Regulation and role of cyclin‐dependent kinase activity in neuronal survival and death

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Neurochemistry

• Publication date

  2010-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1471-4159.2010.07050.xPMID 21044075
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cyclin-Dependent Kinase

  2020cited by this paper
• c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice.

  2011cited by this paper
• Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration.

  2010cited by this paper
• Cyclin I-Cdk5 governs survival in post-mitotic cells.

  2010cited by this paper
• Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39.

  2010cited by this paper
• No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro

  2010cited by this paper
• Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer’s disease

  2010cited by this paper
• Cdk5 Suppresses the Neuronal Cell Cycle by Disrupting the E2F1–DP1 Complex

  2010cited by this paper
• The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death

  2010cited by this paper
• PKCδ regulates cortical radial migration by stabilizing the Cdk5 activator p35

  2009cited by this paper
• Essential Role of Cytoplasmic cdk5 and Prx2 in Multiple Ischemic Injury Models, In Vivo

  2009influential reference
• Phosphorylation of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death

  2009influential reference
• Recent advances in understanding the roles of Cdk5 in synaptic plasticity.

  2009cited by this paper
• Tumor Necrosis Factor-α Regulates Cyclin-dependent Kinase 5 Activity during Pain Signaling through Transcriptional Activation of p35*

  2009cited by this paper
• Commitment of 1-Methyl-4-phenylpyrinidinium Ion-induced Neuronal Cell Death by Proteasome-mediated Degradation of p35 Cyclin-dependent Kinase 5 Activator*

  2009cited by this paper
• Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimer's disease.

  2009cited by this paper
• Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells.

  2009cited by this paper
• Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

  2008cited by this paper
• Cyclin-Dependent Kinase 5 Supports Neuronal Survival through Phosphorylation of Bcl-2

  2008cited by this paper
• Cdk5 Phosphorylation of WAVE2 Regulates Oligodendrocyte Precursor Cell Migration through Nonreceptor Tyrosine Kinase Fyn

  2008cited by this paper
• Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity.

  2008cited by this paper
• Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline‐dependent kinase 5 complexes

  2008cited by this paper
• Aβ Oligomers Induce Neuronal Cell Cycle Events in Alzheimer's Disease

  2008cited by this paper
• Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing.

  2008cited by this paper
• Dopaminergic and Glutamatergic Signaling Crosstalk in Huntington's Disease Neurodegeneration: The Role of p25/Cyclin-Dependent Kinase 5

  2008influential reference
• Cooperative Roles of c-Abl and Cdk5 in Regulation of p53 in Response to Oxidative Stress*

  2008cited by this paper
• Cdk5 Is Involved in BDNF-Stimulated Dendritic Growth in Hippocampal Neurons

  2007cited by this paper
• Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis

  2007cited by this paper
• Abl deregulates Cdk5 kinase activity and subcellular localization in Drosophila neurodegeneration

  2007cited by this paper
• Collapsin response mediator protein‐2 hyperphosphorylation is an early event in Alzheimer’s disease progression

  2007cited by this paper
• Phosphorylation of Protein Phosphatase 1 by Cyclin-dependent Protein Kinase 5 during Nerve Growth Factor-induced PC12 Cell Differentiation*

  2007cited by this paper
• Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation

  2007cited by this paper
• Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism

  2007cited by this paper
• Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death

  2007cited by this paper
• A hippocampal Cdk5 pathway regulates extinction of contextual fear

  2007cited by this paper
• Activation of cyclin‐dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia

  2007cited by this paper
• Activation of cyclin‐dependent kinase 5 by calpains contributes to human immunodeficiency virus‐induced neurotoxicity

  2007cited by this paper
• Regulation of the interaction of Disabled‐1 with CIN85 by phosphorylation with Cyclin‐dependent kinase 5

  2007cited by this paper
• Molecular Pathways Regulating Cytoskeletal Organization and Morphological Changes in Migrating Neurons

  2007cited by this paper
• The roles of cyclin‐dependent kinase 5 in dendrite and synapse development

  2007cited by this paper
• Alternative roles for Cdk5 in learning and synaptic plasticity

  2007cited by this paper
• p25/Cyclin‐dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum‐stressed neurons

  2007cited by this paper
• Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.

  2007cited by this paper
• AKT and CDK5/p35 Mediate Brain-derived Neurotrophic Factor Induction of DARPP-32 in Medium Size Spiny Neurons in Vitro*

  2007cited by this paper
• Activity‐dependent control of bulk endocytosis by protein dephosphorylation in central nerve terminals

  2007cited by this paper
• Suppression of Calpain-dependent Cleavage of the CDK5 Activator p35 to p25 by Site-specific Phosphorylation*

  2007cited by this paper
• Cdk5–p39 is a labile complex with the similar substrate specificity to Cdk5–p35

  2007cited by this paper
• Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression.

  2006cited by this paper
• Enhanced activation of Ca2+/Calmodulin‐dependent protein kinase II upon downregulation of cyclin‐dependent kinase 5‐p35

  2006cited by this paper
• Calpain-Regulated p35/cdk5 Plays a Central Role in Dopaminergic Neuron Death through Modulation of the Transcription Factor Myocyte Enhancer Factor 2

  2006cited by this paper
• 1 Phosphorylation of Protein Phosphatase 1 ( PP 1 ) by Cyclin-dependent Protein Kinase 5 During Nerve Growth Factor-Induced PC 12 Cell Differentiation

  2006cited by this paper
• Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2

  2006cited by this paper
• Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival.

  2006cited by this paper
• Cyclin‐dependent kinase 5 influences Rohon‐Beard neuron survival in zebrafish

  2006cited by this paper
• Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist.

  2006influential reference
• Cyclin-dependent kinase 5 activity regulates pain signaling.

  2006cited by this paper
• Ubiquitin ligases: cell-cycle control and cancer

  2006cited by this paper
• p25/Cyclin-Dependent Kinase 5 Induces Production and Intraneuronal Accumulation of Amyloid β In Vivo

  2006cited by this paper
• Impairment of hippocampal long‐term depression and defective spatial learning and memory in p35–/– mice

  2005cited by this paper
• Differential Roles of Nuclear and Cytoplasmic Cyclin-Dependent Kinase 5 in Apoptotic and Excitotoxic Neuronal Death

  2005cited by this paper
• A Specific Interaction between Muskelin and the Cyclin-dependent Kinase 5 Activator p39 Promotes Peripheral Localization of Muskelin*

  2005cited by this paper
• p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death

  2005cited by this paper
• Phosphorylation of FTDP-17 Mutant tau by Cyclin-dependent Kinase 5 Complexed with p35, p25, or p39*

  2005cited by this paper
• Cyclin-Dependent Kinase 5 Mediates Neurotoxin-Induced Degradation of the Transcription Factor Myocyte Enhancer Factor 2

  2005cited by this paper
• Loss of Neuronal Cell Cycle Control in Ataxia-Telangiectasia: A Unified Disease Mechanism

  2005cited by this paper
• Control of cyclin‐dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability

  2005cited by this paper
• Interferon gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway.

  2005cited by this paper
• Activation of latent cyclin‐dependent kinase 5 (Cdk5)–p35 complexes by membrane dissociation

  2005cited by this paper
• Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium.

  2005cited by this paper
• Interferon γ Induces Neurite Outgrowth by Up-regulation of p35 Neuron-specific Cyclin-dependent Kinase 5 Activator via Activation of ERK1/2 Pathway*

  2005cited by this paper
• Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide.

  2004cited by this paper
• Phosphoproteomic Analysis of the Developing Mouse Brain*S

  2004cited by this paper
• Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity.

  2004cited by this paper
• Role of Cdk5 in Drug Abuse and Plasticity

  2004cited by this paper
• Induction of cyclin‐dependent kinase 5 and its activator p35 through the extracellular‐signal‐regulated kinase and protein kinase A pathways during retinoic‐acid mediated neuronal differentiation in human neuroblastoma SK‐N‐BE(2)C cells

  2004cited by this paper
• Cdk5: mediator of neuronal death and survival.

  2004cited by this paper
• Cdk5 deregulation in the pathogenesis of Alzheimer's disease.

  2004cited by this paper
• Cdk5/p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells.

  2003cited by this paper
• Tau Phosphorylation by Cyclin-dependent Kinase 5/p39 during Brain Development Reduces Its Affinity for Microtubules*

  2003cited by this paper
• The Structural Perspective on CDK5

  2003cited by this paper
• Cyclin-dependent Kinase-5 Is Involved in Neuregulin-dependent Activation of Phosphatidylinositol 3-Kinase and Akt Activity Mediating Neuronal Survival*

  2003cited by this paper
• The cyclin-dependent kinase 5 activator, p39, is expressed in stripes in the mouse cerebellum.

  2003cited by this paper
• The Structural Perspective on CDK 5

  2003cited by this paper
• Kinetic simulation of signal transduction system in hippocampal long-term potentiation with dynamic modeling of protein phosphatase 2A

  2003cited by this paper
• Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

  2003cited by this paper
• Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles.

  2003cited by this paper
• Fas engagement induces neurite growth through ERK activation and p35 upregulation

  2003cited by this paper
• The Regulation of Cyclin-Dependent Kinase 5 Activity through the Metabolism of p35 or p39 Cdk5 Activator

  2003cited by this paper
• Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis.

  2003influential reference
• Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

  2003cited by this paper
• Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles

  2003cited by this paper
• Developmental Regulation of the Proteolysis of the p35 Cyclin-Dependent Kinase 5 Activator by Phosphorylation

  2003cited by this paper
• Deregulation of cdk5, Hyperphosphorylation, and Cytoskeletal Pathology in the Niemann–Pick Type C Murine Model

  2002influential reference
• Cyclin‐dependent kinase 5 (cdk5) activation requires interaction with three domains of p35

  2002cited by this paper
• Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase Pathway*

  2002cited by this paper
• Aspirin provides cyclin‐dependent kinase 5‐dependent protection against subsequent hypoxia/reoxygenation damage in culture

  2002cited by this paper
• Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.

  2002influential reference
• Calpain-mediated Cleavage of the Cyclin-dependent Kinase-5 Activator p39 to p29*

  2002cited by this paper
• A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

  2002cited by this paper
• Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35.

  2002cited by this paper

• FMRP attenuates Tau pathology through the CDK5/p35 signaling pathway.

  2025cites this paper
• Mechanistic Roles of Transcriptional Cyclin-Dependent Kinases in Oncogenesis: Implications for Cancer Therapy

  2025cites this paper
• Roscovitine, a CDK Inhibitor, Reduced Neuronal Toxicity of mHTT by Targeting HTT Phosphorylation at S1181 and S1201 In Vitro

  2024cites this paper
• CDK5 Deficiency Does not Impair Neuronal Differentiation of Human Induced Pluripotent Stem Cells but Affects Neurite Outgrowth

  2024cites this paper
• Cyclin-dependent Kinase 5 and Neurodegenerative Diseases

  2024cites this paper
• Expression of APP, CDK5, and AKT1 Gene Related to Alzheimer Disease in Brain of Long-tailed Macaques

  2023cites this paper
• Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia

  2022cites this paper
• Serotonin-Mediated Activation of Serotonin Receptor Type 1 Oppositely Modulates Voltage-Gated Calcium Channel Currents in Rat Sensory Neurons Innervating Hindlimb Muscle

  2022cites this paper
• Cdk5-p25 as a key element linking amyloid and tau pathologies in Alzheimer's disease: Mechanisms and possible therapeutic interventions.

  2022cites this paper
• Inhibition of hyperactive cyclin dependent kinase 5/p25 is protective in the 6-hydroxydopamine model of Parkinson’s disease

  2022cites this paper
• Neuronal Cytoskeleton in Intellectual Disability: From Systems Biology and Modeling to Therapeutic Opportunities

  2021cites this paper
• Effects of Gαi2 and Gαz protein knockdown on alpha2A-adrenergic and cannabinoid CB1 receptor regulation of MEK-ERK and FADD pathways in mouse cerebral cortex

  2021cites this paper
• Microtubule disruption upon CNS damage triggers mitotic entry via TNF signaling activation.

  2021cites this paper
• RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation

  2020cites this paper
• α‐synuclein abnormalities trigger focal tau pathology, spreading to various brain areas in Parkinson disease

  2020cites this paper
• PARP Inhibition Suppresses GR–MYCN–CDK5–RB1–E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer

  2019cites this paper
• Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT1A receptor via phosphorylation.

  2019cites this paper
• CDK5: Key Regulator of Apoptosis and Cell Survival

  2019influential citation
• Cyclin-dependent kinase 5 acts as a promising biomarker in clear cell Renal Cell Carcinoma

  2019cites this paper
• CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis

  2019cites this paper
• p35 Hemizygous Deletion in 5xFAD Mice Increases Aβ Plaque Load in Males but Not in Females.

  2019cites this paper
• Amyloid-ß promotes neurotoxicity by Cdk5-induced p53 stabilization

  2018cites this paper
• The prognostic value of Cyclin-Dependent Kinase 5 and Protein Phosphatase 2A in Gastric Cancer

  2018cites this paper
• Multifaceted Regulation of ALDH1A1 by Cdk5 in Alzheimer’s Disease Pathogenesis

  2018cites this paper
• Exposure to mild blast forces induces neuropathological effects, neurophysiological deficits and biochemical changes

  2018cites this paper
• Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth

  2017cites this paper
• CDK5 in oncology: recent advances and future prospects.

  2017cites this paper
• Cdk5 is required for the neuroprotective effect of transforming growth factor-β1 against cerebral ischemia-reperfusion.

  2017cites this paper
• A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5

  2017cites this paper
• Characterization of the CDK5 gene in Apis cerana cerana (AccCDK5) and a preliminary identification of its activator gene, AccCDK5r1

  2017cites this paper
• Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer

  2017cites this paper
• The Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer's disease

  2017cites this paper
• p35 hemizygosity activates Akt but does not improve motor function in the YAC128 mouse model of Huntington's disease.

  2017cites this paper
• Changes in the expression level of MAPK pathway components induced by monosodium glutamate-administration produce neuronal death in the hippocampus from neonatal rats.

  2017cites this paper
• Functional Role of Cyclin-Dependent Kinase 5 in the Regulation of Melanogenesis and Epidermal Structure

  2017cites this paper
• Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain

  2017cites this paper
• Role and regulation of p27 in neuronal apoptosis

  2017cites this paper
• Combination of genetic variants in cyclin D1 and retinoblastoma genes predict clinical outcome in oral cancer patients

  2016cites this paper
• The Role of Cdk5 in Alzheimer’s Disease

  2016cites this paper
• Targeting protein kinases to manage or prevent Alzheimer’s disease

  2016cites this paper
• Cdk 5-FOXO 3 a Axis : Initially Neuroprotective , Eventually Neurodegenerative in Alzheimer ’ s Disease Models

  2016cites this paper
• Low Expression of CDK5 and p27 Are Associated with Poor Prognosis in Patients with Gastric Cancer

  2016cites this paper
• Cdk5–Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models

  2016cites this paper
• Inhibitory effects of imidazoline receptor ligands on basal and kainic acid-induced neurotoxic signalling in mice

  2016cites this paper
• Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants

  2016cites this paper
• Heat Shock Inhibition of CDK5 Increases NOXA Levels through miR-23a Repression*

  2015influential citation
• Recent trends in 1,2,3-Triazolo-nucleosides as promising anti-infective and anticancer agents.

  2015cites this paper
• Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination*

  2015cites this paper
• Herpes Simplex Virus 1 Upregulates p35, Alters CDK-5 Localization, and Stimulates CDK-5 Kinase Activity during Acute Infection in Neurons

  2015cites this paper
• Cyclin-Dependent Kinase 5 Decreases in Gastric Cancer and Its Nuclear Accumulation Suppresses Gastric Tumorigenesis

  2015cites this paper
• The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death

  2015cites this paper
• Retinoic acid increases glucocorticoid receptor phosphorylation via cyclin‐dependent kinase 5

  2015cites this paper
• Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

  2015cites this paper
• Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5

  2015cites this paper
• P2‐053: Olfactory deprivation hastens Alzheimer‐like pathologies in a human tau overexpressed mouse model via activation of cdk5

  2015cites this paper
• Regulation of Heat-Induced Apoptosis by Loss of miR-23a-Dependent Control of Noxa in Human Cells and its Suppression by HSP70

  2015influential citation
• Ubiquitin-independent degradation of p 35 1 Two degradation pathways of the p 35 Cdk 5 activation subunit , dependent and independent of ubiquitination

  2015cites this paper
• Novel Therapeutic Strategies in Lung Cancer

  2014cites this paper
• Cyclin-dependent kinase 5 phosphorylates and induces the degradation of ataxin-2.

  2014cites this paper
• Acetylation of cyclin-dependent kinase 5 is mediated by GCN5.

  2014cites this paper
• Interplay Between Viral and Cellular Factors Determines the Fate of Herpes Simplex Virus type I Infection

  2014cites this paper
• The effect of Cyclin‐dependent kinase 5 on voltage‐dependent calcium channels in PC12 cells varies according to channel type and cell differentiation state

  2014cites this paper
• New perspective on the dual functions of indirubins in cancer therapy and neuroprotection.

  2014cites this paper
• Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5

  2014cites this paper
• Involvement of collapsin response mediator protein 2 in posttraumatic sprouting in acquired epilepsy

  2014cites this paper
• LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes

  2014cites this paper
• Physiological and pathological phosphorylation of tau by Cdk5

  2014cites this paper
• Disparity among neural injury models and the unfolded protein response.

  2014cites this paper
• Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality

  2014cites this paper
• Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase.

  2014cites this paper
• Preferential targeting of p39-activated Cdk5 to Rac1-induced lamellipodia.

  2014cites this paper
• Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5*

  2014cites this paper
• Phosphorylation of Drebrin by Cyclin-Dependent Kinase 5 and Its Role in Neuronal Migration

  2014cites this paper
• Role of CDK5/cyclin complexes in ischemia-induced death and survival of renal tubular cells

  2014cites this paper
• Valproic acid downregulates Cdk5 activity via the transcription of the p35 mRNA.

  2014cites this paper
• Cdk5 activity in the brain – multiple paths of regulation

  2014cites this paper
• Disparity among Neural Injury Models and the Unfolded Protein Response

  2014cites this paper
• Isomerase Pin1 Stimulates Dephosphorylation of Tau Protein at Cyclin-dependent Kinase (Cdk5)-dependent Alzheimer Phosphorylation Sites*

  2013cites this paper
• Cyclin I is involved in the regulation of cell cycle progression

  2013cites this paper
• Structural Basis for the Different Stability and Activity between the Cdk5 Complexes with p35 and p39 Activators*

  2013cites this paper
• Phosphoregulation of the WAVE regulatory complex and signal integration.

  2013cites this paper
• Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

  2013cites this paper
• Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate.

  2013cites this paper
• Functional genomic screening identifies dual leucine zipper- bearing kinase as a therapeutic target in glaucoma

  2013cites this paper
• Role of cyclin-dependent kinase 5 in neurodegenerative disorders

  2013cites this paper
• Targeting the Cell Cycle for Cancer Treatment and Neuroprotection

  2013cites this paper
• Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B

  2013cites this paper
• Dab1‐mediated colocalization of multi‐adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons

  2013cites this paper
• Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice

  2013cites this paper
• Rac1 Selective Activation Improves Retina Ganglion Cell Survival and Regeneration

  2013cites this paper
• Identification and Functional Characterisation of CRK12:CYC9, a Novel Cyclin-Dependent Kinase (CDK)-Cyclin Complex in Trypanosoma brucei

  2013cites this paper
• Anticancer mechanism of apigenin and the implications of GLUT-1 expression in head and neck cancers.

  2013cites this paper
• Cdk5-induced neuronal cell death: The activation of the conventional Rb-E2F G1 pathway in post-mitotic neurons

  2012cites this paper
• The Effect of Noxa Serine-13 Phosphorylation on Hyperthermia-Induced Apoptosis

  2012cites this paper
• Kinase inhibitors for CNS diseases: an analysis of the recent patent literature.

  2012cites this paper
• Quantitative analysis of in vivo phosphorylation of Cyclin-dependent kinase activator p35 by Phos-tag SDS-PAGE/immunoblotting

  2012cites this paper
• Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

  2012cites this paper
• Evaluation of Cyclin-Dependent Kinase-Like 1 Expression in Breast Cancer Tissues and Its Regulation in Cancer Cell Growth

  2012cites this paper
• Involvement of Calpain/p35-p25/Cdk5/NMDAR Signaling Pathway in Glutamate-Induced Neurotoxicity in Cultured Rat Retinal Neurons

  2012cites this paper
• Crosstalk between cdk5 and MEK-ERK signalling upon opioid receptor stimulation leads to upregulation of activator p25 and MEK1 inhibition in rat brain.

  2012cites this paper