Neurobiological Markers of Illness Onset in Psychosis and Schizophrenia: The Search for a Moving Target

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Neuropsychology Review

• Publication date

  2009-08-30

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1007/s11065-009-9114-1PMID 19728098
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Recognition and Management of Early Psychosis: Neurobiological endophenotypes of psychosis and schizophrenia: are there biological markers of illness onset?

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• The Neuropsychology of Mental Illness: The role of executive functions in psychiatric disorders

  2009cited by this paper
• Imaging in schizophrenia: looking back and peering ahead.

  2009cited by this paper
• Mapping grey matter reductions in schizophrenia: an anatomical likelihood estimation analysis of voxel-based morphometry studies.

  2009cited by this paper
• Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study

  2009cited by this paper
• The neuropsychology of mental illness

  2009cited by this paper
• Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first‐episode psychosis

  2009cited by this paper
• Brain changes during the onset of schizophrenia: implications for neurodevelopmental theories

  2009cited by this paper
• Progressive brain structural changes mapped as psychosis develops in 'at risk' individuals.

  2009cited by this paper
• Functional integration between the posterior hippocampus and prefrontal cortex is impaired in both first episode schizophrenia and the at risk mental state.

  2009influential reference
• Major psychoses with mixed psychotic and mood symptoms: are mixed psychoses associated with different neurobiological markers?

  2008cited by this paper
• Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individuals.

  2008cited by this paper
• Increased neural response related to neutral faces in individuals at risk for psychosis

  2008cited by this paper
• Reductions in frontal, temporal and parietal volume associated with the onset of psychosis.

  2008cited by this paper
• Neuropsychological course in the prodrome and first episode of psychosis: findings from the PRIME North America Double Blind Treatment Study.

  2008cited by this paper
• Interrelated neuropsychological and anatomical evidence of hippocampal pathology in the at-risk mental state

  2008cited by this paper
• Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis.

  2007cited by this paper
• Cognitive decline following psychosis onset: data from the PACE clinic.

  2007cited by this paper
• Ventricle volumes in emerging psychosis. A cross-sectional and longitudinal MRI study

  2007cited by this paper
• Infant Developmental Milestones and Subsequent Cognitive Function

  2007cited by this paper
• Neurocognitive indicators for a conversion to psychosis: comparison of patients in a potentially initial prodromal state who did or did not convert to a psychosis.

  2007influential reference
• Relationship between subjective and objective cognitive function in the early and late prodrome.

  2007cited by this paper
• Are brain structural abnormalities useful as endophenotypes in schizophrenia?

  2007cited by this paper
• Chapter 17. Neuropathology of Schizophrenia

  2007cited by this paper
• Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia.

  2007cited by this paper
• Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk.

  2007cited by this paper
• Neural correlates of executive function and working memory in the ‘at-risk mental state’

  2007cited by this paper
• The neurobiological underpinnings of risk and conversion in relatives of patients with schizophrenia

  2007cited by this paper
• Regional gray matter volume abnormalities in the at risk mental state.

  2007cited by this paper
• Neuroimaging and emerging psychotic disorders: The Melbourne ultra-high risk studies

  2007cited by this paper
• Cognitive functioning in the schizophrenia prodrome.

  2007cited by this paper
• Effects of acute antipsychotic treatment on brain activation in first episode psychosis: an fMRI study.

  2007cited by this paper
• Neocortical gray matter volume in first-episode schizophrenia and first-episode affective psychosis: a cross-sectional and longitudinal MRI study.

  2007cited by this paper
• Neuroimaging endophenotypes: Strategies for finding genes influencing brain structure and function

  2007cited by this paper
• Sulcal thickness as a vulnerability indicator for schizophrenia

  2007cited by this paper
• Neurocognitive deficits in the (putative) prodrome and first episode of psychosis.

  2007cited by this paper
• Increased prefrontal gyrification in a large high-risk cohort characterizes those who develop schizophrenia and reflects abnormal prefrontal development.

  2007influential reference
• Brain structure and function changes during the development of schizophrenia: the evidence from studies of subjects at increased genetic risk.

  2007cited by this paper
• Antisaccade task performance in patients at ultra high risk for developing psychosis.

  2007cited by this paper
• Increased Prefrontal Cerebral Blood flow in First-Episode Schizophrenia Following Treatment: Longitudinal Positron Emission Tomography Study

  2007cited by this paper
• Generalized and specific neurocognitive deficits in prodromal schizophrenia.

  2006influential reference
• Neurocognitive Functioning in Subjects at Risk for a First Episode of Psychosis Compared with First- and Multiple-episode Schizophrenia

  2006cited by this paper
• Regionally specific cortical thinning and gray matter abnormalities in the healthy relatives of schizophrenia patients.

  2006cited by this paper
• Brain volume in first-episode schizophrenia

  2006cited by this paper
• Prospective investigations of the prodromal state of schizophrenia: review of studies

  2006cited by this paper
• Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of function.

  2006cited by this paper
• Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder.

  2006cited by this paper
• Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals.

  2006cited by this paper
• Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures.

  2006cited by this paper
• Cognitive processes in the development of TOL performance.

  2006cited by this paper
• Olfactory processing and brain maturation

  2006cited by this paper
• Functional imaging as a predictor of schizophrenia.

  2006cited by this paper
• Neuropsychological performance over time in people at high risk of developing schizophrenia and controls.

  2006cited by this paper
• A longitudinal study of neurocognitive function in individuals at-risk for psychosis.

  2006cited by this paper
• Olfaction and the brain

  2006cited by this paper
• Antisaccade performance in monozygotic twins discordant for schizophrenia: the Maudsley twin study.

  2006cited by this paper
• Proton magnetic resonance spectroscopy in subjects at risk for schizophrenia

  2006cited by this paper
• Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people.

  2006cited by this paper
• Infant developmental milestones: a 31-year follow-up.

  2005cited by this paper
• Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis.

  2005cited by this paper
• Sustained attention in young people at high risk of psychosis does not predict transition to psychosis.

  2005cited by this paper
• Cognitive functions in prepsychotic patients.

  2005cited by this paper
• Meta-analysis of the time-course of brain volume reduction in schizophrenia: implications for pathogenesis and early treatment.

  2005cited by this paper
• Neuropathology of schizophrenia

  2005cited by this paper
• Clinical and genetic high-risk strategies in understanding vulnerability to psychosis.

  2005cited by this paper
• Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophrenia.

  2005cited by this paper
• Grey matter changes over time in high risk subjects developing schizophrenia

  2005cited by this paper
• Neurobiology of early psychosis

  2005cited by this paper
• Lateral and medial hypofrontality in first-episode schizophrenia: functional activity in a medication-naive state and effects of short-term atypical antipsychotic treatment.

  2005cited by this paper
• Imaging frontostriatal function in ultra-high-risk, early, and chronic schizophrenia during executive processing.

  2005influential reference
• Mapping brain maturation and cognitive development during adolescence.

  2005cited by this paper
• Hippocampal and anterior cingulate morphology in subjects at ultra-high-risk for psychosis: the role of family history of psychotic illness.

  2005cited by this paper
• Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosis.

  2005cited by this paper
• Neurodevelopment and Schizophrenia: Frontmatter

  2004cited by this paper
• Dynamic mapping of human cortical development during childhood through early adulthood.

  2004cited by this paper
• Structural Magnetic Resonance Imaging of the Adolescent Brain

  2004cited by this paper
• Cognitive development in adolescence: cerebral underpinnings, neural trajectories, and the impact of aberrations

  2004cited by this paper
• Cortical effects of quetiapine in first-episode schizophrenia: a preliminary functional magnetic resonance imaging study.

  2004cited by this paper
• The Emergence of Collaborative Brain Function: fMRI Studies of the Development of Response Inhibition

  2004cited by this paper
• Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia.

  2003influential reference
• Morphology of the anterior cingulate cortex in young men at ultra-high risk of developing a psychotic illness.

  2003cited by this paper
• Proton magnetic resonance spectroscopy in first episode psychosis and ultra high-risk individuals.

  2003cited by this paper
• The endophenotype concept in psychiatry: etymology and strategic intentions.

  2003influential reference
• Quantification of frontal and temporal lobe brain-imaging findings in schizophrenia: a meta-analysis.

  2003cited by this paper
• Phosphorus magnetic resonance spectroscopy: its utility in examining the membrane hypothesis of schizophrenia.

  2003cited by this paper
• Antisaccade performance of 1,273 men: effects of schizotypy, anxiety, and depression.

  2003cited by this paper
• Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison.

  2003cited by this paper
• Normative Data From the Cantab. I: Development of Executive Function Over the Lifespan

  2003cited by this paper
• Neurocognitive profiles of young people at high-risk versus first episode psychosis: A follow-up study

  2003cited by this paper
• Spatial working memory ability is a marker of risk-for-psychosis

  2003cited by this paper
• Sustained attention in young people at high risk for schizophrenia

  2002cited by this paper
• Biological phenotypes and genetic research on schizophrenia.

  2002cited by this paper
• Paracingulate morphologic differences in males with established schizophrenia: a magnetic resonance imaging morphometric study.

  2002cited by this paper
• Wisconsin Card Sorting deficits in the offspring of schizophrenics in the New York High-Risk Project.

  2002cited by this paper
• Implications of Lipid Biology for the Pathogenesis of Schizophrenia

  2002cited by this paper
• Non-reduction in hippocampal volume is associated with higher risk of psychosis.

  2002cited by this paper
• Neuroimaging studies of the hippocampus in schizophrenia

  2001cited by this paper
• Studies of brain and cognitive maturation through childhood and adolescence: a strategy for testing neurodevelopmental hypotheses.

  2001cited by this paper
• Impaired attention as an endophenotype for molecular genetic studies of schizophrenia.

  2001cited by this paper
• Hemispheric and gender-related differences in the gross morphology of the anterior cingulate/paracingulate cortex in normal volunteers: an MRI morphometric study.

  2001cited by this paper

• Alterations in Gray Matter Structure Linked to Frequency-Specific Cortico-Subcortical Connectivity in Schizophrenia via Multimodal Data Fusion

  2025cites this paper
• Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk

  2024cites this paper
• Internal Validation of the Latvian Version of 16‐Item Prodromal Questionnaire in A Help‐Seeking Adolescent Population: Psychometric Analysis and Associated Factors

  2024cites this paper
• Alterations in grey matter structure linked to frequency-specific cortico-subcortical connectivity in schizophrenia via multimodal data fusion

  2023cites this paper
• Perturbed iron biology in the prefrontal cortex of people with schizophrenia

  2023cites this paper
• Cross-modal associative memory impairment in schizophrenia.

  2023cites this paper
• Genetic variation in glutamatergic genes moderates the effects of childhood adversity on brain volume and IQ in treatment-resistant schizophrenia

  2023cites this paper
• How Functional Connectivity Measures Affect the Outcomes of Global Neuronal Network Characteristics in Patients with Schizophrenia Compared to Healthy Controls

  2023cites this paper
• Neurodevelopmental trajectories, polygenic risk, and lipometabolism in vulnerability and resilience to schizophrenia

  2023cites this paper
• Application of a Machine Learning Algorithm for Structural Brain Images in Chronic Schizophrenia to Earlier Clinical Stages of Psychosis and Autism Spectrum Disorder: A Multiprotocol Imaging Dataset Study

  2022cites this paper
• Cognitive trajectories following onset of psychosis: a meta-analysis

  2022cites this paper
• Neurobiologically Based Stratification of Recent-Onset Depression and Psychosis: Identification of Two Distinct Transdiagnostic Phenotypes

  2022cites this paper
• Stable habituation deficits in the early stage of psychosis: a 2-year follow-up study

  2021cites this paper
• Recognition of Electroencephalography-Related Features of Neuronal Network Organization in Patients With Schizophrenia Using the Generalized Choquet Integrals

  2021cites this paper
• Plasma neurofilament light chain protein is not increased in treatment-resistant schizophrenia and first-degree relatives

  2021cites this paper
• Cognitive behavioral markers of neurodevelopmental trajectories in rodents

  2021cites this paper
• Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis

  2021cites this paper
• A meta‐analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium

  2021cites this paper
• Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools

  2021cites this paper
• Relational Memory in the Early Stage of Psychosis: A 2-Year Follow-up Study.

  2020cites this paper
• Altered gamma and theta oscillations during multistable perception in schizophrenia.

  2020cites this paper
• A machine-learning framework for robust and reliable prediction of short- and long-term treatment response in initially antipsychotic-naïve schizophrenia patients based on multimodal neuropsychiatric data

  2020cites this paper
• Early or late gestational exposure to maternal immune activation alters neurodevelopmental trajectories in mice: an integrated neuroimaging, behavioural, and transcriptional study

  2020cites this paper
• White Matter Pathology in Schizophrenia

  2020cites this paper
• Differential effects of age at illness onset on verbal memory functions in antipsychotic-naïve schizophrenia patients aged 12–43 years

  2020cites this paper
• Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia

  2019cites this paper
• Neuroimaging and Staging

  2019cites this paper
• Assessment of Risk for Psychosis

  2019cites this paper
• Neurobiological approaches to the study of clinical and genetic high risk for developing psychosis.

  2019cites this paper
• Disrupted Habituation in the Early Stage of Psychosis.

  2019cites this paper
• Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study

  2018influential citation
• Brain morphologic changes in early stages of psychosis: Implications for clinical application and early intervention

  2018cites this paper
• The neural basis of psychotic-like experiences

  2018cites this paper
• Brain maturation throughout adolescence : an EEG study

  2018cites this paper
• Progressive Brain Changes in the Early Stage of Schizophrenia: A Combined Structural MRI and DTI Study

  2018cites this paper
• Novelty N2-P3a Complex and Theta Oscillations Reflect Improving Neural Coordination Within Frontal Brain Networks During Adolescence

  2018cites this paper
• Structural Brain Correlates of Neurological Soft Signs in Antipsychotic Naïve Individuals at Ultra High-Risk for Psychosis

  2017cites this paper
• The effect of neurobiological changes in the brain of children with schizophrenia, ultra high-risk for psychosis and epilepsy: clinical correlations with EEG and neuroimagistic abnormalities.

  2017cites this paper
• The neural diathesis‐stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities

  2017cites this paper
• White matter connectivity disruptions in early and chronic schizophrenia

  2017cites this paper
• Structural neuroimaging across early-stage psychosis: Aberrations in neurobiological trajectories and implications for the staging model

  2017cites this paper
• The varieties of psychosis in multiple sclerosis: A systematic review of cases.

  2017cites this paper
• A multi-modal assessment of brain alterations in young adults with psychotic experiences : results from the Avon Longitudinal Study of Parents and Children

  2017cites this paper
• Clinical staging models: From general medicine to mental disorders

  2017cites this paper
• Improved individualized prediction of schizophrenia in subjects at familial high risk, based on neuroanatomical data, schizotypal and neurocognitive features.

  2017cites this paper
• Deterioration of visuospatial associative memory following a first psychotic episode: a long-term follow-up study

  2017cites this paper
• Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward

  2017cites this paper
• Neural basis for inferring false beliefs and social emotions in others among individuals with schizophrenia and those at ultra-high risk for psychosis.

  2017cites this paper
• Deficits in social cognition in first episode psychosis: A review of the literature.

  2016cites this paper
• Progressive brain tissue loss in schizophrenia.

  2016cites this paper
• Neuroanatomical Predictors of Functional Outcome in Individuals at Ultra-High Risk for Psychosis

  2016cites this paper
• Maturation of the P3 and concurrent oscillatory processes during adolescence.

  2016cites this paper
• Hyperactivity of caudate, parahippocampal, and prefrontal regions during working memory in never-medicated persons at clinical high-risk for psychosis.

  2016influential citation
• On the notion of psychosis: semantic and epistemic concerns

  2016cites this paper
• Understanding the Etiology and Treatment Approaches of Schizophrenia: Theoretical Perspectives and Their Critique

  2016cites this paper
• Brain change trajectories that differentiate the major psychoses

  2016cites this paper
• The role of schizophrenia susceptibility genes in associative learning

  2016cites this paper
• Déficits neurocognitivos y en cognición social en pacientes esquizofrénicos con un nivel preservado de funcionamiento intelectual general

  2016cites this paper
• The impact of premorbid and current intellect in schizophrenia: cognitive, symptom, and functional outcomes

  2015cites this paper
• Cognitive intervention in early psychosis - preserving abilities versus remediating deficits

  2015cites this paper
• Developmental trajectory of cognitive impairment in bipolar disorder: comparison with schizophrenia.

  2015cites this paper
• Delayed Development of Brain Connectivity in Adolescents With Schizophrenia and Their Unaffected Siblings.

  2015cites this paper
• [Functional magnetic resonance imaging in subjects at high risk for schizophrenia: a review].

  2015cites this paper
• Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia.

  2015cites this paper
• Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study.

  2015cites this paper
• Meta-analysis of Cognitive Impairment in First-Episode Bipolar Disorder: Comparison With First-Episode Schizophrenia and Healthy Controls.

  2015cites this paper
• Variability of structurally constrained and unconstrained functional connectivity in schizophrenia

  2015cites this paper
• A double-blind randomized controlled trial of oxytocin nasal spray and social cognition training for young people with early psychosis.

  2015cites this paper
• Brain correlates of verbal fluency in subthreshold psychosis assessed by functional near-infrared spectroscopy.

  2015influential citation
• Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study

  2015cites this paper
• Reinforcement Learning Performance and Risk for Psychosis in Youth

  2015cites this paper
• An fMRI study of visual lexical decision in patients with schizophrenia and clinical high-risk individuals.

  2014cites this paper
• Social neuroscience in psychiatry: of obvious relevance

  2014cites this paper
• Social neuroscience in psychiatry: pathways to discovering neurobiological risk and resilience

  2014cites this paper
• Response initiation in young adults at risk for psychosis in the Northern Finland 1986 Birth Cohort

  2014cites this paper
• Recent Advances in Neuroimaging Biomarkers of Schizophrenia

  2014cites this paper
• Impaired Theory of Mind in Psychotic and Affective Disorders

  2014cites this paper
• Neurocognitive performance as an endophenotype for bipolar disorder.

  2014cites this paper
• Using longitudinal imaging to map the ‘relapse signature’ of schizophrenia and other psychoses

  2014cites this paper
• Accelerated brain aging in schizophrenia and beyond: a neuroanatomical marker of psychiatric disorders.

  2014cites this paper
• A developmental look at the attentional system in the at risk and first episode of psychosis: Age related changes in attention along the psychosis spectrum

  2013cites this paper
• N-Acetyl-Aspartate Level is Decreased in the Prefrontal Cortex in Subjects At-Risk for Schizophrenia

  2013cites this paper
• Autoantibodies and the Immune Hypothesis in Psychotic Brain Diseases: Challenges and Perspectives

  2013cites this paper
• Soft psychological and sociological factors in a hard psychiatric disorder: The mystery of schizophrenia

  2013cites this paper
• Effects of NRG1 and DAOA genetic variation on transition to psychosis in individuals at ultra-high risk for psychosis

  2013cites this paper
• On altered patterns of brain activation in at-risk adolescents and young adults.

  2013cites this paper
• Contributions of Experimental Psychiatry to Research on the Psychosis Prodrome

  2013cites this paper
• Vulnerability and Social Functioning in Schizophrenia

  2013cites this paper
• Theory of mind impairments in first-episode psychosis, individuals at ultra-high risk for psychosis and in first-degree relatives of schizophrenia: systematic review and meta-analysis.

  2013cites this paper
• Cognitive interventions targeting brain plasticity in the prodromal and early phases of schizophrenia.

  2013cites this paper
• Endophenotypes and biological markers of schizophrenia: from biological signs of illness to novel treatment targets.

  2013cites this paper
• Basic Disturbances of Information Processing in Psychosis Prediction

  2013cites this paper
• WITHDRAWN: Brain structural, neurochemical and neuroinflammatory markers of psychosis onset and relapse: Is there evidence for a psychosis relapse signature?

  2013cites this paper
• Auditory Verbal Hallucinations and Brain Dysconnectivity in the Perisylvian Language Network: A Multimodal Investigation

  2013cites this paper
• Progressive structural brain changes during development of psychosis.

  2012cites this paper
• Palliative models of care for later stages of mental disorder: maximizing recovery, maintaining hope, and building morale

  2012cites this paper
• Translational Neuroimaging for Drug Discovery and Development in Autism Spectrum Disorders: Guidance from Clinical Imaging and Preclinical Research

  2012cites this paper
• Prediction and prevention of psychosis in youth at clinical high risk.

  2012cites this paper
• Frontal delta power associated with negative symptoms in ultra-high risk individuals who transitioned to psychosis.

  2012cites this paper
• The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and Relatives

  2012cites this paper