NHE3: a Na+/H+ exchanger isoform of renal brush border.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  American Journal of Physiology

• Publication date

  1993-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPRENAL.1993.265.5.F736PMID 8238556
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanisms of regulation of the Na+/H+ exchanger

  2005cited by this paper
• Identification of the human NHE-1 form of Na(+)-H+ exchanger in rabbit renal brush border membranes.

  1993cited by this paper
• Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2).

  1993cited by this paper
• Glucocorticoid stimulation of ileal Na+ absorptive cell brush border Na+/H+ exchange and association with an increase in message for NHE-3, an epithelial Na+/H+ exchanger isoform.

  1993cited by this paper
• Assembly of distinctive coated pit and microvillar microdomains in the renal brush border.

  1992cited by this paper
• Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3).

  1992cited by this paper
• Immunocytochemical characterization of Na(+)-H+ exchanger isoform NHE-1 in rabbit kidney.

  1992influential reference
• Vasopressin regulates apical and basolateral Na(+)-H+ antiporters in mouse medullary thick ascending limbs.

  1992cited by this paper
• Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.

  1992cited by this paper
• Polarized distribution of Na+/H+ antiport and Na+/HCO3- cotransport in primary cultures of renal inner medullary collecting duct cells.

  1991cited by this paper
• Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger.

  1991cited by this paper
• cDNA cloning and immunolocalization of a Na(+)-H+ exchanger in LLC-PK1 renal epithelial cells.

  1991cited by this paper
• Cloning, sequence, and tissue distribution of a rabbit renal Na+/H+ exchanger transcript.

  1991cited by this paper
• Inner medullary collecting duct Na(+)-H+ exchanger.

  1991cited by this paper
• H+/base transport in principal cells characterized by confocal fluorescence imaging.

  1990cited by this paper
• New mammalian expression vectors

  1990cited by this paper
• Product review. New mammalian expression vectors.

  1990cited by this paper
• Video microscopy of intracellular pH in primary cultures of rabbit proximal and early distal tubules

  1990cited by this paper
• Apical and basolateral membrane H+ extrusion mechanisms in inner stripe of rabbit outer medullary collecting duct.

  1990cited by this paper
• Cell pH regulation in rabbit outer medullary collecting duct cells: mechanisms of HCO3(-)-independent processes.

  1990cited by this paper
• Mechanisms of intracellular pH regulation in the hamster inner medullary collecting duct perfused in vitro

  1990cited by this paper
• Na(+)-H+ antiporter and Na(+)-(HCO3-)n symporter regulate intracellular pH in mouse medullary thick limbs of Henle.

  1990cited by this paper
• Regulation of intracellular pH in the rabbit cortical collecting tubule.

  1990cited by this paper
• Regulation of rabbit medullary collecting duct cell pH by basolateral Na+/H+ and Cl-/base exchange.

  1989cited by this paper
• Basolateral membrane Na+/H+ antiport, Na+/base cotransport, and Na+-independent Cl-/base exchange in the rabbit S3 proximal tubule.

  1989cited by this paper
• Basolateral sodium-coupled acid-base transport mechanisms of the rabbit proximal tubule.

  1989cited by this paper
• Use of poly(vinylpyrrolidone) and poly(vinyl alcohol) for cryoultramicrotomy

  1989cited by this paper
• Membrane mechanisms in volume and pH regulation in vertebrate cells.

  1989cited by this paper
• Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation.

  1989cited by this paper
• Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.

  1989cited by this paper
• Apical and basolateral Na+/H+ exchange in the rabbit outer medullary thin descending limb of henle: Role in intracellular pH regulation

  1988cited by this paper
• Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

  1988cited by this paper
• Biosynthesis of electroplax sodium channels in Electrophorus electrocytes and Xenopus oocytes.

  1987cited by this paper
• Apical Na+/H+ antiporter and glycolysis-dependent H+-ATPase regulate intracellular pH in the rabbit S3 proximal tubule.

  1987cited by this paper
• Cell pH in the rat proximal convoluted tubule. Regulation by luminal and peritubular pH and sodium concentration.

  1986cited by this paper
• Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex.

  1986cited by this paper
• Application of cryoultramicrotomy to immunocytochemistry

  1986cited by this paper
• Intracellular pH in the isolated perfused rabbit proximal straight tubule.

  1985cited by this paper
• Sodium-dependent bicarbonate absorption by cortical thick ascending limb of rat kidney.

  1985cited by this paper
• Basolateral Na-H exchange in the rabbit cortical collecting tubule

  1985cited by this paper
• Intracellular pH regulation in the renal proximal tubule of the salamander. Na-H exchange

  1983cited by this paper
• Isolation of microgram quantities of proteins from polyacrylamide gels for amino acid sequence analysis.

  1983cited by this paper
• Proton pathways in rat renal brush-border and basolateral membranes.

  1983cited by this paper
• Asymmetric distribution of the Na+/H+ antiporter in the renal proximal tubule epithelial cell.

  1983cited by this paper
• CO2-stimulated NaCl absorption in the mouse renal cortical thick ascending limb of Henle. Evidence for synchronous Na +/H+ and Cl-/HCO3- exchange in apical plasma membranes

  1982cited by this paper
• Energy-dependence of phlorizin binding to isolated renal microvillus membranes

  1978cited by this paper
• Sodium/proton antiport in brush-border-membrane vesicles isolated from rat small intestine and kidney.

  1976cited by this paper
• The molecular weight of the major glycoprotein from the human erythrocyte membrane.

  1974cited by this paper
• PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY

  1974cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Cystinosin is involved in Na+/H+ Exchanger 3 trafficking in the proximal tubular cells: new insights in the renal Fanconi syndrome in cystinosis

  2025cites this paper
• Flow-dependent transport processes 2024: filtration, absorption, secretion.

  2025cites this paper
• Breaking Down Barriers: Epithelial Contributors to Monogenic IBD Pathogenesis.

  2024cites this paper
• Regulation of NHE3 subcellular localization in epididymal principal cells: pH, cyclic adenosine 3,5 monophosphate (cAMP), and adenosine signaling

  2024cites this paper
• Actin cytoskeleton and associated myosin motors within the renal epithelium.

  2024cites this paper
• Proton-driven sodium secretion in a saline water animal

  2024cites this paper
• Single nucleus RNA sequencing reveals cellular and molecular responses to vanadium exposure in duck kidneys.

  2024cites this paper
• Inherited Fanconi syndrome

  2023influential citation
• Insight into SLC9A3 deficiency-mediated micturition dysfunction caused by electrolyte imbalance.

  2023cites this paper
• Intracellular Angiotensin II Stimulation of Sodium Transporter Expression in Proximal Tubule Cells via AT1 (AT1a) Receptor-Mediated, MAP Kinases ERK1/2- and NF-кB-Dependent Signaling Pathways

  2023cites this paper
• Regulation of Na/H Exchanger Isoform 3 by Protein Kinase A in the Renal Proximal Tubule

  2023cites this paper
• A kidney proximal tubule model to evaluate effects of basement membrane stiffening on renal tubular epithelial cells.

  2022cites this paper
• Changes in Proximal Tubular Reabsorption Modulate Microvascular Regulation via the TGF System

  2022cites this paper
• The Na+/H+ Exchanger 3 in the Intestines and the Proximal Tubule of the Kidney: Localization, Physiological Function, and Key Roles in Angiotensin II-Induced Hypertension

  2022cites this paper
• The Remaining Conundrum of the Role of the Na+/H+ Exchanger Isoform 1 (NHE1) in Cardiac Physiology and Pathology: Can It Be Rectified?

  2022cites this paper
• NHE3 in the thick ascending limb is required for sustained but not acute furosemide-induced urinary acidification.

  2022cites this paper
• New Insights into the Critical Importance of Intratubular Na+/H+ Exchanger 3 and Its Potential Therapeutic Implications in Hypertension

  2021cites this paper
• "SLC-omics" of the kidney: Solute transporters along the nephron.

  2021cites this paper
• Postnatal Renal Maturation

  2021cites this paper
• The Na/K-ATPase Signaling and SGLT2 Inhibitor-Mediated Cardiorenal Protection: A Crossed Road?

  2021cites this paper
• A modular and reusable model of epithelial transport in the proximal convoluted tubule

  2021cites this paper
• The Na/K-ATPase Signaling Regulates Natriuresis in Renal Proximal Tubule

  2020cites this paper
• Identification of a Primary Renal AT2 Receptor Defect in Spontaneously Hypertensive Rats

  2020cites this paper
• pH gradient reversal fuels cancer progression.

  2020cites this paper
• Metabolic acidosis and hyperkalemia differentially regulate cation HCN3 channel in the rat nephron

  2020cites this paper
• Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase.

  2019cites this paper
• Effect of Bilastine on Diabetic Nephropathy in DBA2/J Mice

  2019cites this paper
• Application of physiological shear stress to renal tubular epithelial cells.

  2019cites this paper
• Proximal Tubule-Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice.

  2019cites this paper
• Learning Physiology From Inherited Kidney Disorders.

  2019cites this paper
• Contribution of NHE3 and dietary phosphate to lithium pharmacokinetics

  2019cites this paper
• NHE8 attenuates Ca 2 (cid:2) influx into NRK cells and the proximal tubule epithelium

  2019cites this paper
• Identification of loci of functional relevance to Barrett’s esophagus and esophageal adenocarcinoma: Cross-referencing of expression quantitative trait loci data from disease-relevant tissues with genetic association data

  2019cites this paper
• Structural and Functional Changes in the Na+/H+ Exchanger Isoform 1, Induced by Erk1/2 Phosphorylation

  2019cites this paper
• Defective Renal Angiotensin III and AT2 Receptor Signaling in Prehypertensive Spontaneously Hypertensive Rats

  2019cites this paper
• NHE8 attenuates calcium influx into NRK cells and the proximal tubule epithelium.

  2019cites this paper
• The potential role of myosin motor proteins in mediating the subcellular distribution of NHE3 in the renal proximal tubule.

  2019cites this paper
• Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension.

  2019cites this paper
• Genetic and genomic evidence for an important role of the Na+/H+ exchanger 3 in blood pressure regulation and angiotensin II-induced hypertension.

  2019cites this paper
• EGFR as a Negative Regulatory Protein Adjusts the Activity and Mobility of NHE3 in the Cell Membrane of IPEC-J2 Cells With TGEV Infection

  2018cites this paper
• Zebrafish as a Model System for Investigating the Compensatory Regulation of Ionic Balance during Metabolic Acidosis

  2018cites this paper
• Sodium Transporters Are Involved in Lithium Influx in Brain Endothelial Cells.

  2018cites this paper
• Light‐dependent expression of a Na+/H+ exchanger 3‐like transporter in the ctenidium of the giant clam, Tridacna squamosa, can be related to increased H+ excretion during light‐enhanced calcification

  2017cites this paper
• Relative contribution of clear cells and principal cells to luminal pH in the mouse epididymis

  2017cites this paper
• 14 Regulation of Na + / H + Exchanger Isoform 3 by Protein Kinase A in the Renal Proximal Tubule

  2017cites this paper
• RESEARCH ARTICLE Ion Channels and Transporters in Lung Function and Disease TGF- (cid:2) inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis, and transcriptional downregulation of megalin

  2017cites this paper
• Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress

  2017cites this paper
• Relative contribution of clear cells and principal cells to luminal pH in the mouse epididymis†

  2017cites this paper
• Effects of Nitric Oxide on Renal Proximal Tubular Na+ Transport

  2017cites this paper
• Cross talk between the Crumbs complex and Hippo signaling in renal epithelial cells

  2017cites this paper
• Insulin-like growth factor binding protein 7 and tissue inhibitor of metalloproteinases-2: differential expression and secretion in human kidney tubule cells.

  2017cites this paper
• Effects of cardiotonic steroids on isolated perfused kidney and NHE3 activity in renal proximal tubules.

  2017cites this paper
• Solute transport and oxygen consumption along the nephrons: effects of Na+ transport inhibitors.

  2016cites this paper
• Tumor metabolism, cancer cell transporters, and microenvironmental resistance

  2016cites this paper
• The Role of NHE8 in the Regulation of Renal Proximal Tubule Calcium Reabsorption by Shane Wiebe A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science Department of Physiology

  2016cites this paper
• AT2 Receptor Activation Prevents Sodium Retention and Reduces Blood Pressure in Angiotensin II-Dependent Hypertension.

  2016cites this paper
• Free-floating epithelial micro-tissue arrays: a low cost and versatile technique

  2016cites this paper
• acute injury-induced hypertension Responses of proximal tubule sodium transporters to

  2016cites this paper
• The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II.

  2016cites this paper
• The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases.

  2016cites this paper
• exchanger isoform NHE4 in rat thick ascending limbs + /H + Localization and functional characterization of Na

  2016cites this paper
• The Role of NHE8 in the Regulation of Renal Proximal Tubule Calcium Reabsorption

  2016cites this paper
• Angiotensin II counteracts the effects of cAMP/PKA on NHE3 activity and phosphorylation in proximal tubule cells.

  2016cites this paper
• Recent Updates on the Proximal Tubule Renin-Angiotensin System in Angiotensin II-Dependent Hypertension

  2016cites this paper
• A inibição da enzima dipeptidil peptidase IV melhora a função cardiorrenal de ratos com insuficiência cardíaca

  2015cites this paper
• Effect of acute acid-base disturbances on the phosphorylation of phospholipase C-γ1 and Erk1/2 in the renal proximal tubule

  2015influential citation
• Renal acid-base regulation: new insights from animal models

  2015cites this paper
• Renal tubular development

  2015cites this paper
• Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling.

  2015cites this paper
• Ischemic preconditioning inhibits expression of Na(+)/H(+) exchanger 1 (NHE1) in the gerbil hippocampal CA1 region after transient forebrain ischemia.

  2015cites this paper
• Efeito do peptídeo-1 semelhante ao glucagon endógeno sobre a atividade do NHE3 em túbulo proximal renal

  2015cites this paper
• The Na+/H+ Exchanger-3 (NHE3) Activity Requires Ezrin Binding to Phosphoinositide and Its Phosphorylation

  2015cites this paper
• Renal NHE expression and activity in neonatal NHE3- and NHE8-null mice.

  2015cites this paper
• Normal Kidney Function and Structure

  2014cites this paper
• Cardiotonic steroids in adaptation to dietary salt intake.

  2014cites this paper
• Modulation of angiotensin II-induced inflammatory cytokines by the Epac1-Rap1A-NHE3 pathway: implications in renal tubular pathobiology.

  2014cites this paper
• Regulación fisiológica del cotransportador sodio/bicarbonato cardíaco

  2014influential citation
• Molecular mechanisms and regulation of urinary acidification.

  2014cites this paper
• MODULATION OF ANGIOTENSIN II-INDUCED INFLAMMATORY 2 CYTOKINES BY EPAC 1-RAP 1 ANHE 3 PATHWAY : IMPLICATIONS 3 IN RENAL TUBULAR PATHOBIOLOGY

  2014cites this paper
• Novel mechanism of intra‑renal angiotensin II-induced sodium/proton exchanger 3 expression by losartan in spontaneously hypertensive rats.

  2014cites this paper
• AT2 Receptor Activation Induces Natriuresis and Lowers Blood Pressure

  2014cites this paper
• Neurohormonal interactions on the renal oxygen delivery and consumption in haemorrhagic shock‐induced acute kidney injury

  2013influential citation
• exchanger NHE3 in rat renal proximal tubule Dipeptidyl peptidase IV inhibition downregulates Na+-H+

  2013cites this paper
• Sodium-hydrogen exchangers (NHE) in human cardiovascular diseases: interfering strategies and their therapeutic applications.

  2013cites this paper
• Role of NHE1 in Nociception

  2013cites this paper
• Proximal tubular NHEs: sodium, protons and calcium?

  2013cites this paper
• Ezrin Is Required for the Functional Regulation of the Epithelial Sodium Proton Exchanger, NHE3

  2013cites this paper
• Sodium and Chloride Transport: Proximal Nephron

  2013cites this paper
• Proximal tubule specific knockout of the Na+/H+ exchanger NHE3: effects on bicarbonate absorption and ammonium excretion

  2013cites this paper
• Elevated carbon dioxide upregulates NBCn1 Na+/HCO3(-) cotransporter in human embryonic kidney cells.

  2013cites this paper
• Cellular Mechanisms of Renal Tubular Acidification

  2013cites this paper
• The regulation of NHE₁ and NHE₃ activity by angiotensin II is mediated by the activation of the angiotensin II type I receptor/phospholipase C/calcium/calmodulin pathway in distal nephron cells.

  2013cites this paper
• Postnatal Renal Development

  2013cites this paper
• Regulación Fisiológica del Cotransportador Sodio/Bicarbonato Cardíaco

  2013cites this paper
• The acid-base regulation by renal proximal tubule

  2013cites this paper
• Proximal nephron.

  2013cites this paper
• Acidic Conditions in the NHE2-/- Mouse Intestine Result in an Altered Mucosa-Associated Bacterial Population with Changes in Mucus Oligosaccharides

  2013cites this paper
• CALL FOR PAPERS Renal Acid-Base Physiology

  2012cites this paper
• Effects of renal denervation on the NKCC2 cotransporter in the thick ascending limb of the loop of Henle in rats with congestive heart failure

  2012cites this paper
• Increased NHE3 abundance and transport activity in renal proximal tubule of rats with heart failure.

  2012cites this paper