Combination of Vascular Endothelial Growth Factor Receptor/Platelet-Derived Growth Factor Receptor Inhibition Markedly Improves Radiation Tumor Therapy

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Clinical Cancer Research

• Publication date

  2008-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1158/1078-0432.CCR-07-1893PMID 18381963
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transcriptional network governing the angiogenic switch in human pancreatic cancer

  2007cited by this paper
• Dual Targeting of Endothelial Cells and Pericytes in Antivascular Therapy for Ovarian Carcinoma

  2007cited by this paper
• Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo

  2007cited by this paper
• Lessons from phase III clinical trials on anti-VEGF therapy for cancer

  2006cited by this paper
• Small molecule receptor tyrosine kinase inhibitor of platelet-derived growth factor signaling (SU9518) modifies radiation response in fibroblasts and endothelial cells

  2006cited by this paper
• Human Glioblastoma and Carcinoma Xenograft Tumors Treated by Combined Radiation and Imatinib (Gleevec®)

  2006cited by this paper
• Radiation combined with antiangiogenic and antivascular agents.

  2006cited by this paper
• Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy.

  2005cited by this paper
• Enhanced susceptibility of irradiated tumor vessels to vascular endothelial growth factor receptor tyrosine kinase inhibition.

  2005cited by this paper
• Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy.

  2005cited by this paper
• Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis

  2005cited by this paper
• A small molecule–kinase interaction map for clinical kinase inhibitors

  2005cited by this paper
• Differentiation and definition of vascular-targeted therapies.

  2005cited by this paper
• Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma.

  2005cited by this paper
• Endostatin: the logic of antiangiogenic therapy.

  2005cited by this paper
• Inhibition of αvβ3 Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy

  2005cited by this paper
• Broad spectrum receptor tyrosine kinase inhibitor, SU6668, sensitizes radiation via targeting survival pathway of vascular endothelium.

  2004cited by this paper
• Endostatin's antiangiogenic signaling network.

  2004cited by this paper
• Combined inhibition of VEGF‐ and PDGF‐signaling enforces tumor vessel regression by interfering with pericyte‐mediated endothelial cell survival mechanisms

  2004cited by this paper
• Triple combination of irradiation, chemotherapy (pemetrexed), and VEGFR inhibition (SU5416) in human endothelial and tumor cells.

  2004cited by this paper
• Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

  2003cited by this paper
• SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models.

  2003cited by this paper
• Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction.

  2003cited by this paper
• Combined therapy with direct and indirect angiogenesis inhibition results in enhanced antiangiogenic and antitumor effects.

  2003cited by this paper
• Angiogenic tumor markers, antiangiogenic agents and radiation therapy

  2003cited by this paper
• SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro.

  2003cited by this paper
• Double target for tumor mass destruction.

  2003cited by this paper
• Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors.

  2003cited by this paper
• SU 11248 Maintenance Therapy Prevents Tumor Regrowth after Fractionated Irradiation of Murine Tumor Models 1

  2003cited by this paper
• Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response.

  2002cited by this paper
• Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation.

  2002cited by this paper
• The Antiangiogenic Agents SU5416 and SU6668 Increase the Antitumor Effects of Fractionated Irradiation

  2002cited by this paper
• Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms.

  2001cited by this paper
• Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent.

  2000cited by this paper
• Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.

  2000cited by this paper
• SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.

  2000cited by this paper
• SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

  1999cited by this paper
• Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation.

  1999cited by this paper
• Blockade of the Vascular Endothelial Growth Factor Stress Response Increases the Antitumor Effects of Ionizing Radiation

  1999cited by this paper
• Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis.

  1994cited by this paper
• Antiangiogenic agents can increase tumor oxygenation and response to radiation therapy

  1994cited by this paper

• Wnt-associated DKK3 in keratinocytes mediates radiation-induced hyperplasia, dermatitis and skin fibrosis

  2026cites this paper
• Targeting insulin-like growth factor 1 signaling with Linsitinib to modulate fibroblast plasticity and attenuate pulmonary fibrosis.

  2025cites this paper
• New approaches to overcome radioresistance in glioblastoma: mechanisms, targets and role of innovative therapies, new particles and non-photon radiotherapy in 2024. A systematic review

  2025cites this paper
• Anoikis Resistance in Cancer: Mechanisms, Therapeutic Strategies, Potential Targets, and Models for Enhanced Understanding.

  2025cites this paper
• Optical Nanopore Blockade Sensors for Multiplexed Detection of Proteins.

  2025cites this paper
• Anti-angiogenesis agents plus chemoradiotherapy for locally advanced nasopharyngeal cancer: a systematic review and meta-analysis

  2024cites this paper
• The Role of Mesenchymal Reprogramming in Malignant Clonal Evolution and Intra-Tumoral Heterogeneity in Glioblastoma

  2024cites this paper
• Efficacy and safety of anti-angiogenic drug monotherapy and combination therapy for ovarian cancer: a meta-analysis and trial sequential analysis of randomized controlled trials

  2024cites this paper
• Two-dimensional coordination risedronate-manganese nanobelts as adjuvant for cancer radiotherapy and immunotherapy

  2024cites this paper
• Efficacy and safety of neoadjuvant chemotherapy containing anti-angiogenic drugs, immunotherapy, or PARP inhibitors for ovarian cancer.

  2023cites this paper
• Immune Response on Optimal Timing and Fractionation Dose for Hypofractionated Radiotherapy in Non–Small-Cell Lung Cancer

  2022cites this paper
• Improved Long-Term Survival of Patients with Recurrent Medulloblastoma Treated with a “MEMMAT-like” Metronomic Antiangiogenic Approach

  2022cites this paper
• A Prospective, Multi-Center, Veterinary Radiation Therapy Oncology Group Study Reveals Potential Efficacy Of Toceranib Phosphate (Palladia®) As A Primary Or Adjuvant Agent In The Treatment Of Canine Nasal Carcinoma†.

  2021cites this paper
• Perspective of mesenchymal transformation in glioblastoma

  2021cites this paper
• Impact of Local Liver Irradiation Concurrent Versus Sequential with Lenvatinib on Pharmacokinetics and Biodistribution

  2021cites this paper
• Aminopeptidase N-targeting nanomolecule-assisted delivery of VEGF siRNA to potentiate antitumour therapy by suppressing tumour revascularization and enhancing radiation response.

  2021cites this paper
• Evaluation of antitumor immunity by a combination treatment of high-dose irradiation, anti-PDL1, and anti-angiogenic therapy in murine lung tumors

  2020cites this paper
• Sunitinib malate-loaded biodegradable microspheres for the prevention of corneal neovascularization in rats.

  2020cites this paper
• In Vitro Modeling of the Tumor Microenvironment in Tumor Organoids

  2020cites this paper
• Signal Transduction in Diffuse Intrinsic Pontine Glioma

  2019cites this paper
• A second primary synovial sarcoma of pleural developed nine-years after the first synovial sarcoma of plantar pedis: a case report and review of literature.

  2019cites this paper
• Sensitizing endometrial cancer to ionizing radiation by multi-tyrosine kinase inhibition

  2019cites this paper
• Oncogene addiction as a foundation of targeted cancer therapy: The paradigm of the MET receptor tyrosine kinase.

  2019cites this paper
• EMT Regulation by Autophagy: A New Perspective in Glioblastoma Biology

  2019cites this paper
• A Phase 1 Study of Nilotinib Plus Radiation in High-Risk Chordoma.

  2018cites this paper
• Chapter 34 – Proton Therapy for Spinal Chordomas and Chondrosarcomas

  2018cites this paper
• [Adjuvant radiotherapy during anti-VEGF in neovascular age-related macular degeneration].

  2017cites this paper
• Synovial Sarcoma: Advances in Diagnosis and Treatment Identification of New Biologic Targets to Improve Multimodal Therapy

  2017cites this paper
• SU6668 modulates prostate cancer progression by downregulating MTDH/AKT signaling pathway

  2017cites this paper
• Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA-induced cell death in glioblastoma

  2017cites this paper
• Tumor angiogenesis and vascular normalization: alternative therapeutic targets

  2017cites this paper
• Adjuvante Radiotherapie der neovaskulären altersabhängigen Makuladegeneration unter Anti-VEGF

  2017cites this paper
• Treatment-Related Noncontiguous Radiologic Changes in Children With Diffuse Intrinsic Pontine Glioma Treated With Expanded Irradiation Fields and Antiangiogenic Therapy.

  2017cites this paper
• MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma

  2017cites this paper
• Developmentally regulated signaling pathways in glioma invasion

  2017cites this paper
• 12 Novel Therapeutic Targets in Soft Tissue Sarcomas

  2017cites this paper
• Mindfulness Meditation for Fibromyalgia: Mechanistic and Clinical Considerations

  2017cites this paper
• Mechanisms of SU5416, an inhibitor of vascular endothelial growth factor receptor, as a radiosensitizer for colon cancer cells.

  2016cites this paper
• UTILITY OF ASSESSMENT SERUM LEVELS OF VEGF, bFGF AND PDGF-BB AS SUGGESTED ANGIOGENESIS BIOMARKERS PANEL TOOL IN PATIENTS WITH BREAST CANCER

  2016cites this paper
• Phase I study of pre-operative continuous 5-FU and sorafenib with external radiation therapy in locally advanced rectal adenocarcinoma.

  2016cites this paper
• Epithelial-mesenchymal transition in glioblastoma progression

  2016cites this paper
• Mechanisms of SU 5416 , an inhibitor of vascular endothelial growth factor receptor , as a radiosensitizer for colon cancer cells

  2016cites this paper
• Neck Carcinoma Cells by Linifanib , A Receptor Tyrosine Kinase Inhibitor

  2016cites this paper
• Synergistic Effect of Anti-Angiogenic and Radiation Therapy: Quantitative Evaluation with Dynamic Contrast Enhanced MR Imaging

  2016cites this paper
• IL-4, a direct target of miR-340/429, is involved in radiation-induced aggressive tumor behavior in human carcinoma cells

  2016cites this paper
• Cell adhesion molecule control of planar spindle orientation

  2016cites this paper
• Transforming growth factor-β and stem cell markers are highly expressed around necrotic areas in glioblastoma

  2016cites this paper
• Bevacizumab in Ovarian Cancer: State of the Art and Unanswered Questions

  2016cites this paper
• Vascular endothelial growth factor receptor isoforms: are they present in oral squamous cell carcinoma?

  2015cites this paper
• Mechanisms for SU5416 as a radiosensitizer of endothelial cells.

  2015cites this paper
• Antiangiogenic agents in gynecological cancer: State of art and perspectives of clinical research.

  2015cites this paper
• Combined inhibition of TGFβ and PDGF signaling attenuates radiation-induced pulmonary fibrosis

  2015cites this paper
• Vascular Wall-Resident Multipotent Stem Cells within the Process of Vascular Remodelling

  2015cites this paper
• Silibinin attenuates ionizing radiation-induced pro-angiogenic response and EMT in prostate cancer cells.

  2015cites this paper
• [In Process Citation].

  2015cites this paper
• Wnt/β-catenin pathway involvement in ionizing radiation-induced invasion of U87 glioblastoma cells

  2015cites this paper
• Vascular heterogeneity and targeting: the role of YKL-40 in glioblastoma vascularization

  2015cites this paper
• Use of bevacizumab in recurrent glioblastoma.

  2015cites this paper
• Phase 1 trial of bevacizumab with concurrent chemoradiation therapy for squamous cell carcinoma of the head and neck with exploratory functional imaging of tumor hypoxia, proliferation, and perfusion.

  2015cites this paper
• Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth through inhibiting Hedgehog signaling pathway.

  2015cites this paper
• Stellungnahme der Retinologischen Gesellschaft, der Deutschen Ophthalmologischen Gesellschaft und des Berufsverbands der Augenärzte Deutschlands zur Strahlentherapie bei neovaskulärer altersabhängiger Makuladegeneration

  2015cites this paper
• Endothelial Caveolin-1 regulates the radiation response of epithelial prostate tumors

  2015cites this paper
• Targeting angiogenesis in head and neck cancer.

  2015cites this paper
• Mesenchymal stem cells are sensitive to treatment with kinase inhibitors and ionizing radiation

  2014cites this paper
• Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma.

  2014cites this paper
• Physiological modulation approaches to improve cancer chemotherapy : a review.

  2014cites this paper
• Emerging roles of radioresistance in prostate cancer metastasis and radiation therapy

  2014cites this paper
• Phase 1 pharmacogenetic and pharmacodynamic study of sorafenib with concurrent radiation therapy and gemcitabine in locally advanced unresectable pancreatic cancer.

  2014cites this paper
• Sunitinib effects on the radiation response of endothelial and breast tumor cells.

  2014cites this paper
• Association of genetic variants in VEGF-A with clinical recurrence in prostate cancer patients treated with definitive radiotherapy

  2014cites this paper
• The Impact of Conventional and Carbon Ion Irradiation on Metastatic Potential of Tumor Cells

  2014cites this paper
• SKLB-M8 induces apoptosis through the AKT/mTOR signaling pathway in melanoma models and inhibits angiogenesis with decrease of ERK1/2 phosphorylation.

  2014cites this paper
• Biodegradable nanoassemblies of piperlongumine display enhanced anti-angiogenesis and anti-tumor activities.

  2014cites this paper
• Masitinib mesylate does not enhance sensitivity to radiation in three feline injection-site sarcoma cell lines under normal growth conditions.

  2014cites this paper
• Combination antiangiogenic therapy and radiation in head and neck cancers.

  2014cites this paper
• Cancer Therapy : Clinical Phase I Trial , Pharmacokinetics , and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma

  2013cites this paper
• The Molecular Crosstalk between the MET Receptor Tyrosine Kinase and the DNA Damage Response — Biological and Clinical Aspects

  2013cites this paper
• The irradiated tumor microenvironment: role of tumor-associated macrophages in vascular recovery

  2013cites this paper
• Angiogenic endothelial cell invasion into fibrin is stimulated by proliferating smooth muscle cells.

  2013cites this paper
• Linifanib (ABT-869) enhances radiosensitivity of head and neck squamous cell carcinoma cells.

  2013cites this paper
• Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles.

  2013cites this paper
• Anti-Angiogenic Therapy Combined with Chemoradiotherapy for Patients with Localized Advanced Rectal Cancer

  2013cites this paper
• Biodegradable polymeric micelle-encapsulated quercetin suppresses tumor growth and metastasis in both transgenic zebrafish and mouse models.

  2013cites this paper
• [Anti-angiogenic therapies: from theory to practice].

  2013cites this paper
• Radiosensitization of Head & Neck Carcinoma Cells by Linifanib, A Receptor Tyrosine Kinase Inhibitor

  2013cites this paper
• Antiangiogene Therapie in Kombination mit Temozolomid beim experimentellen MGMT-methylierten Glioblastom

  2013cites this paper
• Sunitinib plus androgen deprivation and radiation therapy for patients with localized high-risk prostate cancer: results from a multi-institutional phase 1 study.

  2013cites this paper
• The role of YKL-40 in the progression of glioblastoma

  2013cites this paper
• Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma

  2013cites this paper
• Dose-dependent response of tumor vasculature to radiation therapy in combination with Sunitinib depicted by three-dimensional high-frequency power Doppler ultrasound

  2013cites this paper
• Combining Antiangiogenics to Overcome Resistance: Rationale and Clinical Experience

  2012cites this paper
• The addition of Sunitinib to radiation delays tumor growth in a murine model of glioblastoma

  2012cites this paper
• Epimacular brachytherapy for the treatment of retinal angiomatous proliferation.

  2012cites this paper
• N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.

  2012cites this paper
• The Effects of Smooth Muscle Cells on Engineered Microvasculatures in Fibrin Hydrogels

  2012cites this paper
• Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development.

  2012cites this paper
• Molecular characteristics and pathways of Avastin for the treatment of glioblastoma multiforme.

  2012cites this paper
• Stellungnahme der Retinologischen Gesellschaft, der Deutschen Ophthalmologischen Gesellschaft und des Berufsverbands der Augenärzte Deutschlands zur epimakulären Brachytherapie bei altersbedingter Makuladegeneration

  2012cites this paper
• Platelet-derived endothelial cell growth factor/thymidine phosphorylase inhibitor augments radiotherapeutic efficacy in experimental colorectal cancer.

  2012cites this paper
• Improving Radioresponse Through Modification of the Tumor Immunological Microenvironment

  2012cites this paper