Tracking extranigral degeneration in animal models of Parkinson’s disease: quest for effective therapeutic strategies

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Neurochemistry

• Publication date

  2011-06-17

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1471-4159.2011.07320.xPMID 21615738PMCID PMC3135734
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evolution of Extra-Nigral Damage Predicts Behavioural Deficits in a Rat Proteasome Inhibitor Model of Parkinson's Disease

  2011cited by this paper
• Changes of gene expression profiles in the cervical spinal cord by acupuncture in an MPTP-intoxicated mouse model: microarray analysis.

  2011cited by this paper
• VMAT2-Deficient Mice Display Nigral and Extranigral Pathology and Motor and Nonmotor Symptoms of Parkinson's Disease

  2011cited by this paper
• Different sub-cellular localization of alpha-synuclein in the C57BL\6J mouse's central nervous system by two novel monoclonal antibodies.

  2011cited by this paper
• Spinal cord and parkinsonism: neuromorphological evidences in humans and experimental studies.

  2011cited by this paper
• Locus coeruleus and dorsal raphe neuron activity and response to acute antidepressant administration in a rat model of Parkinson's disease.

  2011cited by this paper
• Restoration of locomotive function in Parkinson’s disease by spinal cord stimulation: mechanistic approach

  2010cited by this paper
• Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice

  2010influential reference
• Selective noradrenergic vulnerability in α-synuclein transgenic mice.

  2010influential reference
• Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

  2010cited by this paper
• Deep Brain Stimulation of the Center Median–Parafascicular Complex of the Thalamus Has Efficient Anti-Parkinsonian Action Associated with Widespread Cellular Responses in the Basal Ganglia Network in a Rat Model of Parkinson's Disease

  2010cited by this paper
• Noradrenergic lesion of the locus coeruleus increases apomorphine-induced circling behavior and the firing activity of substantia nigra pars reticulata neurons in a rat model of Parkinson's disease.

  2010cited by this paper
• Noradrenergic lesion of the locus coeruleus increases the firing activity of the medial prefrontal cortex pyramidal neurons and the role of alpha2-adrenoceptors in normal and medial forebrain bundle lesioned rats.

  2010cited by this paper
• Overview of the extranigral aspects of Parkinson disease.

  2009influential reference
• α-synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice

  2009cited by this paper
• Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide.

  2009influential reference
• Parkin Deficiency Delays Motor Decline and Disease Manifestation in a Mouse Model of Synucleinopathy

  2009cited by this paper
• Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson's Disease

  2009cited by this paper
• Diagnosing premotor Parkinson's disease using a two-step approach combining olfactory testing and DAT SPECT imaging.

  2009cited by this paper
• Nonmotor Symptoms of Parkinson's Disease Revealed in an Animal Model with Reduced Monoamine Storage Capacity

  2009cited by this paper
• Immunolocalization of alpha-synuclein in the rat spinal cord by two novel monoclonal antibodies.

  2009cited by this paper
• Formation and development of Lewy pathology: a critical update

  2009influential reference
• Impact of surgery targeting the caudal intralaminar thalamic nuclei on the pathophysiological functioning of basal ganglia in a rat model of Parkinson's disease.

  2009cited by this paper
• Histaminergic Activity in a Rodent Model of Parkinson’s Disease

  2009cited by this paper
• Rotenone Induces Cell Death of Cholinergic Neurons in an Organotypic Co-Culture Brain Slice Model

  2009influential reference
• Parafascicular thalamic nucleus activity in a rat model of Parkinson's disease.

  2009cited by this paper
• Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria.

  2009influential reference
• Acupuncture inhibits ferric iron deposition and ferritin-heavy chain reduction in an MPTP-induced parkinsonism model.

  2009cited by this paper
• The clinical progression of Parkinson's disease.

  2009cited by this paper
• Firing activity of locus coeruleus noradrenergic neurons increases in a rodent model of Parkinsonism

  2009influential reference
• Non-motor extranigral signs and symptoms in Parkinson's disease.

  2009cited by this paper
• Behavioural effects of a selective NMDA NR1A/2B receptor antagonist in rats with unilateral 6-OHDA+parafascicular lesions.

  2009cited by this paper
• Progressive Dopaminergic Degeneration in the Chronic MPTPp Mouse Model of Parkinson’s Disease

  2009cited by this paper
• Parkinson disease: extranigral, multisystem, and {alpha}-synuclein "plus".

  2009cited by this paper
• Histaminergic activity in adult rats neonatally lesioned with neurotoxins: DSP-4, 5,7-DHT and 6-OHDA (rodent model of Parkinson’s disease)

  2009cited by this paper
• Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice.

  2009influential reference
• Recognition and management of Parkinson’s disease during the premotor (prodromal) phase

  2009cited by this paper
• Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson ’ s Disease

  2009influential reference
• Clinical measures of progression in Parkinson's disease

  2009cited by this paper
• [Olfactory dysfunction in Parkinson's disease: its role as a new cardinal sign in early and differential diagnosis].

  2008cited by this paper
• Animal models of Parkinson’s disease and L-dopa induced dyskinesia: How close are we to the clinic?

  2008cited by this paper
• Fos expression following activation of the ventral pallidum in normal rats and in a model of Parkinson’s Disease: implications for limbic system and basal ganglia interactions

  2008cited by this paper
• Pain as a nonmotor symptom of Parkinson disease: evidence from a case-control study.

  2008cited by this paper
• Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson’s disease patients

  2008cited by this paper
• Spinal cord degeneration in C57BL/6N mice following induction of experimental parkinsonism with MPTP

  2008influential reference
• Extranigral Neurodegeneration in Parkinson's Disease

  2008influential reference
• Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice.

  2008cited by this paper
• Effect of locus coeruleus denervation on levodopa-induced motor fluctuations in hemiparkinsonian rats

  2008cited by this paper
• New insights into the pathology of Parkinson’s disease: does the peripheral autonomic system become central?

  2008cited by this paper
• Calpain as a potential therapeutic target in Parkinson's disease.

  2008influential reference
• Controversies over the staging of α-synuclein pathology in Parkinson’s disease

  2008influential reference
• Animal models of Parkinson’s disease progression

  2008cited by this paper
• Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone‐induced parkinsonian rats

  2008cited by this paper
• Invited Article: Nervous system pathology in sporadic Parkinson disease

  2008cited by this paper
• Involvement of spinal motor neurons in parkin‐positive autosomal recessive juvenile parkinsonism

  2008influential reference
• Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra

  2008cited by this paper
• Basic Research on Dopamine in Parkinson’s Disease and the Discovery of the Nigrostriatal Dopamine Pathway: The View of an Eyewitness

  2008cited by this paper
• Excessive dopamine neuron loss in progressive supranuclear palsy

  2008cited by this paper
• Norepinephrine loss produces more profound motor deficits than MPTP treatment in mice

  2007cited by this paper
• Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model.

  2007cited by this paper
• Riechstörungen bei Morbus Parkinson

  2007cited by this paper
• Antioxidant responses and lipid peroxidation following intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats: increased susceptibility of olfactory bulb.

  2007cited by this paper
• Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice.

  2007cited by this paper
• A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.

  2007cited by this paper
• [Effects of electrical stimulation of the parafascicular nucleus on the neuronal activities of the subthalamic nucleus and the ventromedial nucleus in rats].

  2007cited by this paper
• Parkinson’s disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons

  2007influential reference
• The parkinsonian neurotoxin rotenone activates calpain and caspase-3 leading to motoneuron degeneration in spinal cord of Lewis rats.

  2007influential reference
• Dopamine lesion‐induced changes in subthalamic nucleus activity are not associated with alterations in firing rate or pattern in layer V neurons of the anterior cingulate cortex in anesthetized rats

  2007cited by this paper
• Calpain Activation in Apoptosis of Motoneurons in Cell Culture Models of Experimental Parkinsonism

  2006cited by this paper
• Metabolic activity of cerebellar and basal ganglia-thalamic neurons is reduced in parkinsonism.

  2006cited by this paper
• α-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice

  2006cited by this paper
• α‐Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects

  2006cited by this paper
• Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

  2006cited by this paper
• Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals.

  2006influential reference
• The parkinson's complex: Parkinsonism is just the tip of the iceberg

  2006cited by this paper
• Parkinson’s disease: a rethink of rodent models

  2006cited by this paper
• Parkinson's Disease α-Synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death

  2006cited by this paper
• MPTP Treatment Impairs Tyrosine Hydroxylase Immunopositive Fibers Not Only in the Striatum, but Also in the Amygdala

  2005cited by this paper
• Pattern of brain destruction in Parkinson's and Alzheimer's diseases

  2005cited by this paper
• Regional distributions of manganese, iron, copper, and zinc in the brains of 6-hydroxydopamine-induced parkinsonian rats

  2005cited by this paper
• Behavioural effects of parafascicular thalamic lesions in an animal model of parkinsonism.

  2005cited by this paper
• Alpha‐synuclein immunohistochemistry in two cases of co‐occurring idiopathic Parkinson's disease and motor neuron disease

  2005cited by this paper
• Transplantation of cultured sympathetic ganglionic neurons into Parkinsonian rat brain: Survival and function of graft

  2005cited by this paper
• Dysfunction of the cortico‐basal ganglia‐cortical loop in a rat model of early parkinsonism is reversed by metabotropic glutamate receptor 5 antagonism

  2005cited by this paper
• Mapping Dopamine Function in Primates Using Pharmacologic Magnetic Resonance Imaging

  2004cited by this paper
• Increased dopamine release in vivo by estradiol benzoate from the central amygdaloid nucleus of Parkinson's disease model rats

  2004cited by this paper
• Immunofluorescent labeling of increased calpain expression and neuronal death in the spinal cord of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice.

  2004cited by this paper
• Treatment with α2-adrenoceptor antagonist, 2-methoxy idazoxan, protects 6-hydroxydopamine-induced Parkinsonian symptoms in rats: neurochemical and behavioral evidence

  2004cited by this paper
• The ability of grafted human sympathetic neurons to synthesize and store dopamine: a potential mechanism for the clinical effect of sympathetic neuron autografts in patients with Parkinson's disease.

  2004cited by this paper
• Diagnostic staging of Parkinson’s disease: conceptual aspects

  2004cited by this paper
• Simple movement sequences better correlate to levodopa plasma levels than complex ones.

  2004influential reference
• Mechanism of Toxicity in Rotenone Models of Parkinson's Disease

  2003cited by this paper
• Neuropathology and Neurodegeneration in Rodent Brain Induced by Lentiviral Vectormediated Overexpression of α‐Synuclein

  2003cited by this paper
• Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

  2003cited by this paper
• Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases.

  2003cited by this paper
• Staging of brain pathology related to sporadic Parkinson's disease.

  2003cited by this paper
• Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6‐hydroxydopamine‐induced partial degeneration of substantia nigra in rats

  2003cited by this paper
• Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease

  2002cited by this paper
• Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.

  2002cited by this paper
• Calpain Upregulation and Neuron Death in Spinal Cord of MPTP‐Induced Parkinsonism in Mice

  2002cited by this paper

• Epigallocatechin-3-Gallate, Quercetin, and Kaempferol for Treatment of Parkinson’s Disease Through Prevention of Gut Dysbiosis and Attenuation of Multiple Molecular Mechanisms of Pathogenesis

  2025cites this paper
• Calpain Mediated Neurodegeneration in Parkinson’s disease

  2023cites this paper
• An Antioxidant Drug For The Treatment Of Pd Using Nanoemulsion

  2023cites this paper
• Changes in the number of macrophages, T-lymphocytes, activity of antioxidant enzymes in the brain, behavior and structure of the central nervous system neurons in adult and aging mice of different strains with the MPTP-induced model of parkinsonism

  2023cites this paper
• Therapeutic Viewpoint on Rat Models of Locomotion Abnormalities and Neurobiological Indicators in Parkinson's Disease.

  2023cites this paper
• Contributions and Limitations of Mitochondria-Targeted and Non-Targeted Antioxidants in the Treatment of Parkinsonism: an Updated Review

  2022cites this paper
• Mitochondrial targeting of potent nanoparticulated drugs in combating diseases

  2022cites this paper
• Mice deficient in GM1 manifest both motor and non-motor symptoms of Parkinson's disease; successful treatment with synthetic GM1 ganglioside.

  2020cites this paper
• Calpain mediated expansion of CD4+ cytotoxic T cells in rodent models of Parkinson's disease.

  2020cites this paper
• Sensory neuropathy and nociception in rodent models of Parkinson's disease

  2019cites this paper
• Effects of Melatonin on the Behavioral Indices and Structural Characteristics of Cerebral and Spinal Neurons of Rats with Experimental Hemiparkinsonism

  2018cites this paper
• The role of calpain in spinal cord degeneration in experimental Pаrkinson’s disease

  2018cites this paper
• Effects of Melatonin on the Behavioral Indices and Structural Characteristics of Cerebral and Spinal Neurons of Rats with Experimental Hemiparkinsonism

  2018cites this paper
• ExPPNing how acetylcholine improves gait in Parkinson's disease

  2017cites this paper
• Inhibition of Calpain Activation Protects MPTP-Induced Nigral and Spinal Cord Neurodegeneration, Reduces Inflammation, and Improves Gait Dynamics in Mice

  2015cites this paper
• Effect of neurotoxic lesion of pedunculopontine nucleus in nigral and striatal redox balance and motor performance in rats.

  2015cites this paper
• Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes.

  2014cites this paper
• Is Peripheral Neuropathy occurring in association with Idiopathic Parkinson's Disease, an iatrogenic complication?

  2014cites this paper
• SNJ‐1945, a calpain inhibitor, protects SH‐SY5Y cells against MPP+ and rotenone

  2014cites this paper
• Critical role of calpain in spinal cord degeneration in Parkinson's disease

  2013cites this paper
• The neurobiology of the spinal cord in experimental parkinsonism and Parkinson's disease.

  2013cites this paper
• Current development of acupuncture research in Parkinson's disease.

  2013cites this paper
• Regional, kinetic [(18)F]FDG PET imaging of a unilateral Parkinsonian animal model.

  2013cites this paper
• Aging, circadian rhythms and depressive disorders: a review.

  2013cites this paper
• Motor and non-motor features of Parkinson's disease - a review of clinical and experimental studies.

  2012cites this paper
• Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment.

  2012cites this paper
• Melatonin in Aging and Disease ―Multiple Consequences of Reduced Secretion, Options and Limits of Treatment

  2012cites this paper