Xenobiotic metabolism and berry flavonoid transport across the blood-brain barrier.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Agricultural and Food Chemistry

• Publication date

  2010-02-03

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1021/jf903529mPMID 20128604
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stability of black raspberry anthocyanins in the digestive tract lumen and transport efficiency into gastric and small intestinal tissues in the rat.

  2009cited by this paper
• Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity.

  2009cited by this paper
• A study of the non-covalent interaction between flavonoids and DNA triplexes by electrospray ionization mass spectrometry

  2009cited by this paper
• Anthocyanin stability and recovery: implications for the analysis of clinical and experimental samples.

  2009cited by this paper
• Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption.

  2008cited by this paper
• The neuroprotective potential of flavonoids: a multiplicity of effects

  2008cited by this paper
• Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs.

  2008cited by this paper
• Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research

  2007cited by this paper
• The bioavailability of raspberry anthocyanins and ellagitannins in rats.

  2007cited by this paper
• Phenotypic Heterogeneity of the Endothelium: I. Structure, Function, and Mechanisms

  2007cited by this paper
• Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats

  2006cited by this paper
• Fate of anthocyanins and antioxidant capacity in contents of the gastrointestinal tract of weanling pigs following black raspberry consumption.

  2006cited by this paper
• Microarray profiling of gene expression in human adipocytes in response to anthocyanins.

  2006cited by this paper
• Development of analyses by high-performance liquid chromatography and liquid chromatography/tandem mass spectrometry of bilberry (Vaccinium myrtilus) anthocyanins in human plasma and urine.

  2006cited by this paper
• Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans

  2006cited by this paper
• Interaction of Antioxidant Flavonoids with tRNA: Intercalation or External Binding and Comparison with Flavonoid-DNA Adducts

  2006cited by this paper
• In vitro metabolism of anthocyanins by human gut microflora

  2005cited by this paper
• Anthocyanins exist in the circulation primarily as metabolites in adult men.

  2005cited by this paper
• Fast access of some grape pigments to the brain.

  2005cited by this paper
• Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain.

  2005cited by this paper
• Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora.

  2005cited by this paper
• Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory

  2005cited by this paper
• Flavonoid permeability across an in situ model of the blood-brain barrier.

  2004cited by this paper
• Flavonoids: antioxidants or signalling molecules?

  2004cited by this paper
• Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system.

  2004cited by this paper
• Evidence for an active transport of morphine‐6‐β‐d‐glucuronide but not P‐glycoprotein‐mediated at the blood–brain barrier

  2003cited by this paper
• Flavonoids and MAP kinase signalling

  2002cited by this paper
• Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry.

  2002cited by this paper
• Enzymatic synthesis of [3'-O-methyl-(3)H]malvidin-3-glucoside from petunidin-3-glucoside.

  2002cited by this paper
• Drug and gene targeting to the brain with molecular trojan horses

  2002cited by this paper
• Human metabolic pathways of dietary flavonoids and cinnamates.

  2000cited by this paper
• Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties

  1998cited by this paper
• The Chemistry and Biological Effects of Flavonoids and Phenolic Acids a

  1998cited by this paper
• Solid-State 13C NMR investigation into insoluble deposits adhering to the inner glass surface of bottled red wine

  1994cited by this paper
• Spectroscopic investigation of the equilibria of the ionic forms of sinapic acid

  1989cited by this paper
• Affinity of Proanthocyanidins and Their Oxidation Products for Haze-forming Proteins of Beer and the Formation of Chill Haze

  1984cited by this paper
• Properties of catechol O-methyltransferases from brain and liver of rat and human.

  1975cited by this paper

• Burdock Tea Affects Pulmonary Microbiota and Physiology Through Short-Chain Fatty Acids in Wistar Rats

  2025cites this paper
• Zebrafish as an Integrative Model for Central Nervous System Research: Current Advances and Translational Perspectives

  2025cites this paper
• Effects of Blueberry Supplementation on Depression and Anxiety Symptoms in a Rural Louisiana Population

  2025cites this paper
• Addressing Mental Health in Rural Settings: A Narrative Review of Blueberry Supplementation as a Natural Intervention

  2024cites this paper
• Investigation of Novel Aronia Bioactive Fraction-Alginic Acid Nanocomplex on the Enhanced Modulation of Neuroinflammation and Inhibition of Aβ Aggregation

  2024cites this paper
• A critical appraisal of geroprotective activities of flavonoids in terms of their bio-accessibility and polypharmacology.

  2024cites this paper
• Association of dietary flavonoid intake with the prevalence and all-cause mortality of depressive symptoms: Findings from analysis of NHANES.

  2024cites this paper
• Blueberries in focus: Exploring the phytochemical potentials and therapeutic applications

  2024cites this paper
• Recent advances on cyanidin-3-O-glucoside in preventing obesity-related metabolic disorders: A comprehensive review.

  2024cites this paper
• Effects of Anthocyanins on Cognition and Vascular Function: A Systematic Review.

  2024cites this paper
• Bioavailability of Anthocyanins: Whole Foods versus Extracts

  2024cites this paper
• Antosiyaninlerin Yapısı, Hücrede Biyosentezi, Etkinlikleri ve Kullanım Alanları

  2023cites this paper
• Dietary flavonoids may have a protective and therapeutic effect in Parkinson disease: A systematic review.

  2023cites this paper
• Anthocyanins: Molecular Aspects on Their Neuroprotective Activity

  2023cites this paper
• Anthocyanins as Immunomodulatory Dietary Supplements: A Nutraceutical Perspective and Micro-/Nano-Strategies for Enhanced Bioavailability

  2023cites this paper
• Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders

  2023cites this paper
• Effects of anthocyanin supplementation in diet on glycemic and related cardiovascular biomarkers in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

  2023cites this paper
• Exploration of the Protective Effects of Aronia Melanocarpa Extract in an in vitro Model of Parkinson’s Disease

  2023cites this paper
• Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson’s Disease

  2023cites this paper
• Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants.

  2023cites this paper
• Protective effects of polyphenol-rich extracts against neurotoxicity elicited by paraquat or rotenone in cellular models of Parkinson’s disease

  2023cites this paper
• Phytonutrients: Sources, bioavailability, interaction with gut microbiota, and their impacts on human health

  2022cites this paper
• Neuroinflammation: The Role of Anthocyanins as Neuroprotectants

  2022cites this paper
• Redox Properties, Bioactivity and Health Effects of Indicaxanthin, a Bioavailable Phytochemical from Opuntia ficus indica, L.: A Critical Review of Accumulated Evidence and Perspectives

  2022cites this paper
• Central Neuropathic Pain Development Modulation Using Coffee Extract Major Polyphenolic Compounds in Spinal-Cord-Injured Female Mice

  2022cites this paper
• Dietary Flavonoids and Adult Neurogenesis: Potential Implications for Brain Aging

  2022cites this paper
• The beneficial effects of traditional Chinese medicine on antioxidative status and inflammatory cytokines expression in the liver of piglets

  2022cites this paper
• Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids

  2022cites this paper
• Effects of anthocyanin-rich supplementation on cognition of the cognitively healthy middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials.

  2022cites this paper
• From Foods to Chemotherapeutics: The Antioxidant Potential of Dietary Phytochemicals

  2022cites this paper
• Polar phenol detection in rat brain: Development and validation of a versatile UHPLC-MS method and application on the brain tissues of Corinthian currant (Vitis vinifera L.,var. Apyrena) fed rats.

  2022cites this paper
• Cyanidin-3-O-glucoside, cyanidin, and oxidation products of cyanidin protect neuronal function through alleviating inflammation and oxidative damage.

  2022cites this paper
• Interaction between polyphenols and amyloids: from the view of prevention of protein misfolding disorders related diseases

  2022cites this paper
• Naturally Occurring Antioxidant Therapy in Alzheimer’s Disease

  2022cites this paper
• Current knowledge of anthocyanin metabolism in the digestive tract: absorption, distribution, degradation, and interconversion

  2022cites this paper
• Plinia trunciflora Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats

  2022cites this paper
• Cyanidin 3-O-β-Galactoside Alleviated Cognitive Impairment in Mice by Regulating Brain Energy Metabolism During Aging.

  2022cites this paper
• Effect of Blueberry Anthocyanin-Rich Extracts on Peripheral and Hippocampal Antioxidant Defensiveness: The Analysis of the Serum Fatty Acid Species and Gut Microbiota Profile.

  2021cites this paper
• Anthocyanins, Microbiome and Health Benefits in Aging

  2021cites this paper
• Chondroprotective effects of purple corn anthocyanins on advanced glycation end products induction through suppression of NF-κB and MAPK signaling

  2021cites this paper
• Investigating the acute effect of pomegranate extract on indicators of cognitive function in human volunteers

  2021cites this paper
• The Promise of Nutrient-Derived Bioactive Compounds and Dietary Components to Ameliorate Symptoms of Chemotherapy-Related Cognitive Impairment in Breast Cancer Survivors

  2021cites this paper
• Protective effects of anthocyanins on neurodegenerative diseases

  2021cites this paper
• Polyphenol-Peptide Interactions in Mitigation of Alzheimer’s Disease: Role of Biosurface-Induced Aggregation

  2021cites this paper
• Beneficial Effects of Anthocyanins on Nervous System

  2021cites this paper
• Dietary flavonoids and brain health in aging

  2021cites this paper
• Low Molecular Weight (poly)Phenol Metabolites Across the Blood-Brain Barrier: The Underexplored Journey

  2020cites this paper
• Flavonoids as a Natural Enhancer of Neuroplasticity—An Overview of the Mechanism of Neurorestorative Action

  2020cites this paper
• Hampering Essential Tremor Neurodegeneration in Essential Tremor: Present and Future Directions

  2020cites this paper
• Nutrients and Nutraceuticals for Active & Healthy Ageing

  2020cites this paper
• Fruit Quality Characterization of New Sweet Cherry Cultivars as a Good Source of Bioactive Phenolic Compounds with Antioxidant and Neuroprotective Potential

  2020cites this paper
• The blood-cerebrospinal fluid barrier is selective for red cabbage anthocyanins and their metabolites.

  2020cites this paper
• Assessment of the In Vivo Antioxidant Activity of an Anthocyanin-Rich Bilberry Extract Using the Caenorhabditis elegans Model

  2020cites this paper
• Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics

  2020cites this paper
• Protective effects of anthocyanins against brain ischemic damage

  2020cites this paper
• Beneficial Effects of Dark Chocolate for Episodic Memory in Healthy Young Adults: A Parallel-Groups Acute Intervention with a White Chocolate Control

  2020cites this paper
• Cyanidin-3-glucoside activates Nrf2-antioxidant response element and protects against glutamate-induced oxidative and endoplasmic reticulum stress in HT22 hippocampal neuronal cells

  2020cites this paper
• Low molecular weight metabolites from polyphenols as effectors for attenuating neuroinflammation.

  2020cites this paper
• A critical review on grape polyphenols for neuroprotection: Strategies to enhance bioefficacy

  2020cites this paper
• Nutraceuticals as Cognitive Enhancers

  2020cites this paper
• Chokeberry anthocyanins and their metabolites ability to cross the blood-cerebrospinal fluid barrier.

  2020cites this paper
• Functional Foods and Dietary Patterns for Prevention of Cognitive Decline in Aging

  2020cites this paper
• Potential health benefits of (poly)phenols derived from fruit and 100% fruit juice.

  2019cites this paper
• Recent Research on the Health Benefits of Blueberries and Their Anthocyanins

  2019cites this paper
• Cyanidin-3-O-glucoside protects against cadmium-induced dysfunction of sex hormone secretion via the regulation of hypothalamus-pituitary-gonadal axis in male pubertal mice.

  2019cites this paper
• Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review.

  2019cites this paper
• nAChR: nicotinic acetylcholine receptor ACh: acetylcholine pLGIC: pentameric ligand-gated ion channel Neo: neoflavonoid 5,7-dihydroxy-4-phenylcoumarin TMD: transmembrane domain ECD: extracellular domain Gen: genistein Que: quercetin 5-HI: 5-hydroxyindole PNU-120596: N-(5-Chloro-2,4-dimethoxyphenyl)-

  2019cites this paper
• Berry Supplementation and Their Beneficial Effects on Some Central Nervous System Disorders

  2019cites this paper
• Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

  2019cites this paper
• NF-κB-Mediated Neuroinflammation in Parkinson’s Disease and Potential Therapeutic Effect of Polyphenols

  2019cites this paper
• Dietary Anthocyanins and Stroke: A Review of Pharmacokinetic and Pharmacodynamic Studies

  2019influential citation
• Flavonoids as Modulators of Synaptic Plasticity: Implications for the Development of Novel Therapeutic Strategies for Healthy Lifestyle

  2019cites this paper
• Anthocyanins and Their C6-C3-C6 Metabolites in Humans and Animals

  2019cites this paper
• Flavonoids as positive allosteric modulators of α7 nicotinic receptors.

  2019cites this paper
• Purple sweet potato color protects against high-fat diet-induced cognitive deficits through AMPK-mediated autophagy in mouse hippocampus.

  2019cites this paper
• Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice

  2019cites this paper
• Anthocyanins and Their Metabolites as Therapeutic Agents for Neurodegenerative Disease

  2019cites this paper
• Anthocyanin Tissue Bioavailability in Animals: Possible Implications for Human Health. A Systematic Review.

  2018cites this paper
• Brain Distribution and Modulation of Neuronal Excitability by Indicaxanthin From Opuntia Ficus Indica Administered at Nutritionally-Relevant Amounts

  2018cites this paper
• Inhibition of PP2A by hesperetin may contribute to Akt and ERK1/2 activation status in cortical neurons.

  2018cites this paper
• Antioxidant action of grape seed polyphenols and aerobic exercise in improving neuronal number in the hippocampus is associated with decrease in lipid peroxidation and hydrogen peroxide in adult and middle‐aged rats

  2018cites this paper
• Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings

  2018cites this paper
• Cognitive effects of anodal transcranial direct current stimulation and high-dose cocoa flavonoids on an acutely sleep-deprived, highly educated population: a proposed single-center, phase II, randomized, placebo-controlled, double-blind, factorial study

  2018cites this paper
• Inhibition of PP 2 A by hesperetin contributes to Akt and ERK 1 / 2 activation in primary cortical neurons

  2018cites this paper
• Effect of Fruit Anthocyanin Consumption on Cognition, Blood Pressure and Other Health Parameters in Older Adults

  2018cites this paper
• Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation.

  2017cites this paper
• Biochemical Properties and Neuroprotective Effects of Compounds in Various Species of Berries

  2017cites this paper
• Enhancing Human Cognition with Cocoa Flavonoids

  2017cites this paper
• Anthocyanins in metabolic health and disease

  2017cites this paper
• Dietary Phytochemicals in Neurodegenerative Disease

  2017cites this paper
• Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms.

  2017cites this paper
• Polyphenols Beyond Barriers: A Glimpse into the Brain

  2017cites this paper
• Sweet Potato Anthocyanins

  2017cites this paper
• Flavonoid Metabolites in Human Urine during Blueberry Anthocyanin Intake.

  2017cites this paper
• Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.

  2017cites this paper
• Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat.

  2017cites this paper
• Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment.

  2017cites this paper
• Are Polyphenols Strong Dietary Agents Against Neurotoxicity and Neurodegeneration?

  2016cites this paper
• Recommendations for Development of Botanical Polyphenols as “Natural Drugs” for Promotion of Resilience Against Stress-Induced Depression and Cognitive Impairment

  2016cites this paper
• Anthocyanins Protect SK-N-SH Cells Against Acrolein-Induced Toxicity by Preserving the Cellular Redox State

  2016cites this paper