Cocaine stimulates the human cardiovascular system via a central mechanism of action.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Circulation

• Publication date

  1999-08-03

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.CIR.100.5.497PMID 10430763
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanisms of cutaneous vasoconstriction during upright posture.

  1997cited by this paper
• Effects of intranasal cocaine on sympathetic nerve discharge in humans.

  1997cited by this paper
• Cocaine-induced myocardial ischemia and infarction: pathophysiology, recognition, and management.

  1997influential reference
• Cocaine inhibits sympathetic neural activity by acting in the central nervous system and at the sympathetic ganglion.

  1996cited by this paper
• Central motor command activates sympathetic outflow to the cutaneous circulation in humans.

  1996cited by this paper
• The depletion of monoamines blocks the sympathoinhibitory response to cocaine.

  1996cited by this paper
• Effects of the intracoronary infusion of cocaine on coronary arterial dimensions and blood flow in humans.

  1996cited by this paper
• Involvement of monoamine uptake inhibition and local anesthesia in the cardiovascular response to cocaine in conscious rabbits.

  1995cited by this paper
• Effect of cocaine on vagal tone: a common factors approach.

  1995cited by this paper
• Sympathetic nervous system mediated cardiovascular effects of cocaine are primarily due to a peripheral site of action of the drug.

  1995cited by this paper
• Cholinergic Modulation of the Coronary Vasoconstriction Induced by Cocaine in Conscious Dogs

  1993cited by this paper
• Effects of Cocaine on Cardiac Vagal Tone Before and During Coronary Artery Occlusion: Cocaine Exacerbates the Autonomic Response to Myocardial Ischemia

  1993cited by this paper
• Attenuation of the cardiac effects of cocaine by dizocilpine.

  1993cited by this paper
• Cardiovascular responses to cocaine are initially mediated by the central nervous system in rats.

  1992cited by this paper
• Hemodynamic effects of intranasal cocaine in humans.

  1992cited by this paper
• The effects of acute and chronic cocaine use on the heart.

  1992cited by this paper
• Cocaine Depresses Cardiac Sympathetic Efferent Activity in Anesthetized Dogs

  1991cited by this paper
• Role of the central nervous system in hemodynamic and sympathoadrenal responses to cocaine in rats.

  1990cited by this paper
• Cocaine-induced coronary-artery vasoconstriction.

  1989cited by this paper
• Cardiovascular effects of desipramine in children.

  1989cited by this paper
• Cocaine inhibits muscarinic cholinergic receptors in heart and brain.

  1988cited by this paper
• The pathology and etiology of cocaine-induced heart disease.

  1988cited by this paper
• Acute myocardial infarction temporally related to cocaine use. Clinical, angiographic, and pathophysiologic observations.

  1987cited by this paper
• Acute cardiac events temporally related to cocaine abuse.

  1986influential reference
• Potentiation of the ganglionic blocking action of norepinephrine by cocaine.

  1982cited by this paper
• Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves.

  1979cited by this paper
• Cocaine use by the otolaryngologist: a survey.

  1977cited by this paper
• Acute systemic effects of cocaine in man: a controlled study by intranasal and intravenous routes.

  1977cited by this paper
• Cocaine use by the otolaryngologist: a survey.

  1977cited by this paper
• [Drug addiction and drug abuse].

  1969cited by this paper
• ACTIONS AND INTERACTIONS OF NOREPINEPHRINE, TYRAMINE AND COCAINE ON AORTIC STRIPS OF RABBIT AND LEFT ATRIA OF GUINEA PIG AND CAT.

  1963cited by this paper
• Effect of cocaine and related drugs on the uptake of noradrenaline by heart and spleen.

  1961cited by this paper
• Effect of Cocaine on the Disposition of Noradrenaline labelled with Tritium

  1960cited by this paper

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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
• Risk Factors for Thoracic Aortic Dissection

  2022cites this paper
• Impact of maternal substance use on offspring's cardiovascular health.

  2022cites this paper
• Early Onset Cardiovascular Disease from Cocaine, Amphetamines, Alcohol, and Marijuana.

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
• Natural Sympathomimetic Drugs: From Pharmacology to Toxicology

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• Outcomes in patients with history of cocaine use presenting with chest pain to the emergency department: Insights from the Nationwide Emergency Department Sample 2016–2018

  2022cites this paper
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  2021cites this paper
• Drug overdose and the risk of cardiovascular diseases: a nested case–control study

  2021cites this paper
• OpiTrack

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Cardiovascular Consequences of Addiction

  2020cites this paper
• Cocaine-Related Aortic Dissection: what do we know?

  2020cites this paper
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  2020cites this paper
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  2019cites this paper
• Diferencia entre los signos y síntomas del consumo y la abstinencia por Basuco y Cocaína: estudio piloto en Manizales, Colombia

  2019cites this paper
• Cerebrovascular and cardiovascular diseases caused by drugs of abuse

  2019cites this paper
• Comments to: Valsalva retinopathy associated with intranasal cocaine abuse: A case report

  2019cites this paper
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  2019cites this paper
• In-Hospital and Long-Term Outcomes of Beta-Blocker Treatment in Cocaine Users: A Systematic Review and Meta-analysis

  2019cites this paper
• Wearables technology for drug abuse detection: A survey of recent advancement

  2019cites this paper
• Drug Abuse-Induced Cardiac Arrhythmias: Mechanisms and Management

  2018cites this paper
• Cocaine ’ s Cardiovascular Pathophysiological Pathways cardiomyopathy cocaine stroke Pulmonary hypertension ?

  2017cites this paper
• Complications cardiovasculaires de la toxicomanie

  2017cites this paper
• A new mining method to detect real time substance use events from wearable biosensor data stream

  2017cites this paper
• Measuring and quantifying skin sympathetic nervous system activity in humans.

  2017cites this paper
• Cocaine Postmortem Distribution in Brain

  2017cites this paper
• Tubulointerstitial Injury and Drugs of Abuse.

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Effects of cocaine on the hypothalamic–pituitary–adrenal axis

  2014cites this paper
• Cocaine use disorders and acute myocardial infarction, excess length of hospital stay and overexpenditure.

  2014cites this paper
• Trastornos por cocaína e infarto agudo de miocardio, prolongación de estancias y exceso de costes hospitalarios

  2014cites this paper
• Cocaine use and risk of stroke: a systematic review.

  2014cites this paper
• Cocaine use and delayed myocardial ischaemia and/or infarction

  2014cites this paper
• Assessment of Tear Amount in Subjects Under the Effect of (Inhaled) Cocaine

  2013cites this paper
• Dexmedetomidine as a Novel Countermeasure for Cocaine-Induced Central Sympathoexcitation in Cocaine-Addicted Humans

  2013influential citation
• Electroacupuncture Reduces Cocaine-Induced Seizures and Mortality in Mice

  2013cites this paper
• Cocaine and Specific Cocaine Metabolites Induce von Willebrand Factor Release From Endothelial Cells in a Tissue-Specific Manner

  2013cites this paper
• Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish.

  2013influential citation
• The skinny on cocaine: Insights into eating behavior and body weight in cocaine-dependent men

  2013cites this paper
• Cocaine-Induced Vasoconstriction in the Human Coronary Microcirculation: New Evidence From Myocardial Contrast Echocardiography

  2013cites this paper
• Cocaine induces a reversible stomatocytosis of red blood cells and increases blood viscosity

  2013cites this paper
• Oxidative Stress and Drugs of Abuse: An Update

  2013cites this paper
• Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals.

  2013cites this paper
• Side effects of cocaine abuse: multiorgan toxicity and pathological consequences.

  2012cites this paper
• Priapism: Comorbid Factors and Treatment Outcomes in a Contemporary Series

  2012cites this paper
• Erratum to: Oxidative Stress Biomarkers in Some Rat Brain Structures and Peripheral Organs Underwent Cocaine

  2012cites this paper
• Cardiovascular effects of cocaine: cellular, ionic and molecular mechanisms.

  2012cites this paper
• Oxidative Stress Biomarkers in Some Rat Brain Structures and Peripheral Organs Underwent Cocaine

  2012cites this paper
• Electrocardiographic findings associated with cocaine use in humans: a systematic review

  2012cites this paper
• A Propósito de um Caso Clínico: Enfarte Agudo de Miocárdio Recidivante por Consumo de Cocaína

  2012cites this paper
• Effect of Acute Apelin Injection on Cardiac Muscle Performance in both Normal and Diabetic Rats

  2012cites this paper
• Cocaine and cardiovascular complications.

  2011cites this paper
• Hemodynamic and Arrhythmogenic Effects of Cocaine in Hypertensive Individuals

  2011cites this paper
• Dexmedetomidine Use in the Setting of Cocaine-Induced Hypertensive Emergency and Aortic Dissection: A Novel Indication

  2011cites this paper
• Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Part 12 : Cardiac Arrest in Special Situations : 2010 American Heart Association

  2011cites this paper
• Acupuncture attenuates exercise‐induced increases in skin sympathetic nerve activity

  2011cites this paper
• Aortic dissection and cocaine use.

  2011cites this paper
• Stimulating stuff: the pathological effects of cocaine and amphetamines on the cardiovascular system

  2010cites this paper
• Care Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Part 12: Cardiac Arrest in Special Situations: 2010 American Heart Association

  2010cites this paper
• Contemporary Reviews in Cardiovascular Medicine

  2010cites this paper