De- and remyelination in the CNS white and grey matter induced by cuprizone: the old, the new, and the unexpected.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Histology and Histopathology

• Publication date

  2011-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.14670/HH-26.1585PMID 21972097
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Lack of cuprizone‐induced demyelination in the murine spinal cord despite oligodendroglial alterations substantiates the concept of site‐specific susceptibilities of the central nervous system

  2011cited by this paper
• Cerebellar Cortical Demyelination in the Murine Cuprizone Model

  2010cited by this paper
• Restoring the balance between disease and repair in multiple sclerosis: insights from mouse models

  2010cited by this paper
• Cuprizone induces similar demyelination in male and female C57BL/6 mice and results in disruption of the estrous cycle

  2010cited by this paper
• Cuprizone‐induced demyelination in CNP::GFP transgenic mice

  2010cited by this paper
• Postnatal experiences influence the behavior in adult male and female Fischer and Lewis rats

  2010cited by this paper
• Beneficial Effects of Minocycline on Cuprizone Induced Cortical Demyelination

  2010cited by this paper
• Remyelination after cuprizone induced demyelination is accelerated in mice deficient in the polysialic acid synthesizing enzyme St8siaIV.

  2010cited by this paper
• Age-Related and Cuprizone-Induced Changes in Myelin and Transcription Factor Gene Expression and in Oligodendrocyte Cell Densities in the Rostral Corpus Callosum of Mice

  2010cited by this paper
• Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination.

  2009cited by this paper
• Regional differences between grey and white matter in cuprizone induced demyelination.

  2009cited by this paper
• Demyelination of the hippocampus is prominent in the cuprizone model.

  2009cited by this paper
• Cuprizone Treatment Induces Distinct Demyelination, Astrocytosis, and Microglia Cell Invasion or Proliferation in the Mouse Cerebellum

  2009cited by this paper
• SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination

  2009cited by this paper
• Region-specific susceptibilities to cuprizone-induced lesions in the mouse forebrain: Implications for the pathophysiology of schizophrenia.

  2009cited by this paper
• Cuprizone treatment induces demyelination and astrocytosis in the mouse hippocampus

  2009cited by this paper
• Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone.

  2009cited by this paper
• The cuprizone animal model: new insights into an old story

  2009cited by this paper
• Cuprizone demyelination of the corpus callosum in mice correlates with altered social interaction and impaired bilateral sensorimotor coordination

  2009cited by this paper
• Functional recovery of callosal axons following demyelination: a critical window.

  2009cited by this paper
• A salmon based diet protects mice from behavioural changes in the cuprizone model for demyelination.

  2009cited by this paper
• Models of autoimmune demyelination in the central nervous system: on the way to translational medicine

  2009cited by this paper
• In toxic demyelination oligodendroglial cell death occurs early and is FAS independent

  2009cited by this paper
• Demyelination in the juvenile period, but not in adulthood, leads to long-lasting cognitive impairment and deficient social interaction in mice.

  2009cited by this paper
• Cuprizone effect on myelination, astrogliosis and microglia attraction in the mouse basal ganglia.

  2009cited by this paper
• Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination.

  2009cited by this paper
• Epileptic seizures and hippocampal damage after cuprizone-induced demyelination in C57BL/6 mice.

  2008cited by this paper
• Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse.

  2008cited by this paper
• Polarity Development in Oligodendrocytes: Sorting and Trafficking of Myelin Components

  2008cited by this paper
• MHC class II exacerbates demyelination in vivo independently of T cells.

  2008cited by this paper
• The chemokine receptor CXCR2 is differentially regulated on glial cells in vivo but is not required for successful remyelination after cuprizone‐induced demyelination

  2008cited by this paper
• Cortical demyelination is prominent in the murine cuprizone model and is strain-dependent.

  2008cited by this paper
• Sequential myelin protein expression during remyelination reveals fast and efficient repair after central nervous system demyelination

  2007cited by this paper
• Microglial recruitment, activation, and proliferation in response to primary demyelination.

  2007cited by this paper
• Behavioral deficits in the cuprizone-induced murine model of demyelination/remyelination.

  2007cited by this paper
• Implications of protease M/neurosin in myelination during experimental demyelination and remyelination.

  2006cited by this paper
• A Novel Fluorescent Probe That Is Brain Permeable and Selectively Binds to Myelin

  2006cited by this paper
• Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin.

  2006cited by this paper
• Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice.

  2006cited by this paper
• Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis.

  2006cited by this paper
• Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions.

  2004cited by this paper
• Quantifying the Early Stages of Remyelination Following Cuprizone‐induced Demyelination

  2003cited by this paper
• Sequential loss of myelin proteins during Wallerian degeneration in the rat spinal cord

  2003cited by this paper
• Peripheral macrophage recruitment in cuprizone-induced CNS demyelination despite an intact blood-brain barrier.

  2002cited by this paper
• TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination.

  2001cited by this paper
• Interleukin-1β Promotes Repair of the CNS

  2001cited by this paper
• Biology of oligodendrocyte and myelin in the mammalian central nervous system.

  2001cited by this paper
• TNFα promotes proliferation of oligodendrocyte progenitors and remyelination

  2001cited by this paper
• The Neurotoxicant, Cuprizone, as a Model to Study Demyelination and Remyelination in the Central Nervous System

  2001cited by this paper
• Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre

  2001cited by this paper
• Interleukin-1beta promotes repair of the CNS.

  2001cited by this paper
• Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice.

  1998cited by this paper
• Gene expression in brain during cuprizone-induced demyelination and remyelination.

  1998cited by this paper
• Monocyte/macrophage differentiation in early multiple sclerosis lesions

  1995cited by this paper
• Induction of myelin-associated glycoprotein mRNA in experimental remyelination.

  1990cited by this paper
• Cuprizone neurotoxicity in the rat: morphologic observations.

  1988cited by this paper
• Blood-brain barrier permeability during Cuprizone-induced demyelination. Implications for the pathogenesis of immune-mediated demyelinating diseases.

  1987cited by this paper
• Blood-brain barrier permeability to horseradish peroxidase in twitcher and cuprizone-intoxicated mice.

  1987cited by this paper
• Differences in the in vivo effects of cuprizone on superoxide dismutase activity in rat liver cytosol and mitochondrial intermembrane space.

  1985cited by this paper
• Biochemical changes in cuprizone-induced spongiform encephalopathy

  1983cited by this paper
• Effect of cuprizone on copper exchange and superoxide dismutase activity in rat liver.

  1980cited by this paper
• Chronic demyelination inhibits remyelination in the central nervous system. An analysis of contributing factors.

  1980cited by this paper
• Central nervous system demyelination and remyelination in the mouse: an ultrastructural study of cuprizone toxicity.

  1978cited by this paper
• Profiles of brain glycosidase activity in cuprizone-fed Syrian hamsters and in scrapie-affected mice, rats, Chinese hamsters and Syrian hamsters.

  1976cited by this paper
• The effects of cuprizone toxicity on the incubation period of scrapie in mice.

  1976cited by this paper
• MECHANISM OF THE FORMATION OF MEGAMITOCHONDRIA INDUCED BY COPPER‐CHELATING AGENTS

  1975cited by this paper
• A comparison of the biochemical changes induced in mouse brain cuprizone toxicity and by scrapie infection.

  1974cited by this paper
• Remyelination of the superior cerebellar peduncle in old mice following demyelination induced by cuprizone.

  1974cited by this paper
• Demyelination of the superior cerebellar peduncle in the mouse induced by cuprizone.

  1973cited by this paper
• Permeability of blood vessels in mice affected with scrapie or fed with cuprizone.

  1973cited by this paper
• Clinical and histological recovery from the scrapie‐like spongiform encephalopathy produced in mice by feeding them with cuprizone

  1973cited by this paper
• ENZYMIC ACTIVITIES AND SODIUM, POTASSIUM AND COPPER CONCENTRATIONS IN MOUSE BRAIN AND LIVER AFTER CUPRIZONE TREATMENT IN VIVO

  1973cited by this paper
• Unsuccessful attempts to produce disease with tissues from mice fed on a diet containing cuprizone.

  1973cited by this paper
• Remyelination of the superior cerebellar peduncle in the mouse following demyelination induced by feeding cuprizone.

  1973cited by this paper
• DIVISION OF GIANT MITOCHONDRIA DURING RECOVERY FROM CUPRIZONE INTOXICATION

  1973cited by this paper
• Cuprizone toxicosis in mice--attempts to antidote the toxicity.

  1972cited by this paper
• Observations on oligodendrocyte degeneration, the resolution of status spongiosus and remyelination in cuprizone intoxication in mice

  1972cited by this paper
• Brain cell cultures from mice affected with scrapie or fed with cuprizone.

  1971cited by this paper
• Histopathological Similarities between Scrapie and Cuprizone Toxicity in Mice

  1971cited by this paper
• Histopathologic and enzyme histochemical observations of the cuprizone-induced brain edema.

  1971cited by this paper
• Clinical and histological observations on cuprizone toxicity and scrapie in mice.

  1971cited by this paper
• Ultrastructural changes of cuprizone encephalopathy in mice.

  1971cited by this paper
• Aqueductal stenosis as the cause of hydrocephalus in mice fed the substituted hydrazine, cuprizone.

  1970cited by this paper
• Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone).

  1969cited by this paper
• Spongiform encephalopathy induced in rats and guinea pigs by cuprizone.

  1969cited by this paper
• Giant Hepatic Mitochondria: Production in Mice Fed with Cuprizone

  1969cited by this paper
• Studies on the induction of hydrocephalus and spongy degeneration by cuprizone feeding and attempts to antidote the toxicity.

  1967cited by this paper
• Response of mice to the chelating agents sodium diethyldithiocarbamate, alpha-benzoinoxime, and biscyclohexanone oxaldihydrazone.

  1966cited by this paper

• Testing an inverse link between limbic alpha-synucleinopathy and myelin markers in mice and humans.

  2026cites this paper
• Cuprizone in Peanut Butter: An Alternative Method of Cuprizone Administration to Model Demyelination of the Central Nervous System.

  2026cites this paper
• Neuroprotective Role of Cannabinoid CB1 and GPR55 Receptors in a Cell Model of Multiple Sclerosis

  2026cites this paper
• Pilot functional magnetic resonance imaging study of clemastine‐aided functional recovery on a mouse model of demyelination

  2025cites this paper
• Plasma and Visceral Organ Kynurenine Metabolites Correlate in the Multiple Sclerosis Cuprizone Animal Model

  2025cites this paper
• Apolipoprotein D Expression Dynamics During Cuprizone-Induced Demyelination and Remyelination in a Mouse Model of Multiple Sclerosis

  2025cites this paper
• Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain

  2025cites this paper
• Mitochondria-targeted antioxidant skq1 reverses functional impairment and histopathological insults in a chronic animal model of multiple sclerosis

  2025cites this paper
• Novel Animal Models for Multiple Sclerosis: R-Ras GTPases in Myelin Pathophysiology

  2025cites this paper
• Demyelination Produces a Shift in the Population of Cortical Neurons That Synapse with Callosal Oligodendrocyte Progenitor Cells

  2025cites this paper
• Transient juvenile demyelination impairs maturation and function of parvalbumin-positive interneurons in the prefrontal cortex

  2025cites this paper
• A critical period for prefrontal cortex PV interneuron myelination and maturation

  2025cites this paper
• Treadmill Exercise Impact on Brain Electrophysiological and Glial Immunoreactivity in Cuprizone-Treated Rats

  2025cites this paper
• Remyelination as a therapeutic target in the treatment of multiple sclerosis

  2025cites this paper
• Investigating the use of cuprizone and lysolecithin to model demyelination ex vivo in sagittal rat brain organotypic slice cultures

  2025cites this paper
• How to Use the Cuprizone Model to Study De- and Remyelination

  2024cites this paper
• Quantitative Analysis of Early White Matter Damage in Cuprizone Mouse Model of Demyelination Using 7.0 T MRI Multiparametric Approach

  2024cites this paper
• C1ql1 expression in oligodendrocyte progenitor cells promotes oligodendrocyte differentiation

  2024cites this paper
• BDNF-TrkB Signaling Pathway in Spinal Cord Injury: Insights and Implications

  2024cites this paper
• Ibogaine administration following repeated morphine administration upregulates myelination markers 2′, 3′-cyclic nucleotide 3′-phosphodiesterase (CNP) and myelin basic protein (MBP) mRNA and protein expression in the internal capsule of Sprague Dawley rats

  2024cites this paper
• Age-Related Effects of Inhalational Anesthetics in B4galnt1-Null and Cuprizone-Treated Mice: Clinically Relevant Insights into Demyelinating Diseases

  2024cites this paper
• Magnetic resonance metrics for identification of cuprizone-induced demyelination in the mouse model of neurodegeneration: a review

  2024influential citation
• N-butyl-β-carboline-3-carboxylate (β-CCB) systemic administration promotes remyelination in the cuprizone demyelinating model in mice

  2024cites this paper
• Glutamate delta-1 receptor regulates oligodendrocyte progenitor cell differentiation and myelination in normal and demyelinating conditions

  2023cites this paper
• Rapid and prolonged response of oligodendrocyte lineage cells in standard acute cuprizone demyelination model revealed by in situ hybridization

  2023cites this paper
• Assessing neuroprotective effects of diroximel fumarate and siponimod via modulation of pacemaker channels in an experimental model of remyelination.

  2023cites this paper
• NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores

  2023cites this paper
• An Association of Chitinase-3 Like-Protein-1 With Neuronal Deterioration in Multiple Sclerosis

  2023cites this paper
• Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis.

  2023cites this paper
• The neuroprotective effects of Chalcones from Ashitaba on cuprizone‐induced demyelination via modulation of brain‐derived neurotrophic factor and tumor necrosis factor α

  2023cites this paper
• Endogenous Sox8 is a critical factor for timely remyelination and oligodendroglial cell repletion in the cuprizone model

  2023cites this paper
• Reaction of different cell types of the brain on neurotoxin cuprizone and hormone melatonin treatment in young and aging mice

  2023cites this paper
• Key role of the gut-microbiota-brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain.

  2023cites this paper
• The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis

  2022cites this paper
• Siponimod ameliorates metabolic oligodendrocyte injury via the sphingosine-1 phosphate receptor 5

  2022cites this paper
• Effects of Axonal Demyelination, Inflammatory Cytokines and Divalent Cation Chelators on Thalamic HCN Channels and Oscillatory Bursting

  2022cites this paper
• Astroglial and oligodendroglial markers in the cuprizone animal model for de- and remyelination

  2022influential citation
• Cuprizone feeding induces swollen astrocyte endfeet

  2022cites this paper
• The mechanistic target of rapamycin as a regulator of metabolic function in oligodendroglia during remyelination.

  2022cites this paper
• News and Views on Polysialic Acid: From Tumor Progression and Brain Development to Psychiatric Disorders, Neurodegeneration, Myelin Repair and Immunomodulation

  2022cites this paper
• Characterization of Glial Populations in the Aging and Remyelinating Mouse Corpus Callosum

  2022cites this paper
• Impact of Intraventricular Human Adipose-Derived Stem Cells Transplantation with Pregnenolone Treatment on Remyelination of Corpus Callosum in A Rat Model of Multiple Sclerosis

  2022cites this paper
• Modulation of pacemaker channel function in a model of thalamocortical hyperexcitability by demyelination and cytokines

  2022cites this paper
• Defining milestones for the study of remyelination using the cuprizone mouse model: How early is early?

  2022cites this paper
• CAQK, a peptide associating with extracellular matrix components targets sites of demyelinating injuries

  2022cites this paper
• Abnormal oxidative metabolism in the cuprizone mouse model of demyelination: An in vivo NIRS-MRI study

  2022cites this paper
• Inhomogeneous Magnetization Transfer (ihMT) imaging in the acute cuprizone mouse model of demyelination/remyelination

  2022influential citation
• CSF infusion of TrkB agonist, 7,8-dihydroxyflavone, is ineffective in promoting remyelination in cuprizone and EAE models of multiple sclerosis

  2022cites this paper
• The Effects of Cuprizone on Murine Subventricular Zone-Derived Neural Stem Cells and Progenitor Cells Grown as Neurospheres

  2022cites this paper
• Preclinical model of multiple sclerosis: Focal, chemical or viral demyelination.

  2022cites this paper
• Cuprizone‐mediated demyelination reversibly degrades voiding behavior in mice while sparing brainstem reflex

  2022cites this paper
• PART 2: Mouse models for multiple sclerosis research

  2021cites this paper
• Exploratory study on neurochemical effects of low-intensity pulsed ultrasound in brains of mice

  2021cites this paper
• Central nervous system infusion of TrkB agonist, 7,8-dihydroxyflavone, is ineffective in promoting myelin repair in cuprizone and experimental autoimmune encephalomyelitis mouse models of multiple sclerosis

  2021cites this paper
• Effect and Mechanism of Catalpol on Remyelination via Regulation of the NOTCH1 Signaling Pathway

  2021cites this paper
• Astrocytes as a target for Nogo‐A and implications for synapse formation in vitro and in a model of acute demyelination

  2021cites this paper
• Regenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination

  2021cites this paper
• Electrophysiological Measurements for Brain Network Characterization in Rodents

  2021cites this paper
• Transient astrocyte‐like NG2 glia subpopulation emerges solely following permanent brain ischemia

  2021cites this paper
• Quantification of Oligodendrocytes and Myelin in Human iPSC-Derived 3D Brain Cell Cultures (BrainSpheres)

  2021cites this paper
• N‐myc downstream regulated family member 1 (NDRG1) is enriched in myelinating oligodendrocytes and impacts myelin degradation in response to demyelination

  2021cites this paper
• Small molecule screening as an approach to encounter inefficient myelin repair.

  2021cites this paper
• Matrix metalloproteinases shape the oligodendrocyte (niche) during development and upon demyelination.

  2020cites this paper
• P2x7 receptors control demyelination and inflammation in the cuprizone model

  2020cites this paper
• Functional role of endogenous Kv1.4 in experimental demyelination.

  2020cites this paper
• C57BL6 mouse substrains demonstrate differences in susceptibility to the demyelinating effects of Cuprizone toxin

  2020cites this paper
• Effects of Low Field Magnetic Stimulation on Cognitive Impairment and Brain Pathologies in the Cuprizone Mouse Model of Demyelination

  2020cites this paper
• Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model

  2020cites this paper
• Cognitive disturbances in the cuprizone model of multiple sclerosis

  2020cites this paper
• CD8 T-cell Recruitment Into the Central Nervous System of Cuprizone-Fed Mice: Relevance to Modeling the Etiology of Multiple Sclerosis

  2020cites this paper
• Remodeling of the interstitial extracellular matrix in white matter multiple sclerosis lesions: Implications for remyelination (failure)

  2020cites this paper
• Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination

  2020influential citation
• Effects of Lactobacillus casei Strain T2 (IBRC-M10783) on the Modulation of Th17/Treg and Evaluation of miR-155, miR-25, and IDO-1 Expression in a Cuprizone-Induced C57BL/6 Mouse Model of Demyelination

  2020cites this paper
• Effect of etazolate upon cuprizone induced demyelination in vivo: Behavioral and myelin gene analysis.

  2020cites this paper
• (Examining ABHD6 inhibition to promote remyelination the cuprizone model of primary demyelination)

  2020cites this paper
• A Systematic Review on the Role of Arachidonic Acid Pathway in Multiple Sclerosis.

  2020cites this paper
• Determination of optimal parameters for 3D single‐point macromolecular proton fraction mapping at 7T in healthy and demyelinated mouse brain

  2020cites this paper
• The effect of microglial ablation and mesenchymal stem cell transplantation on a cuprizone‐induced demyelination model

  2020cites this paper
• Inflammation‐driven glial alterations in the cuprizone mouse model probed with diffusion‐weighted magnetic resonance spectroscopy at 11.7 T

  2020cites this paper
• The Protective Effect of Kolaviron on Molecular, Cellular, and Behavioral Characterization of Cerebellum in the Rat Model of Demyelinating Diseases

  2020cites this paper
• Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies.

  2020cites this paper
• The effect of the demyelinating agent cuprizone on binge-like eating of sweetened palatable food in female and male C57BL/6 substrains.

  2020cites this paper
• Deciphering the heterogeneity of myeloid cells during neuroinflammation in the single‐cell era

  2020cites this paper
• Myelination- and immune-mediated MR-based brain network correlates

  2020cites this paper
• Five Decades of Cuprizone, an Updated Model to Replicate Demyelinating Diseases

  2019cites this paper
• Behavioural phenotypes in the cuprizone model of central nervous system demyelination.

  2019cites this paper
• Cordycepin (3'-deoxyadenosine) promotes remyelination via suppression of neuroinflammation in a cuprizone-induced mouse model of demyelination.

  2019cites this paper
• The effects of a combination of ion channel inhibitors on pathology in a model of demyelinating disease.

  2019cites this paper
• Effects of enhanced environment and induced depression on cuprizone mouse model of demyelination.

  2019cites this paper
• The active contribution of OPCs to neuroinflammation is mediated by LRP1

  2019cites this paper
• Genetic Elimination of Connective Tissue Growth Factor in the Forebrain Affects Subplate Neurons in the Cortex and Oligodendrocytes in the Underlying White Matter

  2019cites this paper
• Interferon β-Mediated Protective Functions of Microglia in Central Nervous System Autoimmunity

  2019cites this paper
• Astrocyte ablation induced by La-aminoadipate (L-AAA) potentiates remyelination in a cuprizone demyelinating mouse model

  2019cites this paper
• Ultrahigh field imaging of myelin disease models: Toward specific markers of myelin integrity?

  2019cites this paper
• Effect of mesenchymal stem cells on glial cells population in cuprizone induced demyelination model.

  2019cites this paper
• The demyelinating agent cuprizone induces a male-specific reduction in binge eating in the binge-prone C57BL/6NJ strain

  2019cites this paper
• The emerging role of galectins in (re)myelination and its potential for developing new approaches to treat multiple sclerosis

  2019cites this paper
• Structural adaption of axons during de‐ and remyelination in the Cuprizone mouse model

  2019cites this paper
• Evaluation of Effects of Benzoaric Acid on the I-KB/NF-Kb Complex and Expression of Caspase-8 and -9 in Animal Model of Multiple Sclerosis

  2019cites this paper
• Imaging and Quantification of Myelin Integrity After Injury With Spectral Confocal Reflectance Microscopy

  2019cites this paper