Induction of chromosomal aberrations in cultured human fibroblasts by inorganic and organic arsenic compounds and the different roles of glutathione in such induction.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Mutation research

• Publication date

  1996-10-25

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/0027-5107(96)00092-9PMID 8876688
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Glutathione plays different roles in the induction of the cytotoxic effects of inorganic and organic arsenic compounds in cultured BALB/c 3T3 cells

  1994cited by this paper
• Glutathione as a cellular defence against arsenite toxicity in cultured Chinese hamster ovary cells.

  1993cited by this paper
• Induction of chromatid breaks and tetraploidy in Chinese hamster ovary cells by treatment with sodium arsenite during the G2 phase.

  1993cited by this paper
• Dimethylarsenic acid induces tetraploids in Chinese hamster cells

  1992cited by this paper
• The chemical form and acute toxicity of arsenic compounds in marine organisms

  1992cited by this paper
• Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice.

  1991cited by this paper
• Cellular retention, toxicity and carcinogenic potential of seafood arsenic. I. Lack of cytotoxicity and transforming activity of arsenobetaine in the BALB/3T3 cell line.

  1991cited by this paper
• Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical.

  1990cited by this paper
• Elevation of glutathione levels and glutathione S-transferase activity in arsenic-resistant chinese hamster ovary cells

  1989cited by this paper
• Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice.

  1989cited by this paper
• Induction of gene amplification by arsenic.

  1988cited by this paper
• Determination of inorganic arsenic and organic arsenic compounds in marine organisms by hydride generation/cold trap/gas chromatography— mass spectrometry

  1988cited by this paper
• The Synthesis of (R)-2',3'-Dihydroxypropyl 5-Deoxy-5-Dimethylarsinyl-β-D-Riboside, a Naturally Occurring Arsenic-Containing Carbohydrate

  1987cited by this paper
• Identification of arsenobetaine and a tetramethylarsonium salt in the clam Meretrix lusoria

  1987cited by this paper
• The formation of trimethylarsine oxide from arsenobetaine by biodegradation with marine microorganisms

  1987cited by this paper
• The synthesis of (R)-2',3'-dihydroxypropyl 5-deoxy-5-dimethylarsinoyl-β-D-riboside, a naturally-occurring, arsenic-containing carbohydrate

  1986cited by this paper
• Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture.

  1985cited by this paper
• The acute toxicity of arsenobetaine

  1985cited by this paper
• Mass fragmentographic estimation of trimethylarsine oxide in aquatic organisms

  1985cited by this paper
• Reduction and binding of arsenate in marmoset monkeys

  1985cited by this paper
• Metabolism and excretion of orally administered dimethylarsinic acid in the hamster.

  1984cited by this paper
• Transport of glutathione, as gamma-glutamylcysteinylglycyl ester, into liver and kidney.

  1983cited by this paper
• Selective modification of glutathione metabolism.

  1983cited by this paper
• Evidence for the presence of arsenobetaine and another organoarsenical in shrimps

  1982cited by this paper
• Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man

  1981cited by this paper
• Comparative studies of chromosomal aberration induced by trivalent and pentavalent arsenic.

  1981cited by this paper
• Arseno-sugars from brown kelp (Ecklonia radiata) as intermediates in cycling of arsenic in a marine ecosystem

  1981cited by this paper
• Chromosome aberrations in cultured human lymphocytes exposed to trivalent and pentavalent arsenic.

  1981cited by this paper
• Absence of arsenite mutagenicity in E coli and Chinese hamster cells.

  1980cited by this paper
• Chromosome aberrations in workers exposed to arsenic.

  1977cited by this paper
• Isolation, crystal structure and synthesis of arsenobetaine, the arsenical constituent of the western rock lobster panulirus longipes cygnus George

  1977cited by this paper
• Changes in the chemical speciation of arsenic following ingestion by man.

  1977cited by this paper
• Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.

  1969cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Metal(oid)s in Ulva - should we be worried?

  2025cites this paper
• Risk assessment of complex organoarsenic species in food

  2024cites this paper
• N-acetylcysteine attenuates sodium arsenite-induced oxidative stress and apoptosis in embryonic fibroblast cells

  2024cites this paper
• Simple Co-Precipitation of Iron Minerals for the Removal of Phenylarsonic Acid: Insights into the Adsorption Performance and Mechanism

  2023cites this paper
• Cytogenetic damage in native Baltic Sea fish species: environmental risks associated with chemical munition dumping in the Gotland Basin of the Baltic Sea

  2021cites this paper
• Assessment of light intensity and salinity regimes on the element levels of brown macroalgae, Treptacantha barbata: Application of response surface methodology (RSM)

  2020cites this paper
• Arsenic speciation in a variety of seaweeds and associated food products

  2019cites this paper
• Impact of prenatal arsenate exposure on gene expression in a pure population of migratory cranial neural crest cells.

  2019cites this paper
• Health Functionality and Quality Control of Laver (Porphyra, Pyropia): Current Issues and Future Perspectives as an Edible Seaweed

  2019cites this paper
• Arsenic trioxide induces apoptosis and inhibits the growth of human liver cancer cells

  2018cites this paper
• Substantial Evidences Indicate That Inorganic Arsenic Is a Genotoxic Carcinogen: a Review

  2018cites this paper
• Arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in low-dose exposed mouse embryonic fibroblast cells

  2018cites this paper
• Sodium arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in mouse embryonic fibroblast cells

  2018cites this paper
• Methylarsenic compounds [MAK Value Documentation, 2014]

  2018cites this paper
• HEP-2 CELL LINE AS AN EXPERIMENTAL MODEL TO EVALUATE GENOTOXIC EFFECTS OF PENTAVALENT INORGANIC ARSENIC HEP-2

  2017cites this paper
• MODULATION OF ARYL HYDROCARBON RECEPTOR (AHR)-REGULATED CARCINOGEN ACTIVATING ENZYMES BY ORGANIC ARSENICALS: A POTENTIAL THERAPEUTIC TARGET

  2017cites this paper
• Bioactive Compounds of Edible Purple Laver Porphyra sp. (Nori).

  2017cites this paper
• In Vivo and In Vitro Arsenic Exposition Induces Oxidative Stress in Anterior Pituitary Gland

  2016cites this paper
• Induction of Aneuploidy, Centrosome Abnormality, Multipolar Spindle, and Multipolar Division in Cultured Mammalian Cells Exposed to an Arsenic Metabolite, Dimethylarsinate.

  2016cites this paper
• Arsenic and its Inorganic Compounds (with the Exception of Arsine) [MAK Value Documentation, 2014]

  2016cites this paper
• Monomethylarsonous acid (MMA+3) Inhibits IL-7 Signaling in Mouse Pre-B Cells.

  2016cites this paper
• Toxicological characterisation of a thio-arsenosugar-glycerol in human cells.

  2016cites this paper
• MECHANISMS OF LOW DOSE ARSENIC LYMPHOID STEM CELL IMMUNOTOXICITY AND POTENTIAL INTERACTIONS WITH DIBENZO[def, p]CHRYSENE (DBC)

  2015cites this paper
• Modulation of aryl hydrocarbon receptor-regulated enzymes by trimethylarsine oxide in C57BL/6 mice: In vivo and in vitro studies.

  2015cites this paper
• Genotoxic and epigenetic mechanisms in arsenic carcinogenicity

  2014influential citation
• A comprehensive evaluation of inorganic arsenic in food and considerations for dietary intake analyses.

  2014cites this paper
• Arsenic is cytotoxic and genotoxic to primary human lung cells.

  2014cites this paper
• In vitro toxicological characterization of two arsenosugars and their metabolites

  2013influential citation
• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns

  2012cites this paper
• Quantification of four arsenic species in fruit juices by ion-chromatography–inductively coupled plasma–mass spectrometry

  2012cites this paper
• Arsenic metabolism and thioarsenicals.

  2012cites this paper
• Is there a Trojan-horse effect during magnetic nanoparticles and metalloid cocontamination of human dermal fibroblasts?

  2012cites this paper
• Critical review or scientific opinion paper: Arsenosugars—a class of benign arsenic species or justification for developing partly speciated arsenic fractionation in foodstuffs?

  2011cites this paper
• Genetic and epigenetic effects of environmental arsenicals.

  2011cites this paper
• Genetic Toxicology of Arsenic and Antimony

  2010cites this paper
• X-ray photon-in/photon-out methods for chemical imaging

  2010cites this paper
• Methylated metal(loid) species in humans.

  2010cites this paper
• [Biological effects and metabolism of arsenic compounds present in seafood products].

  2010cites this paper
• Ingestion and excretion of arsenic compounds present in edible brown algae, Hijikia fusiforme, by mice.

  2010cites this paper
• DNA damage, severe organ lesions and high muscle levels of As and Hg in two benthic fish species from a chemical warfare agent dumping site in the Mediterranean Sea.

  2010cites this paper
• Organoarsenicals. Uptake, metabolism, and toxicity.

  2010cites this paper
• Utilidad del ensayo de linfoma de ratón en la determinación de los mecanismos de genotoxicidad del arsénico. Espectro mutacional del trióxido de arsénico

  2009cites this paper
• Oral exposure to inorganic arsenic: evaluation of its carcinogenic and non-carcinogenic effects

  2009cites this paper
• Arsenate-induced apoptosis in murine embryonic maxillary mesenchymal cells via mitochondrial-mediated oxidative injury.

  2009cites this paper
• Effects of arsenate on microcystin content and leakage of Microcystis strain PCC7806 under various phosphate regimes

  2009cites this paper
• Probing the interaction of arsenobetaine with blood plasma constituents in vitro: an SEC-ICP-AES study.

  2009cites this paper
• Effects of arsenate on the growth and microcystin production of Microcystis aeruginosa isolated from Taiwan as influenced by extracellular phosphate

  2009cites this paper
• Mechanistic in vitro tests for genotoxicity and carcinogenicity of heavy metals and their nanoparticles

  2009cites this paper
• OF THE SCIENTIFIC PANEL ON CONTAMINANTS IN THE FOOD CHAIN ON A REQUEST FROM THE COMMISSION RELATED TO ARSENIC AS UNDESIRABLE SUBSTANCE IN ANIMAL FEED Question N ° EFSA-Q-2003-031 Adopted on 31 January 2005

  2008cites this paper
• Cytotoxic, genotoxic and cell-cycle disruptive effects of thio-dimethylarsinate in cultured human cells and the role of glutathione.

  2008cites this paper
• Toxicity Screening of Single Dose of Inorganic and Organic Arsenics on Hematological and Serum Biochemical Parameters in Male Cynomolgus Monkeys

  2008cites this paper
• Molecular mechanisms of arsenic-induced carcinogenesis

  2008cites this paper
• Genetic Polymorphisms in MTHFR 677 and 1298 , GSTM 1 and T 1 , and Metabolism of Arsenic Craig Steinmaus Arsenic Health

  2007cites this paper
• Further evidence against a direct genotoxic mode of action for arsenic-induced cancer.

  2007cites this paper
• Seafood arsenic: implications for human risk assessment.

  2007cites this paper
• Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review.

  2007influential citation
• Adverse effects of organic arsenical compounds towards Vibrio fischeri bacteria.

  2007cites this paper
• Arsenite-Induced Alterations in Ku70-Deficient Cells: A Model to Study Genotoxic Effects

  2007cites this paper
• Effect of arsenic compounds on Vibrio fischeri light emission and butyrylcholinesterase activity

  2007influential citation
• Bewertungsmaßstäbe für Arsen in Böden, Grund- und Trinkwasser

  2007cites this paper
• Optimisation by experimental design of an IEC/ICP-MS speciation method for arsenic in seafood following microwave assisted extraction

  2007cites this paper
• Arsenic in drinking water caused ultra-structural damage in urinary bladder but did not affect expression of DNA damage repair genes or repair of DNA damage in transitional cells

  2007cites this paper
• Toxicological profile for arsenic

  2007cites this paper
• Genetic Polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and Metabolism of Arsenic

  2007cites this paper
• Environmental and Biological Aspects of Organometallic Compounds

  2006cites this paper
• Metal ions and carcinogenesis.

  2006cites this paper
• Elevation of Cellular BPDE Uptake by Human Cells: A Possible Factor Contributing to Co-Carcinogenicity by Arsenite

  2006cites this paper
• Chemical and Biological Studies for the Molecular Mechanisms of Human Trivalent Dimethylarsenic Metabolite-Induced Cytolethality;

  2006cites this paper
• Dimethylarsinic acid: results of chronic toxicity/oncogenicity studies in F344 rats and in B6C3F1 mice.

  2006cites this paper
• Methylated Arsenicals: The Implications of Metabolism and Carcinogenicity Studies in Rodents to Human Risk Assessment

  2006cites this paper
• AMELIORATION BY MELATONIN OF CHROMOSOMAL ANOMALIES INDUCED BY ARSENIC AND/OR FLUORIDE IN HUMAN BLOOD LYMPHOCYTE CULTURES a

  2006cites this paper
• Decrease of arsenic in edible brown algae Hijikia fusiforme by the cooking process

  2006cites this paper
• Depletion of securin increases arsenite-induced chromosome instability and apoptosis via a p53-independent pathway.

  2006cites this paper
• Cytolethality of glutathione conjugates with monomethylarsenic or dimethylarsenic compounds.

  2005cites this paper
• BIOMONITORIZACIÓN GENOTÓXICA DE POBLACIONES HUMANAS EXPUESTAS AMBIENTALMENTE AL ARSÉNICO

  2005cites this paper
• Toxicity of alkylated derivatives of arsenic, antimony and tin in vitro

  2005cites this paper
• Genotoxicity of dimethylarsinous acid: high induction of tetraploids

  2005cites this paper
• DNA-protein cross-links and sister chromatid exchanges induced by dimethylarsinic acid in human fibroblasts cells.

  2005cites this paper
• A comparison of hepatocyte cytotoxic mechanisms for chromate and arsenite.

  2005cites this paper
• Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status.

  2005cites this paper
• Ingested Inorganic Arsenic in Support of Summary Information on the Integrated Risk Information System (iris) Draft -do Not Cite or Quote T Able of Contents -toxicological Review for Inorganic Arsenic

  2005cites this paper
• Caenorhabditis elegans gcs-1 Confers Resistance to Arsenic-Induced Oxidative Stress

  2005cites this paper
• Arsenic intoxication-induced reduction of glutathione level and of the activity of related enzymes in rat brain regions: reversal by dl-α-lipoic acid

  2005cites this paper
• Microbial metabolite of dimethylarsinic acid is highly toxic and genotoxic.

  2004cites this paper
• In vitro cytotoxic and genotoxic effects of diphenylarsinic acid, a degradation product of chemical warfare agents.

  2004cites this paper
• In vitro DNA damage by arsenic compounds in a human lymphoblastoid cell line (TK6) assessed by the alkaline Comet assay.

  2004cites this paper
• Mutagenicity, Carcinogenicity, and Teratogenicity

  2004cites this paper
• Arsenic induces oxidative DNA damage in mammalian cells

  2004cites this paper
• Understanding arsenic carcinogenicity by the use of animal models.

  2004cites this paper
• Vibrational frequencies and structural determination of trimethylarsine oxide.

  2004cites this paper
• Do arsenosugars pose a risk to human health? The comparative toxicities of a trivalent and pentavalent arsenosugar.

  2004cites this paper
• Genotoxicity of organometallic species

  2004cites this paper
• In Vivo Effects of Arsenite on Meiosis, Preimplantation Development, and Apoptosis in the Mouse1

  2004cites this paper
• Environmental Distribution, Analysis, and Toxicity of Organometal(loid) Compounds

  2004cites this paper
• Safety evaluation of organoarsenical species in edible Porphyra from the China Sea.

  2003cites this paper
• Measurement of arsenic species in marine sediments by high-performance liquid chromatography-inductively coupled plasma mass spectrometry

  2003cites this paper
• Mechanism of arsenic carcinogenesis: an integrated approach.

  2003cites this paper
• Induction of structural and numerical changes of chromosome, centrosome abnormality, multipolar spindles and multipolar division in cultured Chinese hamster V79 cells by exposure to a trivalent dimethylarsenic compound.

  2003cites this paper
• Induction of C-anaphase and diplochromosome through dysregulation of spindle assembly checkpoint by sodium arsenite in human fibroblasts.

  2003cites this paper
• Cytogenetic Effect of Organoarsenicals on Cultured Mammalian Cells

  2003cites this paper