1 Negatively Regulates Reactive Oxygen Species Production From NADPH Oxidases

  2011cites this paper
• Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans

  2011cites this paper
• Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis

  2011cites this paper
• Mitotic kinase Aurora‐B is regulated by SUMO‐2/3 conjugation/deconjugation during mitosis

  2011cites this paper
• SUMO2 and SUMO3 transcription is differentially regulated by oxidative stress in an Sp1-dependent manner.

  2011cites this paper
• Caveolin-3 Undergoes SUMOylation by the SUMO E3 Ligase PIASy

  2011cites this paper
• Interaction between Geminivirus Replication Protein and the SUMO-Conjugating Enzyme Is Required for Viral Infection

  2011cites this paper
• SUMO 2 and SUMO 3 transcription is differentially regulated by oxidative stress in an Sp 1-dependent manner

  2011cites this paper
• All the little pieces. -Regulation of mitochondrial fusion and fission by ubiquitin and small ubiquitin-like modifer and their potential relevance in the heart.-.

  2011cites this paper
• All the Little Pieces

  2011cites this paper
• Authors and their affiliations

  2011influential citation
• Implication du processus de sumoylation/désumoylation dans la régulation de l'activité du récepteur ERα

  2011cites this paper
• The Role of Protein SUMOylation in Neuronal Function

  2011cites this paper
• The TRIM (TRipartite Motif) Family as a Novel Class of Ubiquitin E3 Ligases

  2011cites this paper
• Transcriptional control of metabolic and inflammatory pathways by nuclear receptor SUMOylation.

  2011cites this paper
• Mechanisms of the intracellular localization of the SUMO-activating enzyme Aos1/Uba2

  2010cites this paper
• A Novel Proteomics Approach to Identify SUMOylated Proteins and Their Modification Sites in Human Cells*

  2010cites this paper
• Response and transcriptional regulation of rice SUMOylation system during development and stress conditions.

  2010cites this paper
• Functional characterization of an E3 ubiquitin ligase involved in plant response to abiotic stress

  2010cites this paper
• The SUMO pathway functions in mouse oocyte maturation

  2010cites this paper
• Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

  2010cites this paper