Legionella pneumophila multiplication is enhanced by chronic AMPK signalling in mitochondrially diseased Dictyostelium cells

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Disease Models & Mechanisms

• Publication date

  2009-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dmm.003319PMID 19638422
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Purinergic-mediated Ca2+ influx in Dictyostelium discoideum

  2008cited by this paper
• Enzymatic Properties of an Ecto-nucleoside Triphosphate Diphosphohydrolase from Legionella pneumophila

  2008cited by this paper
• Environmental predators as models for bacterial pathogenesis.

  2007cited by this paper
• The role of P2 receptors in controlling infections by intracellular pathogens

  2007cited by this paper
• Mitochondrial biology and disease in Dictyostelium.

  2007cited by this paper
• Human genetics of infectious diseases: a unified theory

  2007cited by this paper
• Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling.

  2007influential reference
• An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum

  2007cited by this paper
• A bacterial ecto‐triphosphate diphosphohydrolase similar to human CD39 is essential for intracellular multiplication of Legionella pneumophila

  2007cited by this paper
• Legionella pneumophila — a human pathogen that co-evolved with fresh water protozoa

  2007cited by this paper
• Function and Mechanism of Action of Dictyostelium Nramp1 (Slc11a1) in Bacterial Infection

  2006cited by this paper
• Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike Episodes (MELAS)

  2006cited by this paper
• Dictyostelium transcriptional host cell response upon infection with Legionella

  2006influential reference
• AMPK: a key sensor of fuel and energy status in skeletal muscle.

  2006influential reference
• Functional genomics in Dictyostelium: MidA, a new conserved protein, is required for mitochondrial function and development

  2006cited by this paper
• Differential requirements for actin polymerization, calmodulin, and Ca2+ define distinct stages of lysosome/phagosome targeting.

  2006influential reference
• Import-Associated Translational Inhibition: Novel In Vivo Evidence for Cotranslational Protein Import into Dictyostelium discoideum Mitochondria

  2006influential reference
• The P2X7 Receptor: A Key Player in IL-1 Processing and Release

  2006cited by this paper
• Legionella pneumophila Exploits PI(4)P to Anchor Secreted Effector Proteins to the Replicative Vacuole

  2006cited by this paper
• The P2X7 Receptor: A Key Player in IL-1 Processing and Release1

  2006cited by this paper
• Planktonic Replication Is Essential for Biofilm Formation by Legionella pneumophila in a Complex Medium under Static and Dynamic Flow Conditions

  2006influential reference
• 5′-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments

  2006cited by this paper
• Association of 3-methylglutaconic aciduria with sensori-neural deafness, encephalopathy, and Leigh-like syndrome (MEGDEL association) in four patients with a disorder of the oxidative phosphorylation.

  2006cited by this paper
• Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells.

  2006cited by this paper
• Amoebae as Training Grounds for Intracellular Bacterial Pathogens

  2005cited by this paper
• AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

  2005cited by this paper
• Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality.

  2005cited by this paper
• Dynamic properties of Legionella‐containing phagosomes in Dictyostelium amoebae

  2005cited by this paper
• Surgical and anesthetic management of patients with mitochondrial dysfunction.

  2004cited by this paper
• Chaperonin 60 and mitochondrial disease in Dictyostelium

  2004influential reference
• The necessity of mitochondrial genome DNA for normal development of Dictyostelium cells

  2004cited by this paper
• The AMP-activated protein kinase pathway – new players upstream and downstream

  2004cited by this paper
• Calnexin, calreticulin and cytoskeleton-associated proteins modulate uptake and growth of Legionella pneumophila in Dictyostelium discoideum.

  2004influential reference
• Inaugural Article: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

  2004cited by this paper
• Mitochondrial Disease: Mutations and Mechanisms

  2004cited by this paper
• Mitochondrial threshold effects.

  2003cited by this paper
• Pelvic lymphocyst infection associated with maternally inherited diabetes mellitus.

  2003cited by this paper
• Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum

  2003influential reference
• Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

  2003cited by this paper
• Signal sequence within FcγRIIA controls calcium wave propagation patterns: Apparent role in phagolysosome fusion

  2003influential reference
• Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

  2003cited by this paper
• The otolaryngological manifestations of mitochondrial disease and the risk of neurodegeneration with infection.

  2002cited by this paper
• Alarming atrioventricular block and mitral valve prolapse in the Kearns-Sayre syndrome.

  2002cited by this paper
• AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

  2002cited by this paper
• ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion.

  2002cited by this paper
• Various bacterial pathogens and symbionts infect the amoeba Dictyostelium discoideum.

  2002influential reference
• Phagosome maturation: aging gracefully.

  2002influential reference
• ATP Stimulates Human Macrophages to Kill Intracellular Virulent Mycobacterium tuberculosis Via Calcium-Dependent Phagosome-Lysosome Fusion1

  2001cited by this paper
• How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane.

  2001influential reference
• Role of AMP-activated protein kinase in mechanism of metformin action.

  2001cited by this paper
• Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis.

  2001cited by this paper
• Increased Adenosine Monophosphate–Activated Protein Kinase Activity in Rat Hearts With Pressure-Overload Hypertrophy

  2001cited by this paper
• AMP‐activated protein kinase: the energy charge hypothesis revisited

  2001cited by this paper
• Superoxide-induced massive apoptosis in cultured skin fibroblasts harboring the neurogenic ataxia retinitis pigmentosa (NARP) mutation in the ATPase-6 gene of the mitochondrial DNA.

  2001cited by this paper
• ATP-Mediated Killing of Intracellular Mycobacteria by Macrophages Is a P2X7-Dependent Process Inducing Bacterial Death by Phagosome-Lysosome Fusion1

  2001cited by this paper
• Clinical heterogeneity in mitochondrial DNA deletion disorders: a diagnostic challenge of Pearson syndrome.

  2000cited by this paper
• Dictyostelium discoideum: a new host model system for intracellular pathogens of the genus Legionella

  2000influential reference
• Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral.

  2000influential reference
• Intracellular Growth of Legionella pneumophila in Dictyostelium discoideum, a System for Genetic Analysis of Host-Pathogen Interactions

  2000influential reference
• Secretion of ATP‐utilizing enzymes, nucleoside diphosphate kinase and ATPase, by Mycobacterium bovis BCG: sequestration of ATP from macrophage P2Z receptors?

  1999cited by this paper
• Epidemic Legionnaires' disease two decades later: old sources, new diagnostic methods.

  1998cited by this paper
• Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake

  1998cited by this paper
• Green fluorescent protein as a noninvasive intracellular pH indicator.

  1998influential reference
• Mitochondrial mutations impair signal transduction in Dictyostelium discoideum slugs.

  1997influential reference
• The molecular ecology of legionellae.

  1996cited by this paper
• Primary pathogenic mtDNA mutations in multigeneration pedigrees with Leber hereditary optic neuropathy.

  1996cited by this paper
• Influence of site specifically altered Mip proteins on intracellular survival of Legionella pneumophila in eukaryotic cells

  1995cited by this paper
• Association of Legionella pneumophila with the macrophage endoplasmic reticulum

  1995cited by this paper
• Mutagenesis of Legionella pneumophila using Jn903 dllIacZ: identification of a growth‐phase‐regulated pigmentation gene

  1994cited by this paper
• The mitochondrial DNA mutation at 8993 associated with NARP slows the rate of ATP synthesis in isolated lymphoblast mitochondria.

  1993cited by this paper
• Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke‐like episodes (MELAS)

  1992cited by this paper
• Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.

  1988cited by this paper
• Legionella pneumophila inhibits acidification of its phagosome in human monocytes

  1984cited by this paper
• Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes

  1983influential reference
• The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes

  1983influential reference
• Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes.

  1980cited by this paper

• Disrupted host-microbiota crosstalk promotes nonalcoholic fatty liver disease progression by impaired mitophagy

  2025cites this paper
• The Multifaceted Interactions of Dictyostelium Atg1 with Mitochondrial Function, Endocytosis, Growth, and Development

  2024cites this paper
• Adenosine 5'-monophosphate-activated protein kinase (AMPK) negatively regulates the immunity and resistance to Vibrio alginolyticus of white shrimp, Penaeus vannamei.

  2023cites this paper
• Host cell sensing and restoration of mitochondrial function and metabolism within Helicobacter pylori VacA intoxicated cells

  2023cites this paper
• Legionella and mitochondria, an intriguing relationship.

  2023cites this paper
• From biosynthesis and beyond—Loss or overexpression of the cytokinin synthesis gene, iptA, alters cytokinesis and mitochondrial and amino acid metabolism in Dictyostelium discoideum

  2023cites this paper
• Cytopathological Outcomes of Knocking down Expression of Mitochondrial Complex II Subunits in Dictyostelium discoideum

  2022influential citation
• Dictyostelium discoideum: A Model System for Neurological Disorders

  2022cites this paper
• The Parkinson’s Disease-Associated Protein DJ-1 Protects Dictyostelium Cells from AMPK-Dependent Outcomes of Oxidative Stress

  2021cites this paper
• Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling

  2021cites this paper
• Interactions and Cytotoxicity of Human Neurodegeneration- Associated Proteins Tau and α-Synuclein in the Simple Model Dictyostelium discoideum

  2021cites this paper
• Metabolic evolutionary roots of the macrophage immune response in amoeba-bacteria interactions: The conserved role of hypoxia-induced Factor and AMP kinase.

  2021cites this paper
• Control of host mitochondria by bacterial pathogens.

  2021cites this paper
• Cytotoxicity and Mitochondrial Dysregulation Caused by α-Synuclein in Dictyostelium discoideum

  2020cites this paper
• The Dictyostelium model for mitochondrial biology and disease.

  2019cites this paper
• Calcineurin Silencing in Dictyostelium discoideum Leads to Cellular Alterations Affecting Mitochondria, Gene Expression, and Oxidative Stress Response.

  2018cites this paper
• Common Traits Spark the Mitophagy/Xenophagy Interplay

  2018cites this paper
• AMP-Activated Protein Kinase and Host Defense against Infection

  2018cites this paper
• The Parkinson's disease-associated protein DJ-1 plays a positive nonmitochondrial role in endocytosis in Dictyostelium cells

  2017cites this paper
• To Eat and to Be Eaten: Mutual Metabolic Adaptations of Immune Cells and Intracellular Bacterial Pathogens upon Infection

  2017cites this paper
• Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model

  2017cites this paper
• Functional characterization of iron transporters Nramp 1 and Nramp 2 from Dictyostelium discoideum : a model of cellular iron homeostasis

  2016cites this paper
• Microsporidia: Why Make Nucleotides if You Can Steal Them?

  2016cites this paper
• AMPK in Pathogens.

  2016cites this paper
• Chapter 12 AMPK in Pathogens

  2016cites this paper
• Heterophilic Cell Adhesion Molecule TgrC1 and its Binding Partners during Dictyostelium discoideum Development

  2014cites this paper
• Dictyostelium, a microbial model for brain disease.

  2014influential citation
• UNIVERSIDADE DE SÃO PAULO INSTITUTO DE QUÍMICA Programa de Pós-Graduação em Ciências Biológicas (Bioquímica)

  2014cites this paper
• Dictyostelium discoideum as a Model in Biomedical Research

  2013cites this paper
• Investigating the effect of emetic and aversive compounds on Dictyostelium identifies a novel non-sentient model for bitter tastant research

  2013cites this paper
• Dictyostelium host response to legionella infection: strategies and assays.

  2013cites this paper
• Iron metabolism and resistance to infection by invasive bacteria in the social amoeba Dictyostelium discoideum

  2013cites this paper
• From amoeba to macrophages: exploring the molecular mechanisms of Legionella pneumophila infection in both hosts.

  2013influential citation
• Legionella pneumophila Infection of Drosophila S2 Cells Induces Only Minor Changes in Mitochondrial Dynamics

  2013cites this paper
• Dictyostelids

  2013cites this paper
• Simple system--substantial share: the use of Dictyostelium in cell biology and molecular medicine.

  2013cites this paper
• Mitochondrial Gene Expression and Dysfunction in Model Protozoa

  2012cites this paper
• eview imple system – substantial share : The use of Dictyostelium in cell biology and olecular medicine nnette

  2012cites this paper
• European Journal of Cell Biology

  2012cites this paper
• Bio-electrospraying and aerodynamically assisted bio-jetting the model eukaryotic Dictyostelium discoideum: assessing stress and developmental competency post treatment

  2011cites this paper
• [Dictyostelium discoideum: a model for the study of bacterial virulence].

  2011cites this paper
• Pathogen-host interactions in Dictyostelium, Legionella, Mycobacterium and other pathogens.

  2011cites this paper
• Listeria infection modulates mitochondrial dynamics

  2011cites this paper
• The Professional Phagocyte Dictyostelium discoideum as a Model Host for Bacterial Pathogens

  2011cites this paper
• The Dictyostelium model for mitochondrial disease.

  2011cites this paper
• Heteroplasmic mitochondrial disease in Dictyostelium discoideum.

  2011influential citation
• Listeria monocytogenes transiently alters mitochondrial dynamics during infection

  2011cites this paper
• Investigating the Effect of Emetic Compounds on Chemotaxis in Dictyostelium Identifies a Non-Sentient Model for Bitter and Hot Tastant Research

  2011cites this paper
• Cytopathological Mechanisms in Mitochondrial Disease

  2010cites this paper
• Dictyostelium Finds New Roles to Model

  2010cites this paper
• Recent insights into host–pathogen interactions from Dictyostelium

  2010cites this paper
• Phosphoinositides differentially regulate bacterial uptake and Nramp1-induced resistance to Legionella infection in Dictyostelium

  2010cites this paper
• Autophagy in Dictyostelium: Genes and pathways, cell death and infection

  2010cites this paper
• European Journal of Cell Biology

  year unknowncites this paper