Ceruloplasmin in neurodegenerative diseases.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Brain research. Brain research reviews

• Publication date

  2005-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/J.BRAINRESREV.2005.03.003PMID 16269323
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evidence that human ceruloplasmin molecule consists of homologous parts.

  2009cited by this paper
• Glycosylphosphatidylinositol-anchored Ceruloplasmin Is Required for Iron Efflux from Cells in the Central Nervous System*

  2003cited by this paper
• Expression of a membrane‐bound form of the ferroxidase ceruloplasmin by leptomeningeal cells

  2003cited by this paper
• Aceruloplasminemia, an iron metabolic disorder

  2003cited by this paper
• The blue copper ceruloplasmin induces aggregation of newly differentiated neurons: a potential modulator of nervous system organization.

  2003cited by this paper
• Astrocytic ceruloplasmin expression, which is induced by IL‐1β and by traumatic brain injury, increases in the absence of the IL‐1 type 1 receptor

  2003cited by this paper
• Increased expression of ceruloplasmin in the retina following photic injury.

  2003cited by this paper
• Genetic defects in copper metabolism.

  2003cited by this paper
• Molecular and Cellular Iron Transport

  2002cited by this paper
• Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1).

  2002cited by this paper
• Astrocytic Deformity and Globular Structures Are Characteristic of the Brains of Patients with Aceruloplasminemia

  2002cited by this paper
• Regulation of Intestinal Iron Transport

  2002cited by this paper
• Purification and partial characterization of camel (Camelus Dromedarius) ceruloplasmin.

  2002cited by this paper
• The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption.

  2002cited by this paper
• A Key Structural Role for Active Site Type 3 Copper Ions in Human Ceruloplasmin*

  2002cited by this paper
• Ceruloplasmin metabolism and function.

  2002cited by this paper
• A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis

  2001cited by this paper
• Ceruloplasmin immunoreactivity in neurodegenerative disorders

  2001cited by this paper
• Copper Transport and Metabolism Are Normal in Aceruloplasminemic Mice*

  2001cited by this paper
• An Iron-Regulated Ferric Reductase Associated with the Absorption of Dietary Iron

  2001cited by this paper
• Copper, ceruloplasmin and superoxide dismutase (SOD1) in patients with Down's syndrome.

  2001cited by this paper
• Ceruloplasmin: Structure and function of an essential ferroxidase

  2000cited by this paper
• Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant.

  2000cited by this paper
• Iron homeostasis: insights from genetics and animal models

  2000cited by this paper
• A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism*

  2000cited by this paper
• Intracellular copper routing: the role of copper chaperones.

  2000cited by this paper
• Alternative RNA Splicing Generates a Glycosylphosphatidylinositol-anchored Form of Ceruloplasmin in Mammalian Brain*

  2000cited by this paper
• The physiopathological significance of ceruloplasmin. A possible therapeutic approach.

  2000cited by this paper
• A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.

  2000cited by this paper
• Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux.

  1999cited by this paper
• Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

  1999cited by this paper
• Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?

  1999cited by this paper
• Glutathione peroxidase‐like activity of caeruloplasmin as an important lung antioxidant

  1999cited by this paper
• The multifunctional oxidase activity of ceruloplasmin as revealed by anion binding studies.

  1999cited by this paper
• Glycosyl phosphatidylinositol-anchored ceruloplasmin is expressed by rat Sertoli cells and is concentrated in detergent-insoluble membrane fractions.

  1999cited by this paper
• Ceruloplasmin Ferroxidase Activity Stimulates Cellular Iron Uptake by a Trivalent Cation-specific Transport Mechanism*

  1999cited by this paper
• Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis.

  1998cited by this paper
• Copper transport.

  1998cited by this paper
• Role of ceruloplasmin in cellular iron uptake.

  1998cited by this paper
• Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders.

  1998cited by this paper
• Ran‐2, a glial lineage marker, is a GPI‐anchored form of ceruloplasmin

  1998cited by this paper
• Molecular properties of ceruloplasmin from different species

  1997cited by this paper
• Multi-Copper Oxidases

  1997cited by this paper
• Cloning and characterization of a mammalian proton-coupled metal-ion transporter

  1997cited by this paper
• hCTR1: a human gene for copper uptake identified by complementation in yeast.

  1997cited by this paper
• EARLY AND MORE RECENT HISTORY IN THE RESEARCH ON MULTI-COPPER OXIDASES

  1997cited by this paper
• Identification of the prooxidant site of human ceruloplasmin: a model for oxidative damage by copper bound to protein surfaces.

  1997cited by this paper
• A Novel Glycosylphosphatidylinositol-anchored Form of Ceruloplasmin Is Expressed by Mammalian Astrocytes*

  1997cited by this paper
• Copper depletion/repletion of human ceruloplasmin is followed by the changes in its spectral features and functional properties.

  1997cited by this paper
• Expression of the ceruloplasmin gene in the human retina and brain: implications for a pathogenic model in aceruloplasminemia.

  1996cited by this paper
• Genetic and molecular basis for copper toxicity.

  1996cited by this paper
• Ceruloplasmin Enhances Smooth Muscle Cell- and Endothelial Cell-mediated Low Density Lipoprotein Oxidation by a Superoxide-dependent Mechanism*

  1996cited by this paper
• Effect of ceruloplasmin on 6-hydroxydopamine oxidation.

  1996cited by this paper
• Hereditary ceruloplasmin deficiency with hemosiderosis

  1996cited by this paper
• Ceruloplasmin gene expression in the murine central nervous system.

  1996cited by this paper
• Lability of iron at the dinuclear centres of ferritin studied by competition with four chelators

  1996cited by this paper
• Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders.

  1996cited by this paper
• The X-ray structure of human serum ceruloplasmin at 3.1 Å: nature of the copper centres

  1996cited by this paper
• Evidence for the molten globule state of human apo-ceruloplasmin.

  1996cited by this paper
• Embryotoxicity of silver ions is diminished by ceruloplasmin—further evidence for its role in the transport of copper

  1995cited by this paper
• Modulation of the redox state of the copper sites of human ceruloplasmin by chloride

  1995cited by this paper
• Hereditary ceruloplasmin deficiency with hemosiderosis: A clinicopathological study of a japanese family

  1995cited by this paper
• Free Radical‐Generated Neurotoxicity of 6‐Hydroxydopamine

  1995cited by this paper
• Fine structure of the human ceruloplasmin gene.

  1995cited by this paper
• Aceruloplasminemia: molecular characterization of this disorder of iron metabolism.

  1995cited by this paper
• A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans

  1995cited by this paper
• Inhibition of the copper incorporation into ceruloplasmin leads to the deficiency in serum ceruloplasmin activity in Long-Evans cinnamon mutant rat.

  1993cited by this paper
• The transport of copper.

  1993cited by this paper
• Ceruloplasmin levels in the human superior temporal gyrus in aging and Alzheimer's disease.

  1993cited by this paper
• Mechanisms of copper incorporation during the biosynthesis of human ceruloplasmin.

  1991cited by this paper
• Primary structure of rat ceruloplasmin and analysis of tissue-specific gene expression during development.

  1990cited by this paper
• Inhibition of superoxide and ferritin-dependent lipid peroxidation by ceruloplasmin.

  1989cited by this paper
• Transcriptional regulation of ceruloplasmin gene expression during inflammation.

  1988cited by this paper
• Synthesis and localization of plasma proteins in the developing human brain. Integrity of the fetal blood-brain barrier to endogenous proteins of hepatic origin.

  1988cited by this paper
• Isolation and characterization of a processed gene for human ceruloplasmin.

  1987cited by this paper
• Familial apoceruloplasmin deficiency associated with blepharospasm and retinal degeneration

  1987cited by this paper
• Rat ceruloplasmin. Molecular cloning and gene expression in liver, choroid plexus, yolk sac, placenta, and testis.

  1987cited by this paper
• Regulation of aortic CuZn-superoxide dismutase with copper. Caeruloplasmin and albumin re-activate and transfer copper to the enzyme in culture.

  1987cited by this paper
• Complete cDNA sequence of human preceruloplasmin.

  1986cited by this paper
• Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin.

  1985cited by this paper
• Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule.

  1984cited by this paper
• Internal triplication in the structure of human ceruloplasmin.

  1983cited by this paper
• Circulating ceruloplasmin is an important source of copper for normal and malignant animal cells.

  1981cited by this paper
• Purification of rat ceruloplasmin. characterization and comparison with human ceruloplasmin.

  1980cited by this paper
• Oxygen free‐radicals and lipid peroxidation: inhibition by the protein caeruloplasmin

  1980cited by this paper
• Caeruloplasmin: a multi-functional metalloprotein of vertebrate plasma.

  1980cited by this paper
• Serum proteins--transferrin, ceruloplasmin, albumin, alpha 1-acid glycoprotein, alpha 1-antitrypsin--in rheumatic disorders.

  1979cited by this paper
• Protective role of ceruloplasmin in inflammation

  1979cited by this paper
• Ceruloplasmin. A scavenger of superoxide anion radicals.

  1979cited by this paper
• New trends in bio-inorganic chemistry

  1978cited by this paper
• Caeruloplasmin: A Plasma Protein, Enzyme, and Antioxidant

  1978cited by this paper
• Plasma ceruloplasmin. Evidence for its presence in and uptake by heart and other organs of the rat.

  1977cited by this paper
• Chemical evidence that proteolytic cleavage causes the heterogeneity present in human ceruloplasmin preparations.

  1977cited by this paper
• Reinvestigation of some physicochemical and chemical properties of human ceruloplasmin (ferroxidase).

  1976cited by this paper
• Biochemical studies on human ceruloplasmin.

  1976cited by this paper
• copper proteins systems containing the “Blue” copper center

  1975cited by this paper
• Evidence for ceruloplasmin as a copper transport protein.

  1975cited by this paper
• The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.

  1974cited by this paper
• Substrate specificity of caeruloplasmin. Phenylalkylamine substrates.

  1974cited by this paper
• The molecular structure of human ceruloplasmin: a proposed model.

  1973cited by this paper

• A conserved copper-binding site in multicopper oxidases regulates the metalation of CueO from Escherichia coli.

  2026cites this paper
• Integrated bulk and single-cell RNA sequencing analysis reveals cuproptosis-related proteins in Crohn's disease.

  2025cites this paper
• Impact of plant-derived antioxidants on heart aging: a mechanistic outlook

  2025cites this paper
• TDMQ20 as A Drug Candidate for Wilson’s Disease: Comparison with D-Penicillamine, Trientine, and Tetrathiomolybdate In Vitro and In Mice

  2025cites this paper
• Ferroptosis in Parkinson's disease -- the iron-related degenerative disease.

  2024cites this paper
• New orphan disease therapies from the proteome of industrial plasma processing waste- a treatment for aceruloplasminemia

  2024cites this paper
• Copper toxicity and deficiency: the vicious cycle at the core of protein aggregation in ALS

  2024cites this paper
• Blood Plasma Proteome: A Meta-Analysis of the Results of Protein Quantification in Human Blood by Targeted Mass Spectrometry

  2023cites this paper
• The expression of ceruloplasmin in astrocytes is essential for postnatal myelination and myelin maintenance in the adult brain.

  2023cites this paper
• Alzheimer’s Disease and Age-Related Changes in the Cu Isotopic Composition of Blood Plasma and Brain Tissues of the APPNL-G-F Murine Model Revealed by Multi-Collector ICP-Mass Spectrometry

  2023cites this paper
• Age-adjusted reference intervals for serum ceruloplasmin levels: Insights from a hospital data based study

  2023cites this paper
• Hematological Normality, Serum Biochemistry, and Acute Phase Proteins in Healthy Beef Calves in the Brazilian Savannah

  2023cites this paper
• Moonlighting enzymes: when cellular context defines specificity

  2023cites this paper
• Iron in Alzheimer’s Disease: From Physiology to Disease Disabilities

  2022cites this paper
• Ceruloplasmin Deficiency Impaired Brain Iron Metabolism and Behavior in Mice

  2022cites this paper
• Cord Blood Proteomic Biomarkers for Predicting Adverse Neurodevelopmental Outcomes in Monoamniotic Twins

  2022cites this paper
• Exosome proteomics study of the effects of traditional cigarettes and electronic cigarettes on human bronchial epithelial cells.

  2022cites this paper
• Quantification of Paramagnetic Ions in Human Brain Tissue Using EPR

  2022cites this paper
• The Relationships Among Metal Homeostasis, Mitochondria, and Locus Coeruleus in Psychiatric and Neurodegenerative Disorders: Potential Pathogenetic Mechanism and Therapeutic Implications

  2022cites this paper
• Cuproptosis regulator-mediated patterns associated with immune infiltration features and construction of cuproptosis-related signatures to guide immunotherapy

  2022cites this paper
• Serum ceruloplasmin as cancer marker in oral pre-cancers and cancers

  2021cites this paper
• Oxidized/deamidated-ceruloplasmin dysregulates choroid plexus epithelial cells functionality and barrier properties via RGD-recognizing integrin binding.

  2021cites this paper
• Thiols and ceruloplasmin levels in serum of children with attention deficit hyperactivity disorder: A cross-sectional study.

  2020cites this paper
• Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

  2020cites this paper
• Assessment of Ceruloplasmin, Hemopexin, and Haptoglobin in Asthmatic Children

  2020cites this paper
• Highly selective and sensitive detection of hydrogen sulfide in aqueous medium and live cells using peptide-based bioprobe to mimic the binding sites of the ceruloplasmin for Cu(II) ions.

  2020cites this paper
• CP Gene

  2020cites this paper
• Aceruloplasminemia

  2020cites this paper
• Therapeutic strategies in Wilson disease: pathophysiology and mode of action

  2020cites this paper
• Role of a Tyrosine Radical in Human Ceruloplasmin Catalysis

  2020cites this paper
• Looking for a partner: ceruloplasmin in protein–protein interactions

  2019cites this paper
• Copper imbalance in Alzheimer’s disease: Convergence of the chemistry and the clinic

  2019cites this paper
• Does Ceruloplasmin Defend Against Neurodegenerative Diseases?

  2019cites this paper
• Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

  2019cites this paper
• Brain Ceruloplasmin Expression After Experimental Intracerebral Hemorrhage and Protection Against Iron-Induced Brain Injury

  2018cites this paper
• The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint

  2018cites this paper
• Capacity of ceruloplasmin to scavenge products of the respiratory burst of neutrophils is not altered by the products of reactions catalyzed by myeloperoxidase.

  2018influential citation
• Characterization of a Drosophila model for Chorea‐Acanthocytosis

  2017cites this paper
• Iron uptake and transport

  2017cites this paper
• Interaction of silver nanoparticles with metallothionein and ceruloplasmin: impact on metal substitution by Ag(i), corona formation and enzymatic activity.

  2017cites this paper
• Characterization of a Drosophila model for Chorea‐Acanthocytosis

  2017cites this paper
• Effects of copper on viability and functional properties of hippocampal neurons in vitro.

  2017cites this paper
• Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function

  2017cites this paper
• Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases.

  2017cites this paper
• Alzheimer’s disease: How metal ions define β-amyloid function

  2017cites this paper
• Copper in Alzheimer’s Disease

  2017cites this paper
• Swayback Disease in Ruminants: A Review

  2016cites this paper
• The Role of Ceruloplasmin in Neurodegeneration in Parkinson’s Disease

  2016cites this paper
• The molecular mechanism for interaction of ceruloplasmin and myeloperoxidase

  2016cites this paper
• Advancing magnetic resonance imaging for the in vivo detection of iron in neurodegeneration

  2016cites this paper
• PS193. MicroRNAs as biomarkers for treatment-resistant depression

  2016cites this paper
• Iron Together with Lipid Downregulates Protein Levels of Ceruloplasmin in Macrophages Associated with Rapid Foam Cell Formation

  2016cites this paper
• Alzheimer's disease due to loss of function: A new synthesis of the available data.

  2016cites this paper
• Ceruloplasmin functional changes in Parkinson’s disease-cerebrospinal fluid

  2015cites this paper
• Cell apoptosis of caprine spleen induced by toxicity of cadmium with different levels of molybdenum.

  2015cites this paper
• Proteomic Analysis of Serum from Patients with Major Depressive Disorder to Compare Their Depressive and Remission Statuses

  2015cites this paper
• Elevated serum brain natriuretic peptide and matrix metalloproteinases 2 and 9 in Wilson’s disease

  2015cites this paper
• Copper mediated neurological disorder: visions into amyotrophic lateral sclerosis, Alzheimer and Menkes disease.

  2015cites this paper
• Increased levels of proteins of the acute inflammatory phase in the peritoneal fluid of women with advanced stages of endometriosis.

  2015cites this paper
• Renal impairment in different phenotypes of Wilson disease

  2015cites this paper
• Single-nucleotide polymorphisms and haplotypes of non-coding area in the CP gene are correlated with Parkinson’s disease

  2015cites this paper
• BRITISH BIOMEDICAL BULLETIN

  2015cites this paper
• Transplanted Neural Stem Cells: Playing a Neuroprotective Role by Ceruloplasmin in the Substantia Nigra of PD Model Rats?

  2015cites this paper
• Interaction of macrophage migration inhibitory factor with ceruloplasmin: role of labile copper ions

  2015cites this paper
• Differentially expressed plasma protein fractions in workers of dyeing unit at a textile industry and comparable controls

  2015cites this paper
• Automation of o-dianisidine assay for ceruloplasmin activity analyses: usefulness of investigation in Wilson’s disease and in hepatic encephalopathy

  2014cites this paper
• Lactoferrin, myeloperoxidase, and ceruloplasmin: complementary gearwheels cranking physiological and pathological processes

  2014cites this paper
• Protective effect of chitosan treatment against acetaminophen‐induced hepatotoxicity

  2014cites this paper
• New Perspectives on Oxidized Genome Damage and Repair Inhibition by Pro-Oxidant Metals in Neurological Diseases

  2014cites this paper
• Does ceruloplasmin differential express in the brain of Ts65Dn: a mouse mode of Down syndrome?

  2014cites this paper
• Ceruloplasmin has two nearly identical sites that bind myeloperoxidase.

  2014cites this paper
• [Ceruloplasmin, hephaestin and zyklopen: the three multicopper oxidases important for human iron metabolism].

  2014cites this paper
• Plasma Protein Profiling of Mild Cognitive Impairment and Alzheimer's Disease Across Two Independent Cohorts

  2014cites this paper
• Induction of ferroxidase enzymatic activity by copper reduces MPP+-evoked neurotoxicity in rats.

  2013cites this paper
• Metal Dysfunction in Alzheimer’s Disease

  2013cites this paper
• OXIDATIVE STRESS AND INFLAMMATION: "THE LESSER OF TWO EVILS" IN CARCINOGENESIS

  2013cites this paper
• Metal dyshomeostasis and oxidative stress in Alzheimer's disease.

  2013cites this paper
• High precision isotope measurements reveal poor control of copper metabolism in parkinsonism.

  2013cites this paper
• Trace Element, Antioxidant Activity, and Lipid Peroxidation Levels in Brain Cortex of Gerbils After Cerebral Ischemic Injury

  2013cites this paper
• Stressed Astrocytes: Insights on the Pathology of Alexander Disease

  2013cites this paper
• The effect of growth of Zajdela ascitic hepatoma on the extracellular antioxidant system of a tumor bearer

  2013cites this paper
• Longitudinal Analysis of Serum Copper and Ceruloplasmin in Alzheimer's Disease

  2013cites this paper
• EPR study of blood of anemic patients with urological cancer

  2013cites this paper
• Oxidation-induced Structural Changes of Ceruloplasmin Foster NGR Motif Deamidation That Promotes Integrin Binding and Signaling

  2013cites this paper
• Effects of Copper and/or Cholesterol Overload on Mitochondrial Function in a Rat Model of Incipient Neurodegeneration

  2013cites this paper
• Preliminary proteomic-based identification of a novel protein for Down's syndrome in maternal serum

  2012cites this paper
• Iron function and dysfunction in the brain: A pediatric neurologist's perspective

  2012cites this paper
• Transcranial sonography in Wilson's disease.

  2012cites this paper
• Physical activity is linked to ceruloplasmin in the striatum of intact but not MPTP-treated primates

  2012cites this paper
• Cytotoxic effects of copper overload on human-derived lung and liver cells in culture.

  2012influential citation
• Altered Biochemical Parameters in Saliva of Pediatric Attention Deficit Hyperactivity Disorder

  2012cites this paper
• Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation.

  2012influential citation
• PRION CHARACTERIZATION USING CELL BASED APPROACHES

  2012cites this paper
• Copper and oxidative stress in the pathogenesis of Alzheimer's disease.

  2012cites this paper
• Brain, blood, and iron: perspectives on the roles of erythrocytes and iron in neurodegeneration.

  2012cites this paper
• Ceruloplasmin and iron in Alzheimer’s disease and Parkinson’s disease: a synopsis of recent studies

  2012influential citation
• The activity of paraoxonase and arylesterase in patients with osteomyelitis

  2012cites this paper
• Neuropathology and iron: Central nervous system iron homeostasis

  2012cites this paper
• Protective role of macrophage-derived ceruloplasmin in inflammatory bowel disease

  2012cites this paper
• Bioinorganic chemistry of Alzheimer's disease.

  2012cites this paper